Recapitulation of acquired immuno deficiency syndrome associated Kaposi's sarcoma
Identifieur interne : 004A61 ( Pmc/Curation ); précédent : 004A60; suivant : 004A62Recapitulation of acquired immuno deficiency syndrome associated Kaposi's sarcoma
Auteurs : Balaji Govindan [Inde]Source :
- Indian Journal of Sexually Transmitted Diseases [ 0253-7184 ] ; 2016.
Abstract
Acquired immuno deficiency syndrome (AIDS) associated Kaposi's sarcoma (KS) is one of the clinical forms of KS. KS is caused by human herpes viruses 8 or KS associated herpes virus (KSHV). In India, till now, only 16 cases of AIDS associated KS was reported. Of all the clinical forms of KS, AIDS associated KS is distinct in many ways viz.; cutaneous manifestations commonly affects face and trunk rather than lower limbs, more mucosal lesions, rapidly progressive, and early systemic involvement. When human immunodeficiency virus (HIV) is co-infected with KSHV, in addition to the other pathogenic factors for the development of KS, HIV Tat protein promotes the proliferation of cytokine-activated endothelial cells and stimulates KS. Moreover, actions of HIV Tat lead to the aggressive course of KS in patients with AIDS, compared with the more confined behavior of KS in HIV-negative persons. Similarly, latency-associated nuclear antigen of KSHV would enhance HIV replication by activating the long terminal repeats of HIV-1 through its association with Tat. Effective antiretroviral treatment in AIDS associated KS results in reduction of the incidence of AIDS-related KS and regression of the existing lesions. Early diagnosis and treatment of AIDS associated KS would definitely increase the life span and quality of the patients.
Url:
DOI: 10.4103/0253-7184.192120
PubMed: 27890943
PubMed Central: 5111294
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recapitulation of acquired immuno deficiency syndrome associated Kaposi's sarcoma</title><author><name sortKey="Govindan, Balaji" sort="Govindan, Balaji" uniqKey="Govindan B" first="Balaji" last="Govindan">Balaji Govindan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of STD, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of STD, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27890943</idno><idno type="pmc">5111294</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111294</idno><idno type="RBID">PMC:5111294</idno><idno type="doi">10.4103/0253-7184.192120</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">004A62</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004A62</idno><idno type="wicri:Area/Pmc/Curation">004A61</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004A61</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recapitulation of acquired immuno deficiency syndrome associated Kaposi's sarcoma</title><author><name sortKey="Govindan, Balaji" sort="Govindan, Balaji" uniqKey="Govindan B" first="Balaji" last="Govindan">Balaji Govindan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of STD, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of STD, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu</wicri:regionArea></affiliation></author></analytic><series><title level="j">Indian Journal of Sexually Transmitted Diseases</title><idno type="ISSN">0253-7184</idno><idno type="eISSN">1998-3816</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Acquired immuno deficiency syndrome (AIDS) associated Kaposi's sarcoma (KS) is one of the clinical forms of KS. KS is caused by human herpes viruses 8 or KS associated herpes virus (KSHV). In India, till now, only 16 cases of AIDS associated KS was reported. Of all the clinical forms of KS, AIDS associated KS is distinct in many ways viz.; cutaneous manifestations commonly affects face and trunk rather than lower limbs, more mucosal lesions, rapidly progressive, and early systemic involvement. When human immunodeficiency virus (HIV) is co-infected with KSHV, in addition to the other pathogenic factors for the development of KS, HIV Tat protein promotes the proliferation of cytokine-activated endothelial cells and stimulates KS. Moreover, actions of HIV Tat lead to the aggressive course of KS in patients with AIDS, compared with the more confined behavior of KS in HIV-negative persons. Similarly, latency-associated nuclear antigen of KSHV would enhance HIV replication by activating the long terminal repeats of HIV-1 through its association with Tat. Effective antiretroviral treatment in AIDS associated KS results in reduction of the incidence of AIDS-related KS and regression of the existing lesions. Early diagnosis and treatment of AIDS associated KS would definitely increase the life span and quality of the patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sternbach, G" uniqKey="Sternbach G">G Sternbach</name></author><author><name sortKey="Varon, J" uniqKey="Varon J">J Varon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campo Trapero, J" uniqKey="Campo Trapero J">J Campo-Trapero</name></author><author><name sortKey="Del Romero Guerrero, J" uniqKey="Del Romero Guerrero J">J Del Romero-Guerrero</name></author><author><name sortKey="Cano Sanchez, J" uniqKey="Cano Sanchez J">J Cano-Sánchez</name></author><author><name sortKey="Rodriguez Martin, C" uniqKey="Rodriguez Martin C">C Rodríguez-Martín</name></author><author><name sortKey="Martinez Gonzalez, Jm" uniqKey="Martinez Gonzalez J">JM Martínez-González</name></author><author><name sortKey="Bascones Martinez, A" uniqKey="Bascones 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Indian J Sex Transm Dis</journal-id><journal-id journal-id-type="iso-abbrev">Indian J Sex Transm Dis</journal-id><journal-id journal-id-type="publisher-id">IJSTD</journal-id><journal-title-group><journal-title>Indian Journal of Sexually Transmitted Diseases</journal-title></journal-title-group><issn pub-type="ppub">0253-7184</issn><issn pub-type="epub">1998-3816</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27890943</article-id><article-id pub-id-type="pmc">5111294</article-id><article-id pub-id-type="publisher-id">IJSTD-37-115</article-id><article-id pub-id-type="doi">10.4103/0253-7184.192120</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Recapitulation of acquired immuno deficiency syndrome associated Kaposi's sarcoma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Govindan</surname><given-names>Balaji</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1">Department of STD, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Balaji Govindan, Department of STD, Government Mohan Kumaramangalam Medical College, Salem - 636 001, Tamil Nadu, India. E-mail: <email xlink:href="ezhilbalaji@gmail.com">ezhilbalaji@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jul-Dec</season><year>2016</year></pub-date><volume>37</volume><issue>2</issue><fpage>115</fpage><lpage>122</lpage><permissions><copyright-statement>Copyright: © 2016 Indian Journal of Sexually Transmitted Diseases and AIDS</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.</license-p></license></permissions><abstract><p>Acquired immuno deficiency syndrome (AIDS) associated Kaposi's sarcoma (KS) is one of the clinical forms of KS. KS is caused by human herpes viruses 8 or KS associated herpes virus (KSHV). In India, till now, only 16 cases of AIDS associated KS was reported. Of all the clinical forms of KS, AIDS associated KS is distinct in many ways viz.; cutaneous manifestations commonly affects face and trunk rather than lower limbs, more mucosal lesions, rapidly progressive, and early systemic involvement. When human immunodeficiency virus (HIV) is co-infected with KSHV, in addition to the other pathogenic factors for the development of KS, HIV Tat protein promotes the proliferation of cytokine-activated endothelial cells and stimulates KS. Moreover, actions of HIV Tat lead to the aggressive course of KS in patients with AIDS, compared with the more confined behavior of KS in HIV-negative persons. Similarly, latency-associated nuclear antigen of KSHV would enhance HIV replication by activating the long terminal repeats of HIV-1 through its association with Tat. Effective antiretroviral treatment in AIDS associated KS results in reduction of the incidence of AIDS-related KS and regression of the existing lesions. Early diagnosis and treatment of AIDS associated KS would definitely increase the life span and quality of the patients.</p></abstract><kwd-group><title>Key words</title><kwd>AIDS</kwd><kwd>Herpes Virus</kwd><kwd>Kaposi's sarcoma associated virus</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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