LymphedemaV1, PubMed, Checkpoint, bibRecord, 001881

Signaling proteins are represented in tissue fluid/lymph from soft tissues of normal human legs at concentrations different from serum.

Identifieur interne : 001881 ( PubMed/Checkpoint ); précédent : 001880; suivant : 001882

Signaling proteins are represented in tissue fluid/lymph from soft tissues of normal human legs at concentrations different from serum.

Auteurs : Marzanna Zaleska [Pologne] ; Waldemar L. Olszewski ; Marek Durlik ; Norman E. Miller

Source :

Lymphatic research and biology [ 1557-8585 ] ; 2013.

RBID : pubmed:24364843

Descripteurs français

English descriptors

KwdEn :
- Cytokines (metabolism), Healthy Volunteers, Humans, Intercellular Signaling Peptides and Proteins (metabolism), Leg (blood supply), Lymph (chemistry), Lymph (metabolism), Lymphatic Vessels (blood supply), Lymphatic Vessels (metabolism), Male, Matrix Metalloproteinase 9 (metabolism), Serum, Signal Transduction (physiology), Tissue Inhibitor of Metalloproteinase-1 (metabolism), Tissue Inhibitor of Metalloproteinase-2 (metabolism).
MESH :
- chemical , metabolism : Cytokines, Intercellular Signaling Peptides and Proteins, Matrix Metalloproteinase 9, Tissue Inhibitor of Metalloproteinase-1, Tissue Inhibitor of Metalloproteinase-2.
- blood supply : Leg, Lymphatic Vessels.
- chemistry : Lymph.
- metabolism : Lymph, Lymphatic Vessels.
- physiology : Signal Transduction.
- Healthy Volunteers, Humans, Male, Serum.

Abstract

The mobile intercellular fluid flowing to and in the lymphatics contains filtered plasma products and substances synthesized and excreted by tissue cells. Among them are signaling proteins such as cytokines, chemokines, enzymes, and growth factors. They act locally in autocrine and paracrine systems regulating cell metabolism, proliferation, and formation of the ground matrix. They play an immunoregulatory role in infections, wound healing, and tumor cell growth.

DOI: 10.1089/lrb.2013.0014
PubMed: 24364843

Affiliations:

Pologne

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001762
to stream PubMed, to step Curation: 001762

Links to Exploration step

pubmed:24364843

Le document en format XML

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<affiliation wicri:level="1"><nlm:affiliation>1 Department of Surgical Research, Transplantation and Epigenetics, Medical Research Center , Polish Academy of Sciences, Warsaw, Poland .</nlm:affiliation>
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<author><name sortKey="Olszewski, Waldemar L" sort="Olszewski, Waldemar L" uniqKey="Olszewski W" first="Waldemar L" last="Olszewski">Waldemar L. Olszewski</name>
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<author><name sortKey="Miller, Norman E" sort="Miller, Norman E" uniqKey="Miller N" first="Norman E" last="Miller">Norman E. Miller</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Signaling proteins are represented in tissue fluid/lymph from soft tissues of normal human legs at concentrations different from serum.</title>
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<author><name sortKey="Olszewski, Waldemar L" sort="Olszewski, Waldemar L" uniqKey="Olszewski W" first="Waldemar L" last="Olszewski">Waldemar L. Olszewski</name>
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<term>Healthy Volunteers</term>
<term>Humans</term>
<term>Intercellular Signaling Peptides and Proteins (metabolism)</term>
<term>Leg (blood supply)</term>
<term>Lymph (chemistry)</term>
<term>Lymph (metabolism)</term>
<term>Lymphatic Vessels (blood supply)</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Male</term>
<term>Matrix Metalloproteinase 9 (metabolism)</term>
<term>Serum</term>
<term>Signal Transduction (physiology)</term>
<term>Tissue Inhibitor of Metalloproteinase-1 (metabolism)</term>
<term>Tissue Inhibitor of Metalloproteinase-2 (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cytokines (métabolisme)</term>
<term>Humains</term>
<term>Inhibiteur tissulaire de métalloprotéinase-1 (métabolisme)</term>
<term>Inhibiteur tissulaire de métalloprotéinase-2 (métabolisme)</term>
<term>Jambe ()</term>
<term>Lymphe ()</term>
<term>Lymphe (métabolisme)</term>
<term>Matrix metalloproteinase 9 (métabolisme)</term>
<term>Mâle</term>
<term>Protéines et peptides de signalisation intercellulaire (métabolisme)</term>
<term>Sérum</term>
<term>Transduction du signal (physiologie)</term>
<term>Vaisseaux lymphatiques ()</term>
<term>Vaisseaux lymphatiques (métabolisme)</term>
<term>Volontaires sains</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
<term>Intercellular Signaling Peptides and Proteins</term>
<term>Matrix Metalloproteinase 9</term>
<term>Tissue Inhibitor of Metalloproteinase-1</term>
<term>Tissue Inhibitor of Metalloproteinase-2</term>
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<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Leg</term>
<term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Lymph</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymph</term>
<term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
<term>Inhibiteur tissulaire de métalloprotéinase-1</term>
<term>Inhibiteur tissulaire de métalloprotéinase-2</term>
<term>Lymphe</term>
<term>Matrix metalloproteinase 9</term>
<term>Protéines et peptides de signalisation intercellulaire</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Healthy Volunteers</term>
<term>Humans</term>
<term>Male</term>
<term>Serum</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Jambe</term>
<term>Lymphe</term>
<term>Mâle</term>
<term>Sérum</term>
<term>Vaisseaux lymphatiques</term>
<term>Volontaires sains</term>
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<front><div type="abstract" xml:lang="en">The mobile intercellular fluid flowing to and in the lymphatics contains filtered plasma products and substances synthesized and excreted by tissue cells. Among them are signaling proteins such as cytokines, chemokines, enzymes, and growth factors. They act locally in autocrine and paracrine systems regulating cell metabolism, proliferation, and formation of the ground matrix. They play an immunoregulatory role in infections, wound healing, and tumor cell growth.</div>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24364843</PMID>
<DateCreated><Year>2013</Year>
<Month>12</Month>
<Day>24</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>07</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>04</Month>
<Day>22</Day>
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<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>4</Issue>
<PubDate><Year>2013</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Lymphatic research and biology</Title>
<ISOAbbreviation>Lymphat Res Biol</ISOAbbreviation>
</Journal>
<ArticleTitle>Signaling proteins are represented in tissue fluid/lymph from soft tissues of normal human legs at concentrations different from serum.</ArticleTitle>
<Pagination><MedlinePgn>203-10</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1089/lrb.2013.0014</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The mobile intercellular fluid flowing to and in the lymphatics contains filtered plasma products and substances synthesized and excreted by tissue cells. Among them are signaling proteins such as cytokines, chemokines, enzymes, and growth factors. They act locally in autocrine and paracrine systems regulating cell metabolism, proliferation, and formation of the ground matrix. They play an immunoregulatory role in infections, wound healing, and tumor cell growth.</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">In this study we measured the concentration of selected cytokines, chemokines, tissue enzymes, and growth factors in tissue fluid/lymph drained from normal human leg soft tissues. Legs exposed to infections and trauma often result in development of lymphedema. Lymph was drained from superficial calf lymphatics using microsurgical techniques. Our studies showed generally higher concentrations of cytokines, chemokines, enzymes, and growth factors in lymph than in serum. The total protein L/S ratio was 0.22, whereas that of various lymph signaling proteins ranged between 1 and 10.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This indicates that in addition to proteins filtered from blood, local cells contribute to lymph concentration by own production, depending on the actual cell requirement. Moreover, there were major individual differences of lymph levels with simultaneous stable serum levels. This suggests existence of a local autonomous regulatory humoral mechanism in tissues, not reflected in serum.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zaleska</LastName>
<ForeName>Marzanna</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>1 Department of Surgical Research, Transplantation and Epigenetics, Medical Research Center , Polish Academy of Sciences, Warsaw, Poland .</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Olszewski</LastName>
<ForeName>Waldemar L</ForeName>
<Initials>WL</Initials>
</Author>
<Author ValidYN="Y"><LastName>Durlik</LastName>
<ForeName>Marek</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Miller</LastName>
<ForeName>Norman E</ForeName>
<Initials>NE</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
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<MedlineJournalInfo><Country>United States</Country>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C560822">TIMP1 protein, human</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C560823">TIMP2 protein, human</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019715">Tissue Inhibitor of Metalloproteinase-1</NameOfSubstance>
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<Chemical><RegistryNumber>127497-59-0</RegistryNumber>
<NameOfSubstance UI="D019716">Tissue Inhibitor of Metalloproteinase-2</NameOfSubstance>
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<Chemical><RegistryNumber>EC 3.4.24.35</RegistryNumber>
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<CitationSubset>IM</CitationSubset>
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<MeshHeading><DescriptorName UI="D019716" MajorTopicYN="N">Tissue Inhibitor of Metalloproteinase-2</DescriptorName>
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<affiliations><list><country><li>Pologne</li>
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<name sortKey="Olszewski, Waldemar L" sort="Olszewski, Waldemar L" uniqKey="Olszewski W" first="Waldemar L" last="Olszewski">Waldemar L. Olszewski</name>
</noCountry>
<country name="Pologne"><noRegion><name sortKey="Zaleska, Marzanna" sort="Zaleska, Marzanna" uniqKey="Zaleska M" first="Marzanna" last="Zaleska">Marzanna Zaleska</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001881 | SxmlIndent | more

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{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:24364843
   |texte=   Signaling proteins are represented in tissue fluid/lymph from soft tissues of normal human legs at concentrations different from serum.
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:24364843" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Signaling proteins are represented in tissue fluid/lymph from soft tissues of normal human legs at concentrations different from serum.

Signaling proteins are represented in tissue fluid/lymph from soft tissues of normal human legs at concentrations different from serum.

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