C-MYC positive angiosarcoma of skin and breast following MammoSite® treatment.
Identifieur interne : 001040 ( PubMed/Checkpoint ); précédent : 001039; suivant : 001041C-MYC positive angiosarcoma of skin and breast following MammoSite® treatment.
Auteurs : W James Tidwell [Oman] ; Jim Haq ; Kamila F. Kozlowski ; Paul B. GoogeSource :
- Dermatology online journal [ 1087-2108 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Biopsie, Curiethérapie (effets indésirables), Diagnostic différentiel, Facteurs de transcription (métabolisme), Femelle, Gènes myc, Humains, Hémangiosarcome (anatomopathologie), Hémangiosarcome (métabolisme), Hémangiosarcome (étiologie), Marqueurs biologiques tumoraux (métabolisme), Mastectomie (effets indésirables), Protéines de liaison à l'ADN (métabolisme), Tumeurs cutanées (anatomopathologie), Tumeurs cutanées (métabolisme), Tumeurs cutanées (étiologie), Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Tumeurs du sein (radiothérapie), Tumeurs radio-induites (anatomopathologie), Tumeurs radio-induites (métabolisme), Tumeurs radio-induites (étiologie).
- MESH :
- anatomopathologie : Hémangiosarcome, Tumeurs cutanées, Tumeurs du sein, Tumeurs radio-induites.
- effets indésirables : Curiethérapie, Mastectomie.
- métabolisme : Facteurs de transcription, Hémangiosarcome, Marqueurs biologiques tumoraux, Protéines de liaison à l'ADN, Tumeurs cutanées, Tumeurs radio-induites.
- radiothérapie : Tumeurs du sein.
- étiologie : Hémangiosarcome, Tumeurs cutanées, Tumeurs radio-induites.
- Adulte d'âge moyen, Biopsie, Diagnostic différentiel, Femelle, Gènes myc, Humains, Tumeurs du sein.
English descriptors
- KwdEn :
- Biomarkers, Tumor (metabolism), Biopsy, Brachytherapy (adverse effects), Breast Neoplasms (pathology), Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), DNA-Binding Proteins (metabolism), Diagnosis, Differential, Female, Genes, myc, Hemangiosarcoma (etiology), Hemangiosarcoma (metabolism), Hemangiosarcoma (pathology), Humans, Mastectomy (adverse effects), Middle Aged, Neoplasms, Radiation-Induced (etiology), Neoplasms, Radiation-Induced (metabolism), Neoplasms, Radiation-Induced (pathology), Skin Neoplasms (etiology), Skin Neoplasms (metabolism), Skin Neoplasms (pathology), Transcription Factors (metabolism).
- MESH :
- chemical , metabolism : Biomarkers, Tumor, DNA-Binding Proteins, Transcription Factors.
- adverse effects : Brachytherapy, Mastectomy.
- etiology : Hemangiosarcoma, Neoplasms, Radiation-Induced, Skin Neoplasms.
- metabolism : Hemangiosarcoma, Neoplasms, Radiation-Induced, Skin Neoplasms.
- pathology : Breast Neoplasms, Hemangiosarcoma, Neoplasms, Radiation-Induced, Skin Neoplasms.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- Biopsy, Diagnosis, Differential, Female, Genes, myc, Humans, Middle Aged.
Abstract
Angiosarcoma of the skin and breast is a known complication of chronic lymphedema following mastectomy or external radiation therapy for breast cancer. We report a 68-year-old woman who presented with a 2.5 cm violaceous plaque on the skin of the right breast and a 3 cm mixed mass of the same breast by ultrasound 9 years after MammoSite® balloon brachytherapy. Biopsy of the skin lesion and the breast mass showed an infiltrating high grade angiosarcoma. The tumor cells in the skin and breast showed immunohistochemical reactivity for C-MYC. A total mastectomy confirmed the presence of high grade angiosarcoma in the skin and parenchyma of the breast and radiation changes in the breast parenchyma. Surgical margins were considered negative. The patient had cutaneous recurrence of angiosarcoma three months after the mastectomy. There have been only two other case reports in the literature of angiosarcoma on the skin following MammoSite® therapy. The c-myc mutation has been shown to be a specific mutation for angiosarcoma following radiation treatment. It is not found in atypical vascular lesions following irradiation or angiosarcoma unrelated to radiation treatment.
PubMed: 26632799
Affiliations:
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pubmed:26632799Le document en format XML
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We report a 68-year-old woman who presented with a 2.5 cm violaceous plaque on the skin of the right breast and a 3 cm mixed mass of the same breast by ultrasound 9 years after MammoSite® balloon brachytherapy. Biopsy of the skin lesion and the breast mass showed an infiltrating high grade angiosarcoma. The tumor cells in the skin and breast showed immunohistochemical reactivity for C-MYC. A total mastectomy confirmed the presence of high grade angiosarcoma in the skin and parenchyma of the breast and radiation changes in the breast parenchyma. Surgical margins were considered negative. The patient had cutaneous recurrence of angiosarcoma three months after the mastectomy. There have been only two other case reports in the literature of angiosarcoma on the skin following MammoSite® therapy. The c-myc mutation has been shown to be a specific mutation for angiosarcoma following radiation treatment. It is not found in atypical vascular lesions following irradiation or angiosarcoma unrelated to radiation treatment.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26632799</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>04</Day></DateCreated><DateCompleted><Year>2016</Year><Month>09</Month><Day>20</Day></DateCompleted><DateRevised><Year>2015</Year><Month>12</Month><Day>04</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1087-2108</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>10</Issue><PubDate><Year>2015</Year><Month>Oct</Month><Day>16</Day></PubDate></JournalIssue><Title>Dermatology online journal</Title><ISOAbbreviation>Dermatol. Online J.</ISOAbbreviation></Journal><ArticleTitle>C-MYC positive angiosarcoma of skin and breast following MammoSite® treatment.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">13030/qt4t65q9nc</ELocationID><Abstract><AbstractText>Angiosarcoma of the skin and breast is a known complication of chronic lymphedema following mastectomy or external radiation therapy for breast cancer. We report a 68-year-old woman who presented with a 2.5 cm violaceous plaque on the skin of the right breast and a 3 cm mixed mass of the same breast by ultrasound 9 years after MammoSite® balloon brachytherapy. Biopsy of the skin lesion and the breast mass showed an infiltrating high grade angiosarcoma. The tumor cells in the skin and breast showed immunohistochemical reactivity for C-MYC. A total mastectomy confirmed the presence of high grade angiosarcoma in the skin and parenchyma of the breast and radiation changes in the breast parenchyma. Surgical margins were considered negative. The patient had cutaneous recurrence of angiosarcoma three months after the mastectomy. There have been only two other case reports in the literature of angiosarcoma on the skin following MammoSite® therapy. The c-myc mutation has been shown to be a specific mutation for angiosarcoma following radiation treatment. It is not found in atypical vascular lesions following irradiation or angiosarcoma unrelated to radiation treatment.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tidwell</LastName><ForeName>W James</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>University of Louisville Division of Dermatology; University of Tennessee Graduate School of Medicine. wjamestidwell@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haq</LastName><ForeName>Jim</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Kozlowski</LastName><ForeName>Kamila F</ForeName><Initials>KF</Initials></Author><Author ValidYN="Y"><LastName>Googe</LastName><ForeName>Paul B</ForeName><Initials>PB</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>10</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Dermatol Online J</MedlineTA><NlmUniqueID>9610776</NlmUniqueID><ISSNLinking>1087-2108</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014408">Biomarkers, Tumor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004268">DNA-Binding Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C116115">MYCBP protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D014408" MajorTopicYN="N">Biomarkers, Tumor</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001918" MajorTopicYN="N">Brachytherapy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000532" MajorTopicYN="N">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004268" MajorTopicYN="N">DNA-Binding Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016259" MajorTopicYN="N">Genes, myc</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006394" MajorTopicYN="N">Hemangiosarcoma</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008408" MajorTopicYN="N">Mastectomy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009381" MajorTopicYN="N">Neoplasms, Radiation-Induced</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012878" MajorTopicYN="N">Skin Neoplasms</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>12</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>12</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26632799</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Oman</li></country></list><tree><noCountry><name sortKey="Googe, Paul B" sort="Googe, Paul B" uniqKey="Googe P" first="Paul B" last="Googe">Paul B. Googe</name><name sortKey="Haq, Jim" sort="Haq, Jim" uniqKey="Haq J" first="Jim" last="Haq">Jim Haq</name><name sortKey="Kozlowski, Kamila F" sort="Kozlowski, Kamila F" uniqKey="Kozlowski K" first="Kamila F" last="Kozlowski">Kamila F. Kozlowski</name></noCountry><country name="Oman"><noRegion><name sortKey="Tidwell, W James" sort="Tidwell, W James" uniqKey="Tidwell W" first="W James" last="Tidwell">W James Tidwell</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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