Adiponectin-mediated modulation of lymphatic vessel formation and lymphedema.
Identifieur interne : 001C65 ( PubMed/Checkpoint ); précédent : 001C64; suivant : 001C66Adiponectin-mediated modulation of lymphatic vessel formation and lymphedema.
Auteurs : Yuuki Shimizu [Japon] ; Rei Shibata ; Masakazu Ishii ; Koji Ohashi ; Takahiro Kambara ; Yusuke Uemura ; Daisuke Yuasa ; Yoshiyuki Kataoka ; Shinji Kihara ; Toyoaki Murohara ; Noriyuki OuchiSource :
- Journal of the American Heart Association [ 2047-9980 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Adiponectine, Cellules endothéliales, Nitric oxide synthase type III, Protéines proto-oncogènes c-akt.
- étiologie : Lymphoedème.
- Animaux, Lymphangiogenèse, Mâle, Souris, Souris knockout.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Adiponectin, Nitric Oxide Synthase Type III, Proto-Oncogene Proteins c-akt.
- etiology : Lymphedema.
- physiology : Endothelial Cells.
- Animals, Lymphangiogenesis, Male, Mice, Mice, Knockout.
Abstract
Obesity is linked with an increased risk of lymphedema, which is a serious clinical problem. Adiponectin is a circulating adipokine that is down-regulated in obese states. We investigated the effects of adiponectin on lymphatic vessel formation in a model of lymphedema and dissected its mechanisms.
DOI: 10.1161/JAHA.113.000438
PubMed: 24052499
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:24052499Le document en format XML
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first="Koji" last="Ohashi">Koji Ohashi</name></author><author><name sortKey="Kambara, Takahiro" sort="Kambara, Takahiro" uniqKey="Kambara T" first="Takahiro" last="Kambara">Takahiro Kambara</name></author><author><name sortKey="Uemura, Yusuke" sort="Uemura, Yusuke" uniqKey="Uemura Y" first="Yusuke" last="Uemura">Yusuke Uemura</name></author><author><name sortKey="Yuasa, Daisuke" sort="Yuasa, Daisuke" uniqKey="Yuasa D" first="Daisuke" last="Yuasa">Daisuke Yuasa</name></author><author><name sortKey="Kataoka, Yoshiyuki" sort="Kataoka, Yoshiyuki" uniqKey="Kataoka Y" first="Yoshiyuki" last="Kataoka">Yoshiyuki Kataoka</name></author><author><name sortKey="Kihara, Shinji" sort="Kihara, Shinji" uniqKey="Kihara S" first="Shinji" last="Kihara">Shinji Kihara</name></author><author><name sortKey="Murohara, Toyoaki" sort="Murohara, Toyoaki" uniqKey="Murohara T" first="Toyoaki" last="Murohara">Toyoaki Murohara</name></author><author><name sortKey="Ouchi, Noriyuki" sort="Ouchi, Noriyuki" 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last="Shimizu">Yuuki Shimizu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Shibata, Rei" sort="Shibata, Rei" uniqKey="Shibata R" first="Rei" last="Shibata">Rei Shibata</name></author><author><name sortKey="Ishii, Masakazu" sort="Ishii, Masakazu" uniqKey="Ishii M" first="Masakazu" last="Ishii">Masakazu Ishii</name></author><author><name sortKey="Ohashi, Koji" sort="Ohashi, Koji" uniqKey="Ohashi K" first="Koji" last="Ohashi">Koji Ohashi</name></author><author><name sortKey="Kambara, Takahiro" sort="Kambara, Takahiro" uniqKey="Kambara T" first="Takahiro" last="Kambara">Takahiro Kambara</name></author><author><name sortKey="Uemura, Yusuke" sort="Uemura, Yusuke" uniqKey="Uemura Y" first="Yusuke" last="Uemura">Yusuke Uemura</name></author><author><name sortKey="Yuasa, Daisuke" sort="Yuasa, Daisuke" uniqKey="Yuasa D" first="Daisuke" last="Yuasa">Daisuke Yuasa</name></author><author><name sortKey="Kataoka, Yoshiyuki" sort="Kataoka, Yoshiyuki" uniqKey="Kataoka Y" first="Yoshiyuki" last="Kataoka">Yoshiyuki Kataoka</name></author><author><name sortKey="Kihara, Shinji" sort="Kihara, Shinji" uniqKey="Kihara S" first="Shinji" last="Kihara">Shinji Kihara</name></author><author><name sortKey="Murohara, Toyoaki" sort="Murohara, Toyoaki" uniqKey="Murohara T" first="Toyoaki" last="Murohara">Toyoaki Murohara</name></author><author><name sortKey="Ouchi, Noriyuki" sort="Ouchi, Noriyuki" uniqKey="Ouchi N" first="Noriyuki" last="Ouchi">Noriyuki Ouchi</name></author></analytic><series><title level="j">Journal of the American Heart Association</title><idno type="eISSN">2047-9980</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adiponectin (physiology)</term><term>Animals</term><term>Endothelial Cells (physiology)</term><term>Lymphangiogenesis</term><term>Lymphedema (etiology)</term><term>Male</term><term>Mice</term><term>Mice, Knockout</term><term>Nitric Oxide Synthase Type III (physiology)</term><term>Proto-Oncogene Proteins c-akt (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adiponectine (physiologie)</term><term>Animaux</term><term>Cellules endothéliales (physiologie)</term><term>Lymphangiogenèse</term><term>Lymphoedème (étiologie)</term><term>Mâle</term><term>Nitric oxide synthase type III (physiologie)</term><term>Protéines proto-oncogènes c-akt (physiologie)</term><term>Souris</term><term>Souris knockout</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Adiponectin</term><term>Nitric Oxide Synthase Type III</term><term>Proto-Oncogene Proteins c-akt</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Adiponectine</term><term>Cellules endothéliales</term><term>Nitric oxide synthase type III</term><term>Protéines proto-oncogènes c-akt</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Lymphangiogenesis</term><term>Male</term><term>Mice</term><term>Mice, Knockout</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Lymphangiogenèse</term><term>Mâle</term><term>Souris</term><term>Souris knockout</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Obesity is linked with an increased risk of lymphedema, which is a serious clinical problem. Adiponectin is a circulating adipokine that is down-regulated in obese states. We investigated the effects of adiponectin on lymphatic vessel formation in a model of lymphedema and dissected its mechanisms.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24052499</PMID><DateCreated><Year>2013</Year><Month>09</Month><Day>20</Day></DateCreated><DateCompleted><Year>2014</Year><Month>01</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2047-9980</ISSN><JournalIssue CitedMedium="Internet"><Volume>2</Volume><Issue>5</Issue><PubDate><Year>2013</Year><Month>Sep</Month><Day>19</Day></PubDate></JournalIssue><Title>Journal of the American Heart Association</Title><ISOAbbreviation>J Am Heart Assoc</ISOAbbreviation></Journal><ArticleTitle>Adiponectin-mediated modulation of lymphatic vessel formation and lymphedema.</ArticleTitle><Pagination><MedlinePgn>e000438</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1161/JAHA.113.000438</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Obesity is linked with an increased risk of lymphedema, which is a serious clinical problem. Adiponectin is a circulating adipokine that is down-regulated in obese states. We investigated the effects of adiponectin on lymphatic vessel formation in a model of lymphedema and dissected its mechanisms.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">A mouse model of lymphedema was created via ablation of tail surface lymphatic network. Adiponectin-knockout mice showed the greater diameter of the injured tail compared with wild-type mice, which was associated with lower numbers of lymphatic endothelial cells (LECs). Systemic delivery of adiponectin reduced the thickness of the injured tail and enhanced LEC formation in wild-type and adiponectin-knockout mice. Adiponectin administration also improved the edema of injured tails in obese KKAy mice. Treatment with adiponectin protein stimulated the differentiation of human LECs into tubelike structures and increased LEC viability. Adiponectin treatment promoted the phosphorylation of AMP-activated protein kinase (AMPK), Akt, and endothelial nitric oxide synthase n LECs. Blockade of AMPK or Akt activity abolished adiponectin-stimulated increase in LEC differentiation and viability and endothelial nitric oxide synthase phosphorylation. Inhibition of AMPK activation also suppressed adiponectin-induced Akt phosphorylation in LECs. In contrast, inactivation of Akt signaling had no effects on adiponectin-mediated AMPK phosphorylation in LECs. Furthermore, adiponectin administration did not affect the thickening of the damaged tail in endothelial nitric oxide synthase-knockout mice.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Adiponectin can promote lymphatic vessel formation via activation of AMPK/Akt/endothelial nitric oxide synthase signaling within LECs, thereby leading to amelioration of lymphedema.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shimizu</LastName><ForeName>Yuuki</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shibata</LastName><ForeName>Rei</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Ishii</LastName><ForeName>Masakazu</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ohashi</LastName><ForeName>Koji</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Kambara</LastName><ForeName>Takahiro</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Uemura</LastName><ForeName>Yusuke</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Yuasa</LastName><ForeName>Daisuke</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Kataoka</LastName><ForeName>Yoshiyuki</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Kihara</LastName><ForeName>Shinji</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Murohara</LastName><ForeName>Toyoaki</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Ouchi</LastName><ForeName>Noriyuki</ForeName><Initials>N</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>09</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Am Heart Assoc</MedlineTA><NlmUniqueID>101580524</NlmUniqueID><ISSNLinking>2047-9980</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052242">Adiponectin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.13.39</RegistryNumber><NameOfSubstance UI="D052250">Nitric Oxide Synthase Type III</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D051057">Proto-Oncogene Proteins c-akt</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2002 Nov;8(11):1288-95</RefSource><PMID 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Version="1">15123726</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D052242" MajorTopicYN="N">Adiponectin</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042783" MajorTopicYN="N">Endothelial Cells</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042583" MajorTopicYN="Y">Lymphangiogenesis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D052250" MajorTopicYN="N">Nitric Oxide Synthase Type III</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051057" MajorTopicYN="N">Proto-Oncogene Proteins c-akt</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3835259</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AMPK</Keyword><Keyword MajorTopicYN="N">Akt</Keyword><Keyword MajorTopicYN="N">adiponectin</Keyword><Keyword MajorTopicYN="N">eNOS</Keyword><Keyword MajorTopicYN="N">lymphangiogenesis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>9</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>9</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>1</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24052499</ArticleId><ArticleId IdType="pii">jah3303</ArticleId><ArticleId IdType="doi">10.1161/JAHA.113.000438</ArticleId><ArticleId IdType="pmc">PMC3835259</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Ishii, Masakazu" sort="Ishii, Masakazu" uniqKey="Ishii M" first="Masakazu" last="Ishii">Masakazu Ishii</name><name sortKey="Kambara, Takahiro" sort="Kambara, Takahiro" uniqKey="Kambara T" first="Takahiro" last="Kambara">Takahiro Kambara</name><name sortKey="Kataoka, Yoshiyuki" sort="Kataoka, Yoshiyuki" uniqKey="Kataoka Y" first="Yoshiyuki" last="Kataoka">Yoshiyuki Kataoka</name><name sortKey="Kihara, Shinji" sort="Kihara, Shinji" uniqKey="Kihara S" first="Shinji" last="Kihara">Shinji Kihara</name><name sortKey="Murohara, Toyoaki" sort="Murohara, Toyoaki" uniqKey="Murohara T" first="Toyoaki" last="Murohara">Toyoaki Murohara</name><name sortKey="Ohashi, Koji" sort="Ohashi, Koji" uniqKey="Ohashi K" first="Koji" last="Ohashi">Koji Ohashi</name><name sortKey="Ouchi, Noriyuki" sort="Ouchi, Noriyuki" uniqKey="Ouchi N" first="Noriyuki" last="Ouchi">Noriyuki Ouchi</name><name sortKey="Shibata, Rei" sort="Shibata, Rei" uniqKey="Shibata R" first="Rei" last="Shibata">Rei Shibata</name><name sortKey="Uemura, Yusuke" sort="Uemura, Yusuke" uniqKey="Uemura Y" first="Yusuke" last="Uemura">Yusuke Uemura</name><name sortKey="Yuasa, Daisuke" sort="Yuasa, Daisuke" uniqKey="Yuasa D" first="Daisuke" last="Yuasa">Daisuke Yuasa</name></noCountry><country name="Japon"><noRegion><name sortKey="Shimizu, Yuuki" sort="Shimizu, Yuuki" uniqKey="Shimizu Y" first="Yuuki" last="Shimizu">Yuuki Shimizu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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