Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential.
Identifieur interne : 000810 ( PubMed/Checkpoint ); précédent : 000809; suivant : 000811Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential.
Auteurs : Homaira Rahimi [États-Unis] ; Richard Bell [États-Unis] ; Echoe M. Bouta [États-Unis] ; Ronald W. Wood [États-Unis] ; Lianping Xing [États-Unis] ; Christopher T. Ritchlin [États-Unis] ; Edward M. Schwarz [États-Unis]Source :
- Arthritis research & therapy [ 1478-6362 ] ; 2016.
Abstract
Proliferation of draining lymphatic vessels coupled with dynamic changes in lymph node volume and flow are characteristic features in rheumatoid arthritis (RA). Furthermore, impaired lymph egress from inflamed synovium is associated with joint flare in murine models of inflammatory-erosive arthritis. Unfortunately, advances towards a greater understanding of lymphatic changes in RA pathogenesis have been slow due to the absence of outcome measures to quantify lymphatic function in vivo. While lymphoscintigraphy is the current standard to assess lymphedema and sentinel lymph nodes in cancer patients, its sensitivity and specificity are inadequate to study lymphatics in RA. The emergence of high-resolution MRI, power Doppler ultrasound, and near-infrared imaging that permits real-time quantification of lymphatic function in animal models has been a major advance, and these techniques have produced a new paradigm of altered lymphatic function that underlies both acute arthritic flare and chronic inflammation. In acute flare, lymphatic drainage increases several fold, whereas no lymphatic contractions are detected in lymph vessels draining chronic arthritic joints. Moreover, these outcomes are now being adapted to study lymphatics in RA towards the development of novel biomarkers of arthritic flare and the discovery of new therapeutic targets. In particular, interventions that directly increase lymphatic egress from diseased joints by opening collateral lymphatic vessels, and that restore lymphatic vessel contractions, provide novel therapeutic approaches with potential for minimal toxicity and immunosuppression. To summarize the origins of this field, recent advances, and future directions, we herein review: current knowledge of lymphatics in RA based on classic literature; new in-vivo imaging modalities that have elucidated how lymphatics modulate acute versus chronic joint inflammation in murine models; and how these preclinical outcome measures are being translated to study lymphatic function in RA inflammation and how effective RA therapies alter lymphatic flow and lymph nodes draining flaring joints.
DOI: 10.1186/s13075-016-1092-0
PubMed: 27586634
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Homaira_Rahimi@urmc.rochester.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bell, Richard" sort="Bell, Richard" uniqKey="Bell R" first="Richard" last="Bell">Richard Bell</name><affiliation wicri:level="2"><nlm:affiliation>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bouta, Echoe M" sort="Bouta, Echoe M" uniqKey="Bouta E" first="Echoe M" last="Bouta">Echoe M. Bouta</name><affiliation wicri:level="2"><nlm:affiliation>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wood, Ronald W" sort="Wood, Ronald W" uniqKey="Wood R" first="Ronald W" last="Wood">Ronald W. Wood</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Xing, Lianping" sort="Xing, Lianping" uniqKey="Xing L" first="Lianping" last="Xing">Lianping Xing</name><affiliation wicri:level="2"><nlm:affiliation>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ritchlin, Christopher T" sort="Ritchlin, Christopher T" uniqKey="Ritchlin C" first="Christopher T" last="Ritchlin">Christopher T. Ritchlin</name><affiliation wicri:level="2"><nlm:affiliation>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Schwarz, Edward M" sort="Schwarz, Edward M" uniqKey="Schwarz E" first="Edward M" last="Schwarz">Edward M. Schwarz</name><affiliation wicri:level="2"><nlm:affiliation>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Arthritis research & therapy</title><idno type="eISSN">1478-6362</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Proliferation of draining lymphatic vessels coupled with dynamic changes in lymph node volume and flow are characteristic features in rheumatoid arthritis (RA). Furthermore, impaired lymph egress from inflamed synovium is associated with joint flare in murine models of inflammatory-erosive arthritis. Unfortunately, advances towards a greater understanding of lymphatic changes in RA pathogenesis have been slow due to the absence of outcome measures to quantify lymphatic function in vivo. While lymphoscintigraphy is the current standard to assess lymphedema and sentinel lymph nodes in cancer patients, its sensitivity and specificity are inadequate to study lymphatics in RA. The emergence of high-resolution MRI, power Doppler ultrasound, and near-infrared imaging that permits real-time quantification of lymphatic function in animal models has been a major advance, and these techniques have produced a new paradigm of altered lymphatic function that underlies both acute arthritic flare and chronic inflammation. In acute flare, lymphatic drainage increases several fold, whereas no lymphatic contractions are detected in lymph vessels draining chronic arthritic joints. Moreover, these outcomes are now being adapted to study lymphatics in RA towards the development of novel biomarkers of arthritic flare and the discovery of new therapeutic targets. In particular, interventions that directly increase lymphatic egress from diseased joints by opening collateral lymphatic vessels, and that restore lymphatic vessel contractions, provide novel therapeutic approaches with potential for minimal toxicity and immunosuppression. To summarize the origins of this field, recent advances, and future directions, we herein review: current knowledge of lymphatics in RA based on classic literature; new in-vivo imaging modalities that have elucidated how lymphatics modulate acute versus chronic joint inflammation in murine models; and how these preclinical outcome measures are being translated to study lymphatic function in RA inflammation and how effective RA therapies alter lymphatic flow and lymph nodes draining flaring joints.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27586634</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>02</Day></DateCreated><DateRevised><Year>2017</Year><Month>05</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1478-6362</ISSN><JournalIssue CitedMedium="Internet"><Volume>18</Volume><PubDate><Year>2016</Year><Month>Sep</Month><Day>01</Day></PubDate></JournalIssue><Title>Arthritis research & therapy</Title><ISOAbbreviation>Arthritis Res. Ther.</ISOAbbreviation></Journal><ArticleTitle>Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential.</ArticleTitle><Pagination><MedlinePgn>194</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13075-016-1092-0</ELocationID><Abstract><AbstractText Label="UNLABELLED">Proliferation of draining lymphatic vessels coupled with dynamic changes in lymph node volume and flow are characteristic features in rheumatoid arthritis (RA). Furthermore, impaired lymph egress from inflamed synovium is associated with joint flare in murine models of inflammatory-erosive arthritis. Unfortunately, advances towards a greater understanding of lymphatic changes in RA pathogenesis have been slow due to the absence of outcome measures to quantify lymphatic function in vivo. While lymphoscintigraphy is the current standard to assess lymphedema and sentinel lymph nodes in cancer patients, its sensitivity and specificity are inadequate to study lymphatics in RA. The emergence of high-resolution MRI, power Doppler ultrasound, and near-infrared imaging that permits real-time quantification of lymphatic function in animal models has been a major advance, and these techniques have produced a new paradigm of altered lymphatic function that underlies both acute arthritic flare and chronic inflammation. In acute flare, lymphatic drainage increases several fold, whereas no lymphatic contractions are detected in lymph vessels draining chronic arthritic joints. Moreover, these outcomes are now being adapted to study lymphatics in RA towards the development of novel biomarkers of arthritic flare and the discovery of new therapeutic targets. In particular, interventions that directly increase lymphatic egress from diseased joints by opening collateral lymphatic vessels, and that restore lymphatic vessel contractions, provide novel therapeutic approaches with potential for minimal toxicity and immunosuppression. To summarize the origins of this field, recent advances, and future directions, we herein review: current knowledge of lymphatics in RA based on classic literature; new in-vivo imaging modalities that have elucidated how lymphatics modulate acute versus chronic joint inflammation in murine models; and how these preclinical outcome measures are being translated to study lymphatic function in RA inflammation and how effective RA therapies alter lymphatic flow and lymph nodes draining flaring joints.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">ClinicalTrials.gov NCT02680067 . Registered 7 December 2015; ClinicalTrials.gov NCT01098201 . Registered 30 March 2010; and ClinicalTrials.gov NCT01083563 . Registered 8 March 2010.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rahimi</LastName><ForeName>Homaira</ForeName><Initials>H</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-4028-7723</Identifier><AffiliationInfo><Affiliation>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Homaira_Rahimi@urmc.rochester.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Homaira_Rahimi@urmc.rochester.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Rochester Medical Center, 601 Elmwood Avenue, Box 777, Rochester, NY, 14642, USA. Homaira_Rahimi@urmc.rochester.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bell</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouta</LastName><ForeName>Echoe M</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wood</LastName><ForeName>Ronald W</ForeName><Initials>RW</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Urology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xing</LastName><ForeName>Lianping</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ritchlin</LastName><ForeName>Christopher T</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Allergy, Immunology, Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwarz</LastName><ForeName>Edward M</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Urology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Allergy, Immunology, Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT02680067</AccessionNumber><AccessionNumber>NCT01098201</AccessionNumber><AccessionNumber>NCT01083563</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>R01 AR063650</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AR069655</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AR048697</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AR056702</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 AR053459</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR000042</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AR061307</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 AI078907</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH 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Version="1">20435928</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2007 Dec;56(12 ):4024-37</RefSource><PMID Version="1">18050199</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Rheum Dis. 1968 May;27(3):253-60</RefSource><PMID Version="1">5655317</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Rheumatol. 2015 Jul;42(7):1112-8</RefSource><PMID Version="1">25934821</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Res Ther. 2011 Aug 31;13(4):R138</RefSource><PMID Version="1">21884592</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Immunol Immunopathol. 1973 Jan;1(2):173-81</RefSource><PMID Version="1">4587206</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Care Res (Hoboken). 2012 May;64(5):675-82</RefSource><PMID Version="1">22183834</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2009 Sep;60(9):2666-76</RefSource><PMID Version="1">19714652</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Rheumatol. 1995 Jul;14 (4):445-50</RefSource><PMID Version="1">7586983</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Res Ther. 2010;12 (3):R98</RefSource><PMID Version="1">20487531</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Res Ther. 2005;7(2):R310-7</RefSource><PMID Version="1">15743478</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rheumatology (Oxford). 2011 Aug;50(8):1395-400</RefSource><PMID Version="1">21378108</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Rheum Dis. 2008 Nov;67(11):1610-6</RefSource><PMID Version="1">18174217</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Rheum Dis. 2010 Jul;69(7):1349-51</RefSource><PMID Version="1">20472599</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 1986 May;29(5):665-74</RefSource><PMID Version="1">3718557</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Rheum Dis. 1987 Aug;46(8):645-6</RefSource><PMID Version="1">3662655</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2003 Apr;48(4):955-62</RefSource><PMID Version="1">12687537</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann N Y Acad Sci. 2007 Nov;1117:106-23</RefSource><PMID Version="1">17646265</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Surg Today. 2004;34(7):581-5</RefSource><PMID Version="1">15221551</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Rheum Dis. 1998 Mar;57(3):152-7</RefSource><PMID Version="1">9640130</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2012 Jun;64(6):2048-50</RefSource><PMID Version="1">22354862</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2013 Jan;65(1):130-8</RefSource><PMID Version="1">23002006</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rheumatology (Oxford). 2000 Jul;39(7):700-6</RefSource><PMID Version="1">10908686</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Res Ther. 2016 Mar 12;18:62</RefSource><PMID Version="1">26970913</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Transl Oncol. 2010 Dec 01;3(6):362-72</RefSource><PMID Version="1">21151475</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Development. 2016 Mar 15;143(6):924-35</RefSource><PMID Version="1">26980792</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Best Pract Res Clin Rheumatol. 2007 Oct;21(5):907-27</RefSource><PMID Version="1">17870035</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2004 Mar;50(3):961-7</RefSource><PMID Version="1">15022340</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>EMBO J. 1996 Apr 1;15(7):1751</RefSource><PMID Version="1">8612600</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Res Ther. 2007;9(6):R118</RefSource><PMID Version="1">17997858</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2012 Jan;64(1):67-76</RefSource><PMID Version="1">21904998</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Biotechnol. 2009 Feb;20(1):74-82</RefSource><PMID Version="1">19233639</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Rheum Dis. 1968 Mar;27(2):167-9</RefSource><PMID Version="1">5651232</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Phys Med Rehabil. 2011 May;92(5):756-764.e1</RefSource><PMID Version="1">21530723</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Manag Care. 2014 May;20(7 Suppl):S128-35</RefSource><PMID Version="1">25180621</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Radiol Diagn (Stockh). 1980;21(5):645-9</RefSource><PMID Version="1">7457195</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Dermatol. 2000 Dec;143(6):1297-301</RefSource><PMID Version="1">11122038</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Bone Miner Res. 2015 Apr;30(4):690-4</RefSource><PMID Version="1">25359523</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Head Neck. 2012 Mar;34(3):448-53</RefSource><PMID Version="1">22311465</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Rheumatol. 2009 Oct;36(10):2335-41</RefSource><PMID Version="1">19684147</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Rheumatol. 1995 Feb;22(2):214-7</RefSource><PMID Version="1">7738940</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Health Qual Life Outcomes. 2003 Oct 17;1:55</RefSource><PMID Version="1">14613567</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Immunopathol Pharmacol. 2016 Jun;29(2):252-66</RefSource><PMID Version="1">26684633</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Semin Arthritis Rheum. 1993 Apr;22(5):350-6</RefSource><PMID Version="1">8511598</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Pathol. 2008;3:367-97</RefSource><PMID Version="1">18039141</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Korean J Radiol. 2005 Apr-Jun;6(2):117-24</RefSource><PMID Version="1">15968151</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acad Radiol. 2006 Jan;13(1):4-13</RefSource><PMID Version="1">16399028</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Rheum Dis. 2008 Dec;67(12 ):1765-72</RefSource><PMID Version="1">18218664</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 1977 Jul-Aug;20(6):1249-62</RefSource><PMID Version="1">302707</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rheumatol Int. 1995;15(4):159-65</RefSource><PMID Version="1">8835298</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 1989 Mar;32(3):330-7</RefSource><PMID Version="1">2564781</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3566-70</RefSource><PMID Version="1">7724599</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 1999 May;42(5):918-29</RefSource><PMID Version="1">10323447</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Surg. 2004 May;91(5):575-9</RefSource><PMID Version="1">15122608</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2011 Aug;63(8):2318-28</RefSource><PMID Version="1">21538325</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biomed Res Int. 2015;2015:420251</RefSource><PMID Version="1">25793195</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2001 Mar;44(3):541-9</RefSource><PMID Version="1">11263768</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Physiol. 2014 Mar 15;592(6):1213-23</RefSource><PMID Version="1">24421350</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2008 Jul;58(7):2019-29</RefSource><PMID Version="1">18576355</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Semin Cell Dev Biol. 2015 Feb;38:90-7</RefSource><PMID Version="1">25598390</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol Methods. 1997 Mar 10;202(1):35-40</RefSource><PMID Version="1">9075769</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rheumatology (Oxford). 2012 Dec;51 Suppl 7:vii36-42</RefSource><PMID Version="1">23230093</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Res Ther. 2014;16(3):114</RefSource><PMID Version="1">25167330</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">PMC5009676</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>9</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>9</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27586634</ArticleId><ArticleId IdType="doi">10.1186/s13075-016-1092-0</ArticleId><ArticleId IdType="pii">10.1186/s13075-016-1092-0</ArticleId><ArticleId IdType="pmc">PMC5009676</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Rahimi, Homaira" sort="Rahimi, Homaira" uniqKey="Rahimi H" first="Homaira" last="Rahimi">Homaira Rahimi</name></region><name sortKey="Bell, Richard" sort="Bell, Richard" uniqKey="Bell R" first="Richard" last="Bell">Richard Bell</name><name sortKey="Bouta, Echoe M" sort="Bouta, Echoe M" uniqKey="Bouta E" first="Echoe M" last="Bouta">Echoe M. Bouta</name><name sortKey="Ritchlin, Christopher T" sort="Ritchlin, Christopher T" uniqKey="Ritchlin C" first="Christopher T" last="Ritchlin">Christopher T. Ritchlin</name><name sortKey="Schwarz, Edward M" sort="Schwarz, Edward M" uniqKey="Schwarz E" first="Edward M" last="Schwarz">Edward M. Schwarz</name><name sortKey="Wood, Ronald W" sort="Wood, Ronald W" uniqKey="Wood R" first="Ronald W" last="Wood">Ronald W. Wood</name><name sortKey="Xing, Lianping" sort="Xing, Lianping" uniqKey="Xing L" first="Lianping" last="Xing">Lianping Xing</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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