LymphedemaV1, PubMed, Checkpoint, bibRecord, 002025

Identification of Wb123 as an early and specific marker of Wuchereria bancrofti infection.

Identifieur interne : 002025 ( PubMed/Checkpoint ); précédent : 002024; suivant : 002026

Identification of Wb123 as an early and specific marker of Wuchereria bancrofti infection.

Auteurs : Joseph Kubofcik [États-Unis] ; Doran L. Fink ; Thomas B. Nutman

Source :

PLoS neglected tropical diseases [ 1935-2735 ] ; 2012.

RBID : pubmed:23236529

Descripteurs français

KwdFr :
- Analyse de séquence d'ADN, Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (génétique), Biologie informatique, Données de séquences moléculaires, Femelle, Filariose lymphatique (diagnostic), Filariose lymphatique (parasitologie), Humains, Immunoprécipitation (), Mâle, Protéines de fusion recombinantes (génétique), Sensibilité et spécificité, Techniques de laboratoire clinique (), Tests diagnostiques courants (), Wuchereria bancrofti (génétique), Wuchereria bancrofti (isolement et purification), Étiquettes de séquences exprimées.
MESH :
- diagnostic : Filariose lymphatique.
- génétique : Antigènes d'helminthe, Protéines de fusion recombinantes, Wuchereria bancrofti.
- isolement et purification : Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- sang : Anticorps antihelminthe.
- Analyse de séquence d'ADN, Animaux, Biologie informatique, Données de séquences moléculaires, Femelle, Humains, Immunoprécipitation, Mâle, Sensibilité et spécificité, Techniques de laboratoire clinique, Tests diagnostiques courants, Étiquettes de séquences exprimées.

English descriptors

KwdEn :
- Animals, Antibodies, Helminth (blood), Antigens, Helminth (genetics), Clinical Laboratory Techniques (methods), Computational Biology, Diagnostic Tests, Routine (methods), Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (parasitology), Expressed Sequence Tags, Female, Humans, Immunoprecipitation (methods), Male, Molecular Sequence Data, Recombinant Fusion Proteins (genetics), Sensitivity and Specificity, Sequence Analysis, DNA, Wuchereria bancrofti (genetics), Wuchereria bancrofti (isolation & purification).
MESH :
- chemical , blood : Antibodies, Helminth.
- chemical , genetics : Antigens, Helminth, Recombinant Fusion Proteins.
- diagnosis : Elephantiasis, Filarial.
- genetics : Wuchereria bancrofti.
- isolation & purification : Wuchereria bancrofti.
- methods : Clinical Laboratory Techniques, Diagnostic Tests, Routine, Immunoprecipitation.
- parasitology : Elephantiasis, Filarial.
- Animals, Computational Biology, Expressed Sequence Tags, Female, Humans, Male, Molecular Sequence Data, Sensitivity and Specificity, Sequence Analysis, DNA.

Abstract

The current antibody tests used for monitoring in lymphatic filariasis (LF) elimination programs suffer from poor specificity because of the considerable geographical overlap with other filarial infections such as Loa loa (Ll), Onchocerca volvulus (Ov), and Mansonella perstans (Mp).

DOI: 10.1371/journal.pntd.0001930
PubMed: 23236529

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001E08
to stream PubMed, to step Curation: 001E08

Links to Exploration step

pubmed:23236529

Le document en format XML

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<term>Antigènes d'helminthe (génétique)</term>
<term>Biologie informatique</term>
<term>Données de séquences moléculaires</term>
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<term>Filariose lymphatique (diagnostic)</term>
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<term>Immunoprécipitation ()</term>
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<term>Protéines de fusion recombinantes</term>
<term>Wuchereria bancrofti</term>
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<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Wuchereria bancrofti</term>
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<term>Immunoprecipitation</term>
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<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term>
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<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Computational Biology</term>
<term>Expressed Sequence Tags</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Molecular Sequence Data</term>
<term>Sensitivity and Specificity</term>
<term>Sequence Analysis, DNA</term>
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<term>Animaux</term>
<term>Biologie informatique</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunoprécipitation</term>
<term>Mâle</term>
<term>Sensibilité et spécificité</term>
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<front><div type="abstract" xml:lang="en">The current antibody tests used for monitoring in lymphatic filariasis (LF) elimination programs suffer from poor specificity because of the considerable geographical overlap with other filarial infections such as Loa loa (Ll), Onchocerca volvulus (Ov), and Mansonella perstans (Mp).</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23236529</PMID>
<DateCreated><Year>2012</Year>
<Month>12</Month>
<Day>13</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>05</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1935-2735</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>6</Volume>
<Issue>12</Issue>
<PubDate><Year>2012</Year>
</PubDate>
</JournalIssue>
<Title>PLoS neglected tropical diseases</Title>
<ISOAbbreviation>PLoS Negl Trop Dis</ISOAbbreviation>
</Journal>
<ArticleTitle>Identification of Wb123 as an early and specific marker of Wuchereria bancrofti infection.</ArticleTitle>
<Pagination><MedlinePgn>e1930</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pntd.0001930</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The current antibody tests used for monitoring in lymphatic filariasis (LF) elimination programs suffer from poor specificity because of the considerable geographical overlap with other filarial infections such as Loa loa (Ll), Onchocerca volvulus (Ov), and Mansonella perstans (Mp).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Using bioinformatics to assemble into contigs 2048 expressed sequence tags (ESTs) from the L3 infective larvae of W. bancrofti (Wb), these were next assessed for homology to known proteins and nucleotides and to similar assemblies of L3 larval ESTs of B. malayi (Bm - n = 5068), Ov (n = 4166), and Ll (n = 3315). Nineteen potential L3- and Wb- and/or Bm-specific antigens were identified. Sixteen of the 19 antigens could be expressed as fusion proteins with Renilla luciferase (Ruc); these were used in a rapid Luciferase Immunopreciptation System (LIPS) assay.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">One of the 16 expressed antigens (Wb123) was both highly immunogenic and specific for Wb. Using Wb123-based IgG and IgG4 LIPS assays on well-defined sera from normal North Americans and those infected exclusively with intestinal helminths, we could detect all of the Wb-infected individuals (from diverse geographic regions) with 100% sensitivity and 100% specificity. Using sera from exclusively Ll-infected, Ov-infected Mp-infected or Bm-infected subjects as the negative comparator, the sensitivities were between 98-100% and the specificities ranged between 84-100% (for IgG anti-Wb123) and between 98-100% (for IgG4 anti-Wb123). Blinded assessments using panels of sera from various Wb-, Bm- or non-Wb helminth-infected subjects demonstrated equally high degrees of sensitivity and specificity.</AbstractText>
<AbstractText Label="SIGNIFICANCE" NlmCategory="CONCLUSIONS">We have identified a Wb-encoded antigen that can be used both as a rapid, high throughput tool to diagnose individual Wb infections and as a sensitive method for early detection of recrudescent infections in areas of control and for mapping new areas of Wb transmission.</AbstractText>
</Abstract>
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<ForeName>Joseph</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.</Affiliation>
</AffiliationInfo>
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<ForeName>Doran L</ForeName>
<Initials>DL</Initials>
</Author>
<Author ValidYN="Y"><LastName>Nutman</LastName>
<ForeName>Thomas B</ForeName>
<Initials>TB</Initials>
</Author>
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<PubMedPubDate PubStatus="accepted"><Year>2012</Year>
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<ArticleId IdType="doi">10.1371/journal.pntd.0001930</ArticleId>
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<affiliations><list><country><li>États-Unis</li>
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   |texte=   Identification of Wb123 as an early and specific marker of Wuchereria bancrofti infection.
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Identification of Wb123 as an early and specific marker of Wuchereria bancrofti infection.

Identification of Wb123 as an early and specific marker of Wuchereria bancrofti infection.

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