Intraoperative radiation therapy for breast cancer patients: current perspectives
Identifieur interne : 004926 ( Pmc/Curation ); précédent : 004925; suivant : 004927Intraoperative radiation therapy for breast cancer patients: current perspectives
Auteurs : Sunil W. Dutta ; Shayna L. Showalter [États-Unis] ; Timothy N. Showalter ; Bruce Libby ; Daniel M. TrifilettiSource :
- Breast Cancer : Targets and Therapy [ 1179-1314 ] ; 2017.
Abstract
Accelerated partial breast irradiation (APBI) provides an attractive alternative to whole breast irradiation (WBI) through normal tissue radiation exposure and reduced treatment duration. Intraoperative radiation therapy (IORT) is a form of APBI with the shortest time interval, as it delivers the entirety of a planned radiation course at the time of breast surgery. However, faster is not always better, and IORT has been met with healthy skepticism. Patients treated with IORT have an increased compliance and overall satisfaction when compared to patients treated with WBI. However, early randomized trial results demonstrated an increased rate of recurrence after IORT, slowing its widespread adoption. Despite these controversies, IORT utilization is increasing nationally and several novel developments are aimed at continuing to minimize the risk of recurrence and treatment-related toxicity while maximizing the patient experience.
Url:
DOI: 10.2147/BCTT.S112516
PubMed: 28458578
PubMed Central: 5402914
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Dutta</name><affiliation><nlm:aff id="af1-bctt-9-257">Department of Radiation Oncology</nlm:aff></affiliation></author><author><name sortKey="Showalter, Shayna L" sort="Showalter, Shayna L" uniqKey="Showalter S" first="Shayna L" last="Showalter">Shayna L. Showalter</name><affiliation wicri:level="1"><nlm:aff id="af2-bctt-9-257">Division of Surgical Oncology, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Surgical Oncology, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA</wicri:regionArea></affiliation></author><author><name sortKey="Showalter, Timothy N" sort="Showalter, Timothy N" uniqKey="Showalter T" first="Timothy N" last="Showalter">Timothy N. Showalter</name><affiliation><nlm:aff id="af1-bctt-9-257">Department of Radiation Oncology</nlm:aff></affiliation></author><author><name sortKey="Libby, Bruce" sort="Libby, Bruce" uniqKey="Libby B" first="Bruce" last="Libby">Bruce Libby</name><affiliation><nlm:aff id="af1-bctt-9-257">Department of Radiation Oncology</nlm:aff></affiliation></author><author><name sortKey="Trifiletti, Daniel M" sort="Trifiletti, Daniel M" uniqKey="Trifiletti D" first="Daniel M" last="Trifiletti">Daniel M. Trifiletti</name><affiliation><nlm:aff id="af1-bctt-9-257">Department of Radiation Oncology</nlm:aff></affiliation></author></analytic><series><title level="j">Breast Cancer : Targets and Therapy</title><idno type="eISSN">1179-1314</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Accelerated partial breast irradiation (APBI) provides an attractive alternative to whole breast irradiation (WBI) through normal tissue radiation exposure and reduced treatment duration. Intraoperative radiation therapy (IORT) is a form of APBI with the shortest time interval, as it delivers the entirety of a planned radiation course at the time of breast surgery. However, faster is not always better, and IORT has been met with healthy skepticism. Patients treated with IORT have an increased compliance and overall satisfaction when compared to patients treated with WBI. However, early randomized trial results demonstrated an increased rate of recurrence after IORT, slowing its widespread adoption. Despite these controversies, IORT utilization is increasing nationally and several novel developments are aimed at continuing to minimize the risk of recurrence and treatment-related toxicity while maximizing the patient experience.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fisher, B" uniqKey="Fisher B">B Fisher</name></author><author><name sortKey="Anderson, S" uniqKey="Anderson S">S Anderson</name></author><author><name sortKey="Bryant, J" uniqKey="Bryant J">J Bryant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hershman, Dl" uniqKey="Hershman D">DL Hershman</name></author><author><name sortKey="Buono, D" uniqKey="Buono D">D Buono</name></author><author><name sortKey="Mcbride, Rb" uniqKey="Mcbride R">RB McBride</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voti, L" uniqKey="Voti L">L Voti</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Breast Cancer (Dove Med Press)</journal-id><journal-id journal-id-type="iso-abbrev">Breast Cancer (Dove Med Press)</journal-id><journal-id journal-id-type="publisher-id">Breast Cancer: Targets and Therapy</journal-id><journal-title-group><journal-title>Breast Cancer : Targets and Therapy</journal-title></journal-title-group><issn pub-type="epub">1179-1314</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28458578</article-id><article-id pub-id-type="pmc">5402914</article-id><article-id pub-id-type="doi">10.2147/BCTT.S112516</article-id><article-id pub-id-type="publisher-id">bctt-9-257</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Intraoperative radiation therapy for breast cancer patients: current perspectives</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Dutta</surname><given-names>Sunil W</given-names></name><xref ref-type="aff" rid="af1-bctt-9-257">1</xref></contrib><contrib contrib-type="author"><name><surname>Showalter</surname><given-names>Shayna L</given-names></name><xref ref-type="aff" rid="af2-bctt-9-257">2</xref></contrib><contrib contrib-type="author"><name><surname>Showalter</surname><given-names>Timothy N</given-names></name><xref ref-type="aff" rid="af1-bctt-9-257">1</xref></contrib><contrib contrib-type="author"><name><surname>Libby</surname><given-names>Bruce</given-names></name><xref ref-type="aff" rid="af1-bctt-9-257">1</xref></contrib><contrib contrib-type="author"><name><surname>Trifiletti</surname><given-names>Daniel M</given-names></name><xref ref-type="aff" rid="af1-bctt-9-257">1</xref><xref ref-type="corresp" rid="c1-bctt-9-257"></xref></contrib></contrib-group><aff id="af1-bctt-9-257"><label>1</label>Department of Radiation Oncology</aff><aff id="af2-bctt-9-257"><label>2</label>Division of Surgical Oncology, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA</aff><author-notes><corresp id="c1-bctt-9-257">Correspondence: Daniel M Trifiletti, Department of Radiation Oncology, University of Virginia Health System, 1240 Lee Street, Box 800383, Charlottesville, VA 22908, USA, Tel +1 434 982 6278, Fax +1 434 982 3262, Email <email>daniel.trifiletti@gmail.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>18</day><month>4</month><year>2017</year></pub-date><volume>9</volume><fpage>257</fpage><lpage>263</lpage><permissions><copyright-statement>© 2017 Dutta et al. This work is published and licensed by Dove Medical Press Limited</copyright-statement><copyright-year>2017</copyright-year><license><license-p>The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link> and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.</license-p></license></permissions><abstract><p>Accelerated partial breast irradiation (APBI) provides an attractive alternative to whole breast irradiation (WBI) through normal tissue radiation exposure and reduced treatment duration. Intraoperative radiation therapy (IORT) is a form of APBI with the shortest time interval, as it delivers the entirety of a planned radiation course at the time of breast surgery. However, faster is not always better, and IORT has been met with healthy skepticism. Patients treated with IORT have an increased compliance and overall satisfaction when compared to patients treated with WBI. However, early randomized trial results demonstrated an increased rate of recurrence after IORT, slowing its widespread adoption. Despite these controversies, IORT utilization is increasing nationally and several novel developments are aimed at continuing to minimize the risk of recurrence and treatment-related toxicity while maximizing the patient experience.</p></abstract><kwd-group><title>Keywords</title><kwd>IORT</kwd><kwd>lumpectomy</kwd><kwd>breast conservation</kwd><kwd>electron</kwd><kwd>photon</kwd><kwd>evidence</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-bctt-9-257" position="float"><label>Figure 1</label><caption><p>A representative axial CT image of a patient treated on the PB-IORT protocol.</p><p><bold>Abbreviation:</bold> PB-IORT, precision breast intraoperative radiation therapy.</p></caption><graphic xlink:href="bctt-9-257Fig1"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:28458578" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |