LymphedemaV1, PubMed, Checkpoint, bibRecord, 001491

Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.

Identifieur interne : 001491 ( PubMed/Checkpoint ); précédent : 001490; suivant : 001492

Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.

Auteurs : Amélie Sabine [Suisse] ; Tatiana V. Petrova

Source :

Advances in anatomy, embryology, and cell biology [ 0301-5556 ] ; 2014.

RBID : pubmed:24276887

Descripteurs français

KwdFr :
- Animaux, Calcineurine (métabolisme), Connexines (métabolisme), Facteurs de transcription Forkhead (métabolisme), Humains, Lymphangiogenèse, Mécanotransduction cellulaire, Régulation de l'expression des gènes au cours du développement, Signalisation du calcium, Vaisseaux lymphatiques (embryologie), Vaisseaux lymphatiques (physiologie).
MESH :
- embryologie : Vaisseaux lymphatiques.
- métabolisme : Calcineurine, Connexines, Facteurs de transcription Forkhead.
- physiologie : Vaisseaux lymphatiques.
- Animaux, Humains, Lymphangiogenèse, Mécanotransduction cellulaire, Régulation de l'expression des gènes au cours du développement, Signalisation du calcium.

English descriptors

KwdEn :
- Animals, Calcineurin (metabolism), Calcium Signaling, Connexins (metabolism), Forkhead Transcription Factors (metabolism), Gene Expression Regulation, Developmental, Humans, Lymphangiogenesis, Lymphatic Vessels (embryology), Lymphatic Vessels (physiology), Mechanotransduction, Cellular.
MESH :
- chemical , metabolism : Calcineurin, Connexins, Forkhead Transcription Factors.
- embryology : Lymphatic Vessels.
- physiology : Lymphatic Vessels.
- Animals, Calcium Signaling, Gene Expression Regulation, Developmental, Humans, Lymphangiogenesis, Mechanotransduction, Cellular.

Abstract

The directional flow of lymph is maintained by hundreds of intraluminal lymphatic valves. Lymphatic valves are crucial to prevent lymphedema, accumulation of fluid in the tissues, and to ensure immune surveillance; yet, the mechanisms of valve formation are only beginning to be elucidated. In this chapter, we will discuss the main steps of lymphatic valve morphogenesis, the important role of mechanotransduction in this process, and the genetic program regulated by the transcription factor Foxc2, which is indispensable for all steps of valve development. Failure to form mature collecting lymphatic vessels and valves causes the majority of postsurgical lymphedema, e.g., in breast cancer patients. Therefore, this knowledge will be useful for diagnostics and development of better treatments of secondary lymphedema.

DOI: 10.1007/978-3-7091-1646-3_6
PubMed: 24276887

Affiliations:

Suisse

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pubmed:24276887

Le document en format XML

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<term>Forkhead Transcription Factors (metabolism)</term>
<term>Gene Expression Regulation, Developmental</term>
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<front><div type="abstract" xml:lang="en">The directional flow of lymph is maintained by hundreds of intraluminal lymphatic valves. Lymphatic valves are crucial to prevent lymphedema, accumulation of fluid in the tissues, and to ensure immune surveillance; yet, the mechanisms of valve formation are only beginning to be elucidated. In this chapter, we will discuss the main steps of lymphatic valve morphogenesis, the important role of mechanotransduction in this process, and the genetic program regulated by the transcription factor Foxc2, which is indispensable for all steps of valve development. Failure to form mature collecting lymphatic vessels and valves causes the majority of postsurgical lymphedema, e.g., in breast cancer patients. Therefore, this knowledge will be useful for diagnostics and development of better treatments of secondary lymphedema.</div>
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Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.

Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki