LymphedemaV1, PubMed, Checkpoint, bibRecord, 000391

Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.

Identifieur interne : 000391 ( PubMed/Checkpoint ); précédent : 000390; suivant : 000392

Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.

Auteurs : Francoise Pujol [Suède] ; Tina Hodgson [Suède] ; Ines Martinez-Corral [Suède] ; Anne-Catherine Prats [Suède] ; Danelle Devenport [Suède] ; Masatoshi Takeichi [Suède] ; Elisabeth Genot [Suède] ; Taija M Kinen [Suède] ; Philippa Francis-West [Suède] ; Barbara Garmy-Susini [Suède] ; Florence Tatin [France]

Source :

Arteriosclerosis, thrombosis, and vascular biology [ 1524-4636 ] ; 2017.

RBID : pubmed:28705793

Descripteurs français

English descriptors

KwdEn :
- Actin Cytoskeleton (metabolism), Actins (metabolism), Animals, Cadherins (deficiency), Cadherins (genetics), Cadherins (metabolism), Cell Movement, Cells, Cultured, Craniofacial Abnormalities (genetics), Craniofacial Abnormalities (metabolism), Craniofacial Abnormalities (pathology), Endothelial Cells (metabolism), Endothelial Cells (pathology), Endothelium, Lymphatic (metabolism), Endothelium, Lymphatic (pathology), Fluorescent Antibody Technique, Genetic Predisposition to Disease, Green Fluorescent Proteins (genetics), Green Fluorescent Proteins (metabolism), Homeodomain Proteins (genetics), Humans, Lymphangiectasis, Intestinal (genetics), Lymphangiectasis, Intestinal (metabolism), Lymphangiectasis, Intestinal (pathology), Lymphangiogenesis, Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphedema (genetics), Lymphedema (metabolism), Lymphedema (pathology), Mice, Knockout, Mutation, Phenotype, Protein Multimerization, Signal Transduction, Transfection, Tumor Suppressor Proteins (genetics).
MESH :
- chemical , deficiency : Cadherins.
- chemical , genetics : Cadherins, Green Fluorescent Proteins, Homeodomain Proteins, Tumor Suppressor Proteins.
- chemical , metabolism : Actins, Cadherins, Green Fluorescent Proteins.
- genetics : Craniofacial Abnormalities, Lymphangiectasis, Intestinal, Lymphedema.
- metabolism : Actin Cytoskeleton, Craniofacial Abnormalities, Endothelial Cells, Endothelium, Lymphatic, Lymphangiectasis, Intestinal, Lymphatic Vessels, Lymphedema.
- pathology : Craniofacial Abnormalities, Endothelial Cells, Endothelium, Lymphatic, Lymphangiectasis, Intestinal, Lymphatic Vessels, Lymphedema.
- Animals, Cell Movement, Cells, Cultured, Fluorescent Antibody Technique, Genetic Predisposition to Disease, Humans, Lymphangiogenesis, Mice, Knockout, Mutation, Phenotype, Protein Multimerization, Signal Transduction, Transfection.

Abstract

The purpose of this study was to investigate the role of Fat4 and Dachsous1 signaling in the lymphatic vasculature.

DOI: 10.1161/ATVBAHA.117.309818
PubMed: 28705793

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000104
to stream PubMed, to step Curation: 000104

Links to Exploration step

pubmed:28705793

Le document en format XML

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<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
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<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
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<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
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<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
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<author><name sortKey="Devenport, Danelle" sort="Devenport, Danelle" uniqKey="Devenport D" first="Danelle" last="Devenport">Danelle Devenport</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
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<author><name sortKey="Takeichi, Masatoshi" sort="Takeichi, Masatoshi" uniqKey="Takeichi M" first="Masatoshi" last="Takeichi">Masatoshi Takeichi</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
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<author><name sortKey="Genot, Elisabeth" sort="Genot, Elisabeth" uniqKey="Genot E" first="Elisabeth" last="Genot">Elisabeth Genot</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
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<region nuts="1">East Middle Sweden</region>
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<author><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
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<region nuts="1">East Middle Sweden</region>
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<author><name sortKey="Francis West, Philippa" sort="Francis West, Philippa" uniqKey="Francis West P" first="Philippa" last="Francis-West">Philippa Francis-West</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
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<region nuts="1">East Middle Sweden</region>
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<author><name sortKey="Garmy Susini, Barbara" sort="Garmy Susini, Barbara" uniqKey="Garmy Susini B" first="Barbara" last="Garmy-Susini">Barbara Garmy-Susini</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
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<author><name sortKey="Tatin, Florence" sort="Tatin, Florence" uniqKey="Tatin F" first="Florence" last="Tatin">Florence Tatin</name>
<affiliation wicri:level="1"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.). florence.tatin@inserm.fr.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.</title>
<author><name sortKey="Pujol, Francoise" sort="Pujol, Francoise" uniqKey="Pujol F" first="Francoise" last="Pujol">Francoise Pujol</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
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<author><name sortKey="Hodgson, Tina" sort="Hodgson, Tina" uniqKey="Hodgson T" first="Tina" last="Hodgson">Tina Hodgson</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
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<region nuts="1">East Middle Sweden</region>
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<author><name sortKey="Martinez Corral, Ines" sort="Martinez Corral, Ines" uniqKey="Martinez Corral I" first="Ines" last="Martinez-Corral">Ines Martinez-Corral</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
<country>Suède</country>
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<region nuts="1">East Middle Sweden</region>
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<author><name sortKey="Prats, Anne Catherine" sort="Prats, Anne Catherine" uniqKey="Prats A" first="Anne-Catherine" last="Prats">Anne-Catherine Prats</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
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<author><name sortKey="Devenport, Danelle" sort="Devenport, Danelle" uniqKey="Devenport D" first="Danelle" last="Devenport">Danelle Devenport</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
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<author><name sortKey="Takeichi, Masatoshi" sort="Takeichi, Masatoshi" uniqKey="Takeichi M" first="Masatoshi" last="Takeichi">Masatoshi Takeichi</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
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<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
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<author><name sortKey="Genot, Elisabeth" sort="Genot, Elisabeth" uniqKey="Genot E" first="Elisabeth" last="Genot">Elisabeth Genot</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
<country>Suède</country>
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<region nuts="1">East Middle Sweden</region>
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<author><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
<country>Suède</country>
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<region nuts="1">East Middle Sweden</region>
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<author><name sortKey="Francis West, Philippa" sort="Francis West, Philippa" uniqKey="Francis West P" first="Philippa" last="Francis-West">Philippa Francis-West</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
<country>Suède</country>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garmy Susini, Barbara" sort="Garmy Susini, Barbara" uniqKey="Garmy Susini B" first="Barbara" last="Garmy-Susini">Barbara Garmy-Susini</name>
<affiliation wicri:level="4"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
<country>Suède</country>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tatin, Florence" sort="Tatin, Florence" uniqKey="Tatin F" first="Florence" last="Tatin">Florence Tatin</name>
<affiliation wicri:level="1"><nlm:affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.). florence.tatin@inserm.fr.</nlm:affiliation>
<country wicri:rule="url">France</country>
</affiliation>
</author>
</analytic>
<series><title level="j">Arteriosclerosis, thrombosis, and vascular biology</title>
<idno type="eISSN">1524-4636</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
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<term>Animals</term>
<term>Cadherins (deficiency)</term>
<term>Cadherins (genetics)</term>
<term>Cadherins (metabolism)</term>
<term>Cell Movement</term>
<term>Cells, Cultured</term>
<term>Craniofacial Abnormalities (genetics)</term>
<term>Craniofacial Abnormalities (metabolism)</term>
<term>Craniofacial Abnormalities (pathology)</term>
<term>Endothelial Cells (metabolism)</term>
<term>Endothelial Cells (pathology)</term>
<term>Endothelium, Lymphatic (metabolism)</term>
<term>Endothelium, Lymphatic (pathology)</term>
<term>Fluorescent Antibody Technique</term>
<term>Genetic Predisposition to Disease</term>
<term>Green Fluorescent Proteins (genetics)</term>
<term>Green Fluorescent Proteins (metabolism)</term>
<term>Homeodomain Proteins (genetics)</term>
<term>Humans</term>
<term>Lymphangiectasis, Intestinal (genetics)</term>
<term>Lymphangiectasis, Intestinal (metabolism)</term>
<term>Lymphangiectasis, Intestinal (pathology)</term>
<term>Lymphangiogenesis</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Lymphatic Vessels (pathology)</term>
<term>Lymphedema (genetics)</term>
<term>Lymphedema (metabolism)</term>
<term>Lymphedema (pathology)</term>
<term>Mice, Knockout</term>
<term>Mutation</term>
<term>Phenotype</term>
<term>Protein Multimerization</term>
<term>Signal Transduction</term>
<term>Transfection</term>
<term>Tumor Suppressor Proteins (genetics)</term>
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<term>Animaux</term>
<term>Cadhérines (déficit)</term>
<term>Cadhérines (génétique)</term>
<term>Cadhérines (métabolisme)</term>
<term>Cellules cultivées</term>
<term>Cellules endothéliales (anatomopathologie)</term>
<term>Cellules endothéliales (métabolisme)</term>
<term>Cytosquelette d'actine (métabolisme)</term>
<term>Endothélium lymphatique (anatomopathologie)</term>
<term>Endothélium lymphatique (métabolisme)</term>
<term>Humains</term>
<term>Lymphangiectasie intestinale (anatomopathologie)</term>
<term>Lymphangiectasie intestinale (génétique)</term>
<term>Lymphangiectasie intestinale (métabolisme)</term>
<term>Lymphangiogenèse</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Lymphoedème (génétique)</term>
<term>Lymphoedème (métabolisme)</term>
<term>Malformations crâniofaciales (anatomopathologie)</term>
<term>Malformations crâniofaciales (génétique)</term>
<term>Malformations crâniofaciales (métabolisme)</term>
<term>Mouvement cellulaire</term>
<term>Multimérisation de protéines</term>
<term>Mutation</term>
<term>Phénotype</term>
<term>Protéines suppresseurs de tumeurs (génétique)</term>
<term>Protéines à fluorescence verte (génétique)</term>
<term>Protéines à fluorescence verte (métabolisme)</term>
<term>Protéines à homéodomaine (génétique)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Souris knockout</term>
<term>Technique d'immunofluorescence</term>
<term>Transduction du signal</term>
<term>Transfection</term>
<term>Vaisseaux lymphatiques (anatomopathologie)</term>
<term>Vaisseaux lymphatiques (métabolisme)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cadherins</term>
<term>Green Fluorescent Proteins</term>
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<term>Tumor Suppressor Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Actins</term>
<term>Cadherins</term>
<term>Green Fluorescent Proteins</term>
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<term>Endothélium lymphatique</term>
<term>Lymphangiectasie intestinale</term>
<term>Lymphoedème</term>
<term>Malformations crâniofaciales</term>
<term>Vaisseaux lymphatiques</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Craniofacial Abnormalities</term>
<term>Lymphangiectasis, Intestinal</term>
<term>Lymphedema</term>
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<term>Lymphoedème</term>
<term>Malformations crâniofaciales</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Protéines à fluorescence verte</term>
<term>Protéines à homéodomaine</term>
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<term>Endothelial Cells</term>
<term>Endothelium, Lymphatic</term>
<term>Lymphangiectasis, Intestinal</term>
<term>Lymphatic Vessels</term>
<term>Lymphedema</term>
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<term>Cellules endothéliales</term>
<term>Cytosquelette d'actine</term>
<term>Endothélium lymphatique</term>
<term>Lymphangiectasie intestinale</term>
<term>Lymphoedème</term>
<term>Malformations crâniofaciales</term>
<term>Protéines à fluorescence verte</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Craniofacial Abnormalities</term>
<term>Endothelial Cells</term>
<term>Endothelium, Lymphatic</term>
<term>Lymphangiectasis, Intestinal</term>
<term>Lymphatic Vessels</term>
<term>Lymphedema</term>
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<term>Cell Movement</term>
<term>Cells, Cultured</term>
<term>Fluorescent Antibody Technique</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Lymphangiogenesis</term>
<term>Mice, Knockout</term>
<term>Mutation</term>
<term>Phenotype</term>
<term>Protein Multimerization</term>
<term>Signal Transduction</term>
<term>Transfection</term>
</keywords>
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<term>Cellules cultivées</term>
<term>Humains</term>
<term>Lymphangiogenèse</term>
<term>Mouvement cellulaire</term>
<term>Multimérisation de protéines</term>
<term>Mutation</term>
<term>Phénotype</term>
<term>Prédisposition génétique à une maladie</term>
<term>Souris knockout</term>
<term>Technique d'immunofluorescence</term>
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<front><div type="abstract" xml:lang="en">The purpose of this study was to investigate the role of Fat4 and Dachsous1 signaling in the lymphatic vasculature.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28705793</PMID>
<DateCreated><Year>2017</Year>
<Month>07</Month>
<Day>14</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>09</Month>
<Day>05</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>06</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4636</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>37</Volume>
<Issue>9</Issue>
<PubDate><Year>2017</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Arteriosclerosis, thrombosis, and vascular biology</Title>
<ISOAbbreviation>Arterioscler. Thromb. Vasc. Biol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.</ArticleTitle>
<Pagination><MedlinePgn>1732-1735</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/ATVBAHA.117.309818</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The purpose of this study was to investigate the role of Fat4 and Dachsous1 signaling in the lymphatic vasculature.</AbstractText>
<AbstractText Label="APPROACH AND RESULTS" NlmCategory="UNASSIGNED">Phenotypic analysis of the lymphatic vasculature was performed in mice lacking functional Fat4 or Dachsous1. The overall architecture of lymphatic vasculature is unaltered, yet both genes are specifically required for lymphatic valve morphogenesis. Valve endothelial cells (Prox1(high) [prospero homeobox protein 1] cells) are disoriented and failed to form proper valve leaflets. Using Lifeact-GFP (green fluorescent protein) mice, we revealed that valve endothelial cells display prominent actin polymerization. Finally, we showed the polarized recruitment of Dachsous1 to membrane protrusions and cellular junctions of valve endothelial cells in vivo and in vitro.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our data demonstrate that Fat4 and Dachsous1 are critical regulators of valve morphogenesis. This study highlights that valve defects may contribute to lymphedema in Hennekam syndrome caused by Fat4 mutations.</AbstractText>
<CopyrightInformation>© 2017 American Heart Association, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pujol</LastName>
<ForeName>Francoise</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hodgson</LastName>
<ForeName>Tina</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martinez-Corral</LastName>
<ForeName>Ines</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Prats</LastName>
<ForeName>Anne-Catherine</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Devenport</LastName>
<ForeName>Danelle</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Takeichi</LastName>
<ForeName>Masatoshi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Genot</LastName>
<ForeName>Elisabeth</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mäkinen</LastName>
<ForeName>Taija</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Francis-West</LastName>
<ForeName>Philippa</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Garmy-Susini</LastName>
<ForeName>Barbara</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tatin</LastName>
<ForeName>Florence</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>From the I2MC INSERM UMR 1048, Toulouse Cedex, France (F.P., A.-C.P., B.G.-S., F.T.); Department Craniofacial Development and Stem Cell Biology, King's College London, United Kingdom (T.H., P.F.-W.); Rudbeck Laboratory, Department Immunology, Genetics and Pathology, Uppsala University, Sweden (I.M.-C., T.M.); Department of Molecular Biology, Princeton University, NJ (D.D.); Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, Kobe, Japan (M.T.); and INSERM, Université de Bordeaux, France (E.G.). florence.tatin@inserm.fr.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>07</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Arterioscler Thromb Vasc Biol</MedlineTA>
<NlmUniqueID>9505803</NlmUniqueID>
<ISSNLinking>1079-5642</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000199">Actins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015820">Cadherins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C506554">Dchs1 protein, mouse</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C506555">Fat4 protein, mouse</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018398">Homeodomain Proteins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D025521">Tumor Suppressor Proteins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C485184">enhanced green fluorescent protein</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C102225">prospero-related homeobox 1 protein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>147336-22-9</RegistryNumber>
<NameOfSubstance UI="D049452">Green Fluorescent Proteins</NameOfSubstance>
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<SupplMeshList><SupplMeshName Type="Disease" UI="C537255">Hennekam lymphangiectasia lymphedema syndrome</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D008841" MajorTopicYN="N">Actin Cytoskeleton</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000199" MajorTopicYN="N">Actins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015820" MajorTopicYN="N">Cadherins</DescriptorName>
<QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002465" MajorTopicYN="Y">Cell Movement</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019465" MajorTopicYN="N">Craniofacial Abnormalities</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042783" MajorTopicYN="N">Endothelial Cells</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004729" MajorTopicYN="N">Endothelium, Lymphatic</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005455" MajorTopicYN="N">Fluorescent Antibody Technique</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049452" MajorTopicYN="N">Green Fluorescent Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018398" MajorTopicYN="N">Homeodomain Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008201" MajorTopicYN="N">Lymphangiectasis, Intestinal</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042583" MajorTopicYN="Y">Lymphangiogenesis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055503" MajorTopicYN="N">Protein Multimerization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014162" MajorTopicYN="N">Transfection</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D025521" MajorTopicYN="N">Tumor Suppressor Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">cell polarity</Keyword>
<Keyword MajorTopicYN="N">endothelial cells</Keyword>
<Keyword MajorTopicYN="N">intercellular junctions</Keyword>
<Keyword MajorTopicYN="N">lymphangiogenesis</Keyword>
<Keyword MajorTopicYN="N">lymphedema</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>10</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>06</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>7</Month>
<Day>15</Day>
<Hour>6</Hour>
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<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>9</Month>
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<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>7</Month>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28705793</ArticleId>
<ArticleId IdType="pii">ATVBAHA.117.309818</ArticleId>
<ArticleId IdType="doi">10.1161/ATVBAHA.117.309818</ArticleId>
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</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
<li>Suède</li>
</country>
<region><li>East Middle Sweden</li>
<li>Svealand</li>
</region>
<settlement><li>Uppsala</li>
</settlement>
<orgName><li>Université d'Uppsala</li>
</orgName>
</list>
<tree><country name="Suède"><region name="Svealand"><name sortKey="Pujol, Francoise" sort="Pujol, Francoise" uniqKey="Pujol F" first="Francoise" last="Pujol">Francoise Pujol</name>
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<name sortKey="Garmy Susini, Barbara" sort="Garmy Susini, Barbara" uniqKey="Garmy Susini B" first="Barbara" last="Garmy-Susini">Barbara Garmy-Susini</name>
<name sortKey="Genot, Elisabeth" sort="Genot, Elisabeth" uniqKey="Genot E" first="Elisabeth" last="Genot">Elisabeth Genot</name>
<name sortKey="Hodgson, Tina" sort="Hodgson, Tina" uniqKey="Hodgson T" first="Tina" last="Hodgson">Tina Hodgson</name>
<name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name>
<name sortKey="Martinez Corral, Ines" sort="Martinez Corral, Ines" uniqKey="Martinez Corral I" first="Ines" last="Martinez-Corral">Ines Martinez-Corral</name>
<name sortKey="Prats, Anne Catherine" sort="Prats, Anne Catherine" uniqKey="Prats A" first="Anne-Catherine" last="Prats">Anne-Catherine Prats</name>
<name sortKey="Takeichi, Masatoshi" sort="Takeichi, Masatoshi" uniqKey="Takeichi M" first="Masatoshi" last="Takeichi">Masatoshi Takeichi</name>
</country>
<country name="France"><noRegion><name sortKey="Tatin, Florence" sort="Tatin, Florence" uniqKey="Tatin F" first="Florence" last="Tatin">Florence Tatin</name>
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</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000391 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000391 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:28705793
   |texte=   Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:28705793" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.

Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.

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Abstract

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