Lymphedema: Pathogenesis and Novel Therapies.
Identifieur interne : 000243 ( PubMed/Checkpoint ); précédent : 000242; suivant : 000244Lymphedema: Pathogenesis and Novel Therapies.
Auteurs : Joseph H. Dayan ; Catherine L. Ly ; Raghu P. Kataru ; Babak J. MehraraSource :
- Annual review of medicine [ 1545-326X ] ; 2017.
Abstract
Lymphedema affects up to 1 in 6 patients who undergo treatment for a solid tumor in the United States. Its prevalence has increased as more effective oncologic therapies have improved patient survival, but there remains no definitive cure. Recent research has elucidated new details in the pathogenesis of the disease and has demonstrated that it is fundamentally an immunologic progress that ultimately results in inflammation, fibroadipose deposition, impaired lymphangiogenesis, and dysfunctional lymphatic pumping. These findings have allowed for the development of novel medical and surgical therapies that may potentially alter the standard of care for a disease that has largely been treated by compression. This review seeks to provide an overview of the emerging therapies and how they can be utilized for effective management of lymphedema. Expected final online publication date for the Annual Review of Medicine Volume 69 is January 29, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
DOI: 10.1146/annurev-med-060116-022900
PubMed: 28877002
Affiliations:
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Kataru</name><affiliation><nlm:affiliation>Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065; email: dayanj@mskcc.org , lyc@mskcc.org , katarur@mskcc.org , mehrarab@mskcc.org.</nlm:affiliation><wicri:noCountry code="subField">mehrarab@mskcc.org.</wicri:noCountry></affiliation></author><author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J" last="Mehrara">Babak J. Mehrara</name><affiliation><nlm:affiliation>Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065; email: dayanj@mskcc.org , lyc@mskcc.org , katarur@mskcc.org , mehrarab@mskcc.org.</nlm:affiliation><wicri:noCountry code="subField">mehrarab@mskcc.org.</wicri:noCountry></affiliation></author></analytic><series><title level="j">Annual review of medicine</title><idno type="eISSN">1545-326X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphedema affects up to 1 in 6 patients who undergo treatment for a solid tumor in the United States. Its prevalence has increased as more effective oncologic therapies have improved patient survival, but there remains no definitive cure. Recent research has elucidated new details in the pathogenesis of the disease and has demonstrated that it is fundamentally an immunologic progress that ultimately results in inflammation, fibroadipose deposition, impaired lymphangiogenesis, and dysfunctional lymphatic pumping. These findings have allowed for the development of novel medical and surgical therapies that may potentially alter the standard of care for a disease that has largely been treated by compression. This review seeks to provide an overview of the emerging therapies and how they can be utilized for effective management of lymphedema. Expected final online publication date for the Annual Review of Medicine Volume 69 is January 29, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28877002</PMID><DateCreated><Year>2017</Year><Month>09</Month><Day>06</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1545-326X</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Sep</Month><Day>06</Day></PubDate></JournalIssue><Title>Annual review of medicine</Title><ISOAbbreviation>Annu. Rev. Med.</ISOAbbreviation></Journal><ArticleTitle>Lymphedema: Pathogenesis and Novel Therapies.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1146/annurev-med-060116-022900</ELocationID><Abstract><AbstractText>Lymphedema affects up to 1 in 6 patients who undergo treatment for a solid tumor in the United States. Its prevalence has increased as more effective oncologic therapies have improved patient survival, but there remains no definitive cure. Recent research has elucidated new details in the pathogenesis of the disease and has demonstrated that it is fundamentally an immunologic progress that ultimately results in inflammation, fibroadipose deposition, impaired lymphangiogenesis, and dysfunctional lymphatic pumping. These findings have allowed for the development of novel medical and surgical therapies that may potentially alter the standard of care for a disease that has largely been treated by compression. This review seeks to provide an overview of the emerging therapies and how they can be utilized for effective management of lymphedema. Expected final online publication date for the Annual Review of Medicine Volume 69 is January 29, 2018. 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Dayan</name><name sortKey="Kataru, Raghu P" sort="Kataru, Raghu P" uniqKey="Kataru R" first="Raghu P" last="Kataru">Raghu P. Kataru</name><name sortKey="Ly, Catherine L" sort="Ly, Catherine L" uniqKey="Ly C" first="Catherine L" last="Ly">Catherine L. Ly</name><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J" last="Mehrara">Babak J. Mehrara</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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