LymphedemaV1, PubMed, Checkpoint, bibRecord, 000837

Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema.

Identifieur interne : 000837 ( PubMed/Checkpoint ); précédent : 000836; suivant : 000838

Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema.

Auteurs : Lisa M. Sedger [Australie] ; Dedreia L. Tull [Australie] ; Malcolm J. Mcconville [Australie] ; David P. De Souza [Australie] ; Thusitha W T. Rupasinghe [Australie] ; Spencer J. Williams [Australie] ; Saravanan Dayalan [Australie] ; Daniel Lanzer [Australie] ; Helen Mackie [Australie] ; Thomas C. Lam [Australie] ; John Boyages [Australie]

Source :

PloS one [ 1932-6203 ] ; 2016.

RBID : pubmed:27182733

Descripteurs français

KwdFr :
- Acides gras (métabolisme), Adolescent, Adulte, Adulte d'âge moyen, Femelle, Humains, Indice de gravité médicale, Jeune adulte, Lipides (sang), Lymphoedème (diagnostic), Lymphoedème (métabolisme), Lymphoedème (étiologie), Mâle, Médiateurs de l'inflammation (métabolisme), Métabolisme des lipides, Métabolomique (), Phospholipides (métabolisme), Sujet âgé, Tissu adipeux (métabolisme), Transport biologique, Tumeurs ().
MESH :
- diagnostic : Lymphoedème.
- métabolisme : Acides gras, Lymphoedème, Médiateurs de l'inflammation, Phospholipides, Tissu adipeux.
- sang : Lipides.
- étiologie : Lymphoedème.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Humains, Indice de gravité médicale, Jeune adulte, Mâle, Métabolisme des lipides, Métabolomique, Sujet âgé, Transport biologique, Tumeurs.

English descriptors

KwdEn :
- Adipose Tissue (metabolism), Adolescent, Adult, Aged, Biological Transport, Fatty Acids (metabolism), Female, Humans, Inflammation Mediators (metabolism), Lipid Metabolism, Lipids (blood), Lymphedema (diagnosis), Lymphedema (etiology), Lymphedema (metabolism), Male, Metabolomics (methods), Middle Aged, Neoplasms (complications), Phospholipids (metabolism), Severity of Illness Index, Young Adult.
MESH :
- chemical , blood : Lipids.
- chemical , metabolism : Fatty Acids, Inflammation Mediators, Phospholipids.
- complications : Neoplasms.
- diagnosis : Lymphedema.
- etiology : Lymphedema.
- metabolism : Adipose Tissue, Lymphedema.
- methods : Metabolomics.
- Adolescent, Adult, Aged, Biological Transport, Female, Humans, Lipid Metabolism, Male, Middle Aged, Severity of Illness Index, Young Adult.

Abstract

Cancer-related and primary lymphedema (LE) are associated with the production of adipose tissue (AT). Nothing is known, however, about the lipid-based molecules that comprise LE AT. We therefore analyzed lipid molecules in lipoaspirates and serum obtained from LE patients, and compared them to lipoaspirates from cosmetic surgery patients and healthy control cohort serum. LE patient serum analysis demonstrated that triglycerides, HDL- and LDL-cholesterol and lipid transport molecules remained within the normal range, with no alterations in individual fatty acids. The lipidomic analysis also identified 275 lipid-based molecules, including triacylglycerides, diacylglycerides, fatty acids and phospholipids in AT oil and fat. Although the majority of lipid molecules were present in a similar abundance in LE and non-LE samples, there were several small changes: increased C20:5-containing triacylglycerides, reduced C10:0 caprinic and C24:1 nervonic acids. LE AT oil also contained a signature of increased cyclopropane-type fatty acids and inflammatory mediators arachidonic acid and ceramides. Interestingly C20:5 and C22:6 omega-3-type lipids are increased in LE AT, correlating with LE years. Hence, LE AT has a normal lipid profile containing a signature of inflammation and omega-3-lipids. It remains unclear, however, whether these differences reflect a small-scale global metabolic disturbance or effects within localised inflammatory foci.

DOI: 10.1371/journal.pone.0154650
PubMed: 27182733

Affiliations:

Australie

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Le document en format XML

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<term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Biological Transport</term>
<term>Fatty Acids (metabolism)</term>
<term>Female</term>
<term>Humans</term>
<term>Inflammation Mediators (metabolism)</term>
<term>Lipid Metabolism</term>
<term>Lipids (blood)</term>
<term>Lymphedema (diagnosis)</term>
<term>Lymphedema (etiology)</term>
<term>Lymphedema (metabolism)</term>
<term>Male</term>
<term>Metabolomics (methods)</term>
<term>Middle Aged</term>
<term>Neoplasms (complications)</term>
<term>Phospholipids (metabolism)</term>
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<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Jeune adulte</term>
<term>Lipides (sang)</term>
<term>Lymphoedème (diagnostic)</term>
<term>Lymphoedème (métabolisme)</term>
<term>Lymphoedème (étiologie)</term>
<term>Mâle</term>
<term>Médiateurs de l'inflammation (métabolisme)</term>
<term>Métabolisme des lipides</term>
<term>Métabolomique ()</term>
<term>Phospholipides (métabolisme)</term>
<term>Sujet âgé</term>
<term>Tissu adipeux (métabolisme)</term>
<term>Transport biologique</term>
<term>Tumeurs ()</term>
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<term>Inflammation Mediators</term>
<term>Phospholipids</term>
</keywords>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adipose Tissue</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Metabolomics</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acides gras</term>
<term>Lymphoedème</term>
<term>Médiateurs de l'inflammation</term>
<term>Phospholipides</term>
<term>Tissu adipeux</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Lipides</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Biological Transport</term>
<term>Female</term>
<term>Humans</term>
<term>Lipid Metabolism</term>
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<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Métabolisme des lipides</term>
<term>Métabolomique</term>
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<front><div type="abstract" xml:lang="en">Cancer-related and primary lymphedema (LE) are associated with the production of adipose tissue (AT). Nothing is known, however, about the lipid-based molecules that comprise LE AT. We therefore analyzed lipid molecules in lipoaspirates and serum obtained from LE patients, and compared them to lipoaspirates from cosmetic surgery patients and healthy control cohort serum. LE patient serum analysis demonstrated that triglycerides, HDL- and LDL-cholesterol and lipid transport molecules remained within the normal range, with no alterations in individual fatty acids. The lipidomic analysis also identified 275 lipid-based molecules, including triacylglycerides, diacylglycerides, fatty acids and phospholipids in AT oil and fat. Although the majority of lipid molecules were present in a similar abundance in LE and non-LE samples, there were several small changes: increased C20:5-containing triacylglycerides, reduced C10:0 caprinic and C24:1 nervonic acids. LE AT oil also contained a signature of increased cyclopropane-type fatty acids and inflammatory mediators arachidonic acid and ceramides. Interestingly C20:5 and C22:6 omega-3-type lipids are increased in LE AT, correlating with LE years. Hence, LE AT has a normal lipid profile containing a signature of inflammation and omega-3-lipids. It remains unclear, however, whether these differences reflect a small-scale global metabolic disturbance or effects within localised inflammatory foci.</div>
</front>
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<Abstract><AbstractText>Cancer-related and primary lymphedema (LE) are associated with the production of adipose tissue (AT). Nothing is known, however, about the lipid-based molecules that comprise LE AT. We therefore analyzed lipid molecules in lipoaspirates and serum obtained from LE patients, and compared them to lipoaspirates from cosmetic surgery patients and healthy control cohort serum. LE patient serum analysis demonstrated that triglycerides, HDL- and LDL-cholesterol and lipid transport molecules remained within the normal range, with no alterations in individual fatty acids. The lipidomic analysis also identified 275 lipid-based molecules, including triacylglycerides, diacylglycerides, fatty acids and phospholipids in AT oil and fat. Although the majority of lipid molecules were present in a similar abundance in LE and non-LE samples, there were several small changes: increased C20:5-containing triacylglycerides, reduced C10:0 caprinic and C24:1 nervonic acids. LE AT oil also contained a signature of increased cyclopropane-type fatty acids and inflammatory mediators arachidonic acid and ceramides. Interestingly C20:5 and C22:6 omega-3-type lipids are increased in LE AT, correlating with LE years. Hence, LE AT has a normal lipid profile containing a signature of inflammation and omega-3-lipids. It remains unclear, however, whether these differences reflect a small-scale global metabolic disturbance or effects within localised inflammatory foci.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sedger</LastName>
<ForeName>Lisa M</ForeName>
<Initials>LM</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Tull</LastName>
<ForeName>Dedreia L</ForeName>
<Initials>DL</Initials>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000273" MajorTopicYN="N">Adipose Tissue</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema.

Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema.

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