LymphedemaV1, PubMed, Checkpoint, bibRecord, 001639

Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.

Identifieur interne : 001639 ( PubMed/Checkpoint ); précédent : 001638; suivant : 001640

Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.

Auteurs : Noëlle Louise O'Regan [Allemagne] ; Svenja Steinfelder [Allemagne] ; Gopinath Venugopal [Allemagne] ; Gopala B. Rao [Inde] ; Richard Lucius [Allemagne] ; Aparna Srikantam [Inde] ; Susanne Hartmann [Allemagne]

Source :

PLoS neglected tropical diseases [ 1935-2735 ] ; 2014.

RBID : pubmed:25275395

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Brugia malayi (immunologie), Femelle, Filariose lymphatique (immunologie), Humains, Immunité acquise (immunologie), Immunité innée (immunologie), Interleukine-10 (immunologie), Interleukine-13 (génétique), Jeune adulte, Lymphocytes T CD4+ (immunologie), Macrophages (immunologie), Microfilaria (immunologie), Monocytes (immunologie), Mâle, Phénotype, Sclérose latérale amyotrophique, Sujet âgé, Wuchereria bancrofti (immunologie).
MESH :
- génétique : Interleukine-13.
- immunologie : Brugia malayi, Filariose lymphatique, Immunité acquise, Immunité innée, Interleukine-10, Lymphocytes T CD4+, Macrophages, Microfilaria, Monocytes, Wuchereria bancrofti.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Jeune adulte, Mâle, Phénotype, Sclérose latérale amyotrophique, Sujet âgé.

English descriptors

KwdEn :
- Adaptive Immunity (immunology), Adolescent, Adult, Aged, Amyotrophic Lateral Sclerosis, Animals, Brugia malayi (immunology), CD4-Positive T-Lymphocytes (immunology), Elephantiasis, Filarial (immunology), Female, Humans, Immunity, Innate (immunology), Interleukin-10 (immunology), Interleukin-13 (genetics), Macrophages (immunology), Male, Microfilariae (immunology), Middle Aged, Monocytes (immunology), Phenotype, Wuchereria bancrofti (immunology), Young Adult.
MESH :
- chemical , genetics : Interleukin-13.
- chemical , immunology : Interleukin-10.
- immunology : Adaptive Immunity, Brugia malayi, CD4-Positive T-Lymphocytes, Elephantiasis, Filarial, Immunity, Innate, Macrophages, Microfilariae, Monocytes, Wuchereria bancrofti.
- Adolescent, Adult, Aged, Amyotrophic Lateral Sclerosis, Animals, Female, Humans, Male, Middle Aged, Phenotype, Young Adult.

Abstract

Monocytes and macrophages contribute to the dysfunction of immune responses in human filariasis. During patent infection monocytes encounter microfilariae in the blood, an event that occurs in asymptomatically infected filariasis patients that are immunologically hyporeactive.

DOI: 10.1371/journal.pntd.0003206
PubMed: 25275395

Affiliations:

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Le document en format XML

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<term>Amyotrophic Lateral Sclerosis</term>
<term>Animals</term>
<term>Brugia malayi (immunology)</term>
<term>CD4-Positive T-Lymphocytes (immunology)</term>
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<term>Monocytes</term>
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<front><div type="abstract" xml:lang="en">Monocytes and macrophages contribute to the dysfunction of immune responses in human filariasis. During patent infection monocytes encounter microfilariae in the blood, an event that occurs in asymptomatically infected filariasis patients that are immunologically hyporeactive.</div>
</front>
</TEI>
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<DateCreated><Year>2014</Year>
<Month>10</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>03</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1935-2735</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>10</Issue>
<PubDate><Year>2014</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>PLoS neglected tropical diseases</Title>
<ISOAbbreviation>PLoS Negl Trop Dis</ISOAbbreviation>
</Journal>
<ArticleTitle>Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.</ArticleTitle>
<Pagination><MedlinePgn>e3206</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pntd.0003206</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Monocytes and macrophages contribute to the dysfunction of immune responses in human filariasis. During patent infection monocytes encounter microfilariae in the blood, an event that occurs in asymptomatically infected filariasis patients that are immunologically hyporeactive.</AbstractText>
<AbstractText Label="AIM" NlmCategory="OBJECTIVE">To determine whether blood microfilariae directly act on blood monocytes and in vitro generated macrophages to induce a regulatory phenotype that interferes with innate and adaptive responses.</AbstractText>
<AbstractText Label="METHODOLOGY AND PRINCIPAL FINDINGS" NlmCategory="RESULTS">Monocytes and in vitro generated macrophages from filaria non-endemic normal donors were stimulated in vitro with Brugia malayi microfilarial (Mf) lysate. We could show that monocytes stimulated with Mf lysate develop a defined regulatory phenotype, characterised by expression of the immunoregulatory markers IL-10 and PD-L1. Significantly, this regulatory phenotype was recapitulated in monocytes from Wuchereria bancrofti asymptomatically infected patients but not patients with pathology or endemic normals. Monocytes from non-endemic donors stimulated with Mf lysate directly inhibited CD4+ T cell proliferation and cytokine production (IFN-γ, IL-13 and IL-10). IFN-γ responses were restored by neutralising IL-10 or PD-1. Furthermore, macrophages stimulated with Mf lysate expressed high levels of IL-10 and had suppressed phagocytic abilities. Finally Mf lysate applied during the differentiation of macrophages in vitro interfered with macrophage abilities to respond to subsequent LPS stimulation in a selective manner.</AbstractText>
<AbstractText Label="CONCLUSIONS AND SIGNIFICANCE" NlmCategory="CONCLUSIONS">Conclusively, our study demonstrates that Mf lysate stimulation of monocytes from healthy donors in vitro induces a regulatory phenotype, characterized by expression of PD-L1 and IL-10. This phenotype is directly reflected in monocytes from filarial patients with asymptomatic infection but not patients with pathology or endemic normals. We suggest that suppression of T cell functions typically seen in lymphatic filariasis is caused by microfilaria-modulated monocytes in an IL-10-dependent manner. Together with suppression of macrophage innate responses, this may contribute to the overall down-regulation of immune responses observed in asymptomatically infected patients.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>O'Regan</LastName>
<ForeName>Noëlle Louise</ForeName>
<Initials>NL</Initials>
<AffiliationInfo><Affiliation>Freie Universität Berlin, Center for Infection Medicine, Institute of Immunology, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Steinfelder</LastName>
<ForeName>Svenja</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Freie Universität Berlin, Center for Infection Medicine, Institute of Immunology, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Venugopal</LastName>
<ForeName>Gopinath</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Freie Universität Berlin, Center for Infection Medicine, Institute of Immunology, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rao</LastName>
<ForeName>Gopala B</ForeName>
<Initials>GB</Initials>
<AffiliationInfo><Affiliation>Blue Peter Public Health and Research Centre-LEPRA Society, Hyderabad, Andhra Pradesh, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lucius</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Humboldt Universität Berlin, Department of Biology, Molecular Parasitology, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Srikantam</LastName>
<ForeName>Aparna</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Blue Peter Public Health and Research Centre-LEPRA Society, Hyderabad, Andhra Pradesh, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hartmann</LastName>
<ForeName>Susanne</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Freie Universität Berlin, Center for Infection Medicine, Institute of Immunology, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>10</Month>
<Day>02</Day>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS Negl Trop Dis</MedlineTA>
<NlmUniqueID>101291488</NlmUniqueID>
<ISSNLinking>1935-2727</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508609">IL10 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018793">Interleukin-13</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>130068-27-8</RegistryNumber>
<NameOfSubstance UI="D016753">Interleukin-10</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D056704" MajorTopicYN="N">Adaptive Immunity</DescriptorName>
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   |texte=   Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.
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Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.

Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.

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