Can methylene blue dye be used as an alternative to patent blue dye to find the sentinel lymph node in breast cancer surgery?
Identifieur interne : 004138 ( Pmc/Curation ); précédent : 004137; suivant : 004139Can methylene blue dye be used as an alternative to patent blue dye to find the sentinel lymph node in breast cancer surgery?
Auteurs : Asieh Sadat Fattahi [Iran] ; Alireza Tavassoli [Iran] ; Omid Rohbakhshfar [Iran] ; Ramin Sadeghi [Iran] ; Abbas Abdollahi [Iran] ; Mohammad Naser Forghani [Iran]Source :
- Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences [ 1735-1995 ] ; 2014.
Abstract
Sentinel lymph node biopsy (SLNB) is standard care to evaluate axillary involvement in early breast cancer. It has fewer complications than complete lymph node dissection; however, using blue dye in SLNB is controversial. We have evaluated the detection rate and local complications associated with methylene blue dye (MBD) used in SLNB in early breast cancer patients and compared these results to patent blue dye (PBD).
In a cohort prospective study, 312 patients with early breast cancer without axillary lymph node involvement were divided into two groups according to dye type. All of the patients received radiotracer and one type of blue dye. We filled out a checklist for the patients that contained demographic data, size of tumor, stage, detection of sentinel lymph node, and complications and then analyzed the data.
Demographic and histopathologic characteristics were not significantly different in both groups. Mean (standard deviation [SD]) tumor size in all patients was 2.4 (0.8) cm. Detection rate in the MBD group was 77.5% with dye alone and 94.2% with dye and radioisotope; and in the PBD group it was 80.1% and 92.9% respectively (
Methylene blue has an acceptable detection rate, which may be a good alternative in SLNB. Complication such as blue discoloration of the skin was also lower with MBD.
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PubMed: 25538772
PubMed Central: 4274565
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Can methylene blue dye be used as an alternative to patent blue dye to find the sentinel lymph node in breast cancer surgery?</title><author><name sortKey="Fattahi, Asieh Sadat" sort="Fattahi, Asieh Sadat" uniqKey="Fattahi A" first="Asieh Sadat" last="Fattahi">Asieh Sadat Fattahi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea></affiliation></author><author><name sortKey="Tavassoli, Alireza" sort="Tavassoli, Alireza" uniqKey="Tavassoli A" first="Alireza" last="Tavassoli">Alireza Tavassoli</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea></affiliation></author><author><name sortKey="Rohbakhshfar, Omid" sort="Rohbakhshfar, Omid" uniqKey="Rohbakhshfar O" first="Omid" last="Rohbakhshfar">Omid Rohbakhshfar</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea></affiliation></author><author><name sortKey="Sadeghi, Ramin" sort="Sadeghi, Ramin" uniqKey="Sadeghi R" first="Ramin" last="Sadeghi">Ramin Sadeghi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Nuclear Medicine, Faculty of Medicine, Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Nuclear Medicine, Faculty of Medicine, Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea></affiliation></author><author><name sortKey="Abdollahi, Abbas" sort="Abdollahi, Abbas" uniqKey="Abdollahi A" first="Abbas" last="Abdollahi">Abbas Abdollahi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Surgery, Faculty of Medicine, Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country 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type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274565</idno><idno type="RBID">PMC:4274565</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">004139</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004139</idno><idno type="wicri:Area/Pmc/Curation">004138</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004138</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Can methylene blue dye be used as an alternative to patent blue dye to find the sentinel lymph node in breast cancer surgery?</title><author><name sortKey="Fattahi, Asieh Sadat" sort="Fattahi, Asieh Sadat" uniqKey="Fattahi A" first="Asieh Sadat" last="Fattahi">Asieh Sadat Fattahi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea></affiliation></author><author><name sortKey="Tavassoli, Alireza" sort="Tavassoli, Alireza" uniqKey="Tavassoli A" first="Alireza" last="Tavassoli">Alireza Tavassoli</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea></affiliation></author><author><name sortKey="Rohbakhshfar, Omid" sort="Rohbakhshfar, Omid" uniqKey="Rohbakhshfar O" first="Omid" last="Rohbakhshfar">Omid Rohbakhshfar</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea></affiliation></author><author><name sortKey="Sadeghi, Ramin" sort="Sadeghi, Ramin" uniqKey="Sadeghi R" first="Ramin" last="Sadeghi">Ramin Sadeghi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Nuclear Medicine, Faculty of Medicine, Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Nuclear Medicine, Faculty of Medicine, Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea></affiliation></author><author><name sortKey="Abdollahi, Abbas" sort="Abdollahi, Abbas" uniqKey="Abdollahi A" first="Abbas" last="Abdollahi">Abbas Abdollahi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Surgery, Faculty of Medicine, Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Surgery, Faculty of Medicine, Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea></affiliation></author><author><name sortKey="Forghani, Mohammad Naser" sort="Forghani, Mohammad Naser" uniqKey="Forghani M" first="Mohammad Naser" last="Forghani">Mohammad Naser Forghani</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Surgery, Faculty of Medicine, Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Surgery, Faculty of Medicine, Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences</title><idno type="ISSN">1735-1995</idno><idno type="eISSN">1735-7136</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>Sentinel lymph node biopsy (SLNB) is standard care to evaluate axillary involvement in early breast cancer. It has fewer complications than complete lymph node dissection; however, using blue dye in SLNB is controversial. We have evaluated the detection rate and local complications associated with methylene blue dye (MBD) used in SLNB in early breast cancer patients and compared these results to patent blue dye (PBD).</p></sec><sec id="st2"><title>Materials and Methods:</title><p>In a cohort prospective study, 312 patients with early breast cancer without axillary lymph node involvement were divided into two groups according to dye type. All of the patients received radiotracer and one type of blue dye. We filled out a checklist for the patients that contained demographic data, size of tumor, stage, detection of sentinel lymph node, and complications and then analyzed the data.</p></sec><sec id="st3"><title>Results:</title><p>Demographic and histopathologic characteristics were not significantly different in both groups. Mean (standard deviation [SD]) tumor size in all patients was 2.4 (0.8) cm. Detection rate in the MBD group was 77.5% with dye alone and 94.2% with dye and radioisotope; and in the PBD group it was 80.1% and 92.9% respectively (<italic>P</italic> > 0.05). We had blue discoloration of the skin in 23.7% in the PBD and 14.1% in the MBD group (<italic>P</italic> < 0.05) local inflammation was detected in one patient in the PBD and five in the MBD group (<italic>P</italic> < 0.05). Skin necrosis and systemic complications were not observed.</p></sec><sec id="st4"><title>Conclusion:</title><p>Methylene blue has an acceptable detection rate, which may be a good alternative in SLNB. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Res Med Sci</journal-id><journal-id journal-id-type="iso-abbrev">J Res Med Sci</journal-id><journal-id journal-id-type="publisher-id">JRMS</journal-id><journal-title-group><journal-title>Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences</journal-title></journal-title-group><issn pub-type="ppub">1735-1995</issn><issn pub-type="epub">1735-7136</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25538772</article-id><article-id pub-id-type="pmc">4274565</article-id><article-id pub-id-type="publisher-id">JRMS-19-918</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Can methylene blue dye be used as an alternative to patent blue dye to find the sentinel lymph node in breast cancer surgery?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Fattahi</surname><given-names>Asieh Sadat</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Tavassoli</surname><given-names>Alireza</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Rohbakhshfar</surname><given-names>Omid</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Sadeghi</surname><given-names>Ramin</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib><contrib contrib-type="author"><name><surname>Abdollahi</surname><given-names>Abbas</given-names></name><xref ref-type="aff" rid="aff3">2</xref></contrib><contrib contrib-type="author"><name><surname>Forghani</surname><given-names>Mohammad Naser</given-names></name><xref ref-type="aff" rid="aff3">2</xref></contrib></contrib-group><aff id="aff1">Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</aff><aff id="aff2"><label>1</label>Department of Nuclear Medicine, Faculty of Medicine, Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</aff><aff id="aff3"><label>2</label>Department of Surgery, Faculty of Medicine, Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Omid Rohbakhshfar, Department of Surgery, Faculty of Medicine, Endoscopic and Minimally Invasive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. E-mail: <email xlink:href="emis@mums.ac.ir">emis@mums.ac.ir</email></corresp></author-notes><pub-date pub-type="ppub"><month>10</month><year>2014</year></pub-date><volume>19</volume><issue>10</issue><fpage>918</fpage><lpage>922</lpage><history><date date-type="received"><day>09</day><month>3</month><year>2014</year></date><date date-type="rev-recd"><day>27</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>12</day><month>7</month><year>2014</year></date></history><permissions><copyright-statement>Copyright: © Journal of Research in Medical Sciences</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Background:</title><p>Sentinel lymph node biopsy (SLNB) is standard care to evaluate axillary involvement in early breast cancer. It has fewer complications than complete lymph node dissection; however, using blue dye in SLNB is controversial. We have evaluated the detection rate and local complications associated with methylene blue dye (MBD) used in SLNB in early breast cancer patients and compared these results to patent blue dye (PBD).</p></sec><sec id="st2"><title>Materials and Methods:</title><p>In a cohort prospective study, 312 patients with early breast cancer without axillary lymph node involvement were divided into two groups according to dye type. All of the patients received radiotracer and one type of blue dye. We filled out a checklist for the patients that contained demographic data, size of tumor, stage, detection of sentinel lymph node, and complications and then analyzed the data.</p></sec><sec id="st3"><title>Results:</title><p>Demographic and histopathologic characteristics were not significantly different in both groups. Mean (standard deviation [SD]) tumor size in all patients was 2.4 (0.8) cm. Detection rate in the MBD group was 77.5% with dye alone and 94.2% with dye and radioisotope; and in the PBD group it was 80.1% and 92.9% respectively (<italic>P</italic> > 0.05). We had blue discoloration of the skin in 23.7% in the PBD and 14.1% in the MBD group (<italic>P</italic> < 0.05) local inflammation was detected in one patient in the PBD and five in the MBD group (<italic>P</italic> < 0.05). Skin necrosis and systemic complications were not observed.</p></sec><sec id="st4"><title>Conclusion:</title><p>Methylene blue has an acceptable detection rate, which may be a good alternative in SLNB. Complication such as blue discoloration of the skin was also lower with MBD.</p></sec></abstract><kwd-group><kwd>Blue dye</kwd><kwd>breast cancer</kwd><kwd>local complication</kwd><kwd>sentinel lymph node</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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