Systemic lymphadenectomy cannot be recommended for low-risk corpus cancer.
Identifieur interne : 002701 ( PubMed/Checkpoint ); précédent : 002700; suivant : 002702Systemic lymphadenectomy cannot be recommended for low-risk corpus cancer.
Auteurs : Takao Hidaka [Japon] ; Akitoshi Nakashima ; Tomoko Shima ; Toru Hasegawa ; Shigeru SaitoSource :
- Obstetrics and gynecology international [ 1687-9597 ] ; 2010.
Abstract
Objective. The objective of this study is to ascertain whether omission of lymphadenectomy could be possible when uterine corpus cancer is considered low-risk based on intraoperative pathologic indicators. Patient and Methods. Between 1998 and 2007, a total of 83 patients with low risk corpus cancer (endometrioid type, grade 1 or 2, myometrial invasion <==50%, and no intraoperative evidence of macroscopic extrauterine spread, including pelvic and paraaortic lymph node swelling and adnexal metastasis) underwent the total abdominal hysterectomy and bilateral salpingo-oophorectomy without lymphadenectomy. A retrospective review of the medical records was performed, and the disease-free survival (DFS), overall survival (OS), peri- and postoperative morbidities and complications were evaluated. Results. The 5-year DFS rates and the 5-year OS rates were 97.6% and 98.8%, respectively. No patient presented postoperative leg lymphedema and deep venous thrombosis. Conclusion. Omission of lymphadenectomy did not worsen the DFS or OS. The present findings suggest that systemic lymphadenectomy could be omitted in low-risk endometrial carcinoma.
DOI: 10.1155/2010/490219
PubMed: 20168975
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The objective of this study is to ascertain whether omission of lymphadenectomy could be possible when uterine corpus cancer is considered low-risk based on intraoperative pathologic indicators. Patient and Methods. Between 1998 and 2007, a total of 83 patients with low risk corpus cancer (endometrioid type, grade 1 or 2, myometrial invasion <==50%, and no intraoperative evidence of macroscopic extrauterine spread, including pelvic and paraaortic lymph node swelling and adnexal metastasis) underwent the total abdominal hysterectomy and bilateral salpingo-oophorectomy without lymphadenectomy. A retrospective review of the medical records was performed, and the disease-free survival (DFS), overall survival (OS), peri- and postoperative morbidities and complications were evaluated. Results. The 5-year DFS rates and the 5-year OS rates were 97.6% and 98.8%, respectively. No patient presented postoperative leg lymphedema and deep venous thrombosis. Conclusion. Omission of lymphadenectomy did not worsen the DFS or OS. The present findings suggest that systemic lymphadenectomy could be omitted in low-risk endometrial carcinoma.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">20168975</PMID><DateCreated><Year>2010</Year><Month>02</Month><Day>19</Day></DateCreated><DateCompleted><Year>2011</Year><Month>07</Month><Day>14</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1687-9597</ISSN><JournalIssue CitedMedium="Internet"><Volume>2010</Volume><PubDate><Year>2010</Year></PubDate></JournalIssue><Title>Obstetrics and gynecology international</Title><ISOAbbreviation>Obstet Gynecol Int</ISOAbbreviation></Journal><ArticleTitle>Systemic lymphadenectomy cannot be recommended for low-risk corpus cancer.</ArticleTitle><Pagination><MedlinePgn>490219</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2010/490219</ELocationID><Abstract><AbstractText>Objective. The objective of this study is to ascertain whether omission of lymphadenectomy could be possible when uterine corpus cancer is considered low-risk based on intraoperative pathologic indicators. Patient and Methods. Between 1998 and 2007, a total of 83 patients with low risk corpus cancer (endometrioid type, grade 1 or 2, myometrial invasion <==50%, and no intraoperative evidence of macroscopic extrauterine spread, including pelvic and paraaortic lymph node swelling and adnexal metastasis) underwent the total abdominal hysterectomy and bilateral salpingo-oophorectomy without lymphadenectomy. A retrospective review of the medical records was performed, and the disease-free survival (DFS), overall survival (OS), peri- and postoperative morbidities and complications were evaluated. Results. The 5-year DFS rates and the 5-year OS rates were 97.6% and 98.8%, respectively. No patient presented postoperative leg lymphedema and deep venous thrombosis. Conclusion. Omission of lymphadenectomy did not worsen the DFS or OS. The present findings suggest that systemic lymphadenectomy could be omitted in low-risk endometrial carcinoma.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hidaka</LastName><ForeName>Takao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nakashima</LastName><ForeName>Akitoshi</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Shima</LastName><ForeName>Tomoko</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Hasegawa</LastName><ForeName>Toru</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Saito</LastName><ForeName>Shigeru</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>02</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Obstet Gynecol Int</MedlineTA><NlmUniqueID>101517078</NlmUniqueID><ISSNLinking>1687-9597</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2001 Oct 15;19(20):4048-53</RefSource><PMID Version="1">11600606</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Obstet Gynecol. 1984 Jun;63(6):825-32</RefSource><PMID Version="1">6728365</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2009 Jan 10;373(9658):125-36</RefSource><PMID Version="1">19070889</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Natl Cancer Inst. 2008 Dec 3;100(23):1707-16</RefSource><PMID Version="1">19033573</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gynecol Oncol. 2004 Dec;95(3):463-8</RefSource><PMID Version="1">15581947</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gynecol Oncol. 1990 Jul;38(1):46-8</RefSource><PMID Version="1">2354826</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gynecol Oncol. 1991 Jan;40(1):55-65</RefSource><PMID Version="1">1989916</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Obstet Gynecol. 1992 Nov;167(5):1317-25</RefSource><PMID Version="1">1442985</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49</RefSource><PMID Version="1">19474385</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Exp Obstet Gynecol. 1994;21(1):30-2</RefSource><PMID Version="1">8020174</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Obstet Gynecol. 2000 Jun;182(6):1506-19</RefSource><PMID Version="1">10871473</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Gynaecol Oncol. 2008;29(5):435-40</RefSource><PMID Version="1">19051807</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gynecol Oncol. 1995 May;57(2):138-44</RefSource><PMID Version="1">7729725</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gynecol Oncol. 1997 Mar;64(3):411-7</RefSource><PMID Version="1">9062142</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 1989 Dec 1;49(23):6828-31</RefSource><PMID Version="1">2819722</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gynecol Oncol. 2005 Mar;96(3):610-5</RefSource><PMID Version="1">15721401</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Obstet Gynecol. 1992 Jun;79(6):998-1001</RefSource><PMID Version="1">1579330</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gynecol Oncol. 2000 Jul;78(1):52-7</RefSource><PMID Version="1">10873410</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer. 1987 Oct 15;60(8 Suppl):2035-41</RefSource><PMID Version="1">3652025</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer. 1990 Sep 15;66(6):1133-8</RefSource><PMID Version="1">2400965</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gynecol Oncol. 1998 Dec;71(3):340-3</RefSource><PMID Version="1">9887227</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2004 Jun 1;22(11):2159-66</RefSource><PMID Version="1">15169803</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Surg Oncol. 2001 Dec;78(4):232-7; 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