LymphedemaV1, PubMed, Checkpoint, bibRecord, 000717

Postoperative Radiotherapy After Breast-Conserving Surgery for Early-Stage Breast Cancer: A Review.

Identifieur interne : 000717 ( PubMed/Checkpoint ); précédent : 000716; suivant : 000718

Postoperative Radiotherapy After Breast-Conserving Surgery for Early-Stage Breast Cancer: A Review.

Auteurs : Corey Speers ; Lori J. Pierce

Source :

JAMA oncology [ 2374-2445 ] ; 2016.

RBID : pubmed:27243924

Descripteurs français

KwdFr :
- Femelle, Humains, Lymphoedème (étiologie), Lésions radio-induites (étiologie), Mastectomie partielle, Noeuds lymphatiques (anatomopathologie), Radiothérapie adjuvante (), Radiothérapie adjuvante (effets indésirables), Stade de la tumeur, Taux de survie, Tumeurs du sein (anatomopathologie), Tumeurs du sein (radiothérapie).
MESH :
- anatomopathologie : Noeuds lymphatiques, Tumeurs du sein.
- effets indésirables : Radiothérapie adjuvante.
- radiothérapie : Tumeurs du sein.
- étiologie : Lymphoedème, Lésions radio-induites.
- Femelle, Humains, Mastectomie partielle, Radiothérapie adjuvante, Stade de la tumeur, Taux de survie.

English descriptors

KwdEn :
- Breast Neoplasms (pathology), Breast Neoplasms (radiotherapy), Female, Humans, Lymph Nodes (pathology), Lymphedema (etiology), Mastectomy, Segmental, Neoplasm Staging, Radiation Injuries (etiology), Radiotherapy, Adjuvant (adverse effects), Radiotherapy, Adjuvant (methods), Survival Rate.
MESH :
- adverse effects : Radiotherapy, Adjuvant.
- etiology : Lymphedema, Radiation Injuries.
- methods : Radiotherapy, Adjuvant.
- pathology : Breast Neoplasms, Lymph Nodes.
- radiotherapy : Breast Neoplasms.
- Female, Humans, Mastectomy, Segmental, Neoplasm Staging, Survival Rate.

Abstract

Radiotherapy (RT) after breast-conserving surgery for early-stage disease has become an integral part of breast cancer treatment. This article reviews the rationale and indications for adjuvant radiotherapy to the breast and regional lymph nodes.

DOI: 10.1001/jamaoncol.2015.5805
PubMed: 27243924

Affiliations:

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pubmed:27243924

Le document en format XML

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<author><name sortKey="Speers, Corey" sort="Speers, Corey" uniqKey="Speers C" first="Corey" last="Speers">Corey Speers</name>
<affiliation><nlm:affiliation>Department of Radiation Oncology, University of Michigan, Ann Arbor.</nlm:affiliation>
<wicri:noCountry code="subField">Ann Arbor</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pierce, Lori J" sort="Pierce, Lori J" uniqKey="Pierce L" first="Lori J" last="Pierce">Lori J. Pierce</name>
<affiliation><nlm:affiliation>Department of Radiation Oncology, University of Michigan, Ann Arbor.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Postoperative Radiotherapy After Breast-Conserving Surgery for Early-Stage Breast Cancer: A Review.</title>
<author><name sortKey="Speers, Corey" sort="Speers, Corey" uniqKey="Speers C" first="Corey" last="Speers">Corey Speers</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (pathology)</term>
<term>Breast Neoplasms (radiotherapy)</term>
<term>Female</term>
<term>Humans</term>
<term>Lymph Nodes (pathology)</term>
<term>Lymphedema (etiology)</term>
<term>Mastectomy, Segmental</term>
<term>Neoplasm Staging</term>
<term>Radiation Injuries (etiology)</term>
<term>Radiotherapy, Adjuvant (adverse effects)</term>
<term>Radiotherapy, Adjuvant (methods)</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term>
<term>Humains</term>
<term>Lymphoedème (étiologie)</term>
<term>Lésions radio-induites (étiologie)</term>
<term>Mastectomie partielle</term>
<term>Noeuds lymphatiques (anatomopathologie)</term>
<term>Radiothérapie adjuvante ()</term>
<term>Radiothérapie adjuvante (effets indésirables)</term>
<term>Stade de la tumeur</term>
<term>Taux de survie</term>
<term>Tumeurs du sein (anatomopathologie)</term>
<term>Tumeurs du sein (radiothérapie)</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radiotherapy, Adjuvant</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Noeuds lymphatiques</term>
<term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Radiothérapie adjuvante</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
<term>Radiation Injuries</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Radiotherapy, Adjuvant</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
<term>Lymph Nodes</term>
</keywords>
<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term>
<term>Lésions radio-induites</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Mastectomy, Segmental</term>
<term>Neoplasm Staging</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Femelle</term>
<term>Humains</term>
<term>Mastectomie partielle</term>
<term>Radiothérapie adjuvante</term>
<term>Stade de la tumeur</term>
<term>Taux de survie</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Radiotherapy (RT) after breast-conserving surgery for early-stage disease has become an integral part of breast cancer treatment. This article reviews the rationale and indications for adjuvant radiotherapy to the breast and regional lymph nodes.</div>
</front>
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<DateCreated><Year>2016</Year>
<Month>08</Month>
<Day>12</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>01</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>01</Month>
<Day>30</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2374-2445</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>2</Volume>
<Issue>8</Issue>
<PubDate><Year>2016</Year>
<Month>Aug</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>JAMA oncology</Title>
<ISOAbbreviation>JAMA Oncol</ISOAbbreviation>
</Journal>
<ArticleTitle>Postoperative Radiotherapy After Breast-Conserving Surgery for Early-Stage Breast Cancer: A Review.</ArticleTitle>
<Pagination><MedlinePgn>1075-82</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1001/jamaoncol.2015.5805</ELocationID>
<Abstract><AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">Radiotherapy (RT) after breast-conserving surgery for early-stage disease has become an integral part of breast cancer treatment. This article reviews the rationale and indications for adjuvant radiotherapy to the breast and regional lymph nodes.</AbstractText>
<AbstractText Label="OBSERVATIONS" NlmCategory="METHODS">Randomized trials have demonstrated a significant benefit in tumor control in the treated breast following whole-breast RT that, in aggregate, has resulted in an overall survival advantage compared with breast-conserving surgery alone. Recent studies have further assessed the impact of regional nodal irradiation in women with either high-risk node-negative or node-positive disease and suggest a significant benefit in regional control and breast cancer recurrence, but not in overall survival. Toxic effects, including lymphedema, were increased in the cohorts receiving comprehensive nodal RT. The benefits from regional RT should be weighed against potential radiation-associated toxic effects. Randomized trials have also demonstrated equal efficacy and toxic effects between hypofractionated and conventionally fractionated RT in appropriately selected patients. In addition, current efforts incorporating clinical, pathologic, and molecular features are under way to identify patients for whom RT to the breast can be safely omitted.</AbstractText>
<AbstractText Label="CONCLUSIONS AND RELEVANCE" NlmCategory="CONCLUSIONS">Adjuvant RT in early-stage breast cancer significantly reduces in-breast tumor recurrence and improves overall survival. Although risk reductions observed in randomized trials have been relatively consistent across series, the absolute benefit of RT is not equal for all women. Efforts are under way to identify which patients benefit the most from local or locoregional RT vs those at very low risk for recurrence in whom RT can be omitted. For patients who will benefit from RT and are appropriate candidates, hypofractionated RT should be strongly considered.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Speers</LastName>
<ForeName>Corey</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Radiation Oncology, University of Michigan, Ann Arbor.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pierce</LastName>
<ForeName>Lori J</ForeName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
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<MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName>
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<MeshHeading><DescriptorName UI="D015412" MajorTopicYN="Y">Mastectomy, Segmental</DescriptorName>
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<MeshHeading><DescriptorName UI="D011832" MajorTopicYN="N">Radiation Injuries</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
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<MeshHeading><DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
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<Month>6</Month>
<Day>1</Day>
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<PubMedPubDate PubStatus="medline"><Year>2017</Year>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Pierce, Lori J" sort="Pierce, Lori J" uniqKey="Pierce L" first="Lori J" last="Pierce">Lori J. Pierce</name>
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Postoperative Radiotherapy After Breast-Conserving Surgery for Early-Stage Breast Cancer: A Review.

Postoperative Radiotherapy After Breast-Conserving Surgery for Early-Stage Breast Cancer: A Review.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki