Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.
Identifieur interne : 002126 ( PubMed/Checkpoint ); précédent : 002125; suivant : 002127Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.
Auteurs : Kirby D. Johnson [États-Unis] ; Amy P. Hsu ; Myung-Jeom Ryu ; Jinyong Wang ; Xin Gao ; Meghan E. Boyer ; Yangang Liu ; Youngsook Lee ; Katherine R. Calvo ; Sunduz Keles ; Jing Zhang ; Steven M. Holland ; Emery H. BresnickSource :
- The Journal of clinical investigation [ 1558-8238 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Cellules souches hématopoïétiques (anatomopathologie), Données de séquences moléculaires, Déficits immunitaires (génétique), Délétion de séquence, Développement embryonnaire (génétique), Endothélium vasculaire (métabolisme), Facteur de transcription GATA-2 (), Facteur de transcription GATA-2 (déficit), Facteur de transcription GATA-2 (génétique), Facteur de transcription GATA-2 (physiologie), Foie (cytologie), Foie (embryologie), Gènes létaux, Génotype, Humains, Hématopoïèse (génétique), Hématopoïèse (physiologie), Hémorragie (embryologie), Hémorragie (génétique), Infections à Mycobacterium (étiologie), Prédisposition génétique à une maladie, Souris, Syndromes myélodysplasiques (), Syndromes myélodysplasiques (génétique), Séquence nucléotidique, Vaisseaux sanguins (anatomopathologie), Vaisseaux sanguins (embryologie), Éléments E-box, Éléments de régulation transcriptionnelle.
- MESH :
- anatomopathologie : Cellules souches hématopoïétiques, Vaisseaux sanguins.
- cytologie : Foie.
- déficit : Facteur de transcription GATA-2.
- embryologie : Foie, Hémorragie, Vaisseaux sanguins.
- génétique : Déficits immunitaires, Développement embryonnaire, Facteur de transcription GATA-2, Hématopoïèse, Hémorragie, Syndromes myélodysplasiques.
- métabolisme : Endothélium vasculaire.
- physiologie : Facteur de transcription GATA-2, Hématopoïèse.
- étiologie : Infections à Mycobacterium.
- Animaux, Données de séquences moléculaires, Délétion de séquence, Facteur de transcription GATA-2, Gènes létaux, Génotype, Humains, Prédisposition génétique à une maladie, Souris, Syndromes myélodysplasiques, Séquence nucléotidique, Éléments E-box, Éléments de régulation transcriptionnelle.
English descriptors
- KwdEn :
- Animals, Base Sequence, Blood Vessels (embryology), Blood Vessels (pathology), E-Box Elements, Embryonic Development (genetics), Endothelium, Vascular (metabolism), GATA2 Transcription Factor (chemistry), GATA2 Transcription Factor (deficiency), GATA2 Transcription Factor (genetics), GATA2 Transcription Factor (physiology), Genes, Lethal, Genetic Predisposition to Disease, Genotype, Hematopoiesis (genetics), Hematopoiesis (physiology), Hematopoietic Stem Cells (pathology), Hemorrhage (embryology), Hemorrhage (genetics), Humans, Immunologic Deficiency Syndromes (genetics), Liver (cytology), Liver (embryology), Mice, Molecular Sequence Data, Mycobacterium Infections (etiology), Myelodysplastic Syndromes (complications), Myelodysplastic Syndromes (genetics), Regulatory Elements, Transcriptional, Sequence Deletion.
- MESH :
- chemical , chemistry : GATA2 Transcription Factor.
- chemical , deficiency : GATA2 Transcription Factor.
- complications : Myelodysplastic Syndromes.
- cytology : Liver.
- embryology : Blood Vessels, Hemorrhage, Liver.
- etiology : Mycobacterium Infections.
- genetics : Embryonic Development, GATA2 Transcription Factor, Hematopoiesis, Hemorrhage, Immunologic Deficiency Syndromes, Myelodysplastic Syndromes.
- metabolism : Endothelium, Vascular.
- pathology : Blood Vessels, Hematopoietic Stem Cells.
- chemical , physiology : GATA2 Transcription Factor, Hematopoiesis.
- Animals, Base Sequence, E-Box Elements, Genes, Lethal, Genetic Predisposition to Disease, Genotype, Humans, Mice, Molecular Sequence Data, Regulatory Elements, Transcriptional, Sequence Deletion.
Abstract
Haploinsufficiency for GATA2 causes human immunodeficiency syndromes characterized by mycobacterial infection, myelodysplasia, lymphedema, or aplastic anemia that progress to myeloid leukemia. GATA2 encodes a master regulator of hematopoiesis that is also linked to endothelial biology. Though the disease-causing mutations commonly occur in the GATA-2 DNA binding domain, we identified a patient with mycobacterial infection and myelodysplasia who had an uncharacterized heterozygous deletion in a GATA2 cis-element consisting of an E-box and a GATA motif. Targeted deletion of the equivalent murine element to yield homozygous mutant mice revealed embryonic lethality later than occurred with global Gata2 knockout, hematopoietic stem/progenitor cell depletion, and impaired vascular integrity. Heterozygous mutant mice were viable, but embryos exhibited deficits in definitive, but not primitive, hematopoietic stem/progenitor activity and reduced expression of Gata2 and its target genes. Mechanistic analysis revealed disruption of the endothelial cell transcriptome and loss of vascular integrity. Thus, the composite element disrupted in a human immunodeficiency is essential for establishment of the murine hematopoietic stem/progenitor cell compartment in the fetal liver and for essential vascular processes.
DOI: 10.1172/JCI61623
PubMed: 22996659
Affiliations:
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pubmed:22996659Le document en format XML
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Johnson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cell and Regenerative Biology, Wisconsin Institutes for Medical Research, UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Regenerative Biology, Wisconsin Institutes for Medical Research, UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705</wicri:regionArea><wicri:noRegion>Wisconsin 53705</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Amy P" sort="Hsu, Amy P" uniqKey="Hsu A" first="Amy P" last="Hsu">Amy P. Hsu</name></author><author><name sortKey="Ryu, Myung Jeom" sort="Ryu, Myung Jeom" uniqKey="Ryu M" first="Myung-Jeom" last="Ryu">Myung-Jeom Ryu</name></author><author><name sortKey="Wang, Jinyong" sort="Wang, Jinyong" uniqKey="Wang J" first="Jinyong" last="Wang">Jinyong Wang</name></author><author><name sortKey="Gao, Xin" sort="Gao, Xin" uniqKey="Gao X" first="Xin" last="Gao">Xin Gao</name></author><author><name sortKey="Boyer, Meghan E" sort="Boyer, Meghan E" uniqKey="Boyer M" first="Meghan E" last="Boyer">Meghan E. Boyer</name></author><author><name sortKey="Liu, Yangang" sort="Liu, Yangang" uniqKey="Liu Y" first="Yangang" last="Liu">Yangang Liu</name></author><author><name sortKey="Lee, Youngsook" sort="Lee, Youngsook" uniqKey="Lee Y" first="Youngsook" last="Lee">Youngsook Lee</name></author><author><name sortKey="Calvo, Katherine R" sort="Calvo, Katherine R" uniqKey="Calvo K" first="Katherine R" last="Calvo">Katherine R. 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Johnson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cell and Regenerative Biology, Wisconsin Institutes for Medical Research, UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Regenerative Biology, Wisconsin Institutes for Medical Research, UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705</wicri:regionArea><wicri:noRegion>Wisconsin 53705</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Amy P" sort="Hsu, Amy P" uniqKey="Hsu A" first="Amy P" last="Hsu">Amy P. Hsu</name></author><author><name sortKey="Ryu, Myung Jeom" sort="Ryu, Myung Jeom" uniqKey="Ryu M" first="Myung-Jeom" last="Ryu">Myung-Jeom Ryu</name></author><author><name sortKey="Wang, Jinyong" sort="Wang, Jinyong" uniqKey="Wang J" first="Jinyong" last="Wang">Jinyong Wang</name></author><author><name sortKey="Gao, Xin" sort="Gao, Xin" uniqKey="Gao X" first="Xin" last="Gao">Xin Gao</name></author><author><name sortKey="Boyer, Meghan E" sort="Boyer, Meghan E" uniqKey="Boyer M" first="Meghan E" last="Boyer">Meghan E. Boyer</name></author><author><name sortKey="Liu, Yangang" sort="Liu, Yangang" uniqKey="Liu Y" first="Yangang" last="Liu">Yangang Liu</name></author><author><name sortKey="Lee, Youngsook" sort="Lee, Youngsook" uniqKey="Lee Y" first="Youngsook" last="Lee">Youngsook Lee</name></author><author><name sortKey="Calvo, Katherine R" sort="Calvo, Katherine R" uniqKey="Calvo K" first="Katherine R" last="Calvo">Katherine R. Calvo</name></author><author><name sortKey="Keles, Sunduz" sort="Keles, Sunduz" uniqKey="Keles S" first="Sunduz" last="Keles">Sunduz Keles</name></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name></author><author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M" last="Holland">Steven M. Holland</name></author><author><name sortKey="Bresnick, Emery H" sort="Bresnick, Emery H" uniqKey="Bresnick E" first="Emery H" last="Bresnick">Emery H. Bresnick</name></author></analytic><series><title level="j">The Journal of clinical investigation</title><idno type="eISSN">1558-8238</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Blood Vessels (embryology)</term><term>Blood Vessels (pathology)</term><term>E-Box Elements</term><term>Embryonic Development (genetics)</term><term>Endothelium, Vascular (metabolism)</term><term>GATA2 Transcription Factor (chemistry)</term><term>GATA2 Transcription Factor (deficiency)</term><term>GATA2 Transcription Factor (genetics)</term><term>GATA2 Transcription Factor (physiology)</term><term>Genes, Lethal</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Hematopoiesis (genetics)</term><term>Hematopoiesis (physiology)</term><term>Hematopoietic Stem Cells (pathology)</term><term>Hemorrhage (embryology)</term><term>Hemorrhage (genetics)</term><term>Humans</term><term>Immunologic Deficiency Syndromes (genetics)</term><term>Liver (cytology)</term><term>Liver (embryology)</term><term>Mice</term><term>Molecular Sequence Data</term><term>Mycobacterium Infections (etiology)</term><term>Myelodysplastic Syndromes (complications)</term><term>Myelodysplastic Syndromes (genetics)</term><term>Regulatory Elements, Transcriptional</term><term>Sequence Deletion</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules souches hématopoïétiques (anatomopathologie)</term><term>Données de séquences moléculaires</term><term>Déficits immunitaires (génétique)</term><term>Délétion de séquence</term><term>Développement embryonnaire (génétique)</term><term>Endothélium vasculaire (métabolisme)</term><term>Facteur de transcription GATA-2 ()</term><term>Facteur de transcription GATA-2 (déficit)</term><term>Facteur de transcription GATA-2 (génétique)</term><term>Facteur de transcription GATA-2 (physiologie)</term><term>Foie (cytologie)</term><term>Foie (embryologie)</term><term>Gènes létaux</term><term>Génotype</term><term>Humains</term><term>Hématopoïèse (génétique)</term><term>Hématopoïèse (physiologie)</term><term>Hémorragie (embryologie)</term><term>Hémorragie (génétique)</term><term>Infections à Mycobacterium (étiologie)</term><term>Prédisposition génétique à une maladie</term><term>Souris</term><term>Syndromes myélodysplasiques ()</term><term>Syndromes myélodysplasiques (génétique)</term><term>Séquence nucléotidique</term><term>Vaisseaux sanguins (anatomopathologie)</term><term>Vaisseaux sanguins (embryologie)</term><term>Éléments E-box</term><term>Éléments de régulation transcriptionnelle</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>GATA2 Transcription Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" 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Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Embryonic Development</term><term>GATA2 Transcription Factor</term><term>Hematopoiesis</term><term>Hemorrhage</term><term>Immunologic Deficiency Syndromes</term><term>Myelodysplastic Syndromes</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Déficits immunitaires</term><term>Développement embryonnaire</term><term>Facteur de transcription GATA-2</term><term>Hématopoïèse</term><term>Hémorragie</term><term>Syndromes myélodysplasiques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelium, Vascular</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Endothélium vasculaire</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Blood Vessels</term><term>Hematopoietic Stem Cells</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Facteur de transcription GATA-2</term><term>Hématopoïèse</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>GATA2 Transcription Factor</term><term>Hematopoiesis</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Infections à Mycobacterium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>E-Box Elements</term><term>Genes, Lethal</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Mice</term><term>Molecular Sequence Data</term><term>Regulatory Elements, Transcriptional</term><term>Sequence Deletion</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Données de séquences moléculaires</term><term>Délétion de séquence</term><term>Facteur de transcription GATA-2</term><term>Gènes létaux</term><term>Génotype</term><term>Humains</term><term>Prédisposition génétique à une maladie</term><term>Souris</term><term>Syndromes myélodysplasiques</term><term>Séquence nucléotidique</term><term>Éléments E-box</term><term>Éléments de régulation transcriptionnelle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Haploinsufficiency for GATA2 causes human immunodeficiency syndromes characterized by mycobacterial infection, myelodysplasia, lymphedema, or aplastic anemia that progress to myeloid leukemia. GATA2 encodes a master regulator of hematopoiesis that is also linked to endothelial biology. Though the disease-causing mutations commonly occur in the GATA-2 DNA binding domain, we identified a patient with mycobacterial infection and myelodysplasia who had an uncharacterized heterozygous deletion in a GATA2 cis-element consisting of an E-box and a GATA motif. Targeted deletion of the equivalent murine element to yield homozygous mutant mice revealed embryonic lethality later than occurred with global Gata2 knockout, hematopoietic stem/progenitor cell depletion, and impaired vascular integrity. Heterozygous mutant mice were viable, but embryos exhibited deficits in definitive, but not primitive, hematopoietic stem/progenitor activity and reduced expression of Gata2 and its target genes. Mechanistic analysis revealed disruption of the endothelial cell transcriptome and loss of vascular integrity. Thus, the composite element disrupted in a human immunodeficiency is essential for establishment of the murine hematopoietic stem/progenitor cell compartment in the fetal liver and for essential vascular processes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22996659</PMID><DateCreated><Year>2012</Year><Month>10</Month><Day>01</Day></DateCreated><DateCompleted><Year>2013</Year><Month>02</Month><Day>01</Day></DateCompleted><DateRevised><Year>2017</Year><Month>05</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1558-8238</ISSN><JournalIssue CitedMedium="Internet"><Volume>122</Volume><Issue>10</Issue><PubDate><Year>2012</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The Journal of clinical investigation</Title><ISOAbbreviation>J. Clin. Invest.</ISOAbbreviation></Journal><ArticleTitle>Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.</ArticleTitle><Pagination><MedlinePgn>3692-704</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1172/JCI61623</ELocationID><ELocationID EIdType="pii" ValidYN="Y">61623</ELocationID><Abstract><AbstractText>Haploinsufficiency for GATA2 causes human immunodeficiency syndromes characterized by mycobacterial infection, myelodysplasia, lymphedema, or aplastic anemia that progress to myeloid leukemia. GATA2 encodes a master regulator of hematopoiesis that is also linked to endothelial biology. Though the disease-causing mutations commonly occur in the GATA-2 DNA binding domain, we identified a patient with mycobacterial infection and myelodysplasia who had an uncharacterized heterozygous deletion in a GATA2 cis-element consisting of an E-box and a GATA motif. Targeted deletion of the equivalent murine element to yield homozygous mutant mice revealed embryonic lethality later than occurred with global Gata2 knockout, hematopoietic stem/progenitor cell depletion, and impaired vascular integrity. Heterozygous mutant mice were viable, but embryos exhibited deficits in definitive, but not primitive, hematopoietic stem/progenitor activity and reduced expression of Gata2 and its target genes. Mechanistic analysis revealed disruption of the endothelial cell transcriptome and loss of vascular integrity. Thus, the composite element disrupted in a human immunodeficiency is essential for establishment of the murine hematopoietic stem/progenitor cell compartment in the fetal liver and for essential vascular processes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Kirby D</ForeName><Initials>KD</Initials><AffiliationInfo><Affiliation>Department of Cell and Regenerative Biology, Wisconsin Institutes for Medical Research, UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hsu</LastName><ForeName>Amy P</ForeName><Initials>AP</Initials></Author><Author ValidYN="Y"><LastName>Ryu</LastName><ForeName>Myung-Jeom</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jinyong</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Xin</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Boyer</LastName><ForeName>Meghan E</ForeName><Initials>ME</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yangang</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Youngsook</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Calvo</LastName><ForeName>Katherine R</ForeName><Initials>KR</Initials></Author><Author ValidYN="Y"><LastName>Keles</LastName><ForeName>Sunduz</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jing</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Holland</LastName><ForeName>Steven M</ForeName><Initials>SM</Initials></Author><Author ValidYN="Y"><LastName>Bresnick</LastName><ForeName>Emery H</ForeName><Initials>EH</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>DK68634</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HG003747</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK050107</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA014520</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HG006716</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 HG006716</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DK50107</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK068634</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA152108</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 DK050107</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R56 DK068634</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA152108</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>09</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Clin Invest</MedlineTA><NlmUniqueID>7802877</NlmUniqueID><ISSNLinking>0021-9738</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050989">GATA2 Transcription Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C494711">GATA2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C494712">Gata2 protein, mouse</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13641-6</RefSource><PMID 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MajorTopicYN="N">Hemorrhage</DescriptorName><QualifierName UI="Q000196" MajorTopicYN="N">embryology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007153" MajorTopicYN="N">Immunologic Deficiency Syndromes</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000196" MajorTopicYN="N">embryology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009164" MajorTopicYN="N">Mycobacterium Infections</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009190" MajorTopicYN="N">Myelodysplastic Syndromes</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050436" MajorTopicYN="Y">Regulatory Elements, Transcriptional</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017384" MajorTopicYN="N">Sequence Deletion</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3461907</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>10</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>07</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>2</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22996659</ArticleId><ArticleId IdType="pii">61623</ArticleId><ArticleId IdType="doi">10.1172/JCI61623</ArticleId><ArticleId IdType="pmc">PMC3461907</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Boyer, Meghan E" sort="Boyer, Meghan E" uniqKey="Boyer M" first="Meghan E" last="Boyer">Meghan E. Boyer</name><name sortKey="Bresnick, Emery H" sort="Bresnick, Emery H" uniqKey="Bresnick E" first="Emery H" last="Bresnick">Emery H. Bresnick</name><name sortKey="Calvo, Katherine R" sort="Calvo, Katherine R" uniqKey="Calvo K" first="Katherine R" last="Calvo">Katherine R. Calvo</name><name sortKey="Gao, Xin" sort="Gao, Xin" uniqKey="Gao X" first="Xin" last="Gao">Xin Gao</name><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M" last="Holland">Steven M. Holland</name><name sortKey="Hsu, Amy P" sort="Hsu, Amy P" uniqKey="Hsu A" first="Amy P" last="Hsu">Amy P. Hsu</name><name sortKey="Keles, Sunduz" sort="Keles, Sunduz" uniqKey="Keles S" first="Sunduz" last="Keles">Sunduz Keles</name><name sortKey="Lee, Youngsook" sort="Lee, Youngsook" uniqKey="Lee Y" first="Youngsook" last="Lee">Youngsook Lee</name><name sortKey="Liu, Yangang" sort="Liu, Yangang" uniqKey="Liu Y" first="Yangang" last="Liu">Yangang Liu</name><name sortKey="Ryu, Myung Jeom" sort="Ryu, Myung Jeom" uniqKey="Ryu M" first="Myung-Jeom" last="Ryu">Myung-Jeom Ryu</name><name sortKey="Wang, Jinyong" sort="Wang, Jinyong" uniqKey="Wang J" first="Jinyong" last="Wang">Jinyong Wang</name><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Johnson, Kirby D" sort="Johnson, Kirby D" uniqKey="Johnson K" first="Kirby D" last="Johnson">Kirby D. Johnson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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