Heterogeneous dynamics, robustness/fragility trade-offs, and the eradication of the macroparasitic disease, lymphatic filariasis.
Identifieur interne : 000882 ( PubMed/Checkpoint ); précédent : 000881; suivant : 000883Heterogeneous dynamics, robustness/fragility trade-offs, and the eradication of the macroparasitic disease, lymphatic filariasis.
Auteurs : Edwin Michael [États-Unis] ; Brajendra K. Singh [États-Unis]Source :
- BMC medicine [ 1741-7015 ] ; 2016.
Descripteurs français
- KwdFr :
- Afrique (épidémiologie), Asie (épidémiologie), Filariose lymphatique (), Filariose lymphatique (épidémiologie), Humains, Maladies négligées (), Maladies négligées (épidémiologie), Modèles statistiques, Papouasie - Nouvelle-Guinée (épidémiologie), Simulation numérique, Théorème de Bayes, Transmission de maladie infectieuse (), Éradication de maladie ().
- MESH :
- Wicri :
- geographic : Papouasie-Nouvelle-Guinée.
English descriptors
- KwdEn :
- Africa (epidemiology), Asia (epidemiology), Bayes Theorem, Computer Simulation, Disease Eradication (statistics & numerical data), Disease Transmission, Infectious (prevention & control), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (prevention & control), Humans, Models, Statistical, Neglected Diseases (epidemiology), Neglected Diseases (prevention & control), Papua New Guinea (epidemiology).
- MESH :
- geographic , epidemiology : Africa, Asia, Papua New Guinea.
- epidemiology : Elephantiasis, Filarial, Neglected Diseases.
- prevention & control : Disease Transmission, Infectious, Elephantiasis, Filarial, Neglected Diseases.
- statistics & numerical data : Disease Eradication.
- Bayes Theorem, Computer Simulation, Humans, Models, Statistical.
Abstract
The current WHO-led initiative to eradicate the macroparasitic disease, lymphatic filariasis (LF), based on single-dose annual mass drug administration (MDA) represents one of the largest health programs devised to reduce the burden of tropical diseases. However, despite the advances made in instituting large-scale MDA programs in affected countries, a challenge to meeting the goal of global eradication is the heterogeneous transmission of LF across endemic regions, and the impact that such complexity may have on the effort required to interrupt transmission in all socioecological settings.
DOI: 10.1186/s12916-016-0557-y
PubMed: 26822124
Affiliations:
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pubmed:26822124Le document en format XML
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Singh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. bsingh1@nd.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, University of Notre Dame, Notre Dame, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26822124</idno><idno type="pmid">26822124</idno><idno type="doi">10.1186/s12916-016-0557-y</idno><idno type="wicri:Area/PubMed/Corpus">000A31</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A31</idno><idno type="wicri:Area/PubMed/Curation">000A31</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A31</idno><idno type="wicri:Area/PubMed/Checkpoint">000A31</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Heterogeneous dynamics, robustness/fragility trade-offs, and the eradication of the macroparasitic disease, lymphatic filariasis.</title><author><name sortKey="Michael, Edwin" sort="Michael, Edwin" uniqKey="Michael E" first="Edwin" last="Michael">Edwin Michael</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. emichael@nd.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, University of Notre Dame, Notre Dame, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Singh, Brajendra K" sort="Singh, Brajendra K" uniqKey="Singh B" first="Brajendra K" last="Singh">Brajendra K. Singh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. bsingh1@nd.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, University of Notre Dame, Notre Dame, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author></analytic><series><title level="j">BMC medicine</title><idno type="eISSN">1741-7015</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa (epidemiology)</term><term>Asia (epidemiology)</term><term>Bayes Theorem</term><term>Computer Simulation</term><term>Disease Eradication (statistics & numerical data)</term><term>Disease Transmission, Infectious (prevention & control)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Humans</term><term>Models, Statistical</term><term>Neglected Diseases (epidemiology)</term><term>Neglected Diseases (prevention & control)</term><term>Papua New Guinea (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Afrique (épidémiologie)</term><term>Asie (épidémiologie)</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Maladies négligées ()</term><term>Maladies négligées (épidémiologie)</term><term>Modèles statistiques</term><term>Papouasie - Nouvelle-Guinée (épidémiologie)</term><term>Simulation numérique</term><term>Théorème de Bayes</term><term>Transmission de maladie infectieuse ()</term><term>Éradication de maladie ()</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Africa</term><term>Asia</term><term>Papua New Guinea</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Neglected Diseases</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Disease Transmission, Infectious</term><term>Elephantiasis, Filarial</term><term>Neglected Diseases</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Disease Eradication</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Afrique</term><term>Asie</term><term>Filariose lymphatique</term><term>Maladies négligées</term><term>Papouasie - Nouvelle-Guinée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Bayes Theorem</term><term>Computer Simulation</term><term>Humans</term><term>Models, Statistical</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Filariose lymphatique</term><term>Humains</term><term>Maladies négligées</term><term>Modèles statistiques</term><term>Simulation numérique</term><term>Théorème de Bayes</term><term>Transmission de maladie infectieuse</term><term>Éradication de maladie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Papouasie-Nouvelle-Guinée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The current WHO-led initiative to eradicate the macroparasitic disease, lymphatic filariasis (LF), based on single-dose annual mass drug administration (MDA) represents one of the largest health programs devised to reduce the burden of tropical diseases. However, despite the advances made in instituting large-scale MDA programs in affected countries, a challenge to meeting the goal of global eradication is the heterogeneous transmission of LF across endemic regions, and the impact that such complexity may have on the effort required to interrupt transmission in all socioecological settings.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26822124</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>29</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>15</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1741-7015</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><PubDate><Year>2016</Year><Month>Jan</Month><Day>28</Day></PubDate></JournalIssue><Title>BMC medicine</Title><ISOAbbreviation>BMC Med</ISOAbbreviation></Journal><ArticleTitle>Heterogeneous dynamics, robustness/fragility trade-offs, and the eradication of the macroparasitic disease, lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12916-016-0557-y</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The current WHO-led initiative to eradicate the macroparasitic disease, lymphatic filariasis (LF), based on single-dose annual mass drug administration (MDA) represents one of the largest health programs devised to reduce the burden of tropical diseases. However, despite the advances made in instituting large-scale MDA programs in affected countries, a challenge to meeting the goal of global eradication is the heterogeneous transmission of LF across endemic regions, and the impact that such complexity may have on the effort required to interrupt transmission in all socioecological settings.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Here, we apply a Bayesian computer simulation procedure to fit transmission models of LF to field data assembled from 18 sites across the major LF endemic regions of Africa, Asia and Papua New Guinea, reflecting different ecological and vector characteristics, to investigate the impacts and implications of transmission heterogeneity and complexity on filarial infection dynamics, system robustness and control.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We find firstly that LF elimination thresholds varied significantly between the 18 study communities owing to site variations in transmission and initial ecological parameters. We highlight how this variation in thresholds lead to the need for applying variable durations of interventions across endemic communities for achieving LF elimination; however, a major new result is the finding that filarial population responses to interventions ultimately reflect outcomes of interplays between dynamics and the biological architectures and processes that generate robustness/fragility trade-offs in parasite transmission. Intervention simulations carried out in this study further show how understanding these factors is also key to the design of options that would effectively eliminate LF from all settings. In this regard, we find how including vector control into MDA programs may not only offer a countermeasure that will reliably increase system fragility globally across all settings and hence provide a control option robust to differential locality-specific transmission dynamics, but by simultaneously reducing transmission regime variability also permit more reliable macroscopic predictions of intervention effects.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our results imply that a new approach, combining adaptive modelling of parasite transmission with the use of biological robustness as a design principle, is required if we are to both enhance understanding of complex parasitic infections and delineate options to facilitate their elimination effectively.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Michael</LastName><ForeName>Edwin</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. emichael@nd.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh</LastName><ForeName>Brajendra K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. bsingh1@nd.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI069387</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI069387-01A1</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Med</MedlineTA><NlmUniqueID>101190723</NlmUniqueID><ISSNLinking>1741-7015</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2010 Jul;7(7):e1000304</RefSource><PMID Version="1">20625549</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1999 Aug;60(2 Pt A):1412-27</RefSource><PMID Version="1">11969901</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2007 Oct 1;23(19):2612-8</RefSource><PMID Version="1">17660526</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Environ Health Perspect. 2002 Sep;110(9):907-15</RefSource><PMID 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Theorem</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003198" MajorTopicYN="N">Computer Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060740" MajorTopicYN="N">Disease Eradication</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018562" MajorTopicYN="N">Disease Transmission, Infectious</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015233" MajorTopicYN="Y">Models, Statistical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058069" MajorTopicYN="N">Neglected Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010219" MajorTopicYN="N" Type="Geographic">Papua New Guinea</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4731922</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>08</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>01</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26822124</ArticleId><ArticleId IdType="doi">10.1186/s12916-016-0557-y</ArticleId><ArticleId IdType="pii">10.1186/s12916-016-0557-y</ArticleId><ArticleId IdType="pmc">PMC4731922</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><country name="États-Unis"><region name="Indiana"><name sortKey="Michael, Edwin" sort="Michael, Edwin" uniqKey="Michael E" first="Edwin" last="Michael">Edwin Michael</name></region><name sortKey="Singh, Brajendra K" sort="Singh, Brajendra K" uniqKey="Singh B" first="Brajendra K" last="Singh">Brajendra K. Singh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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