Acute Truncal Lymphedema Secondary to Axillary Metastatic Melanoma Presenting Like Cellulitis.
Identifieur interne : 000489 ( PubMed/Checkpoint ); précédent : 000488; suivant : 000490Acute Truncal Lymphedema Secondary to Axillary Metastatic Melanoma Presenting Like Cellulitis.
Auteurs : Shelley J E. Hwang [Australie] ; Benjamin Y. Kong [Australie] ; Shaun Chou [Australie] ; Deepal Wakade [Australie] ; Matteo S. Carlino [Australie] ; Pablo Fernandez-Penas [Australie]Source :
- Case reports in medicine [ 1687-9627 ] ; 2017.
Abstract
There are reported cases of diphencyprone used in treating cutaneous metastases of melanoma. Here, we report a patient with previous primary melanoma on his left back treated with surgical excision and lymphadenectomy, followed by radiotherapy for the recurrent tumor on the primary site. Despite radiotherapy and treatment with dabrafenib and trametinib, in-transit metastases have developed and topical diphencyprone was applied to these metastases. Six weeks later, the patient developed fever and a spreading erythematous tender indurated plaque covering the left side of the body including axillae, back, and flank, clinically suggestive of cellulitis. Systemic antibiotic therapy did not improve the condition and a biopsy showed sparse lymphocytic infiltrate. With the diagnosis of possible acute lymphedema, a CT scan was requested that showed significant axillary lymph node metastasis. The fever was considered secondary to dabrafenib and trametinib therapy. This case highlights that, in patients with lymphadenectomy, atypical forms of lymphedema on the body may appear. Truncal lymphedema is an infrequent event.
DOI: 10.1155/2017/5462929
PubMed: 28182109
Affiliations:
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Hwang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Kong, Benjamin Y" sort="Kong, Benjamin Y" uniqKey="Kong B" first="Benjamin Y" last="Kong">Benjamin Y. Kong</name><affiliation wicri:level="1"><nlm:affiliation>Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Chou, Shaun" sort="Chou, Shaun" uniqKey="Chou S" first="Shaun" last="Chou">Shaun Chou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Tissue Pathology, Westmead Hospital, Westmead, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Tissue Pathology, Westmead Hospital, Westmead, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Wakade, Deepal" sort="Wakade, Deepal" uniqKey="Wakade D" first="Deepal" last="Wakade">Deepal Wakade</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Carlino, Matteo S" sort="Carlino, Matteo S" uniqKey="Carlino M" first="Matteo S" last="Carlino">Matteo S. Carlino</name><affiliation wicri:level="1"><nlm:affiliation>Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW, Australia; Melanoma Institute Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW, Australia; Melanoma Institute Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Penas, Pablo" sort="Fernandez Penas, Pablo" uniqKey="Fernandez Penas P" first="Pablo" last="Fernandez-Penas">Pablo Fernandez-Penas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author></analytic><series><title level="j">Case reports in medicine</title><idno type="ISSN">1687-9627</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are reported cases of diphencyprone used in treating cutaneous metastases of melanoma. Here, we report a patient with previous primary melanoma on his left back treated with surgical excision and lymphadenectomy, followed by radiotherapy for the recurrent tumor on the primary site. Despite radiotherapy and treatment with dabrafenib and trametinib, in-transit metastases have developed and topical diphencyprone was applied to these metastases. Six weeks later, the patient developed fever and a spreading erythematous tender indurated plaque covering the left side of the body including axillae, back, and flank, clinically suggestive of cellulitis. Systemic antibiotic therapy did not improve the condition and a biopsy showed sparse lymphocytic infiltrate. With the diagnosis of possible acute lymphedema, a CT scan was requested that showed significant axillary lymph node metastasis. The fever was considered secondary to dabrafenib and trametinib therapy. This case highlights that, in patients with lymphadenectomy, atypical forms of lymphedema on the body may appear. Truncal lymphedema is an infrequent event.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">28182109</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>09</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1687-9627</ISSN><JournalIssue CitedMedium="Print"><Volume>2017</Volume><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Case reports in medicine</Title><ISOAbbreviation>Case Rep Med</ISOAbbreviation></Journal><ArticleTitle>Acute Truncal Lymphedema Secondary to Axillary Metastatic Melanoma Presenting Like Cellulitis.</ArticleTitle><Pagination><MedlinePgn>5462929</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2017/5462929</ELocationID><Abstract><AbstractText>There are reported cases of diphencyprone used in treating cutaneous metastases of melanoma. Here, we report a patient with previous primary melanoma on his left back treated with surgical excision and lymphadenectomy, followed by radiotherapy for the recurrent tumor on the primary site. Despite radiotherapy and treatment with dabrafenib and trametinib, in-transit metastases have developed and topical diphencyprone was applied to these metastases. Six weeks later, the patient developed fever and a spreading erythematous tender indurated plaque covering the left side of the body including axillae, back, and flank, clinically suggestive of cellulitis. Systemic antibiotic therapy did not improve the condition and a biopsy showed sparse lymphocytic infiltrate. With the diagnosis of possible acute lymphedema, a CT scan was requested that showed significant axillary lymph node metastasis. The fever was considered secondary to dabrafenib and trametinib therapy. This case highlights that, in patients with lymphadenectomy, atypical forms of lymphedema on the body may appear. Truncal lymphedema is an infrequent event.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>Shelley J E</ForeName><Initials>SJ</Initials><Identifier Source="ORCID">0000-0003-4387-486X</Identifier><AffiliationInfo><Affiliation>Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kong</LastName><ForeName>Benjamin Y</ForeName><Initials>BY</Initials><AffiliationInfo><Affiliation>Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chou</LastName><ForeName>Shaun</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Tissue Pathology, Westmead Hospital, Westmead, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wakade</LastName><ForeName>Deepal</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carlino</LastName><ForeName>Matteo S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW, Australia; Melanoma Institute Australia, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez-Penas</LastName><ForeName>Pablo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Case Rep Med</MedlineTA><NlmUniqueID>101512910</NlmUniqueID></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Ann Surg. 2004 Nov;240(5):866-74</RefSource><PMID Version="1">15492570</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphat Res Biol. 2010 Dec;8(4):209-15</RefSource><PMID Version="1">21190493</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Australas J Dermatol. 2009 Nov;50(4):266-71</RefSource><PMID Version="1">19916970</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Dermatol. 2016 Jun;43(6):686-9</RefSource><PMID Version="1">26663262</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Breast Cancer Res Treat. 2012 Jan;131(1):147-58</RefSource><PMID Version="1">21960113</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Surg Oncol. 2014 Mar;109(4):308-13</RefSource><PMID Version="1">24522938</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Patient Prefer Adherence. 2016 Jul 04;10:1177-87</RefSource><PMID Version="1">27445465</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Acad Dermatol. 2007 May;56(5):869-71</RefSource><PMID Version="1">17276544</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cancer Ther. 2013 Jul;12(7):1332-42</RefSource><PMID Version="1">23645591</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 1995 Jun;28(2):78-88</RefSource><PMID Version="1">7564495</PMID></CommentsCorrections></CommentsCorrectionsList><CoiStatement>Matteo S. Carlino is on advisory boards for Novartis, Merck, Sharpe and Dohme, Bristol-Myers Squibb, and Amgen. All other authors have no competing interests to declare.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>08</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>12</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>12</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>10</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28182109</ArticleId><ArticleId IdType="doi">10.1155/2017/5462929</ArticleId><ArticleId IdType="pmc">PMC5274679</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Hwang, Shelley J E" sort="Hwang, Shelley J E" uniqKey="Hwang S" first="Shelley J E" last="Hwang">Shelley J E. Hwang</name></noRegion><name sortKey="Carlino, Matteo S" sort="Carlino, Matteo S" uniqKey="Carlino M" first="Matteo S" last="Carlino">Matteo S. Carlino</name><name sortKey="Chou, Shaun" sort="Chou, Shaun" uniqKey="Chou S" first="Shaun" last="Chou">Shaun Chou</name><name sortKey="Fernandez Penas, Pablo" sort="Fernandez Penas, Pablo" uniqKey="Fernandez Penas P" first="Pablo" last="Fernandez-Penas">Pablo Fernandez-Penas</name><name sortKey="Kong, Benjamin Y" sort="Kong, Benjamin Y" uniqKey="Kong B" first="Benjamin Y" last="Kong">Benjamin Y. Kong</name><name sortKey="Wakade, Deepal" sort="Wakade, Deepal" uniqKey="Wakade D" first="Deepal" last="Wakade">Deepal Wakade</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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