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Combination chemotherapy of low-dose 5-fluorouracil and cisplatin for advanced extramammary Paget's disease.

Identifieur interne : 001015 ( PubMed/Checkpoint ); précédent : 001014; suivant : 001016

Combination chemotherapy of low-dose 5-fluorouracil and cisplatin for advanced extramammary Paget's disease.

Auteurs : Yasutaka Tokuda [Japon] ; Fuyuko Arakura ; Hisashi Uhara

Source :

International journal of clinical oncology [ 1437-7772 ] ; 2015.

RBID : pubmed:24687531

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Adénocarcinome (traitement médicamenteux), Cisplatine (administration et posologie), Femelle, Fluorouracil (administration et posologie), Humains, Maladie de Paget extramammaire (traitement médicamenteux), Mâle, Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
MESH :
- administration et posologie : Cisplatine, Fluorouracil.
- traitement médicamenteux : Adénocarcinome, Maladie de Paget extramammaire.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- Adulte d'âge moyen, Femelle, Humains, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.

English descriptors

KwdEn :
- Adenocarcinoma (drug therapy), Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Cisplatin (administration & dosage), Female, Fluorouracil (administration & dosage), Humans, Male, Middle Aged, Paget Disease, Extramammary (drug therapy), Retrospective Studies.
MESH :
- chemical , administration & dosage : Cisplatin, Fluorouracil.
- drug therapy : Adenocarcinoma, Paget Disease, Extramammary.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies.

Abstract

Extramammary Paget's disease (EPD) is a cutaneous adenocarcinoma. It is usually curable by wide local excision. However, the prognosis for EPD patients with metastases is extremely poor because effective chemotherapy for advanced EPD has not been established.

DOI: 10.1007/s10147-014-0686-2
PubMed: 24687531

Affiliations:

Japon

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pubmed:24687531

Le document en format XML

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<author><name sortKey="Tokuda, Yasutaka" sort="Tokuda, Yasutaka" uniqKey="Tokuda Y" first="Yasutaka" last="Tokuda">Yasutaka Tokuda</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Dermatology, Matsumoto Medical Center, Minami, 2-20-30, Murai, Matsumoto, Nagano, 399-8701, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Dermatology, Matsumoto Medical Center, Minami, 2-20-30, Murai, Matsumoto, Nagano, 399-8701</wicri:regionArea>
<wicri:noRegion>399-8701</wicri:noRegion>
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<author><name sortKey="Arakura, Fuyuko" sort="Arakura, Fuyuko" uniqKey="Arakura F" first="Fuyuko" last="Arakura">Fuyuko Arakura</name>
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<author><name sortKey="Uhara, Hisashi" sort="Uhara, Hisashi" uniqKey="Uhara H" first="Hisashi" last="Uhara">Hisashi Uhara</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Combination chemotherapy of low-dose 5-fluorouracil and cisplatin for advanced extramammary Paget's disease.</title>
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<affiliation wicri:level="1"><nlm:affiliation>Division of Dermatology, Matsumoto Medical Center, Minami, 2-20-30, Murai, Matsumoto, Nagano, 399-8701, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Dermatology, Matsumoto Medical Center, Minami, 2-20-30, Murai, Matsumoto, Nagano, 399-8701</wicri:regionArea>
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<author><name sortKey="Arakura, Fuyuko" sort="Arakura, Fuyuko" uniqKey="Arakura F" first="Fuyuko" last="Arakura">Fuyuko Arakura</name>
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<author><name sortKey="Uhara, Hisashi" sort="Uhara, Hisashi" uniqKey="Uhara H" first="Hisashi" last="Uhara">Hisashi Uhara</name>
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<series><title level="j">International journal of clinical oncology</title>
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<imprint><date when="2015" type="published">2015</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (drug therapy)</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term>
<term>Cisplatin (administration & dosage)</term>
<term>Female</term>
<term>Fluorouracil (administration & dosage)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Paget Disease, Extramammary (drug therapy)</term>
<term>Retrospective Studies</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Adénocarcinome (traitement médicamenteux)</term>
<term>Cisplatine (administration et posologie)</term>
<term>Femelle</term>
<term>Fluorouracil (administration et posologie)</term>
<term>Humains</term>
<term>Maladie de Paget extramammaire (traitement médicamenteux)</term>
<term>Mâle</term>
<term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cisplatin</term>
<term>Fluorouracil</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Cisplatine</term>
<term>Fluorouracil</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Adenocarcinoma</term>
<term>Paget Disease, Extramammary</term>
</keywords>
<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Adénocarcinome</term>
<term>Maladie de Paget extramammaire</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Protocoles de polychimiothérapie antinéoplasique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Extramammary Paget's disease (EPD) is a cutaneous adenocarcinoma. It is usually curable by wide local excision. However, the prognosis for EPD patients with metastases is extremely poor because effective chemotherapy for advanced EPD has not been established.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24687531</PMID>
<DateCreated><Year>2015</Year>
<Month>02</Month>
<Day>04</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>10</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>02</Month>
<Day>04</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1437-7772</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>20</Volume>
<Issue>1</Issue>
<PubDate><Year>2015</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>International journal of clinical oncology</Title>
<ISOAbbreviation>Int. J. Clin. Oncol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Combination chemotherapy of low-dose 5-fluorouracil and cisplatin for advanced extramammary Paget's disease.</ArticleTitle>
<Pagination><MedlinePgn>194-7</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s10147-014-0686-2</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Extramammary Paget's disease (EPD) is a cutaneous adenocarcinoma. It is usually curable by wide local excision. However, the prognosis for EPD patients with metastases is extremely poor because effective chemotherapy for advanced EPD has not been established.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We retrospectively analyzed the efficacy of combination chemotherapy consisting of infusions of 5-fluorouracil (5-FU, 600 mg/m(2)/body, 5 days/week) and cisplatin (5-10 mg/body, 5-7 days/week) administered intravenously for 8-24 h (low-dose FP).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The patients were 15 males and 7 females and the ages ranged from 54 to 91 years old (median 71). The toxicities of low-dose FP were as follows: hematopoietic dysfunction (n = 4), gastrointestinal dysfunction (4), nephropathy (1), and phlebitis (1). Almost all toxicities were grade 1 or 2 except for 2 cases with grade 3 leukopenia or pancytopenia. Seventeen patients were treated with low-dose FP only, and the clinical results included 10 partial responses (PR), 4 stable disease (SD), and 3 progressive disease (PD). The overall survival ranges (medians) were 5-51 months (12) in all 22 patients, 6-51 months (13) in the 13 patients showing complete response or PR, and 5-12 months (11) in the 6 SD patients. The reported palliative effects of low-dose FP include control of pain and improvement of lymphedema.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Although the number of cases is limited and there is a bias because cases without clinical effects are less likely to be reported, this regimen might be considered a relatively effective option for advanced EPD.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tokuda</LastName>
<ForeName>Yasutaka</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Division of Dermatology, Matsumoto Medical Center, Minami, 2-20-30, Murai, Matsumoto, Nagano, 399-8701, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arakura</LastName>
<ForeName>Fuyuko</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Uhara</LastName>
<ForeName>Hisashi</ForeName>
<Initials>H</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>04</Month>
<Day>02</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Japan</Country>
<MedlineTA>Int J Clin Oncol</MedlineTA>
<NlmUniqueID>9616295</NlmUniqueID>
<ISSNLinking>1341-9625</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>Q20Q21Q62J</RegistryNumber>
<NameOfSubstance UI="D002945">Cisplatin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>U3P01618RT</RegistryNumber>
<NameOfSubstance UI="D005472">Fluorouracil</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000230" MajorTopicYN="N">Adenocarcinoma</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000971" MajorTopicYN="N">Antineoplastic Combined Chemotherapy Protocols</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002945" MajorTopicYN="N">Cisplatin</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005472" MajorTopicYN="N">Fluorouracil</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010145" MajorTopicYN="N">Paget Disease, Extramammary</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
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</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>01</Month>
<Day>17</Day>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">24687531</ArticleId>
<ArticleId IdType="doi">10.1007/s10147-014-0686-2</ArticleId>
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<tree><noCountry><name sortKey="Arakura, Fuyuko" sort="Arakura, Fuyuko" uniqKey="Arakura F" first="Fuyuko" last="Arakura">Fuyuko Arakura</name>
<name sortKey="Uhara, Hisashi" sort="Uhara, Hisashi" uniqKey="Uhara H" first="Hisashi" last="Uhara">Hisashi Uhara</name>
</noCountry>
<country name="Japon"><noRegion><name sortKey="Tokuda, Yasutaka" sort="Tokuda, Yasutaka" uniqKey="Tokuda Y" first="Yasutaka" last="Tokuda">Yasutaka Tokuda</name>
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Combination chemotherapy of low-dose 5-fluorouracil and cisplatin for advanced extramammary Paget's disease.

Combination chemotherapy of low-dose 5-fluorouracil and cisplatin for advanced extramammary Paget's disease.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki