Serveur d'exploration sur le lymphœdème

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Proposed pathway and mechanism of vascularized lymph node flaps.

Identifieur interne : 000698 ( PubMed/Checkpoint ); précédent : 000697; suivant : 000699

Proposed pathway and mechanism of vascularized lymph node flaps.

Auteurs : Ran Ito [Japon] ; Jonathan Zelken [États-Unis] ; Chin-Yu Yang [République populaire de Chine] ; Chia-Yu Lin [République populaire de Chine] ; Ming-Huei Cheng [République populaire de Chine]

Source :

RBID : pubmed:26773469

Descripteurs français

English descriptors

Abstract

To investigate the pump mechanism and pathway of lymph transit in vascularized lymph node flaps.

DOI: 10.1016/j.ygyno.2016.01.007
PubMed: 26773469


Affiliations:


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Links to Exploration step

pubmed:26773469

Le document en format XML

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<name sortKey="Ito, Ran" sort="Ito, Ran" uniqKey="Ito R" first="Ran" last="Ito">Ran Ito</name>
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<term>Humans</term>
<term>Lymph Nodes (blood supply)</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Rats, Sprague-Dawley</term>
<term>Surgical Flaps</term>
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<term>Lambeaux chirurgicaux</term>
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<term>Noeuds lymphatiques ()</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
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<term>Adolescent</term>
<term>Animals</term>
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<div type="abstract" xml:lang="en">To investigate the pump mechanism and pathway of lymph transit in vascularized lymph node flaps.</div>
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<Month>03</Month>
<Day>26</Day>
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<DateCompleted>
<Year>2016</Year>
<Month>08</Month>
<Day>16</Day>
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<Year>2016</Year>
<Month>03</Month>
<Day>26</Day>
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<Volume>141</Volume>
<Issue>1</Issue>
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<Year>2016</Year>
<Month>Apr</Month>
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<Title>Gynecologic oncology</Title>
<ISOAbbreviation>Gynecol. Oncol.</ISOAbbreviation>
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<ArticleTitle>Proposed pathway and mechanism of vascularized lymph node flaps.</ArticleTitle>
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<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the pump mechanism and pathway of lymph transit in vascularized lymph node flaps.</AbstractText>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Microsurgical treatment of lymphedema with vascularized lymph node transfer can improve signs and symptoms of disease, but the pathways and mechanisms of these flaps warrant further exploration.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">(Animal model) 72 flaps were raised in 18 rats: 36 groin flaps contained lymph nodes (LN), 36 deep inferior epigastric artery perforator flaps did not (non-LN). Indocyanine green (ICG) was added into normal saline (NS), 1%, 3%, 5%, 7% and 10% albumin. Three rats were assigned to each group. LN and non-LN flaps were submerged in solution and surveyed for venous fluorescence. In the 7% albumin and NS groups, volumetric change of solution was measured. (Human model) A similar experiment was performed in humans using five submental LN flaps.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">(Animal model) Fluorescence was detected in the venous pedicle of LN flaps submerged in 5%, 7% and 10% albumin, and half of flaps submerged in 3% albumin. Fluorescence was not detected in LN node flaps submerged in ICG-containing NS or 1% albumin solution. Fluorescence was not detected in non-LN flaps. There was greater volume reduction with LN flaps than non-LN flaps (p<0.001). (Human model) Fluorescence was detected in the venous pedicle of all flaps immersed in lymph.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">ICG fluorescence was detected in the venous pedicle of rat and human LN flaps submerged in lymph or albumin when the concentration was greater than 3%. Based on these results, a pathway for lymphatic uptake is presented.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation>
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