Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis.
Identifieur interne : 001878 ( PubMed/Checkpoint ); précédent : 001877; suivant : 001879Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis.
Auteurs : S K Joseph [États-Unis] ; K. RamaswamySource :
- Vaccine [ 1873-2518 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (administration et posologie), Antigènes d'helminthe (génétique), Antigènes d'helminthe (immunologie), Brugia malayi (immunologie), Cytotoxicité à médiation cellulaire dépendante des anticorps, Filariose lymphatique (), Filariose lymphatique (immunologie), Gerbillinae, Immunisation, Immunoglobuline G (sang), Interféron gamma (immunologie), Interleukine-4 (immunologie), Larve (immunologie), Production d'anticorps, Protéines recombinantes (génétique), Protéines recombinantes (immunologie), Rappel de vaccin, Rate (cytologie), Rate (immunologie), Souris de lignée BALB C, Spécificité des anticorps, Vaccination (), Vaccins (administration et posologie), Vaccins (immunologie), Vaccins à ADN (administration et posologie), Vaccins à ADN (immunologie).
- MESH :
- administration et posologie : Antigènes d'helminthe, Vaccins, Vaccins à ADN.
- cytologie : Rate.
- génétique : Antigènes d'helminthe, Protéines recombinantes.
- immunologie : Antigènes d'helminthe, Brugia malayi, Filariose lymphatique, Interféron gamma, Interleukine-4, Larve, Protéines recombinantes, Rate, Vaccins, Vaccins à ADN.
- sang : Anticorps antihelminthe, Immunoglobuline G.
- Animaux, Cytotoxicité à médiation cellulaire dépendante des anticorps, Filariose lymphatique, Gerbillinae, Immunisation, Production d'anticorps, Rappel de vaccin, Souris de lignée BALB C, Spécificité des anticorps, Vaccination.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (blood), Antibody Formation, Antibody Specificity, Antibody-Dependent Cell Cytotoxicity, Antigens, Helminth (administration & dosage), Antigens, Helminth (genetics), Antigens, Helminth (immunology), Brugia malayi (immunology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (prevention & control), Gerbillinae, Immunization, Immunization, Secondary, Immunoglobulin G (blood), Interferon-gamma (immunology), Interleukin-4 (immunology), Larva (immunology), Mice, Inbred BALB C, Recombinant Proteins (genetics), Recombinant Proteins (immunology), Spleen (cytology), Spleen (immunology), Vaccination (methods), Vaccines (administration & dosage), Vaccines (immunology), Vaccines, DNA (administration & dosage), Vaccines, DNA (immunology).
- MESH :
- chemical , administration & dosage : Antigens, Helminth, Vaccines, Vaccines, DNA.
- chemical , blood : Antibodies, Helminth, Immunoglobulin G.
- chemical , genetics : Antigens, Helminth, Recombinant Proteins.
- chemical , immunology : Antigens, Helminth, Interferon-gamma, Interleukin-4, Recombinant Proteins, Vaccines, Vaccines, DNA.
- cytology : Spleen.
- immunology : Brugia malayi, Elephantiasis, Filarial, Larva, Spleen.
- methods : Vaccination.
- prevention & control : Elephantiasis, Filarial.
- Animals, Antibody Formation, Antibody Specificity, Antibody-Dependent Cell Cytotoxicity, Gerbillinae, Immunization, Immunization, Secondary, Mice, Inbred BALB C.
Abstract
The multivalent vaccine BmHAT, consisting of the Brugia malayi infective larval (L3) antigens heat shock protein12.6 (HSP12.6), abundant larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL), was shown to be protective in rodent models from our laboratory. We hypothesize that since these antigens were identified using protective antibodies from immune endemic normal individuals, the multivalent vaccine can be augmented by natural L3 infections providing protection to the vaccinated host. This hypothesis was tested using single dose of DNA and protein or protein alone of the BmHAT vaccination in gerbils followed by live trickle L3 infection as booster dose. Vaccine-induced protection in gerbils was determined by worm establishment, micropore chamber assay and by antibody dependant cell cytotoxicity (ADCC) assay. Results were compared with the traditional prime-boost vaccination regimen. Gerbils vaccinated with BmHAT and boosted with L3 trickle infection were protected 51% (BmHAT DNA-protein) and 48% (BmHAT protein) respectively. BmHAT vaccination plus L3 trickle booster generated significant titer of antigen-specific IgG antibodies comparable to the traditional prime boost vaccination approach. BmHAT vaccination plus L3 trickle booster also generated antigen-specific cells in the spleen of vaccinated animals and these cells secreted predominantly IFN-γ and IL-4 in response to the vaccine antigens. These studies thus show that single dose of BmHAT multivalent vaccination followed by L3 trickle booster infection can confer significant protection against lymphatic filariasis.
DOI: 10.1016/j.vaccine.2013.05.077
PubMed: 23735679
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:23735679Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis.</title><author><name sortKey="Joseph, S K" sort="Joseph, S K" uniqKey="Joseph S" first="S K" last="Joseph">S K Joseph</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107-1897, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107-1897</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Ramaswamy, K" sort="Ramaswamy, K" uniqKey="Ramaswamy K" first="K" last="Ramaswamy">K. Ramaswamy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23735679</idno><idno type="pmid">23735679</idno><idno type="doi">10.1016/j.vaccine.2013.05.077</idno><idno type="wicri:Area/PubMed/Corpus">001B05</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B05</idno><idno type="wicri:Area/PubMed/Curation">001B05</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B05</idno><idno type="wicri:Area/PubMed/Checkpoint">001B05</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001B05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis.</title><author><name sortKey="Joseph, S K" sort="Joseph, S K" uniqKey="Joseph S" first="S K" last="Joseph">S K Joseph</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107-1897, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107-1897</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Ramaswamy, K" sort="Ramaswamy, K" uniqKey="Ramaswamy K" first="K" last="Ramaswamy">K. Ramaswamy</name></author></analytic><series><title level="j">Vaccine</title><idno type="eISSN">1873-2518</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (blood)</term><term>Antibody Formation</term><term>Antibody Specificity</term><term>Antibody-Dependent Cell Cytotoxicity</term><term>Antigens, Helminth (administration & dosage)</term><term>Antigens, Helminth (genetics)</term><term>Antigens, Helminth (immunology)</term><term>Brugia malayi (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Gerbillinae</term><term>Immunization</term><term>Immunization, Secondary</term><term>Immunoglobulin G (blood)</term><term>Interferon-gamma (immunology)</term><term>Interleukin-4 (immunology)</term><term>Larva (immunology)</term><term>Mice, Inbred BALB C</term><term>Recombinant Proteins (genetics)</term><term>Recombinant Proteins (immunology)</term><term>Spleen (cytology)</term><term>Spleen (immunology)</term><term>Vaccination (methods)</term><term>Vaccines (administration & dosage)</term><term>Vaccines (immunology)</term><term>Vaccines, DNA (administration & dosage)</term><term>Vaccines, DNA (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe (administration et posologie)</term><term>Antigènes d'helminthe (génétique)</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia malayi (immunologie)</term><term>Cytotoxicité à médiation cellulaire dépendante des anticorps</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (immunologie)</term><term>Gerbillinae</term><term>Immunisation</term><term>Immunoglobuline G (sang)</term><term>Interféron gamma (immunologie)</term><term>Interleukine-4 (immunologie)</term><term>Larve (immunologie)</term><term>Production d'anticorps</term><term>Protéines recombinantes (génétique)</term><term>Protéines recombinantes (immunologie)</term><term>Rappel de vaccin</term><term>Rate (cytologie)</term><term>Rate (immunologie)</term><term>Souris de lignée BALB C</term><term>Spécificité des anticorps</term><term>Vaccination ()</term><term>Vaccins (administration et posologie)</term><term>Vaccins (immunologie)</term><term>Vaccins à ADN (administration et posologie)</term><term>Vaccins à ADN (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antigens, Helminth</term><term>Vaccines</term><term>Vaccines, DNA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Helminth</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term><term>Interferon-gamma</term><term>Interleukin-4</term><term>Recombinant Proteins</term><term>Vaccines</term><term>Vaccines, DNA</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Vaccins</term><term>Vaccins à ADN</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Rate</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Protéines recombinantes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia malayi</term><term>Filariose lymphatique</term><term>Interféron gamma</term><term>Interleukine-4</term><term>Larve</term><term>Protéines recombinantes</term><term>Rate</term><term>Vaccins</term><term>Vaccins à ADN</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Larva</term><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibody Formation</term><term>Antibody Specificity</term><term>Antibody-Dependent Cell Cytotoxicity</term><term>Gerbillinae</term><term>Immunization</term><term>Immunization, Secondary</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cytotoxicité à médiation cellulaire dépendante des anticorps</term><term>Filariose lymphatique</term><term>Gerbillinae</term><term>Immunisation</term><term>Production d'anticorps</term><term>Rappel de vaccin</term><term>Souris de lignée BALB C</term><term>Spécificité des anticorps</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The multivalent vaccine BmHAT, consisting of the Brugia malayi infective larval (L3) antigens heat shock protein12.6 (HSP12.6), abundant larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL), was shown to be protective in rodent models from our laboratory. We hypothesize that since these antigens were identified using protective antibodies from immune endemic normal individuals, the multivalent vaccine can be augmented by natural L3 infections providing protection to the vaccinated host. This hypothesis was tested using single dose of DNA and protein or protein alone of the BmHAT vaccination in gerbils followed by live trickle L3 infection as booster dose. Vaccine-induced protection in gerbils was determined by worm establishment, micropore chamber assay and by antibody dependant cell cytotoxicity (ADCC) assay. Results were compared with the traditional prime-boost vaccination regimen. Gerbils vaccinated with BmHAT and boosted with L3 trickle infection were protected 51% (BmHAT DNA-protein) and 48% (BmHAT protein) respectively. BmHAT vaccination plus L3 trickle booster generated significant titer of antigen-specific IgG antibodies comparable to the traditional prime boost vaccination approach. BmHAT vaccination plus L3 trickle booster also generated antigen-specific cells in the spleen of vaccinated animals and these cells secreted predominantly IFN-γ and IL-4 in response to the vaccine antigens. These studies thus show that single dose of BmHAT multivalent vaccination followed by L3 trickle booster infection can confer significant protection against lymphatic filariasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23735679</PMID><DateCreated><Year>2013</Year><Month>07</Month><Day>08</Day></DateCreated><DateCompleted><Year>2014</Year><Month>02</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2518</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>33</Issue><PubDate><Year>2013</Year><Month>Jul</Month><Day>18</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>3320-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2013.05.077</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0264-410X(13)00692-0</ELocationID><Abstract><AbstractText>The multivalent vaccine BmHAT, consisting of the Brugia malayi infective larval (L3) antigens heat shock protein12.6 (HSP12.6), abundant larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL), was shown to be protective in rodent models from our laboratory. We hypothesize that since these antigens were identified using protective antibodies from immune endemic normal individuals, the multivalent vaccine can be augmented by natural L3 infections providing protection to the vaccinated host. This hypothesis was tested using single dose of DNA and protein or protein alone of the BmHAT vaccination in gerbils followed by live trickle L3 infection as booster dose. Vaccine-induced protection in gerbils was determined by worm establishment, micropore chamber assay and by antibody dependant cell cytotoxicity (ADCC) assay. Results were compared with the traditional prime-boost vaccination regimen. Gerbils vaccinated with BmHAT and boosted with L3 trickle infection were protected 51% (BmHAT DNA-protein) and 48% (BmHAT protein) respectively. BmHAT vaccination plus L3 trickle booster generated significant titer of antigen-specific IgG antibodies comparable to the traditional prime boost vaccination approach. BmHAT vaccination plus L3 trickle booster also generated antigen-specific cells in the spleen of vaccinated animals and these cells secreted predominantly IFN-γ and IL-4 in response to the vaccine antigens. These studies thus show that single dose of BmHAT multivalent vaccination followed by L3 trickle booster infection can confer significant protection against lymphatic filariasis.</AbstractText><CopyrightInformation>Copyright © 2013 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Joseph</LastName><ForeName>S K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107-1897, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramaswamy</LastName><ForeName>K</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI064745</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R56 AI064745</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI064745</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>06</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014612">Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019444">Vaccines, DNA</NameOfSubstance></Chemical><Chemical><RegistryNumber>207137-56-2</RegistryNumber><NameOfSubstance UI="D015847">Interleukin-4</NameOfSubstance></Chemical><Chemical><RegistryNumber>82115-62-6</RegistryNumber><NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Microbiol Immunol. 2004;48(12):945-55</RefSource><PMID Version="1">15611611</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitol Today. 1991 Dec;7(12):341-3</RefSource><PMID Version="1">15463411</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vaccine. 2012 Oct 5;30(45):6477-82</RefSource><PMID Version="1">22885273</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>DNA Seq. 2008 Apr;19(2):151-6</RefSource><PMID Version="1">17852334</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2000 Jul;68(7):4174-9</RefSource><PMID Version="1">10858234</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vaccine. 2006 Jul 26;24(31-32):5824-31</RefSource><PMID Version="1">16757067</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2009;3(6):e457</RefSource><PMID Version="1">19513102</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vaccine. 2009 Jul 9;27(32):4263-71</RefSource><PMID Version="1">19450648</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitol Res. 2007 Sep;101(4):981-8</RefSource><PMID Version="1">17558521</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Procedia Vaccinol. 2010;3:12-18</RefSource><PMID Version="1">21709765</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1982;76(3):362-70</RefSource><PMID Version="1">7112659</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitology. 1998 Mar;116 ( Pt 3):243-55</RefSource><PMID Version="1">9550218</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Parasitol. 1990 Oct;20(6):725-30</RefSource><PMID Version="1">2242956</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vaccine. 2013 Mar 15;31(12):1616-22</RefSource><PMID Version="1">23036503</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Filaria J. 2005 May 25;4:3</RefSource><PMID Version="1">15916708</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2004 Aug;72(8):4707-15</RefSource><PMID Version="1">15271932</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Parasitol. 2011 Oct;41(12):1249-52</RefSource><PMID Version="1">21889508</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Res Rep Trop Med. 2011 Mar;2011(2):45-56</RefSource><PMID Version="1">21760754</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2011;5(5):e1166</RefSource><PMID Version="1">21655308</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1994 Jan 15;152(2):735-42</RefSource><PMID Version="1">8283048</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitology. 2000 Mar;120 ( Pt 3):271-80</RefSource><PMID Version="1">10759085</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Med Vet Entomol. 2002 Dec;16(4):409-23</RefSource><PMID Version="1">12510894</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2001 Nov;69(11):7067-73</RefSource><PMID Version="1">11598082</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Parasitol. 1970 Oct;56(5):969-73</RefSource><PMID Version="1">5504534</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Trop. 2011 Dec;120(3):191-205</RefSource><PMID Version="1">21875568</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(4):e34077</RefSource><PMID Version="1">22496777</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Parasitol. 2007 Aug;116(4):483-91</RefSource><PMID Version="1">17442307</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitol Res. 1992;78(3):229-34</RefSource><PMID Version="1">1589431</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Parasitol. 2011 Nov;129(3):247-53</RefSource><PMID Version="1">21864531</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Trop. 2008 Aug;107(2):106-12</RefSource><PMID Version="1">18547532</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 1993 Jul;15(7):423-7</RefSource><PMID Version="1">8414645</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasit Vectors. 2012;5:89</RefSource><PMID Version="1">22564488</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000917" MajorTopicYN="N">Antibody Formation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000918" MajorTopicYN="N">Antibody Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000920" MajorTopicYN="N">Antibody-Dependent Cell Cytotoxicity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017178" MajorTopicYN="N">Brugia malayi</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005849" MajorTopicYN="N">Gerbillinae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007114" MajorTopicYN="N">Immunization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007117" MajorTopicYN="N">Immunization, Secondary</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015847" MajorTopicYN="N">Interleukin-4</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007814" MajorTopicYN="N">Larva</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013154" MajorTopicYN="N">Spleen</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014612" MajorTopicYN="N">Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019444" MajorTopicYN="N">Vaccines, DNA</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS485528</OtherID><OtherID Source="NLM">PMC3713514</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">BmHAT multivalent vaccine</Keyword><Keyword MajorTopicYN="N">Brugia malayi</Keyword><Keyword MajorTopicYN="N">L3 trickle booster</Keyword><Keyword MajorTopicYN="N">Lymphatic filariasis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>03</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>05</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>05</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>6</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>6</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>2</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23735679</ArticleId><ArticleId IdType="pii">S0264-410X(13)00692-0</ArticleId><ArticleId IdType="doi">10.1016/j.vaccine.2013.05.077</ArticleId><ArticleId IdType="pmc">PMC3713514</ArticleId><ArticleId IdType="mid">NIHMS485528</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><noCountry><name sortKey="Ramaswamy, K" sort="Ramaswamy, K" uniqKey="Ramaswamy K" first="K" last="Ramaswamy">K. Ramaswamy</name></noCountry><country name="États-Unis"><region name="Illinois"><name sortKey="Joseph, S K" sort="Joseph, S K" uniqKey="Joseph S" first="S K" last="Joseph">S K Joseph</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001878 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001878 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:23735679
|texte= Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:23735679" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |