Kampo Extract of Shinbuto Improved Refractory Diarrhea in Milroy's Disease.
Identifieur interne : 001A76 ( PubMed/Checkpoint ); précédent : 001A75; suivant : 001A77Kampo Extract of Shinbuto Improved Refractory Diarrhea in Milroy's Disease.
Auteurs : Yuko Horiba [Japon] ; Tetsuhiro Yoshino ; Kenji WatanabeSource :
- Global advances in health and medicine [ 2164-957X ] ; 2013.
Abstract
Milroy's disease is a hereditary congenital lymphedema caused by lymphatic obstruction. The legs are most commonly affected, but impaired intestinal lymphatic flow can cause loose bowel movements. Here, we report the use of the Kampo extract of shinbuto for successful treatment of and abdominal pain in a patient with Milroy's disease. Milroy's disease was diagnosed because of left leg lymph-edema with onset at birth. Conservative therapy with a compression bandage was applied. However, when the patient moved to Manila at 35 years of age, she was exposed to drastic temperature changes between the air-conditioned cold environment in her room and the hot and humid environment outside. She developed a constitutional state of coldness as in hiesho (え). Then sudden lower abdominal pain and diarrhea began to occur 3 times per week and lasted at least 1 hour, sometimes accompanied by vomiting. It happened particularly when she was exposed to the cold environment and was not related to meals. Conventional anti-cholinergic or antidiarrhetic drugs had no therapeutic effect. These attacks continued in the same frequency for 3 years, so the patient visited a Kampo (traditional Japanese medicine) clinic, where her diagnosis of Milroy's disease-associated diarrhea and abdominal pain was augmented by the Kampo diagnosis of hiesho, suitai (body fluid retention). She was prescribed 7.5 g of shinbuto extract per day (TJ-30; Tsumura Co, Tokyo, Japan). The shinbuto extract significantly reduced abdominal pain and refractory diarrhea to about 2 days per month, and it tapered off completely in 3 months. Shinbuto is usually used against cold-induced diarrhea. Rewarming and water movement by shinbuto resulted in significant improvement in symptoms induced by hiesho and suitai triggered by the cold environment, though the patient's leg swelling did not change.
DOI: 10.7453/gahmj.2013.2.1.003
PubMed: 24278839
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The legs are most commonly affected, but impaired intestinal lymphatic flow can cause loose bowel movements. Here, we report the use of the Kampo extract of shinbuto for successful treatment of and abdominal pain in a patient with Milroy's disease. Milroy's disease was diagnosed because of left leg lymph-edema with onset at birth. Conservative therapy with a compression bandage was applied. However, when the patient moved to Manila at 35 years of age, she was exposed to drastic temperature changes between the air-conditioned cold environment in her room and the hot and humid environment outside. She developed a constitutional state of coldness as in hiesho (え). Then sudden lower abdominal pain and diarrhea began to occur 3 times per week and lasted at least 1 hour, sometimes accompanied by vomiting. It happened particularly when she was exposed to the cold environment and was not related to meals. Conventional anti-cholinergic or antidiarrhetic drugs had no therapeutic effect. These attacks continued in the same frequency for 3 years, so the patient visited a Kampo (traditional Japanese medicine) clinic, where her diagnosis of Milroy's disease-associated diarrhea and abdominal pain was augmented by the Kampo diagnosis of hiesho, suitai (body fluid retention). She was prescribed 7.5 g of shinbuto extract per day (TJ-30; Tsumura Co, Tokyo, Japan). The shinbuto extract significantly reduced abdominal pain and refractory diarrhea to about 2 days per month, and it tapered off completely in 3 months. Shinbuto is usually used against cold-induced diarrhea. Rewarming and water movement by shinbuto resulted in significant improvement in symptoms induced by hiesho and suitai triggered by the cold environment, though the patient's leg swelling did not change.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">24278839</PMID><DateCreated><Year>2013</Year><Month>11</Month><Day>26</Day></DateCreated><DateCompleted><Year>2013</Year><Month>11</Month><Day>26</Day></DateCompleted><DateRevised><Year>2017</Year><Month>03</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">2164-957X</ISSN><JournalIssue CitedMedium="Print"><Volume>2</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Global advances in health and medicine</Title><ISOAbbreviation>Glob Adv Health Med</ISOAbbreviation></Journal><ArticleTitle>Kampo Extract of Shinbuto Improved Refractory Diarrhea in Milroy's Disease.</ArticleTitle><Pagination><MedlinePgn>14-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.7453/gahmj.2013.2.1.003</ELocationID><Abstract><AbstractText>Milroy's disease is a hereditary congenital lymphedema caused by lymphatic obstruction. The legs are most commonly affected, but impaired intestinal lymphatic flow can cause loose bowel movements. Here, we report the use of the Kampo extract of shinbuto for successful treatment of and abdominal pain in a patient with Milroy's disease. Milroy's disease was diagnosed because of left leg lymph-edema with onset at birth. Conservative therapy with a compression bandage was applied. However, when the patient moved to Manila at 35 years of age, she was exposed to drastic temperature changes between the air-conditioned cold environment in her room and the hot and humid environment outside. She developed a constitutional state of coldness as in hiesho (え). Then sudden lower abdominal pain and diarrhea began to occur 3 times per week and lasted at least 1 hour, sometimes accompanied by vomiting. It happened particularly when she was exposed to the cold environment and was not related to meals. Conventional anti-cholinergic or antidiarrhetic drugs had no therapeutic effect. These attacks continued in the same frequency for 3 years, so the patient visited a Kampo (traditional Japanese medicine) clinic, where her diagnosis of Milroy's disease-associated diarrhea and abdominal pain was augmented by the Kampo diagnosis of hiesho, suitai (body fluid retention). She was prescribed 7.5 g of shinbuto extract per day (TJ-30; Tsumura Co, Tokyo, Japan). The shinbuto extract significantly reduced abdominal pain and refractory diarrhea to about 2 days per month, and it tapered off completely in 3 months. Shinbuto is usually used against cold-induced diarrhea. Rewarming and water movement by shinbuto resulted in significant improvement in symptoms induced by hiesho and suitai triggered by the cold environment, though the patient's leg swelling did not change.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Horiba</LastName><ForeName>Yuko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Center for Kampo Medicine, Keio University School of Medicine, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yoshino</LastName><ForeName>Tetsuhiro</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Watanabe</LastName><ForeName>Kenji</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Glob Adv Health Med</MedlineTA><NlmUniqueID>101584936</NlmUniqueID><ISSNLinking>2164-9561</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Br J Surg. 2002 Jan;89(1):74-8</RefSource><PMID Version="1">11851667</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chem Pharm Bull (Tokyo). 1986 Sep;34(9):3854-60</RefSource><PMID Version="1">3815607</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Yakugaku Zasshi. 2001 Feb;121(2):173-8</RefSource><PMID Version="1">11218732</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Breast J. 2004 Nov-Dec;10 (6):496-503</RefSource><PMID Version="1">15569205</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circulation. 1981 Dec;64(6):1195-200</RefSource><PMID Version="1">6170474</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Genet. 1985 Aug;22(4):274-8</RefSource><PMID Version="1">4045953</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 2003 Jun;36(2):84-91</RefSource><PMID Version="1">12926833</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Genet. 2007 Feb;71(2):187-9</RefSource><PMID Version="1">17250670</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Radiol. 1996 Dec;69(828):1117-24</RefSource><PMID Version="1">9135466</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2000 Jun;25(2):153-9</RefSource><PMID Version="1">10835628</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Coll Cardiol. 2008 Sep 2;52(10):799-806</RefSource><PMID Version="1">18755341</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Yakugaku Zasshi. 1969 Jul;89(7):893-8</RefSource><PMID Version="1">5387627</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 1998 Sep;31(3):119-27</RefSource><PMID Version="1">9793922</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>QJM. 2003 Oct;96(10):731-8</RefSource><PMID Version="1">14500859</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Pharmacobiodyn. 1984 Nov;7(11):836-48</RefSource><PMID Version="1">6335723</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nihon Yakurigaku Zasshi. 1992 Oct;100(4):307-16</RefSource><PMID Version="1">1446881</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 1988 Sep;21(3):152-60</RefSource><PMID Version="1">3199874</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">PMC3833580</OtherID><OtherAbstract Type="Publisher" Language="chi"><AbstractText>米洛病 (Milroy’s disease) 是 一种因淋巴管阻塞而引起的遗传 性淋巴水肿。此病最易感染患者 腿部，而受损的肠道淋巴流则能 够导致稀便。这里，我们报告的 是，使用汉方 (Kampo) 真武汤 (shinbuto) 提取物可成功治疗米 洛病患者，并缓解其腹痛。米洛 病是因患者出生时左腿淋巴水肿 发作而被诊断出来的。当时采用 的是压缩绷带的保守疗法。但当 该患者在 35 岁迁至马尼拉时， 她经常在凉爽的空调环境与炎热 潮湿的室外环境之间经历极端的 温度变化。她随后变成了寒性体 质，即寒症（hiesho，“冷え 症”）。接着，她突然出现每周 3 次，每次至少持续 1 小时的下 腹疼痛和腹泻，有时还伴有呕 吐。这种症状在其进入寒冷环境 时尤为明显，并且与饮食无关。 传统的抗胆碱能药物或止泻药物 无任何疗效。此病依同样的频率 持续发作了 3 年，于是，该患者 前往汉方（Kampo，传统日本医 学）诊所就诊，在那里，她患有 米洛病相关腹泻和腹痛的诊断得 到了汉方寒症，即 suitai（体液 潴留）诊断的证实。医生给她开 了每天 7.5 克的真武汤提取物 （TJ-30；日本东京津村株式会 社）。真武汤提取物显著缓解了 腹痛和顽固性腹泻，将频率降至 每个月 2 天左右，并在 3 个月内 完全消失。真武汤通常用于治疗 因寒冷引发的腹泻。真武汤可引 起复温和体液流动，进而显著改 善因寒冷环境触发的寒症和体液 潴留而引起的症状，只不过腿部 肿胀并无改善。</AbstractText></OtherAbstract><OtherAbstract Type="Publisher" Language="spa"><AbstractText>La enfermedad de Milroy es un linfoedema congénito hereditario causado por la obstrucción linfática. Suele afectar a las piernas, pero los trastornos del flujo linfático intestinal pueden producir defecaciones blandas. En este texto notificamos el uso del extracto Kampo de Shimbuto (Zhen-Wu-Tang) para el éxito del tratamiento del dolor abdominal en una paciente con enfermedad de Milroy. Esta enfermedad se diagnosticó a causa del linfoedema de la pierna izquierda que había comenzado en el momento del nacimiento. Se aplicó un tratamiento conservador con un vendaje de compresión. Sin embargo, cuando la paciente se trasladó a Manila a los 35 años de edad, se vio expuesta a drásticos cambios de temperatura entre el entorno con aire acondicionado frío de su habitación y el ambiente cálido y húmedo del exterior. Comenzó a sufrir un estado constitucional de frialdad como en el trastorno conocido como hiesho «冷え症». Posteriormente, comenzó a sufrir un dolor en la parte inferior del abdomen y diarrea tres veces por semana que duraban al menos 1 hora, en ocasiones acompañados de vómitos. Esto ocurría especialmente cuando se veía expuesta al entorno frío y no se relacionaba con las comidas. Los fármacos anticolinérgicos o antidiarréicos tradicionales no produjeron efecto terapéutico alguno. Estos ataques continuaron con la misma frecuencia durante 3 años, por lo que la paciente visitó una clínica Kampo (medicina tradicional japonesa) donde se aumentó su diagnóstico de diarrea y dolor abdominal relacionados con la enfermedad de Milroy con el diagnóstico Kampo de hiesho y suitai (retención de líquidos corporales). Se le recetaron 7,5 g de extracto de Shimbu-to al día (TJ-30; Tsumura Co, Tokio, Japón), con lo que se redujo de forma significativa el dolor abdominal y la diarrea resistente al tratamiento a unos 2 días al mes, para terminar desapareciendo gradualmente por completo en 3 meses. El extracto Shimbu-to suele usarse contra la diarrea provocada por el frío. El nuevo calentamiento y el movimiento del agua por parte del extracto Shimbu-to obtuvieron mejoras significativas en los síntomas provocados por hiesho y suitai desencadenados por el entorno frío, aunque la hinchazón de la pierna no ha cambiado.</AbstractText></OtherAbstract><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Diarrhea</Keyword><Keyword MajorTopicYN="N">Kampo medicine</Keyword><Keyword MajorTopicYN="N">Milroy's disease</Keyword><Keyword MajorTopicYN="N">body fluid retention (suitai)</Keyword><Keyword MajorTopicYN="N">coldness (hie)</Keyword><Keyword MajorTopicYN="N">lymphedema</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>11</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24278839</ArticleId><ArticleId IdType="doi">10.7453/gahmj.2013.2.1.003</ArticleId><ArticleId IdType="pii">gahmj.2013.2.1.003</ArticleId><ArticleId IdType="pmc">PMC3833580</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Watanabe, Kenji" sort="Watanabe, Kenji" uniqKey="Watanabe K" first="Kenji" last="Watanabe">Kenji Watanabe</name><name sortKey="Yoshino, Tetsuhiro" sort="Yoshino, Tetsuhiro" uniqKey="Yoshino T" first="Tetsuhiro" last="Yoshino">Tetsuhiro Yoshino</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Horiba, Yuko" sort="Horiba, Yuko" uniqKey="Horiba Y" first="Yuko" last="Horiba">Yuko Horiba</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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