High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.
Identifieur interne : 000319 ( PubMed/Checkpoint ); précédent : 000318; suivant : 000320High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.
Auteurs : Epameinondas Gousopoulos [Suisse] ; Sinem Karaman ; Steven T. Proulx ; Kristin Leu ; Dorina Buschle ; Michael DetmarSource :
- European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes [ 1421-9921 ] ; 2017.
Abstract
Lymphoedema represents the cardinal manifestation of lymphatic dysfunction and is associated with expansion of the adipose tissue in the affected limb. In mice, high-fat diet (HFD)-induced obesity was associated with impaired collecting lymphatic vessel function, and adiposity aggravated surgery-induced lymphoedema in a mouse model. The aim of the current study was to investigate whether adiposity is necessary to impair lymphatic function or whether increased lipid exposure alone might be sufficient in a surgical lymphoedema model.
DOI: 10.1159/000461579
PubMed: 28301852
Affiliations:
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Proulx</name></author><author><name sortKey="Leu, Kristin" sort="Leu, Kristin" uniqKey="Leu K" first="Kristin" last="Leu">Kristin Leu</name></author><author><name sortKey="Buschle, Dorina" sort="Buschle, Dorina" uniqKey="Buschle D" first="Dorina" last="Buschle">Dorina Buschle</name></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28301852</idno><idno type="pmid">28301852</idno><idno type="doi">10.1159/000461579</idno><idno type="wicri:Area/PubMed/Corpus">000305</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000305</idno><idno type="wicri:Area/PubMed/Curation">000305</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000305</idno><idno type="wicri:Area/PubMed/Checkpoint">000305</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000305</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.</title><author><name sortKey="Gousopoulos, Epameinondas" sort="Gousopoulos, Epameinondas" uniqKey="Gousopoulos E" first="Epameinondas" last="Gousopoulos">Epameinondas Gousopoulos</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Karaman, Sinem" sort="Karaman, Sinem" uniqKey="Karaman S" first="Sinem" last="Karaman">Sinem Karaman</name></author><author><name sortKey="Proulx, Steven T" sort="Proulx, Steven T" uniqKey="Proulx S" first="Steven T" last="Proulx">Steven T. Proulx</name></author><author><name sortKey="Leu, Kristin" sort="Leu, Kristin" uniqKey="Leu K" first="Kristin" last="Leu">Kristin Leu</name></author><author><name sortKey="Buschle, Dorina" sort="Buschle, Dorina" uniqKey="Buschle D" first="Dorina" last="Buschle">Dorina Buschle</name></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></analytic><series><title level="j">European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes</title><idno type="eISSN">1421-9921</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphoedema represents the cardinal manifestation of lymphatic dysfunction and is associated with expansion of the adipose tissue in the affected limb. In mice, high-fat diet (HFD)-induced obesity was associated with impaired collecting lymphatic vessel function, and adiposity aggravated surgery-induced lymphoedema in a mouse model. The aim of the current study was to investigate whether adiposity is necessary to impair lymphatic function or whether increased lipid exposure alone might be sufficient in a surgical lymphoedema model.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28301852</PMID><DateCreated><Year>2017</Year><Month>03</Month><Day>16</Day></DateCreated><DateRevised><Year>2017</Year><Month>04</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1421-9921</ISSN><JournalIssue CitedMedium="Internet"><Volume>58</Volume><Issue>3-4</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes</Title><ISOAbbreviation>Eur Surg Res</ISOAbbreviation></Journal><ArticleTitle>High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.</ArticleTitle><Pagination><MedlinePgn>180-192</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1159/000461579</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Lymphoedema represents the cardinal manifestation of lymphatic dysfunction and is associated with expansion of the adipose tissue in the affected limb. In mice, high-fat diet (HFD)-induced obesity was associated with impaired collecting lymphatic vessel function, and adiposity aggravated surgery-induced lymphoedema in a mouse model. The aim of the current study was to investigate whether adiposity is necessary to impair lymphatic function or whether increased lipid exposure alone might be sufficient in a surgical lymphoedema model.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">To investigate the role of increased lipid exposure in lymphoedema development we used a well-established mouse tail lymphoedema model. Female mice were subjected to a short-term (6 weeks) HFD, without development of obesity, before surgical induction of lymphedema. Lymphoedema was followed over a period of 6 weeks measuring oedema, evaluating tissue histology and lymphatic vascular function.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">HFD increased baseline angiogenesis and average lymphatic vessel size in comparison to the chow control group. Upon induction of lymphedema, HFD-treated mice did not exhibit aggravated oedema and no morphological differences were observed in the blood and lymphatic vasculature. Importantly, the levels of fibro-adipose tissue deposition were comparable between the 2 groups and lymphatic vessel function was not impaired as a result of the HFD. Although the net immune cell infiltration was comparable, the HFD group displayed an increased infiltration of macrophages, which exhibited an M2 polarization phenotype.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results indicate that increased adiposity rather than dietary influences determines predisposition to or severity of lymphedema.</AbstractText><CopyrightInformation>© 2017 S. Karger AG, Basel.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gousopoulos</LastName><ForeName>Epameinondas</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karaman</LastName><ForeName>Sinem</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Proulx</LastName><ForeName>Steven T</ForeName><Initials>ST</Initials></Author><Author ValidYN="Y"><LastName>Leu</LastName><ForeName>Kristin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Buschle</LastName><ForeName>Dorina</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Detmar</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Eur Surg Res</MedlineTA><NlmUniqueID>0174752</NlmUniqueID><ISSNLinking>0014-312X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">High-fat diet</Keyword><Keyword MajorTopicYN="N">Lymphatic vessel function</Keyword><Keyword MajorTopicYN="N">Lymphoedema</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>11</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28301852</ArticleId><ArticleId IdType="pii">000461579</ArticleId><ArticleId IdType="doi">10.1159/000461579</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Suisse</li></country></list><tree><noCountry><name sortKey="Buschle, Dorina" sort="Buschle, Dorina" uniqKey="Buschle D" first="Dorina" last="Buschle">Dorina Buschle</name><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><name sortKey="Karaman, Sinem" sort="Karaman, Sinem" uniqKey="Karaman S" first="Sinem" last="Karaman">Sinem Karaman</name><name sortKey="Leu, Kristin" sort="Leu, Kristin" uniqKey="Leu K" first="Kristin" last="Leu">Kristin Leu</name><name sortKey="Proulx, Steven T" sort="Proulx, Steven T" uniqKey="Proulx S" first="Steven T" last="Proulx">Steven T. Proulx</name></noCountry><country name="Suisse"><noRegion><name sortKey="Gousopoulos, Epameinondas" sort="Gousopoulos, Epameinondas" uniqKey="Gousopoulos E" first="Epameinondas" last="Gousopoulos">Epameinondas Gousopoulos</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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