LymphedemaV1, PubMed, Checkpoint, bibRecord, 000583

Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.

Identifieur interne : 000583 ( PubMed/Checkpoint ); précédent : 000582; suivant : 000584

Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.

Auteurs : Jinlong Li [République populaire de Chine] ; Yan Chen [République populaire de Chine] ; Li Zhang [République populaire de Chine] ; Lianping Xing [États-Unis] ; Hao Xu [République populaire de Chine] ; Yongjun Wang [République populaire de Chine] ; Qi Shi [République populaire de Chine] ; Qianqian Liang [République populaire de Chine]

Source :

Journal of ethnopharmacology [ 1872-7573 ] ; 2016.

RBID : pubmed:27553977

Descripteurs français

KwdFr :
- Animal génétiquement modifié, Animaux, Cellules endothéliales (enzymologie), Cellules endothéliales (métabolisme), Danio zébré (embryologie), Facteur de croissance endothéliale vasculaire de type C (métabolisme), Lignée cellulaire, Lymphangiogenèse (), Panax notoginseng (), Phosphatidylinositol 3-kinases (métabolisme), Saponines (pharmacologie), Souris, Système de signalisation des MAP kinases, Transduction du signal, p38 Mitogen-Activated Protein Kinases (métabolisme).
MESH :
- embryologie : Danio zébré.
- enzymologie : Cellules endothéliales.
- métabolisme : Cellules endothéliales, Facteur de croissance endothéliale vasculaire de type C, Phosphatidylinositol 3-kinases, p38 Mitogen-Activated Protein Kinases.
- pharmacologie : Saponines.
- Animal génétiquement modifié, Animaux, Lignée cellulaire, Lymphangiogenèse, Panax notoginseng, Souris, Système de signalisation des MAP kinases, Transduction du signal.

English descriptors

KwdEn :
- Animals, Animals, Genetically Modified, Cell Line, Endothelial Cells (enzymology), Endothelial Cells (metabolism), Lymphangiogenesis (drug effects), MAP Kinase Signaling System, Mice, Panax notoginseng (chemistry), Phosphatidylinositol 3-Kinases (metabolism), Saponins (pharmacology), Signal Transduction, Vascular Endothelial Growth Factor C (metabolism), Zebrafish (embryology), p38 Mitogen-Activated Protein Kinases (metabolism).
MESH :
- chemical , metabolism : Phosphatidylinositol 3-Kinases, Vascular Endothelial Growth Factor C, p38 Mitogen-Activated Protein Kinases.
- chemistry : Panax notoginseng.
- drug effects : Lymphangiogenesis.
- embryology : Zebrafish.
- enzymology : Endothelial Cells.
- metabolism : Endothelial Cells.
- chemical , pharmacology : Saponins.
- Animals, Animals, Genetically Modified, Cell Line, MAP Kinase Signaling System, Mice, Signal Transduction.

Abstract

Lymphatic system plays an important role in maintaining the fluid homeostasis and normal immune responses, anatomic or functional obstruction of which leads to lymphedema, and treatments for therapeutic lymphangiogenesis are efficiency for secondary lymphedema. Total saponins of panaxnotoginseng (PNS) are a mixture isolated from Panaxnotoginseng (Burkill) F.H.Chen, which has been used as traditional Chinese medicine in China for treatment of cardio- and cerebro-vascular diseases. The aim of this study was to determine the effect and mechanism of PNS on lymphangiogenesis.

DOI: 10.1016/j.jep.2016.08.032
PubMed: 27553977

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream PubMed, to step Curation: 000658

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pubmed:27553977

Le document en format XML

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<term>Endothelial Cells (metabolism)</term>
<term>Lymphangiogenesis (drug effects)</term>
<term>MAP Kinase Signaling System</term>
<term>Mice</term>
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<term>Danio zébré (embryologie)</term>
<term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term>
<term>Lignée cellulaire</term>
<term>Lymphangiogenèse ()</term>
<term>Panax notoginseng ()</term>
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<term>Système de signalisation des MAP kinases</term>
<term>Transduction du signal</term>
<term>p38 Mitogen-Activated Protein Kinases (métabolisme)</term>
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<term>p38 Mitogen-Activated Protein Kinases</term>
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<term>Phosphatidylinositol 3-kinases</term>
<term>p38 Mitogen-Activated Protein Kinases</term>
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<term>Animals, Genetically Modified</term>
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<term>MAP Kinase Signaling System</term>
<term>Mice</term>
<term>Signal Transduction</term>
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<term>Animaux</term>
<term>Lignée cellulaire</term>
<term>Lymphangiogenèse</term>
<term>Panax notoginseng</term>
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<front><div type="abstract" xml:lang="en">Lymphatic system plays an important role in maintaining the fluid homeostasis and normal immune responses, anatomic or functional obstruction of which leads to lymphedema, and treatments for therapeutic lymphangiogenesis are efficiency for secondary lymphedema. Total saponins of panaxnotoginseng (PNS) are a mixture isolated from Panaxnotoginseng (Burkill) F.H.Chen, which has been used as traditional Chinese medicine in China for treatment of cardio- and cerebro-vascular diseases. The aim of this study was to determine the effect and mechanism of PNS on lymphangiogenesis.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27553977</PMID>
<DateCreated><Year>2016</Year>
<Month>08</Month>
<Day>24</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>05</Month>
<Day>31</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>05</Month>
<Day>31</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7573</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>193</Volume>
<PubDate><Year>2016</Year>
<Month>Dec</Month>
<Day>04</Day>
</PubDate>
</JournalIssue>
<Title>Journal of ethnopharmacology</Title>
<ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation>
</Journal>
<ArticleTitle>Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.</ArticleTitle>
<Pagination><MedlinePgn>293-302</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0378-8741(16)30552-9</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2016.08.032</ELocationID>
<Abstract><AbstractText Label="ETHNOPHARMACOLOGICAL RELEVANCE" NlmCategory="BACKGROUND">Lymphatic system plays an important role in maintaining the fluid homeostasis and normal immune responses, anatomic or functional obstruction of which leads to lymphedema, and treatments for therapeutic lymphangiogenesis are efficiency for secondary lymphedema. Total saponins of panaxnotoginseng (PNS) are a mixture isolated from Panaxnotoginseng (Burkill) F.H.Chen, which has been used as traditional Chinese medicine in China for treatment of cardio- and cerebro-vascular diseases. The aim of this study was to determine the effect and mechanism of PNS on lymphangiogenesis.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The Tg (fli1: egfp; gata1: dsred) transgenic zebrafish embryos were treated with different concentrations of PNS (10, 50, 100μM) for 48h with or without the 6h pretreatment of the 30μM Vascular endothelial growth factors receptor (VEGFR)-3 kinase inhibitor, followed with morphological observation and lympangiogenesis of thoracic duct assessment. The effect of PNS on cell viability, migration, tube formation and Vascular endothelial growth factors (VEGF)-C mRNA and protein expression of lymphatic endothelial cells (LECs) were determined. The role of phosphatidylinositol-3 (PI-3)-kinase (PI3K), extracellular signal-regulated kinase (ERK)1/2 pathways, c-Jun N-terminal kinase (JNK) and P38 mitogen activated protein kinases (MAPK) signaling in PNS-induced VEGF-C expression of LECs by using pharmacological agents to block each signal.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">PNS promotes lymphangiogenesis of thoracic duct in zebrafish with or without VEGFR3 Kinase inhibitor pre-impairment. PNS promotes proliferation, migration and tube formation of LECs. The tube formation induced by PNS could be blocked by VEGFR3 Kinase inhibitor. PNS induce VEGF-C expression of LEC, which could be blocked by ERK1/2, PI3K and P38MAPK signaling inhibitors.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">PNS activates lymphangiogenesis both in vivo and in vitro by up-regulating VEGF-C expression and activation of ERK1/2, PI3K and P38MAPK signaling. These findings provide a novel insight into the role of PNS in lymphangiogenesis and suggest that it might be an attractive and suitable therapeutic agent for treating secondary lymphedema or other lymphatic system impairment related disease.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Jinlong</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address: phjod@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address: 952026015@qq.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address: 15221152917@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xing</LastName>
<ForeName>Lianping</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA; Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA. Electronic address: Lianping_xing@urmc.rochester.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Hao</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address: hoxu@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yongjun</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address: yjwang8888@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Qi</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address: jzyjs200032@126.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liang</LastName>
<ForeName>Qianqian</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address: liangqianqiantcm@126.com.</Affiliation>
</AffiliationInfo>
</Author>
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<Keyword MajorTopicYN="Y">Ammonium Persulfate (PubChemCID:62648)</Keyword>
<Keyword MajorTopicYN="Y">Chloroform (PubChemCID:6212)</Keyword>
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   |area=    LymphedemaV1
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   |texte=   Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.
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Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.

Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.

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