Insufficient Lymph Drainage Causes Abnormal Lipid Accumulation and Vein Wall Degeneration.
Identifieur interne : 000859 ( PubMed/Checkpoint ); précédent : 000858; suivant : 000860Insufficient Lymph Drainage Causes Abnormal Lipid Accumulation and Vein Wall Degeneration.
Auteurs : Hiroki Tanaka [Japon] ; Naoto Yamamoto [Japon] ; Minoru Suzuki [Japon] ; Yuuki Mano [Japon] ; Masaki Sano [Japon] ; Nobuhiro Zaima [Japon] ; Takeshi Sasaki [Japon] ; Mitsutoshi Setou [Japon] ; Naoki Unno [Japon]Source :
- Annals of vascular diseases [ 1881-641X ] ; 2016.
Abstract
Objective: Previously, we analyzed human varicose veins (VV) using imaging mass spectrometry (IMS) and detected the abnormal accumulation of lipid molecules in the walls of VV, possibly due to insufficient lipid drainage by the lymphatic vessels. In this study, we created an animal model of lymphatic insufficiency to investigate the effects of insufficient lymph drainage on vein walls. Methods: In rats, the lymphatic collecting vessels surrounding the femoral vein were ligated on one side (the model tissue), which caused the local retention of lymphatic fluid in the perivascular tissue. The equivalent contralateral tissue was used as a control. A histological study of the femoral vein and the surrounding perivascular tissue was conducted. IMS was used to analyze the distribution of lipid molecules in the perivascular tissue. Results: Fourteen days after the procedure, the lymphatic vessels in the model tissue were significantly dilated. Furthermore, IMS revealed that the composition of the lipid molecules in the perivascular regions of the model tissue had altered. Compared with the control tissue, the model tissue exhibited marked perivascular accumulation of lysophosphatidylcholine (1-acyl 16:0), phosphatidylcholine (16:0/20:4), and triglycerides (52:2). Interestingly, the walls of the femoral veins running through the model tissue were 3.4-fold thicker than those of the femoral veins running through the control tissue. The number of tumor necrosis factor α-positive adipocytes was increased in the perivascular regions of the model tissue. Conclusion: The findings of this study indicated that the accumulation of lymphatic fluid due to insufficient lymph drainage changes the structure of vein walls, and such changes might be associated with chronic venous insufficiency. (This is a translation of Jpn J Phlebol 2015; 26: 227-235.).
DOI: 10.3400/avd.oa.16-00122
PubMed: 28018498
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Insufficient Lymph Drainage Causes Abnormal Lipid Accumulation and Vein Wall Degeneration.</title><author><name sortKey="Tanaka, Hiroki" sort="Tanaka, Hiroki" uniqKey="Tanaka H" first="Hiroki" last="Tanaka">Hiroki Tanaka</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Medical Physiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Medical Physiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Naoto" sort="Yamamoto, Naoto" uniqKey="Yamamoto N" first="Naoto" last="Yamamoto">Naoto Yamamoto</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Suzuki, Minoru" sort="Suzuki, Minoru" uniqKey="Suzuki M" first="Minoru" last="Suzuki">Minoru Suzuki</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Mano, Yuuki" sort="Mano, Yuuki" uniqKey="Mano Y" first="Yuuki" last="Mano">Yuuki Mano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Sano, Masaki" sort="Sano, Masaki" uniqKey="Sano M" first="Masaki" last="Sano">Masaki Sano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Zaima, Nobuhiro" sort="Zaima, Nobuhiro" uniqKey="Zaima N" first="Nobuhiro" last="Zaima">Nobuhiro Zaima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Applied Biological Chemistry, Graduate School of Agricultural Science, Kinki University, Osaka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Applied Biological Chemistry, Graduate School of Agricultural Science, Kinki University, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Sasaki, Takeshi" sort="Sasaki, Takeshi" uniqKey="Sasaki T" first="Takeshi" last="Sasaki">Takeshi Sasaki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, Hamamatsu</wicri:regionArea><wicri:noRegion>Hamamatsu</wicri:noRegion></affiliation></author><author><name sortKey="Setou, Mitsutoshi" sort="Setou, Mitsutoshi" uniqKey="Setou M" first="Mitsutoshi" last="Setou">Mitsutoshi Setou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Unno, Naoki" sort="Unno, Naoki" uniqKey="Unno N" first="Naoki" last="Unno">Naoki Unno</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:28018498</idno><idno type="pmid">28018498</idno><idno type="doi">10.3400/avd.oa.16-00122</idno><idno type="wicri:Area/PubMed/Corpus">000442</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000442</idno><idno type="wicri:Area/PubMed/Curation">000442</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000442</idno><idno type="wicri:Area/PubMed/Checkpoint">000442</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000442</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Insufficient Lymph Drainage Causes Abnormal Lipid Accumulation and Vein Wall Degeneration.</title><author><name sortKey="Tanaka, Hiroki" sort="Tanaka, Hiroki" uniqKey="Tanaka H" first="Hiroki" last="Tanaka">Hiroki Tanaka</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Medical Physiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Medical Physiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Naoto" sort="Yamamoto, Naoto" uniqKey="Yamamoto N" first="Naoto" last="Yamamoto">Naoto Yamamoto</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Suzuki, Minoru" sort="Suzuki, Minoru" uniqKey="Suzuki M" first="Minoru" last="Suzuki">Minoru Suzuki</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Mano, Yuuki" sort="Mano, Yuuki" uniqKey="Mano Y" first="Yuuki" last="Mano">Yuuki Mano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Sano, Masaki" sort="Sano, Masaki" uniqKey="Sano M" first="Masaki" last="Sano">Masaki Sano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Zaima, Nobuhiro" sort="Zaima, Nobuhiro" uniqKey="Zaima N" first="Nobuhiro" last="Zaima">Nobuhiro Zaima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Applied Biological Chemistry, Graduate School of Agricultural Science, Kinki University, Osaka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Applied Biological Chemistry, Graduate School of Agricultural Science, Kinki University, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Sasaki, Takeshi" sort="Sasaki, Takeshi" uniqKey="Sasaki T" first="Takeshi" last="Sasaki">Takeshi Sasaki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, Hamamatsu</wicri:regionArea><wicri:noRegion>Hamamatsu</wicri:noRegion></affiliation></author><author><name sortKey="Setou, Mitsutoshi" sort="Setou, Mitsutoshi" uniqKey="Setou M" first="Mitsutoshi" last="Setou">Mitsutoshi Setou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author><author><name sortKey="Unno, Naoki" sort="Unno, Naoki" uniqKey="Unno N" first="Naoki" last="Unno">Naoki Unno</name><affiliation wicri:level="1"><nlm:affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka</wicri:regionArea><wicri:noRegion>Shizuoka</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of vascular diseases</title><idno type="ISSN">1881-641X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: Previously, we analyzed human varicose veins (VV) using imaging mass spectrometry (IMS) and detected the abnormal accumulation of lipid molecules in the walls of VV, possibly due to insufficient lipid drainage by the lymphatic vessels. In this study, we created an animal model of lymphatic insufficiency to investigate the effects of insufficient lymph drainage on vein walls. Methods: In rats, the lymphatic collecting vessels surrounding the femoral vein were ligated on one side (the model tissue), which caused the local retention of lymphatic fluid in the perivascular tissue. The equivalent contralateral tissue was used as a control. A histological study of the femoral vein and the surrounding perivascular tissue was conducted. IMS was used to analyze the distribution of lipid molecules in the perivascular tissue. Results: Fourteen days after the procedure, the lymphatic vessels in the model tissue were significantly dilated. Furthermore, IMS revealed that the composition of the lipid molecules in the perivascular regions of the model tissue had altered. Compared with the control tissue, the model tissue exhibited marked perivascular accumulation of lysophosphatidylcholine (1-acyl 16:0), phosphatidylcholine (16:0/20:4), and triglycerides (52:2). Interestingly, the walls of the femoral veins running through the model tissue were 3.4-fold thicker than those of the femoral veins running through the control tissue. The number of tumor necrosis factor α-positive adipocytes was increased in the perivascular regions of the model tissue. Conclusion: The findings of this study indicated that the accumulation of lymphatic fluid due to insufficient lymph drainage changes the structure of vein walls, and such changes might be associated with chronic venous insufficiency. (This is a translation of Jpn J Phlebol 2015; 26: 227-235.).</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">28018498</PMID><DateCreated><Year>2016</Year><Month>12</Month><Day>26</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1881-641X</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><Issue>4</Issue><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Annals of vascular diseases</Title><ISOAbbreviation>Ann Vasc Dis</ISOAbbreviation></Journal><ArticleTitle>Insufficient Lymph Drainage Causes Abnormal Lipid Accumulation and Vein Wall Degeneration.</ArticleTitle><Pagination><MedlinePgn>277-284</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3400/avd.oa.16-00122</ELocationID><Abstract><AbstractText>Objective: Previously, we analyzed human varicose veins (VV) using imaging mass spectrometry (IMS) and detected the abnormal accumulation of lipid molecules in the walls of VV, possibly due to insufficient lipid drainage by the lymphatic vessels. In this study, we created an animal model of lymphatic insufficiency to investigate the effects of insufficient lymph drainage on vein walls. Methods: In rats, the lymphatic collecting vessels surrounding the femoral vein were ligated on one side (the model tissue), which caused the local retention of lymphatic fluid in the perivascular tissue. The equivalent contralateral tissue was used as a control. A histological study of the femoral vein and the surrounding perivascular tissue was conducted. IMS was used to analyze the distribution of lipid molecules in the perivascular tissue. Results: Fourteen days after the procedure, the lymphatic vessels in the model tissue were significantly dilated. Furthermore, IMS revealed that the composition of the lipid molecules in the perivascular regions of the model tissue had altered. Compared with the control tissue, the model tissue exhibited marked perivascular accumulation of lysophosphatidylcholine (1-acyl 16:0), phosphatidylcholine (16:0/20:4), and triglycerides (52:2). Interestingly, the walls of the femoral veins running through the model tissue were 3.4-fold thicker than those of the femoral veins running through the control tissue. The number of tumor necrosis factor α-positive adipocytes was increased in the perivascular regions of the model tissue. Conclusion: The findings of this study indicated that the accumulation of lymphatic fluid due to insufficient lymph drainage changes the structure of vein walls, and such changes might be associated with chronic venous insufficiency. (This is a translation of Jpn J Phlebol 2015; 26: 227-235.).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>Hiroki</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Medical Physiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yamamoto</LastName><ForeName>Naoto</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suzuki</LastName><ForeName>Minoru</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mano</LastName><ForeName>Yuuki</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sano</LastName><ForeName>Masaki</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaima</LastName><ForeName>Nobuhiro</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; Department of Applied Biological Chemistry, Graduate School of Agricultural Science, Kinki University, Osaka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sasaki</LastName><ForeName>Takeshi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Setou</LastName><ForeName>Mitsutoshi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Unno</LastName><ForeName>Naoki</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>12</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Ann Vasc Dis</MedlineTA><NlmUniqueID>101471467</NlmUniqueID><ISSNLinking>1881-641X</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Interact Cardiovasc Thorac Surg. 2007 Apr;6(2):219-24</RefSource><PMID Version="1">17669815</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphat Res Biol. 2007;5(1):11-27</RefSource><PMID Version="1">17508899</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2006 Sep;12 (9):996-7</RefSource><PMID Version="1">16960569</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Nutr Soc. 2001 Aug;60(3):349-56</RefSource><PMID Version="1">11681809</PMID></CommentsCorrections><CommentsCorrections 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veins</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>11</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>12</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>12</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>27</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28018498</ArticleId><ArticleId IdType="doi">10.3400/avd.oa.16-00122</ArticleId><ArticleId IdType="pii">avd.oa.16-00122</ArticleId><ArticleId IdType="pmc">PMC5174986</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Tanaka, Hiroki" sort="Tanaka, Hiroki" uniqKey="Tanaka H" first="Hiroki" last="Tanaka">Hiroki Tanaka</name></noRegion><name sortKey="Mano, Yuuki" sort="Mano, Yuuki" uniqKey="Mano Y" first="Yuuki" last="Mano">Yuuki Mano</name><name sortKey="Sano, Masaki" sort="Sano, Masaki" uniqKey="Sano M" first="Masaki" last="Sano">Masaki Sano</name><name sortKey="Sasaki, Takeshi" sort="Sasaki, Takeshi" uniqKey="Sasaki T" first="Takeshi" last="Sasaki">Takeshi Sasaki</name><name sortKey="Setou, Mitsutoshi" sort="Setou, Mitsutoshi" uniqKey="Setou M" first="Mitsutoshi" last="Setou">Mitsutoshi Setou</name><name sortKey="Suzuki, Minoru" sort="Suzuki, Minoru" uniqKey="Suzuki M" first="Minoru" last="Suzuki">Minoru Suzuki</name><name sortKey="Unno, Naoki" sort="Unno, Naoki" uniqKey="Unno N" first="Naoki" last="Unno">Naoki Unno</name><name sortKey="Yamamoto, Naoto" sort="Yamamoto, Naoto" uniqKey="Yamamoto N" first="Naoto" last="Yamamoto">Naoto Yamamoto</name><name sortKey="Zaima, Nobuhiro" sort="Zaima, Nobuhiro" uniqKey="Zaima N" first="Nobuhiro" last="Zaima">Nobuhiro Zaima</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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