Loco-regional morbidity after breast conservation and axillary lymph node dissection for early breast cancer with or without regional nodes radiotherapy, perspectives in modern breast cancer treatment: the Skagen Trial 1 is active.
Identifieur interne : 000271 ( PubMed/Checkpoint ); précédent : 000270; suivant : 000272Loco-regional morbidity after breast conservation and axillary lymph node dissection for early breast cancer with or without regional nodes radiotherapy, perspectives in modern breast cancer treatment: the Skagen Trial 1 is active.
Auteurs : Hanne Melgaard Nielsen [Danemark] ; Rasmus Blechingberg Friis [Danemark] ; S Ren Linnet [Danemark] ; Birgitte Vrou Offersen [Danemark]Source :
- Acta oncologica (Stockholm, Sweden) [ 1651-226X ] ; 2017.
Abstract
Axillary lymph node dissection (ALND) and adjuvant radiotherapy (RT) in early breast cancer are associated with a risk of morbidity, including lymphedema and impaired shoulder mobility. The aim of this study was to evaluate loco-regional morbidity after breast conserving surgery (BCS), ALND, taxane-based chemotherapy and whole breast irradiation (WBI) with or without regional nodes RT.
DOI: 10.1080/0284186X.2016.1277261
PubMed: 28105873
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wicri:level="1"><nlm:affiliation>a Department of Oncology , Aarhus University Hospital , Aarhus , Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>a Department of Oncology , Aarhus University Hospital , Aarhus </wicri:regionArea><wicri:noRegion>Aarhus </wicri:noRegion></affiliation></author><author><name sortKey="Linnet, S Ren" sort="Linnet, S Ren" uniqKey="Linnet S" first="S Ren" last="Linnet">S Ren Linnet</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Oncology , Herning Hospital , Herning , Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>b Department of Oncology , Herning Hospital , Herning </wicri:regionArea><wicri:noRegion>Herning </wicri:noRegion></affiliation></author><author><name sortKey="Offersen, Birgitte Vrou" sort="Offersen, Birgitte Vrou" uniqKey="Offersen B" first="Birgitte Vrou" last="Offersen">Birgitte Vrou Offersen</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Oncology , Aarhus University Hospital , Aarhus , Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>a Department of Oncology , Aarhus University Hospital , Aarhus </wicri:regionArea><wicri:noRegion>Aarhus </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28105873</idno><idno type="pmid">28105873</idno><idno type="doi">10.1080/0284186X.2016.1277261</idno><idno type="wicri:Area/PubMed/Corpus">000410</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000410</idno><idno type="wicri:Area/PubMed/Curation">000410</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000410</idno><idno type="wicri:Area/PubMed/Checkpoint">000410</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000410</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Loco-regional morbidity after breast conservation and axillary lymph node dissection for early breast cancer with or without regional nodes radiotherapy, perspectives in modern breast cancer treatment: the Skagen Trial 1 is active.</title><author><name sortKey="Nielsen, Hanne Melgaard" sort="Nielsen, Hanne Melgaard" uniqKey="Nielsen H" first="Hanne Melgaard" last="Nielsen">Hanne Melgaard Nielsen</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Oncology , Aarhus University Hospital , Aarhus , Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>a Department of Oncology , Aarhus University Hospital , Aarhus </wicri:regionArea><wicri:noRegion>Aarhus </wicri:noRegion></affiliation></author><author><name sortKey="Friis, Rasmus Blechingberg" sort="Friis, Rasmus Blechingberg" uniqKey="Friis R" first="Rasmus Blechingberg" last="Friis">Rasmus Blechingberg Friis</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Oncology , Aarhus University Hospital , Aarhus , Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>a Department of Oncology , Aarhus University Hospital , Aarhus </wicri:regionArea><wicri:noRegion>Aarhus </wicri:noRegion></affiliation></author><author><name sortKey="Linnet, S Ren" sort="Linnet, S Ren" uniqKey="Linnet S" first="S Ren" last="Linnet">S Ren Linnet</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Oncology , Herning Hospital , Herning , Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>b Department of Oncology , Herning Hospital , Herning </wicri:regionArea><wicri:noRegion>Herning </wicri:noRegion></affiliation></author><author><name sortKey="Offersen, Birgitte Vrou" sort="Offersen, Birgitte Vrou" uniqKey="Offersen B" first="Birgitte Vrou" last="Offersen">Birgitte Vrou Offersen</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Oncology , Aarhus University Hospital , Aarhus , Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>a Department of Oncology , Aarhus University Hospital , Aarhus </wicri:regionArea><wicri:noRegion>Aarhus </wicri:noRegion></affiliation></author></analytic><series><title level="j">Acta oncologica (Stockholm, Sweden)</title><idno type="eISSN">1651-226X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Axillary lymph node dissection (ALND) and adjuvant radiotherapy (RT) in early breast cancer are associated with a risk of morbidity, including lymphedema and impaired shoulder mobility. The aim of this study was to evaluate loco-regional morbidity after breast conserving surgery (BCS), ALND, taxane-based chemotherapy and whole breast irradiation (WBI) with or without regional nodes RT.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28105873</PMID><DateCreated><Year>2017</Year><Month>01</Month><Day>20</Day></DateCreated><DateRevised><Year>2017</Year><Month>04</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1651-226X</ISSN><JournalIssue CitedMedium="Internet"><Volume>56</Volume><Issue>5</Issue><PubDate><Year>2017</Year><Month>May</Month></PubDate></JournalIssue><Title>Acta oncologica (Stockholm, Sweden)</Title><ISOAbbreviation>Acta Oncol</ISOAbbreviation></Journal><ArticleTitle>Loco-regional morbidity after breast conservation and axillary lymph node dissection for early breast cancer with or without regional nodes radiotherapy, perspectives in modern breast cancer treatment: the Skagen Trial 1 is active.</ArticleTitle><Pagination><MedlinePgn>713-718</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/0284186X.2016.1277261</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Axillary lymph node dissection (ALND) and adjuvant radiotherapy (RT) in early breast cancer are associated with a risk of morbidity, including lymphedema and impaired shoulder mobility. The aim of this study was to evaluate loco-regional morbidity after breast conserving surgery (BCS), ALND, taxane-based chemotherapy and whole breast irradiation (WBI) with or without regional nodes RT.</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">Eligible patients had BCS and ALND from 2007 to 2012 followed by adjuvant taxane-based chemotherapy and if indicated, trastuzumab and endocrine treatment. The RT consisted of WBI and regional nodes RT in case of ≥ pN1 disease (group 1) and WBI only in case of pN0-1(mic) disease (group 2). The dose was 50 Gy in 25 fractions. The patients were invited to participate in a cross-sectional study evaluating morbidity.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 347 eligible patients, 277 patients (79%) accepted the invitation. Of these, 185 patients (67%) belonged to group 1 and 92 patients (33%) to group 2. The median time from RT to evaluation of morbidity was 3.3 years (group 1) and 4.3 years (group 2). In group 1, 34 patients (18%) and in group 2, 15 patients (16%) had ≥2 cm enlargement in circumference of ipsilateral upper or lower arm (p = .67). The frequence of impairment of ipsilateral shoulder abduction to ≤120° was 3% in both groups and of shoulder flexion to ≤120° was 1% and 2% (group 1 versus 2). No difference in patient reported outcome measure (PROM) data regarding heaviness or enlargement of ipsilateral upper and lower arm or mobility and sensory disturbances.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The risk of lymphedema was low in patients after ALND and not related to use of regional nodes RT. Impairment of shoulder function was rare, and no differences in PROM were detected regarding use or not of regional nodes RT.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nielsen</LastName><ForeName>Hanne Melgaard</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>a Department of Oncology , Aarhus University Hospital , Aarhus , Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Friis</LastName><ForeName>Rasmus Blechingberg</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>a Department of Oncology , Aarhus University Hospital , Aarhus , Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Linnet</LastName><ForeName>Søren</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>b Department of Oncology , Herning Hospital , Herning , Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Offersen</LastName><ForeName>Birgitte Vrou</ForeName><Initials>BV</Initials><AffiliationInfo><Affiliation>a Department of Oncology , Aarhus University Hospital , Aarhus , Denmark.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Acta Oncol</MedlineTA><NlmUniqueID>8709065</NlmUniqueID><ISSNLinking>0284-186X</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>1</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>1</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28105873</ArticleId><ArticleId IdType="doi">10.1080/0284186X.2016.1277261</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey="Nielsen, Hanne Melgaard" sort="Nielsen, Hanne Melgaard" uniqKey="Nielsen H" first="Hanne Melgaard" last="Nielsen">Hanne Melgaard Nielsen</name></noRegion><name sortKey="Friis, Rasmus Blechingberg" sort="Friis, Rasmus Blechingberg" uniqKey="Friis R" first="Rasmus Blechingberg" last="Friis">Rasmus Blechingberg Friis</name><name sortKey="Linnet, S Ren" sort="Linnet, S Ren" uniqKey="Linnet S" first="S Ren" last="Linnet">S Ren Linnet</name><name sortKey="Offersen, Birgitte Vrou" sort="Offersen, Birgitte Vrou" uniqKey="Offersen B" first="Birgitte Vrou" last="Offersen">Birgitte Vrou Offersen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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