Constitutively Enhanced Lymphatic Pumping in the Upper Limbs of Women Who Later Develop Breast Cancer-Related Lymphedema.
Identifieur interne : 000980 ( PubMed/Checkpoint ); précédent : 000979; suivant : 000981Constitutively Enhanced Lymphatic Pumping in the Upper Limbs of Women Who Later Develop Breast Cancer-Related Lymphedema.
Auteurs : Viviana Cintolesi [Royaume-Uni] ; Anthony W B. Stanton [Royaume-Uni] ; Salena K. Bains [Royaume-Uni] ; Emma Cousins [Royaume-Uni] ; A Michael Peters [Royaume-Uni] ; Arnie D. Purushotham [Royaume-Uni] ; J Rodney Levick [Royaume-Uni] ; Peter S. Mortimer [Royaume-Uni]Source :
- Lymphatic research and biology [ 1557-8585 ] ; 2016.
Abstract
It has previously been shown that the lymph drainage rate in both upper limbs is greater in women destined to develop breast cancer-related lymphedema (BCRL) than in those who do not develop BCRL, indicating a constitutive predisposition. We explored constitutive differences further by measuring the maximum lymphatic pump pressure (Ppump) and the rate of (99m)Tc-Nanocoll transport generated by the contractile upper limb lymphatics before and after breast cancer surgery in a group of women who were followed for 2 years to determine their eventual BCRL or non-BCRL status.
DOI: 10.1089/lrb.2016.0005
PubMed: 27309032
Affiliations:
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Stanton</name><affiliation wicri:level="3"><nlm:affiliation>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bains, Salena K" sort="Bains, Salena K" uniqKey="Bains S" first="Salena K" last="Bains">Salena K. Bains</name><affiliation wicri:level="3"><nlm:affiliation>2 Department of Research Oncology, King's College London, Guy's Hospital , London, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>2 Department of Research Oncology, King's College London, Guy's Hospital , London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cousins, Emma" sort="Cousins, Emma" uniqKey="Cousins E" first="Emma" last="Cousins">Emma Cousins</name><affiliation wicri:level="3"><nlm:affiliation>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Peters, A Michael" sort="Peters, A Michael" uniqKey="Peters A" first="A Michael" last="Peters">A Michael Peters</name><affiliation wicri:level="1"><nlm:affiliation>3 Department of Nuclear Medicine, Brighton and Sussex University Hospitals NHS Trust , Brighton, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>3 Department of Nuclear Medicine, Brighton and Sussex University Hospitals NHS Trust , Brighton</wicri:regionArea><wicri:noRegion>Brighton</wicri:noRegion></affiliation></author><author><name sortKey="Purushotham, Arnie D" sort="Purushotham, Arnie D" uniqKey="Purushotham A" first="Arnie D" last="Purushotham">Arnie D. Purushotham</name><affiliation wicri:level="3"><nlm:affiliation>2 Department of Research Oncology, King's College London, Guy's Hospital , London, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>2 Department of Research Oncology, King's College London, Guy's Hospital , London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Levick, J Rodney" sort="Levick, J Rodney" uniqKey="Levick J" first="J Rodney" last="Levick">J Rodney Levick</name><affiliation wicri:level="3"><nlm:affiliation>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mortimer, Peter S" sort="Mortimer, Peter S" uniqKey="Mortimer P" first="Peter S" last="Mortimer">Peter S. Mortimer</name><affiliation wicri:level="3"><nlm:affiliation>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Lymphatic research and biology</title><idno type="eISSN">1557-8585</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It has previously been shown that the lymph drainage rate in both upper limbs is greater in women destined to develop breast cancer-related lymphedema (BCRL) than in those who do not develop BCRL, indicating a constitutive predisposition. We explored constitutive differences further by measuring the maximum lymphatic pump pressure (Ppump) and the rate of (99m)Tc-Nanocoll transport generated by the contractile upper limb lymphatics before and after breast cancer surgery in a group of women who were followed for 2 years to determine their eventual BCRL or non-BCRL status.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27309032</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>17</Day></DateCreated><DateRevised><Year>2016</Year><Month>06</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1557-8585</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Lymphatic research and biology</Title><ISOAbbreviation>Lymphat Res Biol</ISOAbbreviation></Journal><ArticleTitle>Constitutively Enhanced Lymphatic Pumping in the Upper Limbs of Women Who Later Develop Breast Cancer-Related Lymphedema.</ArticleTitle><Pagination><MedlinePgn>50-61</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/lrb.2016.0005</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">It has previously been shown that the lymph drainage rate in both upper limbs is greater in women destined to develop breast cancer-related lymphedema (BCRL) than in those who do not develop BCRL, indicating a constitutive predisposition. We explored constitutive differences further by measuring the maximum lymphatic pump pressure (Ppump) and the rate of (99m)Tc-Nanocoll transport generated by the contractile upper limb lymphatics before and after breast cancer surgery in a group of women who were followed for 2 years to determine their eventual BCRL or non-BCRL status.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Ppump and tracer transport rate were measured by lymphatic congestion lymphoscintigraphy in the ipsilateral upper limb in 26 women pre- and post-breast cancer surgery. BCRL occurred in 10/26 (38.5%) cases. Ppump in the women who later developed BCRL (40.0 ± 8.2 mmHg) was 1.7-fold higher than in those who did not develop BCRL (23.1 ± 10.8 mmHg, p = 0.001). Moreover, the rate of lymph tracer transport into the forearm was 2.2-fold greater in the women who later developed BCRL (p = 0.052). Surgery did not significantly reduce Ppump measured 21 weeks postsurgery, but impaired forearm tracer transport in pre-BCRL women by 58% (p = 0.047), although not in those who did not develop BCRL.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Women destined to develop BCRL have higher pumping pressures and lymph transport, indicating harder-working lymphatics before cancer treatment. Axillary lymphatic damage from surgery appears to compromise lymph drainage in those women constitutively predisposed to higher lymphatic pressures and lymph transport.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cintolesi</LastName><ForeName>Viviana</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London, United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stanton</LastName><ForeName>Anthony W B</ForeName><Initials>AW</Initials><AffiliationInfo><Affiliation>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London, United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bains</LastName><ForeName>Salena K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>2 Department of Research Oncology, King's College London, Guy's Hospital , London, United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cousins</LastName><ForeName>Emma</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London, United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>A Michael</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>3 Department of Nuclear Medicine, Brighton and Sussex University Hospitals NHS Trust , Brighton, United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Purushotham</LastName><ForeName>Arnie D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>2 Department of Research Oncology, King's College London, Guy's Hospital , London, United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levick</LastName><ForeName>J Rodney</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London, United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mortimer</LastName><ForeName>Peter S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>1 Cardiovascular and Cell Sciences Research Institute, St George's, University of London , London, United Kingdom .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>4 Department of Dermatology, St George's University Hospitals NHS Foundation Trust , London, United Kindom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>5 Skin Unit, The Royal Marsden NHS Foundation Trust , Sutton, Surrey, United Kingdom .</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lymphat Res Biol</MedlineTA><NlmUniqueID>101163587</NlmUniqueID><ISSNLinking>1539-6851</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>6</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>6</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27309032</ArticleId><ArticleId IdType="doi">10.1089/lrb.2016.0005</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Cintolesi, Viviana" sort="Cintolesi, Viviana" uniqKey="Cintolesi V" first="Viviana" last="Cintolesi">Viviana Cintolesi</name></region><name sortKey="Bains, Salena K" sort="Bains, Salena K" uniqKey="Bains S" first="Salena K" last="Bains">Salena K. Bains</name><name sortKey="Cousins, Emma" sort="Cousins, Emma" uniqKey="Cousins E" first="Emma" last="Cousins">Emma Cousins</name><name sortKey="Levick, J Rodney" sort="Levick, J Rodney" uniqKey="Levick J" first="J Rodney" last="Levick">J Rodney Levick</name><name sortKey="Mortimer, Peter S" sort="Mortimer, Peter S" uniqKey="Mortimer P" first="Peter S" last="Mortimer">Peter S. Mortimer</name><name sortKey="Peters, A Michael" sort="Peters, A Michael" uniqKey="Peters A" first="A Michael" last="Peters">A Michael Peters</name><name sortKey="Purushotham, Arnie D" sort="Purushotham, Arnie D" uniqKey="Purushotham A" first="Arnie D" last="Purushotham">Arnie D. Purushotham</name><name sortKey="Stanton, Anthony W B" sort="Stanton, Anthony W B" uniqKey="Stanton A" first="Anthony W B" last="Stanton">Anthony W B. Stanton</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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