T and B cell deficiency associated with yellow nail syndrome.
Identifieur interne : 001D99 ( PubMed/Checkpoint ); précédent : 001D98; suivant : 001E00T and B cell deficiency associated with yellow nail syndrome.
Auteurs : S. Gupta [États-Unis] ; D. Samra ; L. Yel ; S. AgrawalSource :
- Scandinavian journal of immunology [ 1365-3083 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Déficit immunitaire commun variable (immunologie), Déficits immunitaires (immunologie), Femelle, Humains, Immunoglobulines (usage thérapeutique), Jeune adulte, Lymphocytes B (cytologie), Lymphocytes B (immunologie), Lymphocytes T CD4+ (cytologie), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD8+ (cytologie), Lymphocytes T CD8+ (immunologie), Mâle, Sujet âgé, Syndrome des ongles jaunes (), Syndrome des ongles jaunes (immunologie).
- MESH :
- cytologie : Lymphocytes B, Lymphocytes T CD4+, Lymphocytes T CD8+.
- immunologie : Déficit immunitaire commun variable, Déficits immunitaires, Lymphocytes B, Lymphocytes T CD4+, Lymphocytes T CD8+, Syndrome des ongles jaunes.
- usage thérapeutique : Immunoglobulines.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Sujet âgé, Syndrome des ongles jaunes.
English descriptors
- KwdEn :
- Adult, Aged, B-Lymphocytes (cytology), B-Lymphocytes (immunology), CD4-Positive T-Lymphocytes (cytology), CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (cytology), CD8-Positive T-Lymphocytes (immunology), Common Variable Immunodeficiency (immunology), Female, Humans, Immunoglobulins (therapeutic use), Immunologic Deficiency Syndromes (immunology), Male, Middle Aged, Yellow Nail Syndrome (immunology), Yellow Nail Syndrome (therapy), Young Adult.
- MESH :
- chemical , therapeutic use : Immunoglobulins.
- cytology : B-Lymphocytes, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes.
- immunology : B-Lymphocytes, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Common Variable Immunodeficiency, Immunologic Deficiency Syndromes, Yellow Nail Syndrome.
- therapy : Yellow Nail Syndrome.
- Adult, Aged, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology that is characterized by yellow nails associated with lymphoedema and chronic respiratory manifestations. There are no detailed immunological studies in YNS. In this study, we present first extensive immunological analysis of both adaptive and innate immunity in two patients with YNS. One patient has common variable immunodeficiency, whereas second patient has specific antibody deficiency syndrome. Severe lymphopaenia, a striking deficiency of naïve CD4+ and CD8+ T cells and total B cells, and increased transitional B cells were observed. T cell proliferative response to mitogens and antigens was significantly reduced in both patients. Both patients failed to make specific antibody response to pneumococci. Complement, natural killer cell activity and neutrophil oxidative burst were normal. Immunoglobulin administration resulted in decreased frequency and severity of infections, and an impressive effect was observed on lymphoedema and on the recurrence of pleural effusion. Our data show that YNS is associated with both T and B cell defects. Furthermore, Immunoglobulin may be beneficial in clinical manifestations of lymphoedema.
DOI: 10.1111/j.1365-3083.2011.02653.x
PubMed: 21995335
Affiliations:
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Gupta</name><affiliation wicri:level="2"><nlm:affiliation>Division of Basic and Clinical Immunology, University of California, Irvine, CA, USA. sgupta@uci.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Basic and Clinical Immunology, University of California, Irvine, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Samra, D" sort="Samra, D" uniqKey="Samra D" first="D" last="Samra">D. Samra</name></author><author><name sortKey="Yel, L" sort="Yel, L" uniqKey="Yel L" first="L" last="Yel">L. Yel</name></author><author><name sortKey="Agrawal, S" sort="Agrawal, S" uniqKey="Agrawal S" first="S" last="Agrawal">S. 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There are no detailed immunological studies in YNS. In this study, we present first extensive immunological analysis of both adaptive and innate immunity in two patients with YNS. One patient has common variable immunodeficiency, whereas second patient has specific antibody deficiency syndrome. Severe lymphopaenia, a striking deficiency of naïve CD4+ and CD8+ T cells and total B cells, and increased transitional B cells were observed. T cell proliferative response to mitogens and antigens was significantly reduced in both patients. Both patients failed to make specific antibody response to pneumococci. Complement, natural killer cell activity and neutrophil oxidative burst were normal. Immunoglobulin administration resulted in decreased frequency and severity of infections, and an impressive effect was observed on lymphoedema and on the recurrence of pleural effusion. Our data show that YNS is associated with both T and B cell defects. Furthermore, Immunoglobulin may be beneficial in clinical manifestations of lymphoedema.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21995335</PMID><DateCreated><Year>2012</Year><Month>02</Month><Day>14</Day></DateCreated><DateCompleted><Year>2012</Year><Month>06</Month><Day>12</Day></DateCompleted><DateRevised><Year>2014</Year><Month>04</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1365-3083</ISSN><JournalIssue CitedMedium="Internet"><Volume>75</Volume><Issue>3</Issue><PubDate><Year>2012</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Scandinavian journal of immunology</Title><ISOAbbreviation>Scand. J. Immunol.</ISOAbbreviation></Journal><ArticleTitle>T and B cell deficiency associated with yellow nail syndrome.</ArticleTitle><Pagination><MedlinePgn>329-35</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1365-3083.2011.02653.x</ELocationID><Abstract><AbstractText>Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology that is characterized by yellow nails associated with lymphoedema and chronic respiratory manifestations. There are no detailed immunological studies in YNS. In this study, we present first extensive immunological analysis of both adaptive and innate immunity in two patients with YNS. One patient has common variable immunodeficiency, whereas second patient has specific antibody deficiency syndrome. Severe lymphopaenia, a striking deficiency of naïve CD4+ and CD8+ T cells and total B cells, and increased transitional B cells were observed. T cell proliferative response to mitogens and antigens was significantly reduced in both patients. Both patients failed to make specific antibody response to pneumococci. Complement, natural killer cell activity and neutrophil oxidative burst were normal. Immunoglobulin administration resulted in decreased frequency and severity of infections, and an impressive effect was observed on lymphoedema and on the recurrence of pleural effusion. Our data show that YNS is associated with both T and B cell defects. Furthermore, Immunoglobulin may be beneficial in clinical manifestations of lymphoedema.</AbstractText><CopyrightInformation>© 2011 The Authors. Scandinavian Journal of Immunology © 2011 Blackwell Publishing Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Basic and Clinical Immunology, University of California, Irvine, CA, USA. sgupta@uci.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Samra</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Yel</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Agrawal</LastName><ForeName>S</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Scand J Immunol</MedlineTA><NlmUniqueID>0323767</NlmUniqueID><ISSNLinking>0300-9475</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007136">Immunoglobulins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001402" MajorTopicYN="N">B-Lymphocytes</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017074" MajorTopicYN="N">Common Variable Immunodeficiency</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007136" MajorTopicYN="N">Immunoglobulins</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007153" MajorTopicYN="N">Immunologic Deficiency Syndromes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056684" MajorTopicYN="N">Yellow Nail Syndrome</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>6</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21995335</ArticleId><ArticleId IdType="doi">10.1111/j.1365-3083.2011.02653.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Agrawal, S" sort="Agrawal, S" uniqKey="Agrawal S" first="S" last="Agrawal">S. Agrawal</name><name sortKey="Samra, D" sort="Samra, D" uniqKey="Samra D" first="D" last="Samra">D. Samra</name><name sortKey="Yel, L" sort="Yel, L" uniqKey="Yel L" first="L" last="Yel">L. Yel</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Gupta, S" sort="Gupta, S" uniqKey="Gupta S" first="S" last="Gupta">S. Gupta</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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