What Is a False Negative Sentinel Node Biopsy: Definition, Reasons and Ways to Minimize It?
Identifieur interne : 000552 ( PubMed/Checkpoint ); précédent : 000551; suivant : 000553What Is a False Negative Sentinel Node Biopsy: Definition, Reasons and Ways to Minimize It?
Auteurs : Kamal Kataria [Inde] ; Anurag Srivastava [Inde] ; Darakhshan Qaiser [Inde]Source :
- The Indian journal of surgery [ 0972-2068 ] ; 2016.
Abstract
Sentinel node biopsy helps in assessing the involvement of axillary lymph node without the morbidity of full axillary lymph node dissection, namely arm and shoulder pain, paraesthesia and lymphoedema. The various methods described in the literature identify the sentinel lymph nodes in approximately 96 % of cases and associated with a false negativity rate of 5 to 10 %. A false negative sentinel node is defined as the proportion of cases in whom sentinel node biopsy is reported as negative, but the rest of axillary lymph node(s) harbours cancer cells. The possible causes of a false negative sentinel lymph node may be because of blocked lymphatics either by cancer cells or following fibrosis of previous surgery/radiotherapy, and an alternative pathway opens draining the blue dye or isotope to another uninvolved node. The other reasons may be two lymphatic pathways for a tumour area, the one opening to a superficial node and the other in deep nodes. Sometimes, lymphatics do not relay into a node but traverse it going to a higher node. In some patients, the microscopic focus of metastasis inside a lymph node is so small-micrometastasis (i.e. between 0.2 and 2 mm) or isolated tumour cells (i.e. less than 0.2 mm) that is missed by the pathologist. The purpose of this review is to clear some fears lurking in the mind of most surgeons about the false negative sentinel lymph node (FNSLN).
DOI: 10.1007/s12262-016-1531-9
PubMed: 27994336
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The various methods described in the literature identify the sentinel lymph nodes in approximately 96 % of cases and associated with a false negativity rate of 5 to 10 %. A false negative sentinel node is defined as the proportion of cases in whom sentinel node biopsy is reported as negative, but the rest of axillary lymph node(s) harbours cancer cells. The possible causes of a false negative sentinel lymph node may be because of blocked lymphatics either by cancer cells or following fibrosis of previous surgery/radiotherapy, and an alternative pathway opens draining the blue dye or isotope to another uninvolved node. The other reasons may be two lymphatic pathways for a tumour area, the one opening to a superficial node and the other in deep nodes. Sometimes, lymphatics do not relay into a node but traverse it going to a higher node. In some patients, the microscopic focus of metastasis inside a lymph node is so small-micrometastasis (i.e. between 0.2 and 2 mm) or isolated tumour cells (i.e. less than 0.2 mm) that is missed by the pathologist. The purpose of this review is to clear some fears lurking in the mind of most surgeons about the false negative sentinel lymph node (FNSLN).</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27994336</PMID><DateCreated><Year>2016</Year><Month>12</Month><Day>20</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0972-2068</ISSN><JournalIssue CitedMedium="Print"><Volume>78</Volume><Issue>5</Issue><PubDate><Year>2016</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The Indian journal of surgery</Title><ISOAbbreviation>Indian J Surg</ISOAbbreviation></Journal><ArticleTitle>What Is a False Negative Sentinel Node Biopsy: Definition, Reasons and Ways to Minimize It?</ArticleTitle><Pagination><MedlinePgn>396-401</MedlinePgn></Pagination><Abstract><AbstractText>Sentinel node biopsy helps in assessing the involvement of axillary lymph node without the morbidity of full axillary lymph node dissection, namely arm and shoulder pain, paraesthesia and lymphoedema. The various methods described in the literature identify the sentinel lymph nodes in approximately 96 % of cases and associated with a false negativity rate of 5 to 10 %. A false negative sentinel node is defined as the proportion of cases in whom sentinel node biopsy is reported as negative, but the rest of axillary lymph node(s) harbours cancer cells. The possible causes of a false negative sentinel lymph node may be because of blocked lymphatics either by cancer cells or following fibrosis of previous surgery/radiotherapy, and an alternative pathway opens draining the blue dye or isotope to another uninvolved node. The other reasons may be two lymphatic pathways for a tumour area, the one opening to a superficial node and the other in deep nodes. Sometimes, lymphatics do not relay into a node but traverse it going to a higher node. In some patients, the microscopic focus of metastasis inside a lymph node is so small-micrometastasis (i.e. between 0.2 and 2 mm) or isolated tumour cells (i.e. less than 0.2 mm) that is missed by the pathologist. The purpose of this review is to clear some fears lurking in the mind of most surgeons about the false negative sentinel lymph node (FNSLN).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kataria</LastName><ForeName>Kamal</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Surgical Disciplines, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Srivastava</LastName><ForeName>Anurag</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Surgical Disciplines, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qaiser</LastName><ForeName>Darakhshan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Surgical Disciplines, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>India</Country><MedlineTA>Indian J Surg</MedlineTA><NlmUniqueID>0373026</NlmUniqueID><ISSNLinking>0973-9793</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Ann Surg. 2016 Apr;263(4):802-7</RefSource><PMID Version="1">26649589</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Surg Oncol Clin N Am. 2007 Jan;16(1):55-70</RefSource><PMID Version="1">17336236</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Coll Surg. 2008 Oct;207(4):543-8</RefSource><PMID Version="1">18926457</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Oncol. 2013 Apr;14(4):297-305</RefSource><PMID Version="1">23491275</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 1997 Jun 28;349(9069):1864-7</RefSource><PMID Version="1">9217757</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Surg. 2002 Oct;184(4):341-5</RefSource><PMID Version="1">12383897</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 1996 Dec 11;276(22):1818-22</RefSource><PMID Version="1">8946902</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Pathol. 2002 Dec;55(12):926-31</RefSource><PMID Version="1">12461060</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Breast. 2009 Oct;18(5):322-6</RefSource><PMID Version="1">19819141</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Surg Oncol. 2003 Apr;10(3):242-7</RefSource><PMID Version="1">12679308</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Surg. 2010 Apr;251(4):595-600</RefSource><PMID Version="1">20195151</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Breast Cancer Res Treat. 2005 Jan;89(2):159-63</RefSource><PMID Version="1">15692758</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Surg Oncol. 2010 Jul;17(7):1854-61</RefSource><PMID Version="1">20300966</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Surg. 2010 Nov;97(11):1659-65</RefSource><PMID Version="1">20799288</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Oncol. 2010 Oct;11(10):927-33</RefSource><PMID Version="1">20863759</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2011 Jul 27;306(4):385-93</RefSource><PMID Version="1">21791687</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Oncol. 2014 Nov;15(12):1303-10</RefSource><PMID Version="1">25439688</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Surg Oncol. 1993 Dec;2(6):335-9; discussion 340</RefSource><PMID Version="1">8130940</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2014 May 1;32(13):1365-83</RefSource><PMID Version="1">24663048</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Surg Oncol. 2007 Feb 1;95(2):175-9</RefSource><PMID Version="1">17262724</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Oncol. 2013 Jun;14(7):609-18</RefSource><PMID Version="1">23683750</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Surg. 2010 Sep;252(3):426-32; discussion 432-3</RefSource><PMID Version="1">20739842</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Surg. 1994 Sep;220(3):391-8; discussion 398-401</RefSource><PMID Version="1">8092905</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Clinically overt</Keyword><Keyword MajorTopicYN="N">False negative</Keyword><Keyword MajorTopicYN="N">Micrometastasis</Keyword><Keyword MajorTopicYN="N">Sentinel lymph node biopsy</Keyword><Keyword MajorTopicYN="N">Tumour emboli</Keyword></KeywordList><CoiStatement>Compliance with Ethical Standards Funding None. Presentation or Prior Publication None. Conflict of Interest The authors declare that they have no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>01</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>07</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2017</Year><Month>10</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>12</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>12</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>21</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27994336</ArticleId><ArticleId IdType="doi">10.1007/s12262-016-1531-9</ArticleId><ArticleId IdType="pii">1531</ArticleId><ArticleId IdType="pmc">PMC5127992</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Kataria, Kamal" sort="Kataria, Kamal" uniqKey="Kataria K" first="Kamal" last="Kataria">Kamal Kataria</name></noRegion><name sortKey="Qaiser, Darakhshan" sort="Qaiser, Darakhshan" uniqKey="Qaiser D" first="Darakhshan" last="Qaiser">Darakhshan Qaiser</name><name sortKey="Srivastava, Anurag" sort="Srivastava, Anurag" uniqKey="Srivastava A" first="Anurag" last="Srivastava">Anurag Srivastava</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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