New approaches to lymphatic imaging.
Identifieur interne : 002B60 ( PubMed/Checkpoint ); précédent : 002B59; suivant : 002B61New approaches to lymphatic imaging.
Auteurs : Richard T. Lucarelli [États-Unis] ; Mikako Ogawa ; Nobuyuki Kosaka ; Baris Turkbey ; Hisataka Kobayashi ; Peter L. ChoykeSource :
- Lymphatic research and biology [ 1557-8585 ] ; 2009.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Système lymphatique.
- diagnostic : Maladies lymphatiques.
- Animaux, Biopsie de noeud lymphatique sentinelle, Diagnostic par imagerie, Humains.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Lymphatic Diseases.
- pathology : Lymphatic System.
- Animals, Diagnostic Imaging, Humans, Sentinel Lymph Node Biopsy.
Abstract
Accurate imaging of the lymphatic system can aid in cancer staging, optimize surgical procedures to reduce lymphedema, and may one day be a means of delivering intralymphatic therapy. The Sentinel Lymph Node (SLN) concept has been pivotal in driving new imaging techniques. Metastasis to a SLN is a critical indicator of advanced disease. However, presently, few tools are available for imaging the lymphatics, and even fewer are available for locating the SLN for biopsy. Recently, new macromolecular agents, including gadolinium-labeled dendrimers, fluorescent quantum dots, and fluorescently-labeled immunoglobins, have been used to image the lymphatics and SLN with MRI and optical techniques, and new fluorescent nanoparticles such as upconverting nanocrystals are potential future agents. Additionally, multi-modality probes combining two modalities such as optical/MR dendrimers have been designed to provide both preoperative imaging, and intraoperative guidance during lymph node resections. These probes can map the lymphatic system for maximal therapeutic benefit while minimizing complications such as lymphedema. Advances in the understanding of the molecular mechanisms of lymphangiogenesis and lymphatic spread of tumors offer the opportunity for more targeted imaging of the lymphatic system. Additionally, these imaging agents could be used as powerful research tools for tracking immunological cells and monitoring the immune response as well as providing the means to deliver lymphatic-targeted therapies. The future holds great promise for the translation of these methods to the clinic.
DOI: 10.1089/lrb.2009.0021
PubMed: 20143919
Affiliations:
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Lucarelli</name><affiliation wicri:level="1"><nlm:affiliation>Molecular Imaging Program, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Imaging Program, National Cancer Institute, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Ogawa, Mikako" sort="Ogawa, Mikako" uniqKey="Ogawa M" first="Mikako" last="Ogawa">Mikako Ogawa</name></author><author><name sortKey="Kosaka, Nobuyuki" sort="Kosaka, Nobuyuki" uniqKey="Kosaka N" first="Nobuyuki" last="Kosaka">Nobuyuki Kosaka</name></author><author><name sortKey="Turkbey, Baris" sort="Turkbey, Baris" uniqKey="Turkbey B" first="Baris" last="Turkbey">Baris Turkbey</name></author><author><name sortKey="Kobayashi, Hisataka" sort="Kobayashi, Hisataka" uniqKey="Kobayashi H" first="Hisataka" last="Kobayashi">Hisataka Kobayashi</name></author><author><name sortKey="Choyke, Peter L" sort="Choyke, Peter L" uniqKey="Choyke P" first="Peter L" last="Choyke">Peter L. 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Lucarelli</name><affiliation wicri:level="1"><nlm:affiliation>Molecular Imaging Program, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Imaging Program, National Cancer Institute, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Ogawa, Mikako" sort="Ogawa, Mikako" uniqKey="Ogawa M" first="Mikako" last="Ogawa">Mikako Ogawa</name></author><author><name sortKey="Kosaka, Nobuyuki" sort="Kosaka, Nobuyuki" uniqKey="Kosaka N" first="Nobuyuki" last="Kosaka">Nobuyuki Kosaka</name></author><author><name sortKey="Turkbey, Baris" sort="Turkbey, Baris" uniqKey="Turkbey B" first="Baris" last="Turkbey">Baris Turkbey</name></author><author><name sortKey="Kobayashi, Hisataka" sort="Kobayashi, Hisataka" uniqKey="Kobayashi H" first="Hisataka" last="Kobayashi">Hisataka Kobayashi</name></author><author><name sortKey="Choyke, Peter L" sort="Choyke, Peter L" uniqKey="Choyke P" first="Peter L" last="Choyke">Peter L. Choyke</name></author></analytic><series><title level="j">Lymphatic research and biology</title><idno type="eISSN">1557-8585</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Diagnostic Imaging</term><term>Humans</term><term>Lymphatic Diseases (diagnosis)</term><term>Lymphatic System (pathology)</term><term>Sentinel Lymph Node Biopsy</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Biopsie de noeud lymphatique sentinelle</term><term>Diagnostic par imagerie</term><term>Humains</term><term>Maladies lymphatiques (diagnostic)</term><term>Système lymphatique (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphatic Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladies lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Diagnostic Imaging</term><term>Humans</term><term>Sentinel Lymph Node Biopsy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Biopsie de noeud lymphatique sentinelle</term><term>Diagnostic par imagerie</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Accurate imaging of the lymphatic system can aid in cancer staging, optimize surgical procedures to reduce lymphedema, and may one day be a means of delivering intralymphatic therapy. The Sentinel Lymph Node (SLN) concept has been pivotal in driving new imaging techniques. Metastasis to a SLN is a critical indicator of advanced disease. However, presently, few tools are available for imaging the lymphatics, and even fewer are available for locating the SLN for biopsy. Recently, new macromolecular agents, including gadolinium-labeled dendrimers, fluorescent quantum dots, and fluorescently-labeled immunoglobins, have been used to image the lymphatics and SLN with MRI and optical techniques, and new fluorescent nanoparticles such as upconverting nanocrystals are potential future agents. Additionally, multi-modality probes combining two modalities such as optical/MR dendrimers have been designed to provide both preoperative imaging, and intraoperative guidance during lymph node resections. These probes can map the lymphatic system for maximal therapeutic benefit while minimizing complications such as lymphedema. Advances in the understanding of the molecular mechanisms of lymphangiogenesis and lymphatic spread of tumors offer the opportunity for more targeted imaging of the lymphatic system. Additionally, these imaging agents could be used as powerful research tools for tracking immunological cells and monitoring the immune response as well as providing the means to deliver lymphatic-targeted therapies. The future holds great promise for the translation of these methods to the clinic.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20143919</PMID><DateCreated><Year>2010</Year><Month>02</Month><Day>10</Day></DateCreated><DateCompleted><Year>2010</Year><Month>05</Month><Day>11</Day></DateCompleted><DateRevised><Year>2014</Year><Month>12</Month><Day>04</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1557-8585</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>4</Issue><PubDate><Year>2009</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Lymphatic research and biology</Title><ISOAbbreviation>Lymphat Res Biol</ISOAbbreviation></Journal><ArticleTitle>New approaches to lymphatic imaging.</ArticleTitle><Pagination><MedlinePgn>205-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/lrb.2009.0021</ELocationID><Abstract><AbstractText>Accurate imaging of the lymphatic system can aid in cancer staging, optimize surgical procedures to reduce lymphedema, and may one day be a means of delivering intralymphatic therapy. The Sentinel Lymph Node (SLN) concept has been pivotal in driving new imaging techniques. Metastasis to a SLN is a critical indicator of advanced disease. However, presently, few tools are available for imaging the lymphatics, and even fewer are available for locating the SLN for biopsy. Recently, new macromolecular agents, including gadolinium-labeled dendrimers, fluorescent quantum dots, and fluorescently-labeled immunoglobins, have been used to image the lymphatics and SLN with MRI and optical techniques, and new fluorescent nanoparticles such as upconverting nanocrystals are potential future agents. Additionally, multi-modality probes combining two modalities such as optical/MR dendrimers have been designed to provide both preoperative imaging, and intraoperative guidance during lymph node resections. These probes can map the lymphatic system for maximal therapeutic benefit while minimizing complications such as lymphedema. Advances in the understanding of the molecular mechanisms of lymphangiogenesis and lymphatic spread of tumors offer the opportunity for more targeted imaging of the lymphatic system. Additionally, these imaging agents could be used as powerful research tools for tracking immunological cells and monitoring the immune response as well as providing the means to deliver lymphatic-targeted therapies. The future holds great promise for the translation of these methods to the clinic.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lucarelli</LastName><ForeName>Richard T</ForeName><Initials>RT</Initials><AffiliationInfo><Affiliation>Molecular Imaging Program, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ogawa</LastName><ForeName>Mikako</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kosaka</LastName><ForeName>Nobuyuki</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Turkbey</LastName><ForeName>Baris</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Kobayashi</LastName><ForeName>Hisataka</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Choyke</LastName><ForeName>Peter L</ForeName><Initials>PL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lymphat Res Biol</MedlineTA><NlmUniqueID>101163587</NlmUniqueID><ISSNLinking>1539-6851</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Blood. 2007 Feb 1;109(3):1010-7</RefSource><PMID Version="1">17032920</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Contrast Media Mol Imaging. 2006 Nov-Dec;1(6):230-45</RefSource><PMID Version="1">17191764</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Contrast Media Mol Imaging. 2007 Mar-Apr;2(2):82-7</RefSource><PMID Version="1">17451166</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nano Lett. 2007 Jun;7(6):1711-6</RefSource><PMID Version="1">17530812</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J 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Version="1">17345640</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003952" MajorTopicYN="Y">Diagnostic Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008206" MajorTopicYN="N">Lymphatic Diseases</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D021701" MajorTopicYN="Y">Sentinel Lymph Node Biopsy</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC2883526</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>2</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>2</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>5</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20143919</ArticleId><ArticleId IdType="doi">10.1089/lrb.2009.0021</ArticleId><ArticleId IdType="pmc">PMC2883526</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Choyke, Peter L" sort="Choyke, Peter L" uniqKey="Choyke P" first="Peter L" last="Choyke">Peter L. Choyke</name><name sortKey="Kobayashi, Hisataka" sort="Kobayashi, Hisataka" uniqKey="Kobayashi H" first="Hisataka" last="Kobayashi">Hisataka Kobayashi</name><name sortKey="Kosaka, Nobuyuki" sort="Kosaka, Nobuyuki" uniqKey="Kosaka N" first="Nobuyuki" last="Kosaka">Nobuyuki Kosaka</name><name sortKey="Ogawa, Mikako" sort="Ogawa, Mikako" uniqKey="Ogawa M" first="Mikako" last="Ogawa">Mikako Ogawa</name><name sortKey="Turkbey, Baris" sort="Turkbey, Baris" uniqKey="Turkbey B" first="Baris" last="Turkbey">Baris Turkbey</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Lucarelli, Richard T" sort="Lucarelli, Richard T" uniqKey="Lucarelli R" first="Richard T" last="Lucarelli">Richard T. Lucarelli</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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