Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.
Identifieur interne : 002085 ( PubMed/Checkpoint ); précédent : 002084; suivant : 002086Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.
Auteurs : Sabine Mand [Allemagne] ; Alexander Yaw Debrah ; Ute Klarmann ; Linda Batsa ; Yeboah Marfo-Debrekyei ; Alexander Kwarteng ; Sabine Specht ; Aurea Belda-Domene ; Rolf Fimmers ; Mark Taylor ; Ohene Adjei ; Achim HoeraufSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2012.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Amoxicilline (usage thérapeutique), Cheville (anatomopathologie), Cheville (imagerie diagnostique), Doxycycline (usage thérapeutique), Estimation de Kaplan-Meier, Femelle, Filaricides (usage thérapeutique), Filarioses (anatomopathologie), Filarioses (sang), Filarioses (traitement médicamenteux), Ghana, Humains, Jambe (anatomopathologie), Lymphoedème (anatomopathologie), Lymphoedème (parasitologie), Lymphoedème (sang), Lymphoedème (traitement médicamenteux), Mâle, Peau (anatomopathologie), Peau (imagerie diagnostique), Récepteur-3 au facteur croissance endothéliale vasculaire (sang), Statistique non paramétrique, Échographie.
- MESH :
- anatomopathologie : Cheville, Filarioses, Jambe, Lymphoedème, Peau.
- imagerie diagnostique : Cheville, Peau.
- parasitologie : Lymphoedème.
- sang : Filarioses, Lymphoedème, Récepteur-3 au facteur croissance endothéliale vasculaire.
- traitement médicamenteux : Filarioses, Lymphoedème.
- usage thérapeutique : Amoxicilline, Doxycycline, Filaricides.
- Adolescent, Adulte, Adulte d'âge moyen, Estimation de Kaplan-Meier, Femelle, Ghana, Humains, Mâle, Statistique non paramétrique, Échographie.
English descriptors
- KwdEn :
- Adolescent, Adult, Amoxicillin (therapeutic use), Ankle (diagnostic imaging), Ankle (pathology), Doxycycline (therapeutic use), Female, Filariasis (blood), Filariasis (drug therapy), Filariasis (pathology), Filaricides (therapeutic use), Ghana, Humans, Kaplan-Meier Estimate, Leg (pathology), Lymphedema (blood), Lymphedema (drug therapy), Lymphedema (parasitology), Lymphedema (pathology), Male, Middle Aged, Skin (diagnostic imaging), Skin (pathology), Statistics, Nonparametric, Ultrasonography, Vascular Endothelial Growth Factor Receptor-3 (blood).
- MESH :
- chemical , blood : Vascular Endothelial Growth Factor Receptor-3.
- chemical , therapeutic use : Amoxicillin, Doxycycline, Filaricides.
- blood : Filariasis, Lymphedema.
- diagnostic imaging : Ankle, Skin.
- drug therapy : Filariasis, Lymphedema.
- parasitology : Lymphedema.
- pathology : Ankle, Filariasis, Leg, Lymphedema, Skin.
- Adolescent, Adult, Female, Ghana, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Statistics, Nonparametric, Ultrasonography.
Abstract
The aim of this study was to determine whether improvement of filarial lymphedema (LE) by doxycycline is restricted to patients with ongoing infection (positive for circulating filarial antigen [CFA]), or whether the majority of CFA-negative patients with LE would also show a reduction in LE severity.
DOI: 10.1093/cid/cis486
PubMed: 22610930
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:22610930Le document en format XML
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xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Ghana</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Male</term><term>Middle Aged</term><term>Statistics, Nonparametric</term><term>Ultrasonography</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Mâle</term><term>Statistique non paramétrique</term><term>Échographie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to determine whether improvement of filarial lymphedema (LE) by doxycycline is restricted to patients with ongoing infection (positive for circulating filarial antigen [CFA]), or whether the majority of CFA-negative patients with LE would also show a reduction in LE severity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22610930</PMID><DateCreated><Year>2012</Year><Month>08</Month><Day>07</Day></DateCreated><DateCompleted><Year>2013</Year><Month>07</Month><Day>08</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><Volume>55</Volume><Issue>5</Issue><PubDate><Year>2012</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.</ArticleTitle><Pagination><MedlinePgn>621-30</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/cis486</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The aim of this study was to determine whether improvement of filarial lymphedema (LE) by doxycycline is restricted to patients with ongoing infection (positive for circulating filarial antigen [CFA]), or whether the majority of CFA-negative patients with LE would also show a reduction in LE severity.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">One hundred sixty-two Ghanaian participants with LE stage 1-5 (Dreyer) were randomized blockwise into 2 groups (CFA positive or negative) and allocated to 3 treatment arms of 6 weeks: (1) amoxicillin (1000 mg/d), (2) doxycycline (200 mg/d), or (3) placebo matching doxycycline. All groups received standard hygiene morbidity management. The primary outcome was reduction of LE stages. Secondary outcomes included frequency of acute attacks and ultrasonographic assessment of skin thickness at the ankles. Parameters were assessed before treatment and after 3, 12, and 24 months.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Doxycycline-treated patients with LE stage 2-3 showed significant reductions in LE severity after 12 and 24 months, regardless of CFA status. Improvement was observed in 43.9% of doxycycline-treated patients, compared with only 3.2% and 5.6% in the amoxicillin and placebo arms, respectively. Skin thickness was correlated with LE stage improvement. Both doxycycline and amoxicillin were able to reduce acute dermatolymphangioadenitis attacks.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Doxycycline treatment improves mild to moderate LE independent of ongoing infection. This finding expands the benefits of doxycycline to the entire population of patients suffering from LE. Patients with LE stage 1-3 should benefit from a 6-week course of doxycycline every other year or yearly, which should be considered as an improved tool to manage morbidity in filarial LE. Clinical Trials Registration. ISRCTN 90861344.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mand</LastName><ForeName>Sabine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Debrah</LastName><ForeName>Alexander Yaw</ForeName><Initials>AY</Initials></Author><Author ValidYN="Y"><LastName>Klarmann</LastName><ForeName>Ute</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Batsa</LastName><ForeName>Linda</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Marfo-Debrekyei</LastName><ForeName>Yeboah</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Kwarteng</LastName><ForeName>Alexander</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Specht</LastName><ForeName>Sabine</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Belda-Domene</LastName><ForeName>Aurea</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Fimmers</LastName><ForeName>Rolf</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Adjei</LastName><ForeName>Ohene</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Hoerauf</LastName><ForeName>Achim</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ISRCTN</DataBankName><AccessionNumberList><AccessionNumber>ISRCTN23868518</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>05</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005369">Filaricides</NameOfSubstance></Chemical><Chemical><RegistryNumber>804826J2HU</RegistryNumber><NameOfSubstance UI="D000658">Amoxicillin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="D040321">Vascular Endothelial Growth Factor Receptor-3</NameOfSubstance></Chemical><Chemical><RegistryNumber>N12000U13O</RegistryNumber><NameOfSubstance UI="D004318">Doxycycline</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 2000 Jul-Aug;94(4):437-43</RefSource><PMID Version="1">11127253</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 2009 Oct;81(4):702-11</RefSource><PMID Version="1">19815891</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 2009 Jun;80(6):956-63</RefSource><PMID Version="1">19478258</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1999 Jul-Aug;93(4):413-7</RefSource><PMID Version="1">10674092</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1995 Jul-Aug;89(4):441-3</RefSource><PMID Version="1">7570894</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2000 Apr 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MajorTopicYN="N">Doxycycline</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005369" MajorTopicYN="N">Filaricides</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N">Ghana</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053208" MajorTopicYN="N">Kaplan-Meier Estimate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007866" MajorTopicYN="N">Leg</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018709" MajorTopicYN="N">Statistics, Nonparametric</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014463" MajorTopicYN="N">Ultrasonography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D040321" MajorTopicYN="N">Vascular Endothelial Growth Factor Receptor-3</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3412691</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>5</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>5</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22610930</ArticleId><ArticleId IdType="pii">cis486</ArticleId><ArticleId IdType="doi">10.1093/cid/cis486</ArticleId><ArticleId IdType="pmc">PMC3412691</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Bonn</li></settlement></list><tree><noCountry><name sortKey="Adjei, Ohene" sort="Adjei, Ohene" uniqKey="Adjei O" first="Ohene" last="Adjei">Ohene Adjei</name><name sortKey="Batsa, Linda" sort="Batsa, Linda" uniqKey="Batsa L" first="Linda" last="Batsa">Linda Batsa</name><name sortKey="Belda Domene, Aurea" sort="Belda Domene, Aurea" uniqKey="Belda Domene A" first="Aurea" last="Belda-Domene">Aurea Belda-Domene</name><name sortKey="Debrah, Alexander Yaw" sort="Debrah, Alexander Yaw" uniqKey="Debrah A" first="Alexander Yaw" last="Debrah">Alexander Yaw Debrah</name><name sortKey="Fimmers, Rolf" sort="Fimmers, Rolf" uniqKey="Fimmers R" first="Rolf" last="Fimmers">Rolf Fimmers</name><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name><name sortKey="Klarmann, Ute" sort="Klarmann, Ute" uniqKey="Klarmann U" first="Ute" last="Klarmann">Ute Klarmann</name><name sortKey="Kwarteng, Alexander" sort="Kwarteng, Alexander" uniqKey="Kwarteng A" first="Alexander" last="Kwarteng">Alexander Kwarteng</name><name sortKey="Marfo Debrekyei, Yeboah" sort="Marfo Debrekyei, Yeboah" uniqKey="Marfo Debrekyei Y" first="Yeboah" last="Marfo-Debrekyei">Yeboah Marfo-Debrekyei</name><name sortKey="Specht, Sabine" sort="Specht, Sabine" uniqKey="Specht S" first="Sabine" last="Specht">Sabine Specht</name><name sortKey="Taylor, Mark" sort="Taylor, Mark" uniqKey="Taylor M" first="Mark" last="Taylor">Mark Taylor</name></noCountry><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Mand, Sabine" sort="Mand, Sabine" uniqKey="Mand S" first="Sabine" last="Mand">Sabine Mand</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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