Chemical composition, toxicity and non-target effects of Pinus kesiya essential oil: An eco-friendly and novel larvicide against malaria, dengue and lymphatic filariasis mosquito vectors.
Identifieur interne : 000A19 ( PubMed/Checkpoint ); précédent : 000A18; suivant : 000A20Chemical composition, toxicity and non-target effects of Pinus kesiya essential oil: An eco-friendly and novel larvicide against malaria, dengue and lymphatic filariasis mosquito vectors.
Auteurs : Marimuthu Govindarajan [Inde] ; Mohan Rajeswary [Inde] ; Giovanni Benelli [Italie]Source :
- Ecotoxicology and environmental safety [ 1090-2414 ] ; 2016.
Descripteurs français
- KwdFr :
- Aedes (), Alcènes (analyse), Animaux, Anopheles (), Composés bicycliques pontés (analyse), Culex (), Dengue, Femelle, Feuilles de plante, Filariose lymphatique, Huile essentielle (), Huile essentielle (pharmacologie), Insecticides (), Insecticides (pharmacologie), Larve (), Monoterpènes (analyse), Moustiques vecteurs (), Paludisme, Pinus, Sesquiterpènes de type germacrane (analyse).
- MESH :
- analyse : Alcènes, Composés bicycliques pontés, Monoterpènes, Sesquiterpènes de type germacrane.
- pharmacologie : Huile essentielle, Insecticides.
- Aedes, Animaux, Anopheles, Culex, Dengue, Femelle, Feuilles de plante, Filariose lymphatique, Huile essentielle, Insecticides, Larve, Moustiques vecteurs, Paludisme, Pinus.
English descriptors
- KwdEn :
- Aedes (drug effects), Alkenes (analysis), Animals, Anopheles (drug effects), Bridged Bicyclo Compounds (analysis), Culex (drug effects), Dengue, Elephantiasis, Filarial, Female, Insecticides (chemistry), Insecticides (pharmacology), Larva (drug effects), Malaria, Monoterpenes (analysis), Mosquito Vectors (drug effects), Oils, Volatile (chemistry), Oils, Volatile (pharmacology), Pinus, Plant Leaves, Sesquiterpenes, Germacrane (analysis).
- MESH :
- chemical , analysis : Alkenes, Bridged Bicyclo Compounds, Monoterpenes, Sesquiterpenes, Germacrane.
- chemical , chemistry : Insecticides, Oils, Volatile.
- drug effects : Aedes, Anopheles, Culex, Larva, Mosquito Vectors.
- chemical , pharmacology : Insecticides, Oils, Volatile.
- Animals, Dengue, Elephantiasis, Filarial, Female, Malaria, Pinus, Plant Leaves.
Abstract
Mosquitoes (Diptera: Culicidae) are vectors of important parasites and pathogens causing death, poverty and social disability worldwide, with special reference to tropical and subtropical countries. The overuse of synthetic insecticides to control mosquito vectors lead to resistance, adverse environmental effects and high operational costs. Therefore, the development of eco-friendly control tools is an important public health challenge. In this study, the mosquito larvicidal activity of Pinus kesiya leaf essential oil (EO) was evaluated against the malaria vector Anopheles stephensi, the dengue vector Aedes aegypti and the lymphatic filariasis vector Culex quinquefasciatus. The chemical composition of the EO was analyzed by gas chromatography-mass spectroscopy. GC-MS revealed that the P. kesiya EO contained 18 compounds. Major constituents were α-pinene, β-pinene, myrcene and germacrene D. In acute toxicity assays, the EO showed significant toxicity against early third-stage larvae of An. stephensi, Ae. aegypti and Cx. quinquefasciatus, with LC50 values of 52, 57, and 62µg/ml, respectively. Notably, the EO was safer towards several aquatic non-target organisms Anisops bouvieri, Diplonychus indicus and Gambusia affinis, with LC50 values ranging from 4135 to 8390µg/ml. Overall, this research adds basic knowledge to develop newer and safer natural larvicides from Pinaceae plants against malaria, dengue and filariasis mosquito vectors.
DOI: 10.1016/j.ecoenv.2016.03.007
PubMed: 26995063
Affiliations:
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pubmed:26995063Le document en format XML
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<term>Alkenes (analysis)</term>
<term>Animals</term>
<term>Anopheles (drug effects)</term>
<term>Bridged Bicyclo Compounds (analysis)</term>
<term>Culex (drug effects)</term>
<term>Dengue</term>
<term>Elephantiasis, Filarial</term>
<term>Female</term>
<term>Insecticides (chemistry)</term>
<term>Insecticides (pharmacology)</term>
<term>Larva (drug effects)</term>
<term>Malaria</term>
<term>Monoterpenes (analysis)</term>
<term>Mosquito Vectors (drug effects)</term>
<term>Oils, Volatile (chemistry)</term>
<term>Oils, Volatile (pharmacology)</term>
<term>Pinus</term>
<term>Plant Leaves</term>
<term>Sesquiterpenes, Germacrane (analysis)</term>
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<term>Alcènes (analyse)</term>
<term>Animaux</term>
<term>Anopheles ()</term>
<term>Composés bicycliques pontés (analyse)</term>
<term>Culex ()</term>
<term>Dengue</term>
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<term>Feuilles de plante</term>
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<term>Huile essentielle (pharmacologie)</term>
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<term>Moustiques vecteurs ()</term>
<term>Paludisme</term>
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<term>Sesquiterpenes, Germacrane</term>
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<term>Composés bicycliques pontés</term>
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<term>Sesquiterpènes de type germacrane</term>
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<term>Anopheles</term>
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<term>Mosquito Vectors</term>
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<term>Dengue</term>
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<term>Malaria</term>
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<term>Culex</term>
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<front><div type="abstract" xml:lang="en">Mosquitoes (Diptera: Culicidae) are vectors of important parasites and pathogens causing death, poverty and social disability worldwide, with special reference to tropical and subtropical countries. The overuse of synthetic insecticides to control mosquito vectors lead to resistance, adverse environmental effects and high operational costs. Therefore, the development of eco-friendly control tools is an important public health challenge. In this study, the mosquito larvicidal activity of Pinus kesiya leaf essential oil (EO) was evaluated against the malaria vector Anopheles stephensi, the dengue vector Aedes aegypti and the lymphatic filariasis vector Culex quinquefasciatus. The chemical composition of the EO was analyzed by gas chromatography-mass spectroscopy. GC-MS revealed that the P. kesiya EO contained 18 compounds. Major constituents were α-pinene, β-pinene, myrcene and germacrene D. In acute toxicity assays, the EO showed significant toxicity against early third-stage larvae of An. stephensi, Ae. aegypti and Cx. quinquefasciatus, with LC50 values of 52, 57, and 62µg/ml, respectively. Notably, the EO was safer towards several aquatic non-target organisms Anisops bouvieri, Diplonychus indicus and Gambusia affinis, with LC50 values ranging from 4135 to 8390µg/ml. Overall, this research adds basic knowledge to develop newer and safer natural larvicides from Pinaceae plants against malaria, dengue and filariasis mosquito vectors.</div>
</front>
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<Abstract><AbstractText>Mosquitoes (Diptera: Culicidae) are vectors of important parasites and pathogens causing death, poverty and social disability worldwide, with special reference to tropical and subtropical countries. The overuse of synthetic insecticides to control mosquito vectors lead to resistance, adverse environmental effects and high operational costs. Therefore, the development of eco-friendly control tools is an important public health challenge. In this study, the mosquito larvicidal activity of Pinus kesiya leaf essential oil (EO) was evaluated against the malaria vector Anopheles stephensi, the dengue vector Aedes aegypti and the lymphatic filariasis vector Culex quinquefasciatus. The chemical composition of the EO was analyzed by gas chromatography-mass spectroscopy. GC-MS revealed that the P. kesiya EO contained 18 compounds. Major constituents were α-pinene, β-pinene, myrcene and germacrene D. In acute toxicity assays, the EO showed significant toxicity against early third-stage larvae of An. stephensi, Ae. aegypti and Cx. quinquefasciatus, with LC50 values of 52, 57, and 62µg/ml, respectively. Notably, the EO was safer towards several aquatic non-target organisms Anisops bouvieri, Diplonychus indicus and Gambusia affinis, with LC50 values ranging from 4135 to 8390µg/ml. Overall, this research adds basic knowledge to develop newer and safer natural larvicides from Pinaceae plants against malaria, dengue and filariasis mosquito vectors.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Govindarajan</LastName>
<ForeName>Marimuthu</ForeName>
<Initials>M</Initials>
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<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124 Pisa, Italy. Electronic address: g.benelli@sssup.it.</Affiliation>
</AffiliationInfo>
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<tree><country name="Inde"><noRegion><name sortKey="Govindarajan, Marimuthu" sort="Govindarajan, Marimuthu" uniqKey="Govindarajan M" first="Marimuthu" last="Govindarajan">Marimuthu Govindarajan</name>
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<name sortKey="Rajeswary, Mohan" sort="Rajeswary, Mohan" uniqKey="Rajeswary M" first="Mohan" last="Rajeswary">Mohan Rajeswary</name>
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<country name="Italie"><region name="Toscane"><name sortKey="Benelli, Giovanni" sort="Benelli, Giovanni" uniqKey="Benelli G" first="Giovanni" last="Benelli">Giovanni Benelli</name>
</region>
</country>
</tree>
</affiliations>
</record>
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