[A case of advanced breast carcinoma treated with topical S-1 plus letrozole].
Identifieur interne : 001D40 ( PubMed/Checkpoint ); précédent : 001D39; suivant : 001D41[A case of advanced breast carcinoma treated with topical S-1 plus letrozole].
Auteurs : Katsuhisa Enomoto [Japon] ; Kenichi SakuraiSource :
- Gan to kagaku ryoho. Cancer & chemotherapy [ 0385-0684 ] ; 2012.
Descripteurs français
- KwdFr :
- Acide oxonique (administration et posologie), Adulte d'âge moyen, Association médicamenteuse, Biopsie, Femelle, Humains, Nitriles (administration et posologie), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Résultat thérapeutique, Stade de la tumeur, Triazoles (administration et posologie), Tumeurs du sein (anatomopathologie), Tumeurs du sein (traitement médicamenteux), Tégafur (administration et posologie).
- MESH :
- administration et posologie : Acide oxonique, Nitriles, Triazoles, Tégafur.
- anatomopathologie : Tumeurs du sein.
- traitement médicamenteux : Tumeurs du sein.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- Adulte d'âge moyen, Association médicamenteuse, Biopsie, Femelle, Humains, Résultat thérapeutique, Stade de la tumeur.
English descriptors
- KwdEn :
- Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Biopsy, Breast Neoplasms (drug therapy), Breast Neoplasms (pathology), Drug Combinations, Female, Humans, Middle Aged, Neoplasm Staging, Nitriles (administration & dosage), Oxonic Acid (administration & dosage), Tegafur (administration & dosage), Treatment Outcome, Triazoles (administration & dosage).
- MESH :
- chemical , administration & dosage : Nitriles, Oxonic Acid, Tegafur, Triazoles.
- chemical : Drug Combinations.
- drug therapy : Breast Neoplasms.
- pathology : Breast Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Biopsy, Female, Humans, Middle Aged, Neoplasm Staging, Treatment Outcome.
Abstract
The patient was a 75-year-old woman. Her chief complaint was edema in the right upper arm since December 2009. The right breast displayed a skin ulcer. The local findings were apparent in the right breast and the right axilla, and palpation revealed a mass under the skin ulcer that was diagnosed as papillotubular carcinoma by needle biopsy. The classification was T4bN1M1, stage IV, ER (+), PgR (+), and human epidermal growth factor receptor type 2 score 0. Because of failed cardiac function and lubricity, S-1(80 mg/body) and letrozole(2.5 mg/po) were administered. Lymph node reduction, disappearance of ulcerated skin, tumor reduction, and upper arm lymphedema were improved markedly after drug administration, and the tumor marker level decreased. Chemotherapies cause significant side effects, and the use of medicine in elderly patients with advanced breast carcinoma is limited. A clinical partial remission was achieved by administration of S-1 as the third-line therapy. Therefore, first-line administration of S-1 may be effective in such cases.
PubMed: 23267930
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Her chief complaint was edema in the right upper arm since December 2009. The right breast displayed a skin ulcer. The local findings were apparent in the right breast and the right axilla, and palpation revealed a mass under the skin ulcer that was diagnosed as papillotubular carcinoma by needle biopsy. The classification was T4bN1M1, stage IV, ER (+), PgR (+), and human epidermal growth factor receptor type 2 score 0. Because of failed cardiac function and lubricity, S-1(80 mg/body) and letrozole(2.5 mg/po) were administered. Lymph node reduction, disappearance of ulcerated skin, tumor reduction, and upper arm lymphedema were improved markedly after drug administration, and the tumor marker level decreased. Chemotherapies cause significant side effects, and the use of medicine in elderly patients with advanced breast carcinoma is limited. A clinical partial remission was achieved by administration of S-1 as the third-line therapy. Therefore, first-line administration of S-1 may be effective in such cases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23267930</PMID><DateCreated><Year>2012</Year><Month>12</Month><Day>26</Day></DateCreated><DateCompleted><Year>2013</Year><Month>04</Month><Day>09</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0385-0684</ISSN><JournalIssue CitedMedium="Print"><Volume>39</Volume><Issue>12</Issue><PubDate><Year>2012</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Gan to kagaku ryoho. Cancer & chemotherapy</Title><ISOAbbreviation>Gan To Kagaku Ryoho</ISOAbbreviation></Journal><ArticleTitle>[A case of advanced breast carcinoma treated with topical S-1 plus letrozole].</ArticleTitle><Pagination><MedlinePgn>1920-2</MedlinePgn></Pagination><Abstract><AbstractText>The patient was a 75-year-old woman. Her chief complaint was edema in the right upper arm since December 2009. The right breast displayed a skin ulcer. The local findings were apparent in the right breast and the right axilla, and palpation revealed a mass under the skin ulcer that was diagnosed as papillotubular carcinoma by needle biopsy. The classification was T4bN1M1, stage IV, ER (+), PgR (+), and human epidermal growth factor receptor type 2 score 0. Because of failed cardiac function and lubricity, S-1(80 mg/body) and letrozole(2.5 mg/po) were administered. Lymph node reduction, disappearance of ulcerated skin, tumor reduction, and upper arm lymphedema were improved markedly after drug administration, and the tumor marker level decreased. Chemotherapies cause significant side effects, and the use of medicine in elderly patients with advanced breast carcinoma is limited. A clinical partial remission was achieved by administration of S-1 as the third-line therapy. Therefore, first-line administration of S-1 may be effective in such cases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Enomoto</LastName><ForeName>Katsuhisa</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Dept. of Surgery, Nihon University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sakurai</LastName><ForeName>Kenichi</ForeName><Initials>K</Initials></Author></AuthorList><Language>jpn</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Gan To Kagaku Ryoho</MedlineTA><NlmUniqueID>7810034</NlmUniqueID><ISSNLinking>0385-0684</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009570">Nitriles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014230">Triazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>150863-82-4</RegistryNumber><NameOfSubstance UI="C079198">S 1 (combination)</NameOfSubstance></Chemical><Chemical><RegistryNumber>1548R74NSZ</RegistryNumber><NameOfSubstance UI="D005641">Tegafur</NameOfSubstance></Chemical><Chemical><RegistryNumber>5VT6420TIG</RegistryNumber><NameOfSubstance UI="D010094">Oxonic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>7LKK855W8I</RegistryNumber><NameOfSubstance UI="C067431">letrozole</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000971" MajorTopicYN="N">Antineoplastic Combined Chemotherapy Protocols</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009367" MajorTopicYN="N">Neoplasm Staging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009570" MajorTopicYN="N">Nitriles</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010094" MajorTopicYN="N">Oxonic Acid</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005641" MajorTopicYN="N">Tegafur</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014230" MajorTopicYN="N">Triazoles</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>12</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>12</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23267930</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Sakurai, Kenichi" sort="Sakurai, Kenichi" uniqKey="Sakurai K" first="Kenichi" last="Sakurai">Kenichi Sakurai</name></noCountry><country name="Japon"><noRegion><name sortKey="Enomoto, Katsuhisa" sort="Enomoto, Katsuhisa" uniqKey="Enomoto K" first="Katsuhisa" last="Enomoto">Katsuhisa Enomoto</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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