Eph/Ephrin Profiling in Human Breast Cancer Reveals Significant Associations between Expression Level and Clinical Outcome
Identifieur interne : 004518 ( Pmc/Curation ); précédent : 004517; suivant : 004519Eph/Ephrin Profiling in Human Breast Cancer Reveals Significant Associations between Expression Level and Clinical Outcome
Auteurs : Dana M. Brantley-Sieders ; Aixiang Jiang [États-Unis] ; Krishna Sarma ; Akosua Badu-Nkansah [États-Unis] ; Debra L. Walter ; Yu Shyr [États-Unis] ; Jin Chen [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2011.
Abstract
Pre-clinical studies provide compelling evidence that Eph family receptor tyrosine kinases (RTKs) and ligands promote cancer growth, neovascularization, invasion, and metastasis. Tumor suppressive roles have also been reported for the receptors, however, creating a potential barrier for clinical application. Determining how these observations relate to clinical outcome is a crucial step for translating the biological and mechanistic data into new molecularly targeted therapies. We investigated
Url:
DOI: 10.1371/journal.pone.0024426
PubMed: 21935409
PubMed Central: 3174170
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :004519
Links to Exploration step
PMC:3174170Curation
No country items
Dana M. Brantley-Sieders<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Eph/Ephrin Profiling in Human Breast Cancer Reveals Significant Associations between Expression Level and Clinical Outcome</title>
<author><name sortKey="Brantley Sieders, Dana M" sort="Brantley Sieders, Dana M" uniqKey="Brantley Sieders D" first="Dana M." last="Brantley-Sieders">Dana M. Brantley-Sieders</name>
<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jiang, Aixiang" sort="Jiang, Aixiang" uniqKey="Jiang A" first="Aixiang" last="Jiang">Aixiang Jiang</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sarma, Krishna" sort="Sarma, Krishna" uniqKey="Sarma K" first="Krishna" last="Sarma">Krishna Sarma</name>
<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Badu Nkansah, Akosua" sort="Badu Nkansah, Akosua" uniqKey="Badu Nkansah A" first="Akosua" last="Badu-Nkansah">Akosua Badu-Nkansah</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Walter, Debra L" sort="Walter, Debra L" uniqKey="Walter D" first="Debra L." last="Walter">Debra L. Walter</name>
<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shyr, Yu" sort="Shyr, Yu" uniqKey="Shyr Y" first="Yu" last="Shyr">Yu Shyr</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Jin" sort="Chen, Jin" uniqKey="Chen J" first="Jin" last="Chen">Jin Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21935409</idno>
<idno type="pmc">3174170</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174170</idno>
<idno type="RBID">PMC:3174170</idno>
<idno type="doi">10.1371/journal.pone.0024426</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">004519</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004519</idno>
<idno type="wicri:Area/Pmc/Curation">004518</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004518</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Eph/Ephrin Profiling in Human Breast Cancer Reveals Significant Associations between Expression Level and Clinical Outcome</title>
<author><name sortKey="Brantley Sieders, Dana M" sort="Brantley Sieders, Dana M" uniqKey="Brantley Sieders D" first="Dana M." last="Brantley-Sieders">Dana M. Brantley-Sieders</name>
<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jiang, Aixiang" sort="Jiang, Aixiang" uniqKey="Jiang A" first="Aixiang" last="Jiang">Aixiang Jiang</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sarma, Krishna" sort="Sarma, Krishna" uniqKey="Sarma K" first="Krishna" last="Sarma">Krishna Sarma</name>
<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Badu Nkansah, Akosua" sort="Badu Nkansah, Akosua" uniqKey="Badu Nkansah A" first="Akosua" last="Badu-Nkansah">Akosua Badu-Nkansah</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Walter, Debra L" sort="Walter, Debra L" uniqKey="Walter D" first="Debra L." last="Walter">Debra L. Walter</name>
<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shyr, Yu" sort="Shyr, Yu" uniqKey="Shyr Y" first="Yu" last="Shyr">Yu Shyr</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Jin" sort="Chen, Jin" uniqKey="Chen J" first="Jin" last="Chen">Jin Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="aff2"><addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United State of America</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Pre-clinical studies provide compelling evidence that Eph family receptor tyrosine kinases (RTKs) and ligands promote cancer growth, neovascularization, invasion, and metastasis. Tumor suppressive roles have also been reported for the receptors, however, creating a potential barrier for clinical application. Determining how these observations relate to clinical outcome is a crucial step for translating the biological and mechanistic data into new molecularly targeted therapies. We investigated <italic>eph</italic>
and <italic>ephrin</italic>
expression in human breast cancer relative to endpoints of overall and/or recurrence-free survival in large microarray datasets. We also investigated protein expression in commercial human breast tissue microarrays (TMA) and Stage I prognostic TMAs linked to recurrence outcome data. We found significant correlations between <italic>ephA2</italic>
, <italic>ephA4</italic>
, <italic>ephA7</italic>
, <italic>ephB4</italic>
, and <italic>ephB6</italic>
and overall and/or recurrence-free survival in large microarray datasets. Protein expression in TMAs supported these trends. While observed no correlation between <italic>ephrin</italic>
ligand expression and clinical outcome in microarray datasets, ephrin-A1 and EphA2 protein co-expression was significantly associated with recurrence in Stage I prognostic breast cancer TMAs. Our data suggest that several Eph family members are clinically relevant and tractable targets for intervention in human breast cancer. Moreover, profiling Eph receptor expression patterns in the context of relevant ligands and in the context of stage may be valuable in terms of diagnostics and treatment.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Michael, S" uniqKey="Michael S">S Michael</name>
</author>
<author><name sortKey="Charikleia, S" uniqKey="Charikleia S">S Charikleia</name>
</author>
<author><name sortKey="Konstantinos, K" uniqKey="Konstantinos K">K Konstantinos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Azim, Ha" uniqKey="Azim H">HA Azim</name>
</author>
<author><name sortKey="De Azambuja, E" uniqKey="De Azambuja E">E de Azambuja</name>
</author>
<author><name sortKey="Colozza, M" uniqKey="Colozza M">M Colozza</name>
</author>
<author><name sortKey="Bines, J" uniqKey="Bines J">J Bines</name>
</author>
<author><name sortKey="Piccart, Mj" uniqKey="Piccart M">MJ Piccart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stewart, Fa" uniqKey="Stewart F">FA Stewart</name>
</author>
<author><name sortKey="Hoving, S" uniqKey="Hoving S">S Hoving</name>
</author>
<author><name sortKey="Russell, Ns" uniqKey="Russell N">NS Russell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tonezzer, T" uniqKey="Tonezzer T">T Tonezzer</name>
</author>
<author><name sortKey="Pereira, Cm" uniqKey="Pereira C">CM Pereira</name>
</author>
<author><name sortKey="Filho, Up" uniqKey="Filho U">UP Filho</name>
</author>
<author><name sortKey="Marx, A" uniqKey="Marx A">A Marx</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pasquale, Eb" uniqKey="Pasquale E">EB Pasquale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brantley Sieders, Dm" uniqKey="Brantley Sieders D">DM Brantley-Sieders</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brantley Sieders, D" uniqKey="Brantley Sieders D">D Brantley-Sieders</name>
</author>
<author><name sortKey="Schmidt, S" uniqKey="Schmidt S">S Schmidt</name>
</author>
<author><name sortKey="Parker, M" uniqKey="Parker M">M Parker</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vaught, D" uniqKey="Vaught D">D Vaught</name>
</author>
<author><name sortKey="Brantley Sieders, Dm" uniqKey="Brantley Sieders D">DM Brantley-Sieders</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lackmann, M" uniqKey="Lackmann M">M Lackmann</name>
</author>
<author><name sortKey="Boyd, Aw" uniqKey="Boyd A">AW Boyd</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van De Vijver, Mj" uniqKey="Van De Vijver M">MJ van de Vijver</name>
</author>
<author><name sortKey="He, Yd" uniqKey="He Y">YD He</name>
</author>
<author><name sortKey="Van T Veer, Lj" uniqKey="Van T Veer L">LJ van't Veer</name>
</author>
<author><name sortKey="Dai, H" uniqKey="Dai H">H Dai</name>
</author>
<author><name sortKey="Hart, Aa" uniqKey="Hart A">AA Hart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van T Veer, Lj" uniqKey="Van T Veer L">LJ van 't Veer</name>
</author>
<author><name sortKey="Dai, H" uniqKey="Dai H">H Dai</name>
</author>
<author><name sortKey="Van De Vijver, Mj" uniqKey="Van De Vijver M">MJ van de Vijver</name>
</author>
<author><name sortKey="He, Yd" uniqKey="He Y">YD He</name>
</author>
<author><name sortKey="Hart, Aa" uniqKey="Hart A">AA Hart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vaught, D" uniqKey="Vaught D">D Vaught</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
<author><name sortKey="Brantley Sieders, Dm" uniqKey="Brantley Sieders D">DM Brantley-Sieders</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kouros Mehr, H" uniqKey="Kouros Mehr H">H Kouros-Mehr</name>
</author>
<author><name sortKey="Werb, Z" uniqKey="Werb Z">Z Werb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brantley, Dm" uniqKey="Brantley D">DM Brantley</name>
</author>
<author><name sortKey="Cheng, N" uniqKey="Cheng N">N Cheng</name>
</author>
<author><name sortKey="Thompson, Ej" uniqKey="Thompson E">EJ Thompson</name>
</author>
<author><name sortKey="Lin, Q" uniqKey="Lin Q">Q Lin</name>
</author>
<author><name sortKey="Brekken, Ra" uniqKey="Brekken R">RA Brekken</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ogawa, K" uniqKey="Ogawa K">K Ogawa</name>
</author>
<author><name sortKey="Pasqualini, R" uniqKey="Pasqualini R">R Pasqualini</name>
</author>
<author><name sortKey="Lindberg, Ra" uniqKey="Lindberg R">RA Lindberg</name>
</author>
<author><name sortKey="Kain, R" uniqKey="Kain R">R Kain</name>
</author>
<author><name sortKey="Freeman, Al" uniqKey="Freeman A">AL Freeman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zelinski, Dp" uniqKey="Zelinski D">DP Zelinski</name>
</author>
<author><name sortKey="Zantek, Nd" uniqKey="Zantek N">ND Zantek</name>
</author>
<author><name sortKey="Stewart, Jc" uniqKey="Stewart J">JC Stewart</name>
</author>
<author><name sortKey="Irizarry, Ar" uniqKey="Irizarry A">AR Irizarry</name>
</author>
<author><name sortKey="Kinch, Ms" uniqKey="Kinch M">MS Kinch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pan, M" uniqKey="Pan M">M Pan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brantley Sieders, Dm" uniqKey="Brantley Sieders D">DM Brantley-Sieders</name>
</author>
<author><name sortKey="Zhuang, G" uniqKey="Zhuang G">G Zhuang</name>
</author>
<author><name sortKey="Hicks, D" uniqKey="Hicks D">D Hicks</name>
</author>
<author><name sortKey="Fang, Wb" uniqKey="Fang W">WB Fang</name>
</author>
<author><name sortKey="Hwang, Y" uniqKey="Hwang Y">Y Hwang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fang, Wb" uniqKey="Fang W">WB Fang</name>
</author>
<author><name sortKey="Brantley Sieders, Dm" uniqKey="Brantley Sieders D">DM Brantley-Sieders</name>
</author>
<author><name sortKey="Parker, Ma" uniqKey="Parker M">MA Parker</name>
</author>
<author><name sortKey="Reith, Ad" uniqKey="Reith A">AD Reith</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhuang, G" uniqKey="Zhuang G">G Zhuang</name>
</author>
<author><name sortKey="Brantley Sieders, Dm" uniqKey="Brantley Sieders D">DM Brantley-Sieders</name>
</author>
<author><name sortKey="Vaught, D" uniqKey="Vaught D">D Vaught</name>
</author>
<author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name>
</author>
<author><name sortKey="Xie, L" uniqKey="Xie L">L Xie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gokmen Polar, Y" uniqKey="Gokmen Polar Y">Y Gokmen-Polar</name>
</author>
<author><name sortKey="Toroni, Ra" uniqKey="Toroni R">RA Toroni</name>
</author>
<author><name sortKey="Hocevar, Ba" uniqKey="Hocevar B">BA Hocevar</name>
</author>
<author><name sortKey="Badve, S" uniqKey="Badve S">S Badve</name>
</author>
<author><name sortKey="Zhao, Q" uniqKey="Zhao Q">Q Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Q" uniqKey="Wu Q">Q Wu</name>
</author>
<author><name sortKey="Suo, Z" uniqKey="Suo Z">Z Suo</name>
</author>
<author><name sortKey="Risberg, B" uniqKey="Risberg B">B Risberg</name>
</author>
<author><name sortKey="Karlsson, Mg" uniqKey="Karlsson M">MG Karlsson</name>
</author>
<author><name sortKey="Villman, K" uniqKey="Villman K">K Villman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, Sr" uniqKey="Kumar S">SR Kumar</name>
</author>
<author><name sortKey="Singh, J" uniqKey="Singh J">J Singh</name>
</author>
<author><name sortKey="Xia, G" uniqKey="Xia G">G Xia</name>
</author>
<author><name sortKey="Krasnoperov, V" uniqKey="Krasnoperov V">V Krasnoperov</name>
</author>
<author><name sortKey="Hassanieh, L" uniqKey="Hassanieh L">L Hassanieh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munarini, N" uniqKey="Munarini N">N Munarini</name>
</author>
<author><name sortKey="Jager, R" uniqKey="Jager R">R Jager</name>
</author>
<author><name sortKey="Abderhalden, S" uniqKey="Abderhalden S">S Abderhalden</name>
</author>
<author><name sortKey="Zuercher, G" uniqKey="Zuercher G">G Zuercher</name>
</author>
<author><name sortKey="Rohrbach, V" uniqKey="Rohrbach V">V Rohrbach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Berclaz, G" uniqKey="Berclaz G">G Berclaz</name>
</author>
<author><name sortKey="Andres, Ac" uniqKey="Andres A">AC Andres</name>
</author>
<author><name sortKey="Albrecht, D" uniqKey="Albrecht D">D Albrecht</name>
</author>
<author><name sortKey="Dreher, E" uniqKey="Dreher E">E Dreher</name>
</author>
<author><name sortKey="Ziemiecki, A" uniqKey="Ziemiecki A">A Ziemiecki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Berclaz, G" uniqKey="Berclaz G">G Berclaz</name>
</author>
<author><name sortKey="Flutsch, B" uniqKey="Flutsch B">B Flutsch</name>
</author>
<author><name sortKey="Altermatt, Hj" uniqKey="Altermatt H">HJ Altermatt</name>
</author>
<author><name sortKey="Rohrbach, V" uniqKey="Rohrbach V">V Rohrbach</name>
</author>
<author><name sortKey="Djonov, V" uniqKey="Djonov V">V Djonov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Noren, Nk" uniqKey="Noren N">NK Noren</name>
</author>
<author><name sortKey="Foos, G" uniqKey="Foos G">G Foos</name>
</author>
<author><name sortKey="Hauser, Ca" uniqKey="Hauser C">CA Hauser</name>
</author>
<author><name sortKey="Pasquale, Eb" uniqKey="Pasquale E">EB Pasquale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Noren, Nk" uniqKey="Noren N">NK Noren</name>
</author>
<author><name sortKey="Pasquale, Eb" uniqKey="Pasquale E">EB Pasquale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salvucci, O" uniqKey="Salvucci O">O Salvucci</name>
</author>
<author><name sortKey="Maric, D" uniqKey="Maric D">D Maric</name>
</author>
<author><name sortKey="Economopoulou, M" uniqKey="Economopoulou M">M Economopoulou</name>
</author>
<author><name sortKey="Sakakibara, S" uniqKey="Sakakibara S">S Sakakibara</name>
</author>
<author><name sortKey="Merlin, S" uniqKey="Merlin S">S Merlin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fu, Dy" uniqKey="Fu D">DY Fu</name>
</author>
<author><name sortKey="Wang, Zm" uniqKey="Wang Z">ZM Wang</name>
</author>
<author><name sortKey="Wang, Bl" uniqKey="Wang B">BL Wang</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
<author><name sortKey="Yang, Wt" uniqKey="Yang W">WT Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fox, Bp" uniqKey="Fox B">BP Fox</name>
</author>
<author><name sortKey="Kandpal, Rp" uniqKey="Kandpal R">RP Kandpal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fox, Bp" uniqKey="Fox B">BP Fox</name>
</author>
<author><name sortKey="Tabone, Cj" uniqKey="Tabone C">CJ Tabone</name>
</author>
<author><name sortKey="Kandpal, Rp" uniqKey="Kandpal R">RP Kandpal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fox, Bp" uniqKey="Fox B">BP Fox</name>
</author>
<author><name sortKey="Kandpal, Rp" uniqKey="Kandpal R">RP Kandpal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fox, Bp" uniqKey="Fox B">BP Fox</name>
</author>
<author><name sortKey="Kandpal, Rp" uniqKey="Kandpal R">RP Kandpal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Truitt, L" uniqKey="Truitt L">L Truitt</name>
</author>
<author><name sortKey="Freywald, T" uniqKey="Freywald T">T Freywald</name>
</author>
<author><name sortKey="Decoteau, J" uniqKey="Decoteau J">J DeCoteau</name>
</author>
<author><name sortKey="Sharfe, N" uniqKey="Sharfe N">N Sharfe</name>
</author>
<author><name sortKey="Freywald, A" uniqKey="Freywald A">A Freywald</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Macrae, M" uniqKey="Macrae M">M Macrae</name>
</author>
<author><name sortKey="Neve, Rm" uniqKey="Neve R">RM Neve</name>
</author>
<author><name sortKey="Rodriguez Viciana, P" uniqKey="Rodriguez Viciana P">P Rodriguez-Viciana</name>
</author>
<author><name sortKey="Haqq, C" uniqKey="Haqq C">C Haqq</name>
</author>
<author><name sortKey="Yeh, J" uniqKey="Yeh J">J Yeh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miao, H" uniqKey="Miao H">H Miao</name>
</author>
<author><name sortKey="Wei, Br" uniqKey="Wei B">BR Wei</name>
</author>
<author><name sortKey="Peehl, Dm" uniqKey="Peehl D">DM Peehl</name>
</author>
<author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
<author><name sortKey="Alexandrou, T" uniqKey="Alexandrou T">T Alexandrou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, H" uniqKey="Guo H">H Guo</name>
</author>
<author><name sortKey="Miao, H" uniqKey="Miao H">H Miao</name>
</author>
<author><name sortKey="Gerber, L" uniqKey="Gerber L">L Gerber</name>
</author>
<author><name sortKey="Singh, J" uniqKey="Singh J">J Singh</name>
</author>
<author><name sortKey="Denning, Mf" uniqKey="Denning M">MF Denning</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakamura, R" uniqKey="Nakamura R">R Nakamura</name>
</author>
<author><name sortKey="Kataoka, H" uniqKey="Kataoka H">H Kataoka</name>
</author>
<author><name sortKey="Sato, N" uniqKey="Sato N">N Sato</name>
</author>
<author><name sortKey="Kanamori, M" uniqKey="Kanamori M">M Kanamori</name>
</author>
<author><name sortKey="Ihara, M" uniqKey="Ihara M">M Ihara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frieden, La" uniqKey="Frieden L">LA Frieden</name>
</author>
<author><name sortKey="Townsend, Ta" uniqKey="Townsend T">TA Townsend</name>
</author>
<author><name sortKey="Vaught, Db" uniqKey="Vaught D">DB Vaught</name>
</author>
<author><name sortKey="Delaughter, Dm" uniqKey="Delaughter D">DM Delaughter</name>
</author>
<author><name sortKey="Hwang, Y" uniqKey="Hwang Y">Y Hwang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Team, Rdc" uniqKey="Team R">RDC Team</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harrington, Dp" uniqKey="Harrington D">DP Harrington</name>
</author>
<author><name sortKey="Fleming, Tr" uniqKey="Fleming T">TR Fleming</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Newson, R" uniqKey="Newson R">R Newson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Therneau, Tm" uniqKey="Therneau T">TM Therneau</name>
</author>
<author><name sortKey="Grambsch, Pm" uniqKey="Grambsch P">PM Grambsch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ripley, Bd" uniqKey="Ripley B">BD Ripley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Becker, Ra" uniqKey="Becker R">RA Becker</name>
</author>
<author><name sortKey="Chambers, Jm" uniqKey="Chambers J">JM Chambers</name>
</author>
<author><name sortKey="Wilks, Ar" uniqKey="Wilks A">AR Wilks</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21935409</article-id>
<article-id pub-id-type="pmc">3174170</article-id>
<article-id pub-id-type="publisher-id">PONE-D-11-14906</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0024426</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Biology</subject>
<subj-group><subject>Biochemistry</subject>
<subj-group><subject>Biomacromolecule-Ligand Interactions</subject>
</subj-group>
</subj-group>
<subj-group><subject>Biophysics</subject>
<subj-group><subject>Biomacromolecule-Ligand Interactions</subject>
</subj-group>
</subj-group>
<subj-group><subject>Computational Biology</subject>
<subj-group><subject>Molecular Genetics</subject>
<subj-group><subject>Gene Expression</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group><subject>Genetics</subject>
<subj-group><subject>Gene Expression</subject>
</subj-group>
</subj-group>
<subj-group><subject>Molecular Cell Biology</subject>
<subj-group><subject>Signal Transduction</subject>
<subj-group><subject>Signaling Cascades</subject>
<subj-group><subject>Tyrosine Kinase Signaling Cascade</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group><subject>Gene Expression</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject>
<subj-group><subject>Diagnostic Medicine</subject>
<subj-group><subject>Pathology</subject>
<subj-group><subject>General Pathology</subject>
<subj-group><subject>Biomarkers</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group><subject>Obstetrics and Gynecology</subject>
<subj-group><subject>Breast Cancer</subject>
</subj-group>
</subj-group>
<subj-group><subject>Oncology</subject>
<subj-group><subject>Cancers and Neoplasms</subject>
<subj-group><subject>Breast Tumors</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Physics</subject>
<subj-group><subject>Biophysics</subject>
<subj-group><subject>Biomacromolecule-Ligand Interactions</subject>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Eph/Ephrin Profiling in Human Breast Cancer Reveals Significant Associations between Expression Level and Clinical Outcome</article-title>
<alt-title alt-title-type="running-head">Eph/Ephrin Expression Breast Cancer Outcome</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Brantley-Sieders</surname>
<given-names>Dana M.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jiang</surname>
<given-names>Aixiang</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sarma</surname>
<given-names>Krishna</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Badu-Nkansah</surname>
<given-names>Akosua</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Walter</surname>
<given-names>Debra L.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shyr</surname>
<given-names>Yu</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Jin</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America</addr-line>
</aff>
<aff id="aff3"><label>3</label>
<addr-line>Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</aff>
<aff id="aff4"><label>4</label>
<addr-line>Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</aff>
<aff id="aff5"><label>5</label>
<addr-line>Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</aff>
<aff id="aff6"><label>6</label>
<addr-line>Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</aff>
<aff id="aff7"><label>7</label>
<addr-line>Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Zhang</surname>
<given-names>Lin</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1">University of Pennsylvania School of Medicine, United States of America</aff>
<author-notes><corresp id="cor1">* E-mail: <email>jin.chen@vanderbilt.edu</email>
</corresp>
<fn fn-type="con"><p>Conceived and designed the experiments: DB-S YS JC. Performed the experiments: DB-S AJ KS AB-N DW. Analyzed the data: DB-S AJ KS AB-N DW. Contributed reagents/materials/analysis tools: DB-S AJ JC. Wrote the paper: DB-S AJ YS JC.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>9</month>
<year>2011</year>
</pub-date>
<volume>6</volume>
<issue>9</issue>
<elocation-id>e24426</elocation-id>
<history><date date-type="received"><day>2</day>
<month>8</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>8</day>
<month>8</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>Brantley-Sieders et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p>Pre-clinical studies provide compelling evidence that Eph family receptor tyrosine kinases (RTKs) and ligands promote cancer growth, neovascularization, invasion, and metastasis. Tumor suppressive roles have also been reported for the receptors, however, creating a potential barrier for clinical application. Determining how these observations relate to clinical outcome is a crucial step for translating the biological and mechanistic data into new molecularly targeted therapies. We investigated <italic>eph</italic>
and <italic>ephrin</italic>
expression in human breast cancer relative to endpoints of overall and/or recurrence-free survival in large microarray datasets. We also investigated protein expression in commercial human breast tissue microarrays (TMA) and Stage I prognostic TMAs linked to recurrence outcome data. We found significant correlations between <italic>ephA2</italic>
, <italic>ephA4</italic>
, <italic>ephA7</italic>
, <italic>ephB4</italic>
, and <italic>ephB6</italic>
and overall and/or recurrence-free survival in large microarray datasets. Protein expression in TMAs supported these trends. While observed no correlation between <italic>ephrin</italic>
ligand expression and clinical outcome in microarray datasets, ephrin-A1 and EphA2 protein co-expression was significantly associated with recurrence in Stage I prognostic breast cancer TMAs. Our data suggest that several Eph family members are clinically relevant and tractable targets for intervention in human breast cancer. Moreover, profiling Eph receptor expression patterns in the context of relevant ligands and in the context of stage may be valuable in terms of diagnostics and treatment.</p>
</abstract>
<counts><page-count count="9"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004518 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 004518 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:3174170 |texte= Eph/Ephrin Profiling in Human Breast Cancer Reveals Significant Associations between Expression Level and Clinical Outcome }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:21935409" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |