LymphedemaV1, PubMed, Checkpoint, bibRecord, 001874

Sox18 genetically interacts with VegfC to regulate lymphangiogenesis in zebrafish.

Identifieur interne : 001874 ( PubMed/Checkpoint ); précédent : 001873; suivant : 001875

Sox18 genetically interacts with VegfC to regulate lymphangiogenesis in zebrafish.

Auteurs : Solei Cermenati [Italie] ; Silvia Moleri ; Christine Neyt ; Erica Bresciani ; Silvia Carra ; Daniela R. Grassini ; Alice Omini ; Michela Goi ; Franco Cotelli ; Mathias François ; Benjamin M. Hogan ; Monica Beltrame

Source :

Arteriosclerosis, thrombosis, and vascular biology [ 1524-4636 ] ; 2013.

RBID : pubmed:23520166

Descripteurs français

English descriptors

KwdEn :
- Animals, Animals, Genetically Modified, Blood Vessels (embryology), DNA-Binding Proteins (genetics), DNA-Binding Proteins (metabolism), Gene Expression Regulation, Developmental, Lymphangiogenesis (genetics), Mice, Models, Animal, Protein Interaction Domains and Motifs (genetics), SOXF Transcription Factors (genetics), SOXF Transcription Factors (metabolism), Sensitivity and Specificity, Signal Transduction (genetics), Vascular Endothelial Growth Factor C (genetics), Vascular Endothelial Growth Factor C (metabolism), Zebrafish.
MESH :
- chemical , genetics : DNA-Binding Proteins, SOXF Transcription Factors, Vascular Endothelial Growth Factor C.
- embryology : Blood Vessels.
- genetics : Lymphangiogenesis, Protein Interaction Domains and Motifs, Signal Transduction.
- chemical , metabolism : DNA-Binding Proteins, SOXF Transcription Factors, Vascular Endothelial Growth Factor C.
- Animals, Animals, Genetically Modified, Gene Expression Regulation, Developmental, Mice, Models, Animal, Sensitivity and Specificity, Zebrafish.

Abstract

Lymphangiogenesis is regulated by transcription factors and by growth factor pathways, but their interplay has not been extensively studied so far. We addressed this issue in zebrafish.

DOI: 10.1161/ATVBAHA.112.300254
PubMed: 23520166

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001C39
to stream PubMed, to step Curation: 001C39

Links to Exploration step

pubmed:23520166

Le document en format XML

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<author><name sortKey="Omini, Alice" sort="Omini, Alice" uniqKey="Omini A" first="Alice" last="Omini">Alice Omini</name>
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<author><name sortKey="Goi, Michela" sort="Goi, Michela" uniqKey="Goi M" first="Michela" last="Goi">Michela Goi</name>
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<author><name sortKey="Francois, Mathias" sort="Francois, Mathias" uniqKey="Francois M" first="Mathias" last="François">Mathias François</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Animals, Genetically Modified</term>
<term>Blood Vessels (embryology)</term>
<term>DNA-Binding Proteins (genetics)</term>
<term>DNA-Binding Proteins (metabolism)</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Lymphangiogenesis (genetics)</term>
<term>Mice</term>
<term>Models, Animal</term>
<term>Protein Interaction Domains and Motifs (genetics)</term>
<term>SOXF Transcription Factors (genetics)</term>
<term>SOXF Transcription Factors (metabolism)</term>
<term>Sensitivity and Specificity</term>
<term>Signal Transduction (genetics)</term>
<term>Vascular Endothelial Growth Factor C (genetics)</term>
<term>Vascular Endothelial Growth Factor C (metabolism)</term>
<term>Zebrafish</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animal génétiquement modifié</term>
<term>Animaux</term>
<term>Danio zébré</term>
<term>Facteur de croissance endothéliale vasculaire de type C (génétique)</term>
<term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term>
<term>Facteurs de transcription SOX-F (génétique)</term>
<term>Facteurs de transcription SOX-F (métabolisme)</term>
<term>Lymphangiogenèse (génétique)</term>
<term>Modèles animaux</term>
<term>Motifs et domaines d'intéraction protéique (génétique)</term>
<term>Protéines de liaison à l'ADN (génétique)</term>
<term>Protéines de liaison à l'ADN (métabolisme)</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Sensibilité et spécificité</term>
<term>Souris</term>
<term>Transduction du signal (génétique)</term>
<term>Vaisseaux sanguins (embryologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA-Binding Proteins</term>
<term>SOXF Transcription Factors</term>
<term>Vascular Endothelial Growth Factor C</term>
</keywords>
<keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Vaisseaux sanguins</term>
</keywords>
<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Blood Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphangiogenesis</term>
<term>Protein Interaction Domains and Motifs</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Facteurs de transcription SOX-F</term>
<term>Lymphangiogenèse</term>
<term>Motifs et domaines d'intéraction protéique</term>
<term>Protéines de liaison à l'ADN</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA-Binding Proteins</term>
<term>SOXF Transcription Factors</term>
<term>Vascular Endothelial Growth Factor C</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Facteurs de transcription SOX-F</term>
<term>Protéines de liaison à l'ADN</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Animals, Genetically Modified</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Mice</term>
<term>Models, Animal</term>
<term>Sensitivity and Specificity</term>
<term>Zebrafish</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animal génétiquement modifié</term>
<term>Animaux</term>
<term>Danio zébré</term>
<term>Modèles animaux</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Sensibilité et spécificité</term>
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<front><div type="abstract" xml:lang="en">Lymphangiogenesis is regulated by transcription factors and by growth factor pathways, but their interplay has not been extensively studied so far. We addressed this issue in zebrafish.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23520166</PMID>
<DateCreated><Year>2013</Year>
<Month>05</Month>
<Day>16</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>07</Month>
<Day>31</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>06</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4636</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>33</Volume>
<Issue>6</Issue>
<PubDate><Year>2013</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Arteriosclerosis, thrombosis, and vascular biology</Title>
<ISOAbbreviation>Arterioscler. Thromb. Vasc. Biol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Sox18 genetically interacts with VegfC to regulate lymphangiogenesis in zebrafish.</ArticleTitle>
<Pagination><MedlinePgn>1238-47</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/ATVBAHA.112.300254</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Lymphangiogenesis is regulated by transcription factors and by growth factor pathways, but their interplay has not been extensively studied so far. We addressed this issue in zebrafish.</AbstractText>
<AbstractText Label="APPROACH AND RESULTS" NlmCategory="RESULTS">Mutations in the transcription factor-coding gene SOX18 and in VEGFR3 cause lymphedema, and the VEGFR3/Flt4 ligand VEGFC plays an evolutionarily conserved role in lymphangiogenesis. Here, we report a strong genetic interaction between Sox18 and VegfC in the early phases of lymphatic development in zebrafish. Knockdown of sox18 selectively impaired lymphatic sprouting from the cardinal vein and resulted in defective lymphatic thoracic duct formation. Sox18 and the related protein Sox7 play redundant roles in arteriovenous differentiation. We used a novel transgenic line that enables inducible expression of a dominant-negative mutant form of mouse Sox18 protein. Our data led us to conclude that Sox18 is crucially involved in lymphangiogenesis after arteriovenous differentiation. Combined partial knockdown of sox18 and vegfc, using subcritical doses of specific morpholinos, revealed a synergistic interaction in both venous and lymphatic sprouting from the cardinal vein and greatly impaired thoracic duct formation.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This interaction suggests a previously unappreciated crosstalk between the growth factor and transcription factor pathways that regulate lymphangiogenesis in development and disease.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cermenati</LastName>
<ForeName>Solei</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita' degli Studi di Milano, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moleri</LastName>
<ForeName>Silvia</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Neyt</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bresciani</LastName>
<ForeName>Erica</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Carra</LastName>
<ForeName>Silvia</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Grassini</LastName>
<ForeName>Daniela R</ForeName>
<Initials>DR</Initials>
</Author>
<Author ValidYN="Y"><LastName>Omini</LastName>
<ForeName>Alice</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Goi</LastName>
<ForeName>Michela</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cotelli</LastName>
<ForeName>Franco</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>François</LastName>
<ForeName>Mathias</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hogan</LastName>
<ForeName>Benjamin M</ForeName>
<Initials>BM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Beltrame</LastName>
<ForeName>Monica</ForeName>
<Initials>M</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>03</Month>
<Day>21</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Arterioscler Thromb Vasc Biol</MedlineTA>
<NlmUniqueID>9505803</NlmUniqueID>
<ISSNLinking>1079-5642</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004268">DNA-Binding Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D055760">SOXF Transcription Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C490653">Sox18 protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D042582">Vascular Endothelial Growth Factor C</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D030801" MajorTopicYN="N">Animals, Genetically Modified</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001808" MajorTopicYN="N">Blood Vessels</DescriptorName>
<QualifierName UI="Q000196" MajorTopicYN="N">embryology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004268" MajorTopicYN="N">DNA-Binding Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018507" MajorTopicYN="Y">Gene Expression Regulation, Developmental</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042583" MajorTopicYN="N">Lymphangiogenesis</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D023421" MajorTopicYN="N">Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054730" MajorTopicYN="N">Protein Interaction Domains and Motifs</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D055760" MajorTopicYN="N">SOXF Transcription Factors</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042582" MajorTopicYN="N">Vascular Endothelial Growth Factor C</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015027" MajorTopicYN="N">Zebrafish</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Sox transcription factors</Keyword>
<Keyword MajorTopicYN="N">lymphangiogenesis</Keyword>
<Keyword MajorTopicYN="N">lymphedema</Keyword>
<Keyword MajorTopicYN="N">vascular development</Keyword>
<Keyword MajorTopicYN="N">zebrafish</Keyword>
</KeywordList>
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<name sortKey="Hogan, Benjamin M" sort="Hogan, Benjamin M" uniqKey="Hogan B" first="Benjamin M" last="Hogan">Benjamin M. Hogan</name>
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<name sortKey="Neyt, Christine" sort="Neyt, Christine" uniqKey="Neyt C" first="Christine" last="Neyt">Christine Neyt</name>
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<country name="Italie"><region name="Lombardie"><name sortKey="Cermenati, Solei" sort="Cermenati, Solei" uniqKey="Cermenati S" first="Solei" last="Cermenati">Solei Cermenati</name>
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       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Sox18 genetically interacts with VegfC to regulate lymphangiogenesis in zebrafish.

Sox18 genetically interacts with VegfC to regulate lymphangiogenesis in zebrafish.

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