Diagnostic Accuracy of Lymphoscintigraphy for Lymphedema and Analysis of False-Negative Tests.
Identifieur interne : 000382 ( PubMed/Checkpoint ); précédent : 000381; suivant : 000383Diagnostic Accuracy of Lymphoscintigraphy for Lymphedema and Analysis of False-Negative Tests.
Auteurs : Aladdin H. Hassanein ; Reid A. Maclellan ; Frederick D. Grant ; Arin K. GreeneSource :
- Plastic and reconstructive surgery. Global open [ 2169-7574 ] ; 2017.
Abstract
Lymphedema is the chronic enlargement of tissue due to inadequate lymphatic function. Diagnosis is made by history and physical examination and confirmed with lymphoscintigraphy. The purpose of this study was to assess the accuracy of lymphoscintigraphy for the diagnosis of lymphedema and to determine characteristics of patients with false-negative tests.
DOI: 10.1097/GOX.0000000000001396
PubMed: 28831342
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnostic Accuracy of Lymphoscintigraphy for Lymphedema and Analysis of False-Negative Tests.</title><author><name sortKey="Hassanein, Aladdin H" sort="Hassanein, Aladdin H" uniqKey="Hassanein A" first="Aladdin H" last="Hassanein">Aladdin H. Hassanein</name><affiliation><nlm:affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author><author><name sortKey="Maclellan, Reid A" sort="Maclellan, Reid A" uniqKey="Maclellan R" first="Reid A" last="Maclellan">Reid A. Maclellan</name><affiliation><nlm:affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author><author><name sortKey="Grant, Frederick D" sort="Grant, Frederick D" uniqKey="Grant F" first="Frederick D" last="Grant">Frederick D. Grant</name><affiliation><nlm:affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author><author><name sortKey="Greene, Arin K" sort="Greene, Arin K" uniqKey="Greene A" first="Arin K" last="Greene">Arin K. Greene</name><affiliation><nlm:affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28831342</idno><idno type="pmid">28831342</idno><idno type="doi">10.1097/GOX.0000000000001396</idno><idno type="wicri:Area/PubMed/Corpus">000037</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000037</idno><idno type="wicri:Area/PubMed/Curation">000037</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000037</idno><idno type="wicri:Area/PubMed/Checkpoint">000037</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000037</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Diagnostic Accuracy of Lymphoscintigraphy for Lymphedema and Analysis of False-Negative Tests.</title><author><name sortKey="Hassanein, Aladdin H" sort="Hassanein, Aladdin H" uniqKey="Hassanein A" first="Aladdin H" last="Hassanein">Aladdin H. Hassanein</name><affiliation><nlm:affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author><author><name sortKey="Maclellan, Reid A" sort="Maclellan, Reid A" uniqKey="Maclellan R" first="Reid A" last="Maclellan">Reid A. Maclellan</name><affiliation><nlm:affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author><author><name sortKey="Grant, Frederick D" sort="Grant, Frederick D" uniqKey="Grant F" first="Frederick D" last="Grant">Frederick D. Grant</name><affiliation><nlm:affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author><author><name sortKey="Greene, Arin K" sort="Greene, Arin K" uniqKey="Greene A" first="Arin K" last="Greene">Arin K. Greene</name><affiliation><nlm:affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</nlm:affiliation><wicri:noCountry code="subField">Mass</wicri:noCountry></affiliation></author></analytic><series><title level="j">Plastic and reconstructive surgery. Global open</title><idno type="ISSN">2169-7574</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphedema is the chronic enlargement of tissue due to inadequate lymphatic function. Diagnosis is made by history and physical examination and confirmed with lymphoscintigraphy. The purpose of this study was to assess the accuracy of lymphoscintigraphy for the diagnosis of lymphedema and to determine characteristics of patients with false-negative tests.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">28831342</PMID><DateCreated><Year>2017</Year><Month>08</Month><Day>23</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>27</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2169-7574</ISSN><JournalIssue CitedMedium="Print"><Volume>5</Volume><Issue>7</Issue><PubDate><Year>2017</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Plastic and reconstructive surgery. Global open</Title><ISOAbbreviation>Plast Reconstr Surg Glob Open</ISOAbbreviation></Journal><ArticleTitle>Diagnostic Accuracy of Lymphoscintigraphy for Lymphedema and Analysis of False-Negative Tests.</ArticleTitle><Pagination><MedlinePgn>e1396</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/GOX.0000000000001396</ELocationID><Abstract><AbstractText>Lymphedema is the chronic enlargement of tissue due to inadequate lymphatic function. Diagnosis is made by history and physical examination and confirmed with lymphoscintigraphy. The purpose of this study was to assess the accuracy of lymphoscintigraphy for the diagnosis of lymphedema and to determine characteristics of patients with false-negative tests.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Individuals referred to our lymphedema program with "lymphedema" between 2009 and 2016 were analyzed. Subjects were assessed by history, physical examination, and lymphoscintigraphy. Patient age at presentation, duration of lymphedema, location of disease, gender, previous infections, and lymphedema type were analyzed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The study included 227 patients (454 limbs); lymphedema was diagnosed clinically in 169 subjects and confirmed by lymphoscintigraphy in 162 (117 primary, 45 secondary; 96% sensitivity). Fifty-eight patients were thought to have a condition other than lymphedema, and all had negative lymphoscintigrams (100% specificity). A subgroup analysis of the 7 individuals with lymphedema clinically, but normal lymphoscintigrams, showed that all had primary lymphedema; duration of disease and infection history were not different between true-positive and false-negative lymphoscintigram results (P = 0.5). Two patients with a false-negative test underwent repeat lymphoscintigraphy, which then showed lymphatic dysfunction consistent with lymphedema.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Lymphoscintigraphy is very sensitive and specific for lymphedema. All patients with false-negative studies had primary lymphedema. A patient with a high clinical suspicion of lymphedema and a normal lymphoscintigram should be treated conservatively for the disease and undergo repeat lymphoscintigraphy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hassanein</LastName><ForeName>Aladdin H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maclellan</LastName><ForeName>Reid A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grant</LastName><ForeName>Frederick D</ForeName><Initials>FD</Initials><AffiliationInfo><Affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greene</LastName><ForeName>Arin K</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.; and Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>07</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Plast Reconstr Surg Glob Open</MedlineTA><NlmUniqueID>101622231</NlmUniqueID><ISSNLinking>2169-7574</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Plast Reconstr Surg Glob Open. 2013 Nov 07;1(7):e59</RefSource><PMID Version="1">25289254</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vasa. 1976;5(3):261-2</RefSource><PMID Version="1">969857</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Plast Reconstr Surg. 2016 Sep;138(3 Suppl):209S-18S</RefSource><PMID Version="1">27556764</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2003 Jan;44(1):43-57</RefSource><PMID Version="1">12515876</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nuklearmedizin. 2014;53(5):190-6</RefSource><PMID Version="1">24999013</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Plast Reconstr Surg. 1998 Sep;102(4):1058-67; 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The Article Processing Charge was paid for by the authors.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>12</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28831342</ArticleId><ArticleId IdType="doi">10.1097/GOX.0000000000001396</ArticleId><ArticleId IdType="pmc">PMC5548565</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Grant, Frederick D" sort="Grant, Frederick D" uniqKey="Grant F" first="Frederick D" last="Grant">Frederick D. Grant</name><name sortKey="Greene, Arin K" sort="Greene, Arin K" uniqKey="Greene A" first="Arin K" last="Greene">Arin K. Greene</name><name sortKey="Hassanein, Aladdin H" sort="Hassanein, Aladdin H" uniqKey="Hassanein A" first="Aladdin H" last="Hassanein">Aladdin H. Hassanein</name><name sortKey="Maclellan, Reid A" sort="Maclellan, Reid A" uniqKey="Maclellan R" first="Reid A" last="Maclellan">Reid A. Maclellan</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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