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Assessment of morbidity following regional nodal dissection in the axilla and groin for metastatic melanoma.

Identifieur interne : 000466 ( PubMed/Checkpoint ); précédent : 000465; suivant : 000467

Assessment of morbidity following regional nodal dissection in the axilla and groin for metastatic melanoma.

Auteurs : Jane E. Theodore [Australie] ; Adam J. Frankel [Australie] ; Janine M. Thomas [Australie] ; Andrew P. Barbour [Australie] ; Gerard J. Bayley [Australie] ; Christopher P. Allan [Australie] ; Michael Wagels [Australie] ; B Mark Smithers [Australie]

Source :

RBID : pubmed:27102082

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English descriptors

Abstract

This study assessed and compared the morbidity of nodal dissection in the axilla and groin including sentinel lymph node biopsy (SLNB), completion lymph node dissection for a positive SLNB (CLND) and therapeutic lymph node dissection (TLND) with and without adjuvant radiotherapy (RT).

DOI: 10.1111/ans.13526
PubMed: 27102082


Affiliations:


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pubmed:27102082

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<term>Adult</term>
<term>Aged</term>
<term>Axilla</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Forecasting</term>
<term>Humans</term>
<term>Lymph Node Excision (methods)</term>
<term>Lymphatic Metastasis</term>
<term>Male</term>
<term>Melanoma (epidemiology)</term>
<term>Melanoma (secondary)</term>
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<term>Aisselle</term>
<term>Biopsie de noeud lymphatique sentinelle</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphadénectomie ()</term>
<term>Morbidité (tendances)</term>
<term>Mâle</term>
<term>Mélanome ()</term>
<term>Mélanome (secondaire)</term>
<term>Mélanome (épidémiologie)</term>
<term>Métastase lymphatique</term>
<term>Prévision</term>
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<term>Melanoma</term>
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<term>Lymph Node Excision</term>
<term>Neoplasm Staging</term>
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<term>Mélanome</term>
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<term>Melanoma</term>
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<term>Melanoma</term>
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<term>Morbidité</term>
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<term>Aged</term>
<term>Axilla</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Forecasting</term>
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<term>Lymphatic Metastasis</term>
<term>Male</term>
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<term>Retrospective Studies</term>
<term>Sentinel Lymph Node Biopsy</term>
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<term>Adulte d'âge moyen</term>
<term>Aisselle</term>
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<div type="abstract" xml:lang="en">This study assessed and compared the morbidity of nodal dissection in the axilla and groin including sentinel lymph node biopsy (SLNB), completion lymph node dissection for a positive SLNB (CLND) and therapeutic lymph node dissection (TLND) with and without adjuvant radiotherapy (RT).</div>
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<Year>2016</Year>
<Month>04</Month>
<Day>22</Day>
</DateCreated>
<DateCompleted>
<Year>2017</Year>
<Month>02</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised>
<Year>2017</Year>
<Month>08</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1445-2197</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>87</Volume>
<Issue>1-2</Issue>
<PubDate>
<Year>2017</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>ANZ journal of surgery</Title>
<ISOAbbreviation>ANZ J Surg</ISOAbbreviation>
</Journal>
<ArticleTitle>Assessment of morbidity following regional nodal dissection in the axilla and groin for metastatic melanoma.</ArticleTitle>
<Pagination>
<MedlinePgn>44-48</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/ans.13526</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">This study assessed and compared the morbidity of nodal dissection in the axilla and groin including sentinel lymph node biopsy (SLNB), completion lymph node dissection for a positive SLNB (CLND) and therapeutic lymph node dissection (TLND) with and without adjuvant radiotherapy (RT).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Patients who had nodal dissection in the axilla or groin for cutaneous melanoma over an 18-year period (1995-2013) were prospectively documented on a database. The median follow-up was nearly 3 years. Early complications and clinically relevant lymphoedema were retrospectively analysed to assess the incidence and differences between the region and type of nodal surgery.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Included were 1521 patients following nodal dissection in the axilla (916 patients) and groin (605 patients). Less early complications occurred following SLNB in the axilla compared with the groin (5% versus 14%, P = 0.0001). Early complications were similar for CLND and TLND in the groin (49% versus 43%, P = 0.879) and axilla (28% versus 33%, P = 0.607). Moderate to severe lymphoedema rates were similar following axillary SLNB and CLND (6% versus 8%, P = 0.407). The lymphoedema rate for groin SLNB was lower than CLND (10% versus 20%, P = 0.063). No significant difference in lymphoedema rates followed CLND and TLND in each region. Following TLND, RT increased lymphoedema rates.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Morbidity may occur following SLNB with the groin having a higher rate of early complications and lymphoedema compared with the axilla. The morbidity following CLND and TLND were similar. Lymphoedema rates were increased following RT.</AbstractText>
<CopyrightInformation>© 2016 Royal Australasian College of Surgeons.</CopyrightInformation>
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<LastName>Theodore</LastName>
<ForeName>Jane E</ForeName>
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<Affiliation>The Queensland Melanoma Project, Princess Alexandra Hospital, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>The University of Queensland, Mater Health Services, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
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<Affiliation>Mater Research Institute, Mater Health Services, Brisbane, Queensland, Australia.</Affiliation>
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</AffiliationInfo>
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</AffiliationInfo>
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<AffiliationInfo>
<Affiliation>Princess Alexandra Hospital, The University of Queensland, Brisbane, Queensland, Australia.</Affiliation>
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<AffiliationInfo>
<Affiliation>The Queensland Melanoma Project, Princess Alexandra Hospital, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Princess Alexandra Hospital, The University of Queensland, Brisbane, Queensland, Australia.</Affiliation>
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<AffiliationInfo>
<Affiliation>Mater Research Institute, Mater Health Services, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
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<PublicationType UI="D016428">Journal Article</PublicationType>
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<Month>04</Month>
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<SupplMeshName Type="Disease" UI="C562393">Melanoma, Cutaneous Malignant</SupplMeshName>
</SupplMeshList>
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<DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
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<DescriptorName UI="D005544" MajorTopicYN="Y">Forecasting</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName>
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<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">general surgery</Keyword>
<Keyword MajorTopicYN="N">plastic and reconstructive surgery</Keyword>
<Keyword MajorTopicYN="N">surgical oncology</Keyword>
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<Year>2015</Year>
<Month>11</Month>
<Day>16</Day>
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<PubMedPubDate PubStatus="revised">
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<name sortKey="Theodore, Jane E" sort="Theodore, Jane E" uniqKey="Theodore J" first="Jane E" last="Theodore">Jane E. Theodore</name>
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<name sortKey="Allan, Christopher P" sort="Allan, Christopher P" uniqKey="Allan C" first="Christopher P" last="Allan">Christopher P. Allan</name>
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<name sortKey="Frankel, Adam J" sort="Frankel, Adam J" uniqKey="Frankel A" first="Adam J" last="Frankel">Adam J. Frankel</name>
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