Microvascular filtration is increased in the forearms of patients with breast cancer-related lymphedema.
Identifieur interne : 001A05 ( PubMed/Checkpoint ); précédent : 001A04; suivant : 001A06Microvascular filtration is increased in the forearms of patients with breast cancer-related lymphedema.
Auteurs : Mads Radmer Jensen [Danemark] ; Lene Simonsen ; Tonny Karlsmark ; Jens BülowSource :
- Journal of applied physiology (Bethesda, Md. : 1985) [ 1522-1601 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Avant-bras (), Avant-bras (physiopathologie), Débit sanguin régional (physiologie), Femelle, Humains, Lymphoedème (), Lymphoedème (physiopathologie), Microcirculation (physiologie), Muscles (), Muscles (physiopathologie), Peau (physiopathologie), Perméabilité capillaire (physiologie), Pression sanguine (physiologie), Réflexe (physiologie), Tumeurs du sein (), Tumeurs du sein (physiopathologie), Vaisseaux capillaires (physiopathologie).
- MESH :
- physiologie : Débit sanguin régional, Microcirculation, Perméabilité capillaire, Pression sanguine, Réflexe.
- physiopathologie : Avant-bras, Lymphoedème, Muscles, Peau, Tumeurs du sein, Vaisseaux capillaires.
- Adulte d'âge moyen, Avant-bras, Femelle, Humains, Lymphoedème, Muscles, Tumeurs du sein.
English descriptors
- KwdEn :
- Blood Pressure (physiology), Breast Neoplasms (chemistry), Breast Neoplasms (physiopathology), Capillaries (physiopathology), Capillary Permeability (physiology), Female, Forearm (blood supply), Forearm (physiopathology), Humans, Lymphedema (chemically induced), Lymphedema (physiopathology), Microcirculation (physiology), Middle Aged, Muscles (blood supply), Muscles (physiopathology), Reflex (physiology), Regional Blood Flow (physiology), Skin (physiopathology).
- MESH :
- blood supply : Forearm, Muscles.
- chemically induced : Lymphedema.
- chemistry : Breast Neoplasms.
- physiology : Blood Pressure, Capillary Permeability, Microcirculation, Reflex, Regional Blood Flow.
- physiopathology : Breast Neoplasms, Capillaries, Forearm, Lymphedema, Muscles, Skin.
- Female, Humans, Middle Aged.
Abstract
Breast cancer-related lymphedema (BCRL) is a frequent and debilitating complication of breast cancer treatment. The pathophysiology is complex and remains poorly understood; however, data suggest that changes in the peripheral circulation may contribute to edema formation. In 13 volunteers with unilateral BCRL, the following aspects of upper extremity peripheral circulation were examined: muscle relative microvascular volume; capillary filtration coefficient; central and local sympathetic vascular reflexes; skin blood flow; and forearm blood flow. These were studied via real-time, contrast-enhanced ultrasound; venous occlusion strain-gauge plethysmography; lower-body negative pressure; noninvasive blood pressure measurements; and skin (99m)Tc-pertechnetate clearance technique. Measurements were performed bilaterally and simultaneously in the forearms, enabling use of the nonedematous forearm as a control. Capillary filtration coefficients were additionally measured in healthy, age-matched controls. The capillary filtration coefficient was 7.98 ± 2.52 μl·100 ml(-1)·mmHg(-1)·min(-1) (mean ± SD) in edematous forearms and 6.09 ± 1.83 μl·100ml·(-1)·mmHg(-1)·min(-1) in nonedematous forearms in the patient group (P < 0.001). The capillary filtration coefficient was 3.32 ± 1.17 μl·100ml(-1)·mmHg(-1)·min(-1) in the forearms of healthy controls; significantly less than the both the edematous and nonedematous forearms of the patient group (P < 0.001). No significant differences were found in muscle relative microvascular volume, forearm blood flow, skin blood flow, or central or local sympathetic vascular reflexes. Forearm microvascular filtration is increased in patients with BCRL, and more so in the edematous arm. The vascular sympathetic control mechanisms seem to be preserved. We propose that the increased capillary permeability may be due to low-grade inflammation promoted by reduced clearance of inflammatory mediators.
DOI: 10.1152/japplphysiol.01116.2012
PubMed: 23123353
Affiliations:
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last="Simonsen">Lene Simonsen</name></author><author><name sortKey="Karlsmark, Tonny" sort="Karlsmark, Tonny" uniqKey="Karlsmark T" first="Tonny" last="Karlsmark">Tonny Karlsmark</name></author><author><name sortKey="Bulow, Jens" sort="Bulow, Jens" uniqKey="Bulow J" first="Jens" last="Bülow">Jens Bülow</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23123353</idno><idno type="pmid">23123353</idno><idno type="doi">10.1152/japplphysiol.01116.2012</idno><idno type="wicri:Area/PubMed/Corpus">001E79</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001E79</idno><idno type="wicri:Area/PubMed/Curation">001E79</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001E79</idno><idno type="wicri:Area/PubMed/Checkpoint">001E79</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" 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uniqKey="Simonsen L" first="Lene" last="Simonsen">Lene Simonsen</name></author><author><name sortKey="Karlsmark, Tonny" sort="Karlsmark, Tonny" uniqKey="Karlsmark T" first="Tonny" last="Karlsmark">Tonny Karlsmark</name></author><author><name sortKey="Bulow, Jens" sort="Bulow, Jens" uniqKey="Bulow J" first="Jens" last="Bülow">Jens Bülow</name></author></analytic><series><title level="j">Journal of applied physiology (Bethesda, Md. : 1985)</title><idno type="eISSN">1522-1601</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood Pressure (physiology)</term><term>Breast Neoplasms (chemistry)</term><term>Breast Neoplasms (physiopathology)</term><term>Capillaries (physiopathology)</term><term>Capillary Permeability (physiology)</term><term>Female</term><term>Forearm (blood supply)</term><term>Forearm (physiopathology)</term><term>Humans</term><term>Lymphedema (chemically induced)</term><term>Lymphedema (physiopathology)</term><term>Microcirculation (physiology)</term><term>Middle Aged</term><term>Muscles (blood supply)</term><term>Muscles (physiopathology)</term><term>Reflex (physiology)</term><term>Regional Blood Flow (physiology)</term><term>Skin (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Avant-bras ()</term><term>Avant-bras (physiopathologie)</term><term>Débit sanguin régional (physiologie)</term><term>Femelle</term><term>Humains</term><term>Lymphoedème ()</term><term>Lymphoedème (physiopathologie)</term><term>Microcirculation (physiologie)</term><term>Muscles ()</term><term>Muscles (physiopathologie)</term><term>Peau (physiopathologie)</term><term>Perméabilité capillaire (physiologie)</term><term>Pression sanguine (physiologie)</term><term>Réflexe (physiologie)</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (physiopathologie)</term><term>Vaisseaux capillaires (physiopathologie)</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Forearm</term><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Débit sanguin régional</term><term>Microcirculation</term><term>Perméabilité capillaire</term><term>Pression sanguine</term><term>Réflexe</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term><term>Capillary Permeability</term><term>Microcirculation</term><term>Reflex</term><term>Regional Blood Flow</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Avant-bras</term><term>Lymphoedème</term><term>Muscles</term><term>Peau</term><term>Tumeurs du sein</term><term>Vaisseaux capillaires</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Breast Neoplasms</term><term>Capillaries</term><term>Forearm</term><term>Lymphedema</term><term>Muscles</term><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Avant-bras</term><term>Femelle</term><term>Humains</term><term>Lymphoedème</term><term>Muscles</term><term>Tumeurs du sein</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Breast cancer-related lymphedema (BCRL) is a frequent and debilitating complication of breast cancer treatment. The pathophysiology is complex and remains poorly understood; however, data suggest that changes in the peripheral circulation may contribute to edema formation. In 13 volunteers with unilateral BCRL, the following aspects of upper extremity peripheral circulation were examined: muscle relative microvascular volume; capillary filtration coefficient; central and local sympathetic vascular reflexes; skin blood flow; and forearm blood flow. These were studied via real-time, contrast-enhanced ultrasound; venous occlusion strain-gauge plethysmography; lower-body negative pressure; noninvasive blood pressure measurements; and skin (99m)Tc-pertechnetate clearance technique. Measurements were performed bilaterally and simultaneously in the forearms, enabling use of the nonedematous forearm as a control. Capillary filtration coefficients were additionally measured in healthy, age-matched controls. The capillary filtration coefficient was 7.98 ± 2.52 μl·100 ml(-1)·mmHg(-1)·min(-1) (mean ± SD) in edematous forearms and 6.09 ± 1.83 μl·100ml·(-1)·mmHg(-1)·min(-1) in nonedematous forearms in the patient group (P < 0.001). The capillary filtration coefficient was 3.32 ± 1.17 μl·100ml(-1)·mmHg(-1)·min(-1) in the forearms of healthy controls; significantly less than the both the edematous and nonedematous forearms of the patient group (P < 0.001). No significant differences were found in muscle relative microvascular volume, forearm blood flow, skin blood flow, or central or local sympathetic vascular reflexes. Forearm microvascular filtration is increased in patients with BCRL, and more so in the edematous arm. The vascular sympathetic control mechanisms seem to be preserved. We propose that the increased capillary permeability may be due to low-grade inflammation promoted by reduced clearance of inflammatory mediators.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23123353</PMID><DateCreated><Year>2013</Year><Month>01</Month><Day>02</Day></DateCreated><DateCompleted><Year>2013</Year><Month>07</Month><Day>08</Day></DateCompleted><DateRevised><Year>2013</Year><Month>09</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1522-1601</ISSN><JournalIssue CitedMedium="Internet"><Volume>114</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Jan</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of applied physiology (Bethesda, Md. : 1985)</Title><ISOAbbreviation>J. Appl. Physiol.</ISOAbbreviation></Journal><ArticleTitle>Microvascular filtration is increased in the forearms of patients with breast cancer-related lymphedema.</ArticleTitle><Pagination><MedlinePgn>19-27</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1152/japplphysiol.01116.2012</ELocationID><Abstract><AbstractText>Breast cancer-related lymphedema (BCRL) is a frequent and debilitating complication of breast cancer treatment. The pathophysiology is complex and remains poorly understood; however, data suggest that changes in the peripheral circulation may contribute to edema formation. In 13 volunteers with unilateral BCRL, the following aspects of upper extremity peripheral circulation were examined: muscle relative microvascular volume; capillary filtration coefficient; central and local sympathetic vascular reflexes; skin blood flow; and forearm blood flow. These were studied via real-time, contrast-enhanced ultrasound; venous occlusion strain-gauge plethysmography; lower-body negative pressure; noninvasive blood pressure measurements; and skin (99m)Tc-pertechnetate clearance technique. Measurements were performed bilaterally and simultaneously in the forearms, enabling use of the nonedematous forearm as a control. Capillary filtration coefficients were additionally measured in healthy, age-matched controls. The capillary filtration coefficient was 7.98 ± 2.52 μl·100 ml(-1)·mmHg(-1)·min(-1) (mean ± SD) in edematous forearms and 6.09 ± 1.83 μl·100ml·(-1)·mmHg(-1)·min(-1) in nonedematous forearms in the patient group (P < 0.001). The capillary filtration coefficient was 3.32 ± 1.17 μl·100ml(-1)·mmHg(-1)·min(-1) in the forearms of healthy controls; significantly less than the both the edematous and nonedematous forearms of the patient group (P < 0.001). No significant differences were found in muscle relative microvascular volume, forearm blood flow, skin blood flow, or central or local sympathetic vascular reflexes. Forearm microvascular filtration is increased in patients with BCRL, and more so in the edematous arm. The vascular sympathetic control mechanisms seem to be preserved. We propose that the increased capillary permeability may be due to low-grade inflammation promoted by reduced clearance of inflammatory mediators.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jensen</LastName><ForeName>Mads Radmer</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark. mjen0221@bbh.regionh.dk</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simonsen</LastName><ForeName>Lene</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Karlsmark</LastName><ForeName>Tonny</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Bülow</LastName><ForeName>Jens</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>11</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Appl Physiol (1985)</MedlineTA><NlmUniqueID>8502536</NlmUniqueID><ISSNLinking>0161-7567</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002196" MajorTopicYN="N">Capillaries</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002199" MajorTopicYN="N">Capillary Permeability</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005542" MajorTopicYN="N">Forearm</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="Y">blood supply</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008833" MajorTopicYN="N">Microcirculation</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009132" MajorTopicYN="N">Muscles</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="N">blood supply</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012018" MajorTopicYN="N">Reflex</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012039" MajorTopicYN="N">Regional Blood Flow</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23123353</ArticleId><ArticleId IdType="pii">japplphysiol.01116.2012</ArticleId><ArticleId IdType="doi">10.1152/japplphysiol.01116.2012</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Danemark</li></country><region><li>Hovedstaden</li></region><settlement><li>Copenhague</li></settlement></list><tree><noCountry><name sortKey="Bulow, Jens" sort="Bulow, Jens" uniqKey="Bulow J" first="Jens" last="Bülow">Jens Bülow</name><name sortKey="Karlsmark, Tonny" sort="Karlsmark, Tonny" uniqKey="Karlsmark T" first="Tonny" last="Karlsmark">Tonny Karlsmark</name><name sortKey="Simonsen, Lene" sort="Simonsen, Lene" uniqKey="Simonsen L" first="Lene" last="Simonsen">Lene Simonsen</name></noCountry><country name="Danemark"><region name="Hovedstaden"><name sortKey="Jensen, Mads Radmer" sort="Jensen, Mads Radmer" uniqKey="Jensen M" first="Mads Radmer" last="Jensen">Mads Radmer Jensen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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