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Regulatory T-cell neutralization in mice during filariasis helps in parasite clearance by enhancing T helper type 17-mediated pro-inflammatory response.

Identifieur interne : 000672 ( PubMed/Checkpoint ); précédent : 000671; suivant : 000673

Regulatory T-cell neutralization in mice during filariasis helps in parasite clearance by enhancing T helper type 17-mediated pro-inflammatory response.

Auteurs : Manisha Pathak [Inde] ; Pankaj Sharma [Inde] ; Aditi Sharma [Inde] ; Meenakshi Verma [Inde] ; Mrigank Srivastava [Inde] ; Shailja Misra-Bhattacharya [Inde]

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RBID : pubmed:26501838

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Abstract

Lymphatic filariasis leads to profound impairment of parasite-specific T helper type 1 (Th1) and Th2 immune responses and significantly increases the expression of regulatory networks and regulatory effectors like transforming growth factor-β, CD25, cytotoxic T-lymphocyte antigen 4, glucocorticoid-induced tumour necrosis factor receptor (GITR) and regulatory T (Treg) cells, which together play an important role in immunosuppression. While Treg cells suppress the activity of effector cells, monocyte dysfunction, characterized by an alternatively activated immunoregulatory phenotype, is one hypothesis that explains the lack of an antigen-specific T-cell response in infected individuals. In the present study, we administered neutralizing antibodies against the Treg cell-associated markers CD25 and GITR and observed its effects on filaria-induced immunosuppression. Our results show that administration of anti-CD25 and anti-GITR in infected animals not only arrested the accumulation of Treg cells and reduced arginase activity, but also led to an increase in the percentages of Th17 cells in the secondary lymphoid organs of mice. Elevated levels of interferon-γ and decreased levels of interleukin-10 were also noted in the culture supernatants of mouse splenocytes that were treated with neutralizing antibodies. Furthermore, treatment with neutralizing antibodies enhanced the expression of inducible nitric oxide synthase on host macrophages and CD40 on host dendritic cells with concomitant decreased expression of alternative activation markers Arg1, Ym1 and Fizz1, which together lead to reduced parasite burden in treated animals. In summary, administration of neutralizing antibodies helps in breaking the regulatory network in mice and limits parasite-induced immunosuppression at the earliest host-parasite interface.

DOI: 10.1111/imm.12550
PubMed: 26501838


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<term>Antibodies, Neutralizing (pharmacology)</term>
<term>Antigens, CD40 (immunology)</term>
<term>Antigens, CD40 (metabolism)</term>
<term>Bacterial Outer Membrane Proteins (immunology)</term>
<term>Cells, Cultured</term>
<term>Dendritic Cells (drug effects)</term>
<term>Dendritic Cells (immunology)</term>
<term>Dendritic Cells (parasitology)</term>
<term>Disease Models, Animal</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (metabolism)</term>
<term>Elephantiasis, Filarial (parasitology)</term>
<term>Eosinophils (drug effects)</term>
<term>Eosinophils (immunology)</term>
<term>Eosinophils (parasitology)</term>
<term>Glucocorticoid-Induced TNFR-Related Protein (antagonists & inhibitors)</term>
<term>Glucocorticoid-Induced TNFR-Related Protein (immunology)</term>
<term>Glucocorticoid-Induced TNFR-Related Protein (metabolism)</term>
<term>Host-Parasite Interactions</term>
<term>Immunization</term>
<term>Inflammation Mediators (immunology)</term>
<term>Inflammation Mediators (metabolism)</term>
<term>Interferon-gamma (immunology)</term>
<term>Interferon-gamma (metabolism)</term>
<term>Interleukin-10 (immunology)</term>
<term>Interleukin-10 (metabolism)</term>
<term>Interleukin-2 Receptor alpha Subunit (antagonists & inhibitors)</term>
<term>Interleukin-2 Receptor alpha Subunit (immunology)</term>
<term>Interleukin-2 Receptor alpha Subunit (metabolism)</term>
<term>Macrophage Activation (drug effects)</term>
<term>Mice, Inbred BALB C</term>
<term>T-Lymphocytes, Regulatory (drug effects)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>T-Lymphocytes, Regulatory (metabolism)</term>
<term>T-Lymphocytes, Regulatory (parasitology)</term>
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<term>Cellules Th17 (immunologie)</term>
<term>Cellules Th17 (métabolisme)</term>
<term>Cellules Th17 (parasitologie)</term>
<term>Cellules cultivées</term>
<term>Cellules dendritiques ()</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Cellules dendritiques (parasitologie)</term>
<term>Facteurs temps</term>
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<term>Filariose lymphatique (métabolisme)</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
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<term>Souris de lignée BALB C</term>
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<term>Sous-unité alpha du récepteur à l'interleukine-2 (immunologie)</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2 (métabolisme)</term>
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<term>Glucocorticoid-Induced TNFR-Related Protein</term>
<term>Interleukin-2 Receptor alpha Subunit</term>
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<term>Antigens, CD40</term>
<term>Bacterial Outer Membrane Proteins</term>
<term>Glucocorticoid-Induced TNFR-Related Protein</term>
<term>Inflammation Mediators</term>
<term>Interferon-gamma</term>
<term>Interleukin-10</term>
<term>Interleukin-2 Receptor alpha Subunit</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Antigens, CD40</term>
<term>Glucocorticoid-Induced TNFR-Related Protein</term>
<term>Inflammation Mediators</term>
<term>Interferon-gamma</term>
<term>Interleukin-10</term>
<term>Interleukin-2 Receptor alpha Subunit</term>
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<term>Antibodies, Neutralizing</term>
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<term>Protéine associée au récepteur du TNF induit par les corticoïdes</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2</term>
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<term>Dendritic Cells</term>
<term>Eosinophils</term>
<term>Macrophage Activation</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Antigènes CD40</term>
<term>Cellules Th17</term>
<term>Cellules dendritiques</term>
<term>Filariose lymphatique</term>
<term>Granulocytes éosinophiles</term>
<term>Interféron gamma</term>
<term>Interleukine-10</term>
<term>Lymphocytes T régulateurs</term>
<term>Médiateurs de l'inflammation</term>
<term>Protéine associée au récepteur du TNF induit par les corticoïdes</term>
<term>Protéines de la membrane externe bactérienne</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Dendritic Cells</term>
<term>Elephantiasis, Filarial</term>
<term>Eosinophils</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en">
<term>Elephantiasis, Filarial</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>Antigènes CD40</term>
<term>Cellules Th17</term>
<term>Filariose lymphatique</term>
<term>Interféron gamma</term>
<term>Interleukine-10</term>
<term>Lymphocytes T régulateurs</term>
<term>Médiateurs de l'inflammation</term>
<term>Protéine associée au récepteur du TNF induit par les corticoïdes</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2</term>
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<term>Cellules Th17</term>
<term>Cellules dendritiques</term>
<term>Filariose lymphatique</term>
<term>Granulocytes éosinophiles</term>
<term>Lymphocytes T régulateurs</term>
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<keywords scheme="MESH" qualifier="parasitology" xml:lang="en">
<term>Dendritic Cells</term>
<term>Elephantiasis, Filarial</term>
<term>Eosinophils</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr">
<term>Anticorps neutralisants</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr">
<term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Cells, Cultured</term>
<term>Disease Models, Animal</term>
<term>Host-Parasite Interactions</term>
<term>Immunization</term>
<term>Mice, Inbred BALB C</term>
<term>Time Factors</term>
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<term>Activation des macrophages</term>
<term>Animaux</term>
<term>Cellules Th17</term>
<term>Cellules cultivées</term>
<term>Cellules dendritiques</term>
<term>Facteurs temps</term>
<term>Granulocytes éosinophiles</term>
<term>Immunisation</term>
<term>Interactions hôte-parasite</term>
<term>Lymphocytes T régulateurs</term>
<term>Modèles animaux de maladie humaine</term>
<term>Souris de lignée BALB C</term>
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<front>
<div type="abstract" xml:lang="en">Lymphatic filariasis leads to profound impairment of parasite-specific T helper type 1 (Th1) and Th2 immune responses and significantly increases the expression of regulatory networks and regulatory effectors like transforming growth factor-β, CD25, cytotoxic T-lymphocyte antigen 4, glucocorticoid-induced tumour necrosis factor receptor (GITR) and regulatory T (Treg) cells, which together play an important role in immunosuppression. While Treg cells suppress the activity of effector cells, monocyte dysfunction, characterized by an alternatively activated immunoregulatory phenotype, is one hypothesis that explains the lack of an antigen-specific T-cell response in infected individuals. In the present study, we administered neutralizing antibodies against the Treg cell-associated markers CD25 and GITR and observed its effects on filaria-induced immunosuppression. Our results show that administration of anti-CD25 and anti-GITR in infected animals not only arrested the accumulation of Treg cells and reduced arginase activity, but also led to an increase in the percentages of Th17 cells in the secondary lymphoid organs of mice. Elevated levels of interferon-γ and decreased levels of interleukin-10 were also noted in the culture supernatants of mouse splenocytes that were treated with neutralizing antibodies. Furthermore, treatment with neutralizing antibodies enhanced the expression of inducible nitric oxide synthase on host macrophages and CD40 on host dendritic cells with concomitant decreased expression of alternative activation markers Arg1, Ym1 and Fizz1, which together lead to reduced parasite burden in treated animals. In summary, administration of neutralizing antibodies helps in breaking the regulatory network in mice and limits parasite-induced immunosuppression at the earliest host-parasite interface.</div>
</front>
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<DateCreated>
<Year>2016</Year>
<Month>01</Month>
<Day>19</Day>
</DateCreated>
<DateCompleted>
<Year>2016</Year>
<Month>05</Month>
<Day>31</Day>
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<Year>2017</Year>
<Month>02</Month>
<Day>01</Day>
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<ISSN IssnType="Electronic">1365-2567</ISSN>
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<Volume>147</Volume>
<Issue>2</Issue>
<PubDate>
<Year>2016</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Immunology</Title>
<ISOAbbreviation>Immunology</ISOAbbreviation>
</Journal>
<ArticleTitle>Regulatory T-cell neutralization in mice during filariasis helps in parasite clearance by enhancing T helper type 17-mediated pro-inflammatory response.</ArticleTitle>
<Pagination>
<MedlinePgn>190-203</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/imm.12550</ELocationID>
<Abstract>
<AbstractText>Lymphatic filariasis leads to profound impairment of parasite-specific T helper type 1 (Th1) and Th2 immune responses and significantly increases the expression of regulatory networks and regulatory effectors like transforming growth factor-β, CD25, cytotoxic T-lymphocyte antigen 4, glucocorticoid-induced tumour necrosis factor receptor (GITR) and regulatory T (Treg) cells, which together play an important role in immunosuppression. While Treg cells suppress the activity of effector cells, monocyte dysfunction, characterized by an alternatively activated immunoregulatory phenotype, is one hypothesis that explains the lack of an antigen-specific T-cell response in infected individuals. In the present study, we administered neutralizing antibodies against the Treg cell-associated markers CD25 and GITR and observed its effects on filaria-induced immunosuppression. Our results show that administration of anti-CD25 and anti-GITR in infected animals not only arrested the accumulation of Treg cells and reduced arginase activity, but also led to an increase in the percentages of Th17 cells in the secondary lymphoid organs of mice. Elevated levels of interferon-γ and decreased levels of interleukin-10 were also noted in the culture supernatants of mouse splenocytes that were treated with neutralizing antibodies. Furthermore, treatment with neutralizing antibodies enhanced the expression of inducible nitric oxide synthase on host macrophages and CD40 on host dendritic cells with concomitant decreased expression of alternative activation markers Arg1, Ym1 and Fizz1, which together lead to reduced parasite burden in treated animals. In summary, administration of neutralizing antibodies helps in breaking the regulatory network in mice and limits parasite-induced immunosuppression at the earliest host-parasite interface.</AbstractText>
<CopyrightInformation>© 2015 John Wiley & Sons Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Pathak</LastName>
<ForeName>Manisha</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Parasitology Division, CSIR-Central Drug Research Institute, Lucknow, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Sharma</LastName>
<ForeName>Pankaj</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Parasitology Division, CSIR-Central Drug Research Institute, Lucknow, India.</Affiliation>
</AffiliationInfo>
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<LastName>Sharma</LastName>
<ForeName>Aditi</ForeName>
<Initials>A</Initials>
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<CommentsCorrectionsList>
<CommentsCorrections RefType="Cites">
<RefSource>Nat Immunol. 2002 Feb;3(2):135-42</RefSource>
<PMID Version="1">11812990</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Immunol. 2001 Nov 1;167(9):5348-54</RefSource>
<PMID Version="1">11673551</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Arch Med Res. 2002 Jul-Aug;33(4):422-4</RefSource>
<PMID Version="1">12234534</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Immunity. 2003 Jul;19(1):71-82</RefSource>
<PMID Version="1">12871640</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Nat Rev Immunol. 2003 Sep;3(9):733-44</RefSource>
<PMID Version="1">12949497</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Eur J Immunol. 2004 Mar;34(3):613-22</RefSource>
<PMID Version="1">14991590</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Immunol. 2004 Jul 1;173(1):437-45</RefSource>
<PMID Version="1">15210803</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Exp Med. 2004 Jul 19;200(2):149-57</RefSource>
<PMID Version="1">15249593</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Exp Med. 2004 Jul 19;200(2):201-10</RefSource>
<PMID Version="1">15263027</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Immunol Rev. 2004 Oct;201:89-116</RefSource>
<PMID Version="1">15361235</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Immunol. 2004 Oct 15;173(8):5008-20</RefSource>
<PMID Version="1">15470044</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Eur J Immunol. 1981 Oct;11(10):805-15</RefSource>
<PMID Version="1">7308288</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Neuroscience. 1990;39(1):151-70</RefSource>
<PMID Version="1">2089275</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Annu Rev Immunol. 2005;23:23-68</RefSource>
<PMID Version="1">15771565</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Immunol. 2005 Apr 15;174(8):4924-33</RefSource>
<PMID Version="1">15814720</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Parasite Immunol. 2005 Oct-Nov;27(10-11):417-29</RefSource>
<PMID Version="1">16179035</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Nat Immunol. 2006 Mar;7(3):311-7</RefSource>
<PMID Version="1">16462739</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Immunol. 2006 Mar 1;176(5):3248-56</RefSource>
<PMID Version="1">16493086</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Immunol. 2006 Jun 1;176(11):6434-42</RefSource>
<PMID Version="1">16709800</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Immunol. 2006 Jun 1;176(11):6918-27</RefSource>
<PMID Version="1">16709852</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Infect Immun. 2006 Aug;74(8):4409-17</RefSource>
<PMID Version="1">16861626</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Parasite Immunol. 2007 Feb;29(2):73-9</RefSource>
<PMID Version="1">17241395</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Int J Parasitol. 2007 Apr;37(5):457-64</RefSource>
<PMID Version="1">17313951</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Eur J Immunol. 2007 May;37(5):1165-9</RefSource>
<PMID Version="1">17407102</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Trends Immunol. 2007 Jun;28(6):267-73</RefSource>
<PMID Version="1">17481953</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Nat Rev Immunol. 2007 Jul;7(7):532-42</RefSource>
<PMID Version="1">17589543</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Exp Parasitol. 2008 Feb;118(2):285-9</RefSource>
<PMID Version="1">17919582</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Mol Pharmacol. 2008 Jun;73(6):1610-21</RefSource>
<PMID Version="1">18322000</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>PLoS Negl Trop Dis. 2009;3(4):e420</RefSource>
<PMID Version="1">19381284</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Annu Rev Immunol. 2009;27:669-92</RefSource>
<PMID Version="1">19132917</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Infect Dis. 2009 Jun 15;199(12):1827-37</RefSource>
<PMID Version="1">19456233</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Immunol. 2010 Mar 1;184(5):2583-92</RefSource>
<PMID Version="1">20139272</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Adv Exp Med Biol. 2013;785:49-56</RefSource>
<PMID Version="1">23456837</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Immunology. 2015 Feb;144(2):231-44</RefSource>
<PMID Version="1">25059495</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>J Immunol. 2000 Jun 15;164(12):6453-60</RefSource>
<PMID Version="1">10843701</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Infect Immun. 2001 Sep;69(9):5813-22</RefSource>
<PMID Version="1">11500459</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites">
<RefSource>Methods. 2001 Dec;25(4):402-8</RefSource>
<PMID Version="1">11846609</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
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