Chemical composition, toxicity and non-target effects of Pinus kesiya essential oil: An eco-friendly and novel larvicide against malaria, dengue and lymphatic filariasis mosquito vectors.
Identifieur interne : 000A19 ( PubMed/Checkpoint ); précédent : 000A18; suivant : 000A20Chemical composition, toxicity and non-target effects of Pinus kesiya essential oil: An eco-friendly and novel larvicide against malaria, dengue and lymphatic filariasis mosquito vectors.
Auteurs : Marimuthu Govindarajan [Inde] ; Mohan Rajeswary [Inde] ; Giovanni Benelli [Italie]Source :
- Ecotoxicology and environmental safety [ 1090-2414 ] ; 2016.
Descripteurs français
- KwdFr :
- Aedes (), Alcènes (analyse), Animaux, Anopheles (), Composés bicycliques pontés (analyse), Culex (), Dengue, Femelle, Feuilles de plante, Filariose lymphatique, Huile essentielle (), Huile essentielle (pharmacologie), Insecticides (), Insecticides (pharmacologie), Larve (), Monoterpènes (analyse), Moustiques vecteurs (), Paludisme, Pinus, Sesquiterpènes de type germacrane (analyse).
- MESH :
- analyse : Alcènes, Composés bicycliques pontés, Monoterpènes, Sesquiterpènes de type germacrane.
- pharmacologie : Huile essentielle, Insecticides.
- Aedes, Animaux, Anopheles, Culex, Dengue, Femelle, Feuilles de plante, Filariose lymphatique, Huile essentielle, Insecticides, Larve, Moustiques vecteurs, Paludisme, Pinus.
English descriptors
- KwdEn :
- Aedes (drug effects), Alkenes (analysis), Animals, Anopheles (drug effects), Bridged Bicyclo Compounds (analysis), Culex (drug effects), Dengue, Elephantiasis, Filarial, Female, Insecticides (chemistry), Insecticides (pharmacology), Larva (drug effects), Malaria, Monoterpenes (analysis), Mosquito Vectors (drug effects), Oils, Volatile (chemistry), Oils, Volatile (pharmacology), Pinus, Plant Leaves, Sesquiterpenes, Germacrane (analysis).
- MESH :
- chemical , analysis : Alkenes, Bridged Bicyclo Compounds, Monoterpenes, Sesquiterpenes, Germacrane.
- chemical , chemistry : Insecticides, Oils, Volatile.
- drug effects : Aedes, Anopheles, Culex, Larva, Mosquito Vectors.
- chemical , pharmacology : Insecticides, Oils, Volatile.
- Animals, Dengue, Elephantiasis, Filarial, Female, Malaria, Pinus, Plant Leaves.
Abstract
Mosquitoes (Diptera: Culicidae) are vectors of important parasites and pathogens causing death, poverty and social disability worldwide, with special reference to tropical and subtropical countries. The overuse of synthetic insecticides to control mosquito vectors lead to resistance, adverse environmental effects and high operational costs. Therefore, the development of eco-friendly control tools is an important public health challenge. In this study, the mosquito larvicidal activity of Pinus kesiya leaf essential oil (EO) was evaluated against the malaria vector Anopheles stephensi, the dengue vector Aedes aegypti and the lymphatic filariasis vector Culex quinquefasciatus. The chemical composition of the EO was analyzed by gas chromatography-mass spectroscopy. GC-MS revealed that the P. kesiya EO contained 18 compounds. Major constituents were α-pinene, β-pinene, myrcene and germacrene D. In acute toxicity assays, the EO showed significant toxicity against early third-stage larvae of An. stephensi, Ae. aegypti and Cx. quinquefasciatus, with LC50 values of 52, 57, and 62µg/ml, respectively. Notably, the EO was safer towards several aquatic non-target organisms Anisops bouvieri, Diplonychus indicus and Gambusia affinis, with LC50 values ranging from 4135 to 8390µg/ml. Overall, this research adds basic knowledge to develop newer and safer natural larvicides from Pinaceae plants against malaria, dengue and filariasis mosquito vectors.
DOI: 10.1016/j.ecoenv.2016.03.007
PubMed: 26995063
Affiliations:
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The overuse of synthetic insecticides to control mosquito vectors lead to resistance, adverse environmental effects and high operational costs. Therefore, the development of eco-friendly control tools is an important public health challenge. In this study, the mosquito larvicidal activity of Pinus kesiya leaf essential oil (EO) was evaluated against the malaria vector Anopheles stephensi, the dengue vector Aedes aegypti and the lymphatic filariasis vector Culex quinquefasciatus. The chemical composition of the EO was analyzed by gas chromatography-mass spectroscopy. GC-MS revealed that the P. kesiya EO contained 18 compounds. Major constituents were α-pinene, β-pinene, myrcene and germacrene D. In acute toxicity assays, the EO showed significant toxicity against early third-stage larvae of An. stephensi, Ae. aegypti and Cx. quinquefasciatus, with LC50 values of 52, 57, and 62µg/ml, respectively. Notably, the EO was safer towards several aquatic non-target organisms Anisops bouvieri, Diplonychus indicus and Gambusia affinis, with LC50 values ranging from 4135 to 8390µg/ml. Overall, this research adds basic knowledge to develop newer and safer natural larvicides from Pinaceae plants against malaria, dengue and filariasis mosquito vectors.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26995063</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>22</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2414</ISSN><JournalIssue CitedMedium="Internet"><Volume>129</Volume><PubDate><Year>2016</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Ecotoxicology and environmental safety</Title><ISOAbbreviation>Ecotoxicol. Environ. Saf.</ISOAbbreviation></Journal><ArticleTitle>Chemical composition, toxicity and non-target effects of Pinus kesiya essential oil: An eco-friendly and novel larvicide against malaria, dengue and lymphatic filariasis mosquito vectors.</ArticleTitle><Pagination><MedlinePgn>85-90</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ecoenv.2016.03.007</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0147-6513(16)30065-3</ELocationID><Abstract><AbstractText>Mosquitoes (Diptera: Culicidae) are vectors of important parasites and pathogens causing death, poverty and social disability worldwide, with special reference to tropical and subtropical countries. The overuse of synthetic insecticides to control mosquito vectors lead to resistance, adverse environmental effects and high operational costs. Therefore, the development of eco-friendly control tools is an important public health challenge. In this study, the mosquito larvicidal activity of Pinus kesiya leaf essential oil (EO) was evaluated against the malaria vector Anopheles stephensi, the dengue vector Aedes aegypti and the lymphatic filariasis vector Culex quinquefasciatus. The chemical composition of the EO was analyzed by gas chromatography-mass spectroscopy. GC-MS revealed that the P. kesiya EO contained 18 compounds. Major constituents were α-pinene, β-pinene, myrcene and germacrene D. In acute toxicity assays, the EO showed significant toxicity against early third-stage larvae of An. stephensi, Ae. aegypti and Cx. quinquefasciatus, with LC50 values of 52, 57, and 62µg/ml, respectively. Notably, the EO was safer towards several aquatic non-target organisms Anisops bouvieri, Diplonychus indicus and Gambusia affinis, with LC50 values ranging from 4135 to 8390µg/ml. Overall, this research adds basic knowledge to develop newer and safer natural larvicides from Pinaceae plants against malaria, dengue and filariasis mosquito vectors.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Govindarajan</LastName><ForeName>Marimuthu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unit of Vector Control, Phytochemistry and Nanotechnology, Department of Zoology, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India. 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Electronic address: g.benelli@sssup.it.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Ecotoxicol Environ Saf</MedlineTA><NlmUniqueID>7805381</NlmUniqueID><ISSNLinking>0147-6513</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000475">Alkenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001643">Bridged Bicyclo Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007306">Insecticides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D039821">Monoterpenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009822">Oils, Volatile</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D045788">Sesquiterpenes, Germacrane</NameOfSubstance></Chemical><Chemical><RegistryNumber>28387-44-2</RegistryNumber><NameOfSubstance UI="C471077">germacrene A</NameOfSubstance></Chemical><Chemical><RegistryNumber>3M39CZS25B</RegistryNumber><NameOfSubstance UI="C509595">myrcene</NameOfSubstance></Chemical><Chemical><RegistryNumber>4MS8VHZ1HJ</RegistryNumber><NameOfSubstance UI="C010789">beta-pinene</NameOfSubstance></Chemical><Chemical><RegistryNumber>JPF3YI7O34</RegistryNumber><NameOfSubstance UI="C005451">alpha-pinene</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000330" MajorTopicYN="N">Aedes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000475" MajorTopicYN="N">Alkenes</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000852" MajorTopicYN="N">Anopheles</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001643" MajorTopicYN="N">Bridged Bicyclo Compounds</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003465" MajorTopicYN="N">Culex</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003715" MajorTopicYN="N">Dengue</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007306" MajorTopicYN="N">Insecticides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007814" MajorTopicYN="N">Larva</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008288" MajorTopicYN="N">Malaria</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D039821" MajorTopicYN="N">Monoterpenes</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000072138" MajorTopicYN="N">Mosquito Vectors</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug 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MajorTopicYN="N">Pinaceae</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>12</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>03</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>03</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26995063</ArticleId><ArticleId IdType="pii">S0147-6513(16)30065-3</ArticleId><ArticleId 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