Lymphedema development and lymphatic function following lymph node excision in sheep.
Identifieur interne : 002B99 ( PubMed/Checkpoint ); précédent : 002B98; suivant : 002C00Lymphedema development and lymphatic function following lymph node excision in sheep.
Auteurs : Dalia Tobbia [Canada] ; John Semple ; Amy Baker ; Dan Dumont ; Adam Semple ; Miles JohnstonSource :
- Journal of vascular research [ 1423-0135 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Femelle, Immunohistochimie, Lymphadénectomie, Lymphangiogenèse (physiologie), Lymphoedème (anatomopathologie), Lymphoedème (imagerie diagnostique), Lymphoedème (physiopathologie), Lymphographie, Membre pelvien, Modèles animaux de maladie humaine, Modèles biologiques, Mâle, Ovis, Radio-isotopes de l'iode, Récupération fonctionnelle (physiologie), Sérumalbumine (pharmacocinétique), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (imagerie diagnostique), Vaisseaux lymphatiques (physiopathologie).
- MESH :
- anatomopathologie : Lymphoedème, Vaisseaux lymphatiques.
- imagerie diagnostique : Lymphoedème, Vaisseaux lymphatiques.
- pharmacocinétique : Sérumalbumine.
- physiologie : Lymphangiogenèse, Récupération fonctionnelle.
- physiopathologie : Lymphoedème, Vaisseaux lymphatiques.
- Animaux, Femelle, Immunohistochimie, Lymphadénectomie, Lymphographie, Membre pelvien, Modèles animaux de maladie humaine, Modèles biologiques, Mâle, Ovis, Radio-isotopes de l'iode.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Female, Hindlimb, Immunohistochemistry, Iodine Radioisotopes, Lymph Node Excision, Lymphangiogenesis (physiology), Lymphatic Vessels (diagnostic imaging), Lymphatic Vessels (pathology), Lymphatic Vessels (physiopathology), Lymphedema (diagnostic imaging), Lymphedema (pathology), Lymphedema (physiopathology), Lymphography, Male, Models, Biological, Recovery of Function (physiology), Serum Albumin (pharmacokinetics), Sheep.
- MESH :
- chemical , pharmacokinetics : Serum Albumin.
- chemical : Iodine Radioisotopes.
- diagnostic imaging : Lymphatic Vessels, Lymphedema.
- pathology : Lymphatic Vessels, Lymphedema.
- physiology : Lymphangiogenesis, Recovery of Function.
- physiopathology : Lymphatic Vessels, Lymphedema.
- Animals, Disease Models, Animal, Female, Hindlimb, Immunohistochemistry, Lymph Node Excision, Lymphography, Male, Models, Biological, Sheep.
Abstract
Our objective was to develop an animal model of postsurgical lymphedema that would permit quantitation of edema and lymphatic function after the removal of a single popliteal lymph node in sheep.
DOI: 10.1159/000194273
PubMed: 19155634
Affiliations:
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pubmed:19155634Le document en format XML
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Baker</name></author><author><name sortKey="Dumont, Dan" sort="Dumont, Dan" uniqKey="Dumont D" first="Dan" last="Dumont">Dan Dumont</name></author><author><name sortKey="Semple, Adam" sort="Semple, Adam" uniqKey="Semple A" first="Adam" last="Semple">Adam Semple</name></author><author><name sortKey="Johnston, Miles" sort="Johnston, Miles" uniqKey="Johnston M" first="Miles" last="Johnston">Miles Johnston</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19155634</idno><idno type="pmid">19155634</idno><idno type="doi">10.1159/000194273</idno><idno type="wicri:Area/PubMed/Corpus">003002</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003002</idno><idno type="wicri:Area/PubMed/Curation">003002</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003002</idno><idno type="wicri:Area/PubMed/Checkpoint">003002</idno><idno 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Semple</name></author><author><name sortKey="Baker, Amy" sort="Baker, Amy" uniqKey="Baker A" first="Amy" last="Baker">Amy Baker</name></author><author><name sortKey="Dumont, Dan" sort="Dumont, Dan" uniqKey="Dumont D" first="Dan" last="Dumont">Dan Dumont</name></author><author><name sortKey="Semple, Adam" sort="Semple, Adam" uniqKey="Semple A" first="Adam" last="Semple">Adam Semple</name></author><author><name sortKey="Johnston, Miles" sort="Johnston, Miles" uniqKey="Johnston M" first="Miles" last="Johnston">Miles Johnston</name></author></analytic><series><title level="j">Journal of vascular research</title><idno type="eISSN">1423-0135</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Hindlimb</term><term>Immunohistochemistry</term><term>Iodine Radioisotopes</term><term>Lymph Node Excision</term><term>Lymphangiogenesis (physiology)</term><term>Lymphatic Vessels (diagnostic imaging)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphatic Vessels (physiopathology)</term><term>Lymphedema (diagnostic imaging)</term><term>Lymphedema (pathology)</term><term>Lymphedema (physiopathology)</term><term>Lymphography</term><term>Male</term><term>Models, Biological</term><term>Recovery of Function (physiology)</term><term>Serum Albumin (pharmacokinetics)</term><term>Sheep</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Immunohistochimie</term><term>Lymphadénectomie</term><term>Lymphangiogenèse (physiologie)</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (imagerie diagnostique)</term><term>Lymphoedème (physiopathologie)</term><term>Lymphographie</term><term>Membre pelvien</term><term>Modèles animaux de maladie humaine</term><term>Modèles biologiques</term><term>Mâle</term><term>Ovis</term><term>Radio-isotopes de l'iode</term><term>Récupération fonctionnelle (physiologie)</term><term>Sérumalbumine (pharmacocinétique)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (imagerie diagnostique)</term><term>Vaisseaux lymphatiques (physiopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Serum Albumin</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Iodine Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Lymphoedème</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Sérumalbumine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphangiogenèse</term><term>Récupération fonctionnelle</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphangiogenesis</term><term>Recovery of Function</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Hindlimb</term><term>Immunohistochemistry</term><term>Lymph Node Excision</term><term>Lymphography</term><term>Male</term><term>Models, Biological</term><term>Sheep</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Immunohistochimie</term><term>Lymphadénectomie</term><term>Lymphographie</term><term>Membre pelvien</term><term>Modèles animaux de maladie humaine</term><term>Modèles biologiques</term><term>Mâle</term><term>Ovis</term><term>Radio-isotopes de l'iode</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our objective was to develop an animal model of postsurgical lymphedema that would permit quantitation of edema and lymphatic function after the removal of a single popliteal lymph node in sheep.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19155634</PMID><DateCreated><Year>2009</Year><Month>08</Month><Day>17</Day></DateCreated><DateCompleted><Year>2009</Year><Month>09</Month><Day>11</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1423-0135</ISSN><JournalIssue CitedMedium="Internet"><Volume>46</Volume><Issue>5</Issue><PubDate><Year>2009</Year></PubDate></JournalIssue><Title>Journal of vascular research</Title><ISOAbbreviation>J. Vasc. Res.</ISOAbbreviation></Journal><ArticleTitle>Lymphedema development and lymphatic function following lymph node excision in sheep.</ArticleTitle><Pagination><MedlinePgn>426-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1159/000194273</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Our objective was to develop an animal model of postsurgical lymphedema that would permit quantitation of edema and lymphatic function after the removal of a single popliteal lymph node in sheep.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">As a measure of lymph transport, (125)I-human serum albumin was injected into prenodal vessels at 8, 12 and 16 weeks after nodal excision, and plasma levels of the protein tracer were used to calculate the transport rate of the tracer to blood (percent injected per hour). Edema was quantified from the circumferential measurement of the hind limbs.</AbstractText><AbstractText Label="RESULTS AND CONCLUSIONS" NlmCategory="CONCLUSIONS">Following nodal excision, the limbs became progressively more edematous up to 3 days after nodectomy. After this, the swelling decreased but had not resolved even at 16 weeks after surgery. Compared with control limbs (17.2 +/- 0.6; n = 7), lymphatic function was depressed at 8 weeks after surgery (10.6 +/- 1.5; n = 7). At 12 (14.4 +/- 1.0; n = 7) and 16 weeks (13.9 +/- 1.0; n = 6), regeneration of lymphatic vessels at the excision site helped to restore about 80% of lymphatic capacity. These techniques may be helpful in understanding the pathophysiology associated with cancer-related postsurgical lymphedema and may facilitate the development of new strategies to treat or prevent this condition.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tobbia</LastName><ForeName>Dalia</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Surgery, Women's College Hospital, University of Toronto, Ont., Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Semple</LastName><ForeName>John</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Baker</LastName><ForeName>Amy</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Dumont</LastName><ForeName>Dan</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Semple</LastName><ForeName>Adam</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Johnston</LastName><ForeName>Miles</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>01</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>J Vasc Res</MedlineTA><NlmUniqueID>9206092</NlmUniqueID><ISSNLinking>1018-1172</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007457">Iodine Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012709">Serum Albumin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006614" MajorTopicYN="N">Hindlimb</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007457" MajorTopicYN="N">Iodine Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="Y">Lymph Node Excision</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042583" MajorTopicYN="N">Lymphangiogenesis</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008220" MajorTopicYN="N">Lymphography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020127" MajorTopicYN="N">Recovery of Function</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012709" MajorTopicYN="N">Serum Albumin</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012756" MajorTopicYN="N">Sheep</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2008</Year><Month>04</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2008</Year><Month>09</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>1</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>1</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19155634</ArticleId><ArticleId IdType="pii">000194273</ArticleId><ArticleId IdType="doi">10.1159/000194273</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Baker, Amy" sort="Baker, Amy" uniqKey="Baker A" first="Amy" last="Baker">Amy Baker</name><name sortKey="Dumont, Dan" sort="Dumont, Dan" uniqKey="Dumont D" first="Dan" last="Dumont">Dan Dumont</name><name sortKey="Johnston, Miles" sort="Johnston, Miles" uniqKey="Johnston M" first="Miles" last="Johnston">Miles Johnston</name><name sortKey="Semple, Adam" sort="Semple, Adam" uniqKey="Semple A" first="Adam" last="Semple">Adam Semple</name><name sortKey="Semple, John" sort="Semple, John" uniqKey="Semple J" first="John" last="Semple">John Semple</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Tobbia, Dalia" sort="Tobbia, Dalia" uniqKey="Tobbia D" first="Dalia" last="Tobbia">Dalia Tobbia</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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