Chronic High-Fat Diet Impairs Collecting Lymphatic Vessel Function in Mice
Identifieur interne : 004503 ( Pmc/Curation ); précédent : 004502; suivant : 004504Chronic High-Fat Diet Impairs Collecting Lymphatic Vessel Function in Mice
Auteurs : Katrin S. Blum [Suisse] ; Sinem Karaman [Suisse] ; Steven T. Proulx [Suisse] ; Alexandra M. Ochsenbein [Suisse] ; Paola Luciani [Suisse] ; Jean-Christophe Leroux [Suisse] ; Christian Wolfrum [Suisse] ; Michael Detmar [Suisse]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Lymphatic vessels play an essential role in intestinal lipid uptake, and impairment of lymphatic vessel function leads to enhanced adipose tissue accumulation in patients with lymphedema and in genetic mouse models of lymphatic dysfunction. However, the effects of obesity on lymphatic function have been poorly studied. We investigated if and how adipose tissue accumulation influences lymphatic function. Using a lymphatic specific tracer, we performed
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DOI: 10.1371/journal.pone.0094713
PubMed: 24714646
PubMed Central: 3979858
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Blum</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Karaman, Sinem" sort="Karaman, Sinem" uniqKey="Karaman S" first="Sinem" last="Karaman">Sinem Karaman</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Proulx, Steven T" sort="Proulx, Steven T" uniqKey="Proulx S" first="Steven T." last="Proulx">Steven T. Proulx</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Ochsenbein, Alexandra M" sort="Ochsenbein, Alexandra M" uniqKey="Ochsenbein A" first="Alexandra M." last="Ochsenbein">Alexandra M. 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Blum</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Karaman, Sinem" sort="Karaman, Sinem" uniqKey="Karaman S" first="Sinem" last="Karaman">Sinem Karaman</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Proulx, Steven T" sort="Proulx, Steven T" uniqKey="Proulx S" first="Steven T." last="Proulx">Steven T. Proulx</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Ochsenbein, Alexandra M" sort="Ochsenbein, Alexandra M" uniqKey="Ochsenbein A" first="Alexandra M." last="Ochsenbein">Alexandra M. Ochsenbein</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Luciani, Paola" sort="Luciani, Paola" uniqKey="Luciani P" first="Paola" last="Luciani">Paola Luciani</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Leroux, Jean Christophe" sort="Leroux, Jean Christophe" uniqKey="Leroux J" first="Jean-Christophe" last="Leroux">Jean-Christophe Leroux</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Wolfrum, Christian" sort="Wolfrum, Christian" uniqKey="Wolfrum C" first="Christian" last="Wolfrum">Christian Wolfrum</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology, ETH Zurich, Schwerzenbach, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology, ETH Zurich, Schwerzenbach</wicri:regionArea></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lymphatic vessels play an essential role in intestinal lipid uptake, and impairment of lymphatic vessel function leads to enhanced adipose tissue accumulation in patients with lymphedema and in genetic mouse models of lymphatic dysfunction. However, the effects of obesity on lymphatic function have been poorly studied. We investigated if and how adipose tissue accumulation influences lymphatic function. Using a lymphatic specific tracer, we performed <italic>in vivo</italic> near-infrared (NIR) imaging to assess the function of collecting lymphatic vessels in mice fed normal chow or high-fat diet (HFD). Histological and whole mount analyses were performed to investigate the morphological changes in initial and the collecting lymphatic vessels. HFD was associated with impaired collecting lymphatic vessel function, as evidenced by reduced frequency of contractions and diminished response to mechanostimulation. Moreover, we found a significant negative correlation between collecting lymphatic vessel function and body weight. Whole mount analyses showed an enlargement of contractile collecting lymphatic vessels of the hind limb. In K14-VEGF-C mice, HFD resulted in a reduced spreading of the tracer within dermal lymphatic vessels. These findings indicate that adipose tissue expansion due to HFD leads to a functional impairment of the lymphatic vasculature, predominantly in collecting lymphatic vessels.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cueni, L" uniqKey="Cueni L">L Cueni</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dixon, Jb" uniqKey="Dixon J">JB Dixon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brorson, H" uniqKey="Brorson H">H Brorson</name></author><author><name sortKey="Ohlin, K" uniqKey="Ohlin K">K Ohlin</name></author><author><name sortKey="Olsson, G" uniqKey="Olsson G">G Olsson</name></author><author><name sortKey="Karlsson, Mk" uniqKey="Karlsson M">MK Karlsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harvey, Nl" uniqKey="Harvey N">NL 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Baumgartner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blum, Ks" uniqKey="Blum K">KS Blum</name></author><author><name sortKey="Proulx, St" uniqKey="Proulx S">ST Proulx</name></author><author><name sortKey="Luciani, P" uniqKey="Luciani P">P Luciani</name></author><author><name sortKey="Leroux, Jc" uniqKey="Leroux J">JC Leroux</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, Hy" uniqKey="Lim H">HY Lim</name></author><author><name sortKey="Rutkowski, Jm" uniqKey="Rutkowski J">JM Rutkowski</name></author><author><name sortKey="Helft, J" uniqKey="Helft J">J Helft</name></author><author><name sortKey="Reddy, St" uniqKey="Reddy S">ST Reddy</name></author><author><name sortKey="Swartz, Ma" uniqKey="Swartz M">MA Swartz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24714646</article-id><article-id pub-id-type="pmc">3979858</article-id><article-id pub-id-type="publisher-id">PONE-D-14-03936</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0094713</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology and Life Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Cardiovascular Anatomy</subject><subject>Lymphatic System</subject></subj-group></subj-group><subj-group><subject>Nutrition</subject></subj-group><subj-group><subject>Physiology</subject><subj-group><subject>Physiological Parameters</subject><subj-group><subject>Body Weight</subject><subj-group><subject>Obesity</subject></subj-group></subj-group></subj-group><subj-group><subject>Immune Physiology</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine and Health Sciences</subject><subj-group><subject>Cardiology</subject></subj-group><subj-group><subject>Diagnostic Medicine</subject><subj-group><subject>Diagnostic Radiology</subject><subj-group><subject>Fluorography</subject></subj-group></subj-group></subj-group><subj-group><subject>Radiology and Imaging</subject></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Research and Analysis Methods</subject><subj-group><subject>Animal Models of Disease</subject></subj-group><subj-group><subject>Research Design</subject><subj-group><subject>Clinical Research Design</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Chronic High-Fat Diet Impairs Collecting Lymphatic Vessel Function in Mice</article-title><alt-title alt-title-type="running-head">Obesity Induces Lymphatic Dysfunction</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Blum</surname><given-names>Katrin S.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Karaman</surname><given-names>Sinem</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Proulx</surname><given-names>Steven T.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ochsenbein</surname><given-names>Alexandra M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Luciani</surname><given-names>Paola</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Leroux</surname><given-names>Jean-Christophe</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wolfrum</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Detmar</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology, ETH Zurich, Schwerzenbach, Switzerland</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Hogan</surname><given-names>Ben</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Queensland, Australia</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>michael.detmar@pharma.ethz.ch</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: KSB SK STP CW MD. Performed the experiments: KSB SK STP. Analyzed the data: KSB SK STP MD. Contributed reagents/materials/analysis tools: AMO PL JCL. Wrote the paper: KSB SK STP MD.</p></fn></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>8</day><month>4</month><year>2014</year></pub-date><volume>9</volume><issue>4</issue><elocation-id>e94713</elocation-id><history><date date-type="received"><day>26</day><month>1</month><year>2014</year></date><date date-type="accepted"><day>18</day><month>3</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><copyright-holder>Blum et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><p>Lymphatic vessels play an essential role in intestinal lipid uptake, and impairment of lymphatic vessel function leads to enhanced adipose tissue accumulation in patients with lymphedema and in genetic mouse models of lymphatic dysfunction. However, the effects of obesity on lymphatic function have been poorly studied. We investigated if and how adipose tissue accumulation influences lymphatic function. Using a lymphatic specific tracer, we performed <italic>in vivo</italic> near-infrared (NIR) imaging to assess the function of collecting lymphatic vessels in mice fed normal chow or high-fat diet (HFD). Histological and whole mount analyses were performed to investigate the morphological changes in initial and the collecting lymphatic vessels. HFD was associated with impaired collecting lymphatic vessel function, as evidenced by reduced frequency of contractions and diminished response to mechanostimulation. Moreover, we found a significant negative correlation between collecting lymphatic vessel function and body weight. Whole mount analyses showed an enlargement of contractile collecting lymphatic vessels of the hind limb. In K14-VEGF-C mice, HFD resulted in a reduced spreading of the tracer within dermal lymphatic vessels. These findings indicate that adipose tissue expansion due to HFD leads to a functional impairment of the lymphatic vasculature, predominantly in collecting lymphatic vessels.</p></abstract><funding-group><funding-statement>This work was supported by Swiss National Science Foundation grants 31003A_130627 and 310030B_137087, Advanced European Research Council Grant LYVICAM, and Fondation Leducq Transatlantic Networks of Excellence in Cardiovascular Research (to MD). KSB received a research fellowship from the German Research Foundation (DFG: BL 1136/1-1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="8"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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