Serveur d'exploration sur le lymphœdème

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Sentinel Lymph Node Biopsy in Uterine Cervical Cancer Patients: Ready for Clinical Use? A Review of the Literature

Identifieur interne : 003E97 ( Pmc/Curation ); précédent : 003E96; suivant : 003E98

Sentinel Lymph Node Biopsy in Uterine Cervical Cancer Patients: Ready for Clinical Use? A Review of the Literature

Auteurs : Viktoria-Varvara Palla [Grèce] ; Georgios Karaolanis [Grèce] ; Demetrios Moris [Grèce] ; Aristides Antsaklis [Grèce]

Source :

RBID : PMC:3914400

Abstract

Sentinel lymph node biopsy has been widely studied in a number of cancer types. As far as cervical cancer is concerned, this technique has already been used, revealing both positive results and several issues to be solved. The debate on the role of sentinel lymph node biopsy in cervical cancer is still open although most of the studies have already revealed its superiority over complete lymphadenectomy and the best handling possible of the emerging practical problems. Further research should be made in order to standardize this method and include it in the clinical routine.


Url:
DOI: 10.1155/2014/841618
PubMed: 24527233
PubMed Central: 3914400

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PMC:3914400

Le document en format XML

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<p>Sentinel lymph node biopsy has been widely studied in a number of cancer types. As far as cervical cancer is concerned, this technique has already been used, revealing both positive results and several issues to be solved. The debate on the role of sentinel lymph node biopsy in cervical cancer is still open although most of the studies have already revealed its superiority over complete lymphadenectomy and the best handling possible of the emerging practical problems. Further research should be made in order to standardize this method and include it in the clinical routine.</p>
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<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">ISRN Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">ISRN Surg</journal-id>
<journal-id journal-id-type="publisher-id">ISRN.SURGERY</journal-id>
<journal-title-group>
<journal-title>ISRN Surgery</journal-title>
</journal-title-group>
<issn pub-type="ppub">2090-5785</issn>
<issn pub-type="epub">2090-5793</issn>
<publisher>
<publisher-name>Hindawi Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">24527233</article-id>
<article-id pub-id-type="pmc">3914400</article-id>
<article-id pub-id-type="doi">10.1155/2014/841618</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Review Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Sentinel Lymph Node Biopsy in Uterine Cervical Cancer Patients: Ready for Clinical Use? A Review of the Literature</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Palla</surname>
<given-names>Viktoria-Varvara</given-names>
</name>
<xref ref-type="aff" rid="I1">
<sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Karaolanis</surname>
<given-names>Georgios</given-names>
</name>
<xref ref-type="aff" rid="I2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Moris</surname>
<given-names>Demetrios</given-names>
</name>
<xref ref-type="aff" rid="I3">
<sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Antsaklis</surname>
<given-names>Aristides</given-names>
</name>
<xref ref-type="aff" rid="I1">
<sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="I1">
<sup>1</sup>
1st Department of Obstetrics and Gynecology, School of Medicine, National & Kapodistrian University of Athens, “Alexandra” General Hospital, Athens, Greece</aff>
<aff id="I2">
<sup>2</sup>
2nd Department of Surgery, Vascular Surgery Unit, Laiko General Hospital, Medical School of Athens, Athens, Greece</aff>
<aff id="I3">
<sup>3</sup>
1st Department of Surgery, Vascular Surgery Unit, Laiko General Hospital, Medical School of Athens, Athens, Greece</aff>
<author-notes>
<corresp id="cor1">*Viktoria-Varvara Palla:
<email>vickypalla21@gmail.com</email>
</corresp>
<fn fn-type="other">
<p>Academic Editors: M. G. Chiofalo, D. Galetta, S. Ng, G. I. Salti, and J. R. Van Der Sijp</p>
</fn>
</author-notes>
<pub-date pub-type="collection">
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>16</day>
<month>1</month>
<year>2014</year>
</pub-date>
<volume>2014</volume>
<elocation-id>841618</elocation-id>
<history>
<date date-type="received">
<day>21</day>
<month>10</month>
<year>2013</year>
</date>
<date date-type="accepted">
<day>11</day>
<month>12</month>
<year>2013</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © 2014 Viktoria-Varvara Palla et al.</copyright-statement>
<copyright-year>2014</copyright-year>
<license xlink:href="https://creativecommons.org/licenses/by/3.0/">
<license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract>
<p>Sentinel lymph node biopsy has been widely studied in a number of cancer types. As far as cervical cancer is concerned, this technique has already been used, revealing both positive results and several issues to be solved. The debate on the role of sentinel lymph node biopsy in cervical cancer is still open although most of the studies have already revealed its superiority over complete lymphadenectomy and the best handling possible of the emerging practical problems. Further research should be made in order to standardize this method and include it in the clinical routine.</p>
</abstract>
</article-meta>
</front>
<floats-group>
<table-wrap id="tab1" orientation="portrait" position="float">
<label>Table 1</label>
<caption>
<p>Summary of clinical trials reviewed that served to validate the importance of sentinel lymph node mapping in cervical cancer patients.</p>
</caption>
<table frame="hsides" rules="groups">
<tbody>
<tr>
<td align="left" rowspan="1" colspan="1">Roca et al. [
<xref rid="B28" ref-type="bibr">28</xref>
]</td>
<td align="left" rowspan="1" colspan="1">Sentinel lymph node biopsy is a beneficial technique in order to avoid lymph node dissection in early stages of cervical cancer. It has a high negative predictive value and is simple to be incorporated into clinical routine. </td>
</tr>
<tr>
<td align="left" colspan="2" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">Coutant et al. [
<xref rid="B29" ref-type="bibr">29</xref>
]</td>
<td align="left" rowspan="1" colspan="1">Combination of sentinel lymph node biopsy and HPV DNA screening of the excised nodes serves better evaluation of lymph node status and better identification of women at high risk of recurrence.</td>
</tr>
<tr>
<td align="left" colspan="2" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">Altgassen et al. [
<xref rid="B30" ref-type="bibr">30</xref>
]</td>
<td align="left" rowspan="1" colspan="1">(i) Systemic lymphadenectomy cannot be omitted from the management of cervical cancer patients.
<break></break>
(ii) Sentinel lymph node biopsy may be profitable for patients with tumour diameter < or = 20 mm.</td>
</tr>
<tr>
<td align="left" colspan="2" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">Darlin et al. [
<xref rid="B27" ref-type="bibr">27</xref>
]</td>
<td align="left" rowspan="1" colspan="1">(i) The negative predictive value of sentinel lymph node biopsy reaches 100% in tumours < or = 20 mm and 95% in larger tumours.
<break></break>
(ii) In case of unilateral sentinel lymph node detection, complete lymphadenectomy should be performed on the radionegative side.
<break></break>
(iii) All bulky nodes should be removed.</td>
</tr>
<tr>
<td align="left" colspan="2" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">Gortzak-Uzan et al. [
<xref rid="B13" ref-type="bibr">13</xref>
]</td>
<td align="left" rowspan="1" colspan="1">Sentinel lymph node biopsy is a more sensitive procedure in early cervical cancer compared to complete lymphadenectomy (false-negative value = 0%, negative predictive value = 100%).</td>
</tr>
<tr>
<td align="left" colspan="2" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">Vicus and Covens [
<xref rid="B31" ref-type="bibr">31</xref>
]</td>
<td align="left" rowspan="1" colspan="1">Sentinel lymph node biopsy techniques improve the detection rate of lymph node metastases by 2.8-fold.</td>
</tr>
<tr>
<td align="left" colspan="2" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">Díaz-Feijoo et al. [
<xref rid="B32" ref-type="bibr">32</xref>
]</td>
<td align="left" rowspan="1" colspan="1">SPECT/CT imaging improves the detection rate of lymph node metastases and allows easier intraoperative detection with gamma probe.</td>
</tr>
<tr>
<td align="left" colspan="2" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">Du et al. [
<xref rid="B14" ref-type="bibr">14</xref>
]</td>
<td align="left" rowspan="1" colspan="1">(i) Sentinel lymph node biopsy is associated with stage, tumour size, histologic type, preoperative treatment, and history of preoperative conization.
<break></break>
(ii) Sentinel lymph node biopsy has a sensitivity rate of 100%, an accuracy value of 100%, a false-negative predictive value of 0%, and a negative predictive value of 100% in stages IA2–IB1.
<break></break>
(iii) Sentinel lymph node navigation surgery can provide large benefits for selected patients who desire fertility preservation.</td>
</tr>
<tr>
<td align="left" colspan="2" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">Roy et al. [
<xref rid="B12" ref-type="bibr">12</xref>
]</td>
<td align="left" rowspan="1" colspan="1">Sentinel lymph node mapping in combination with ultrastaging can identify patients with micrometastases and isolated tumour cells in the nodes and eventually the patients with high risk of recurrence.</td>
</tr>
<tr>
<td align="left" colspan="2" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">Diaz et al. [
<xref rid="B33" ref-type="bibr">33</xref>
]</td>
<td align="left" rowspan="1" colspan="1">(i) Sentinel lymph node mapping reduces the morbidity of surgical management of early-stage cervical cancer.
<break></break>
(ii) Sentinel lymph node negative patients are safe to undergo a less radical parametrial resection for small tumour volume.</td>
</tr>
<tr>
<td align="left" colspan="2" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">Devaja et al. [
<xref rid="B34" ref-type="bibr">34</xref>
]</td>
<td align="left" rowspan="1" colspan="1">Sentinel lymph node mapping techniques reach a detection rate of 97.5% (73.3% bilaterally), with no false-negative cases and no adverse reactions.</td>
</tr>
<tr>
<td align="left" colspan="2" rowspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" rowspan="1" colspan="1">Cibula et al. [
<xref rid="B35" ref-type="bibr">35</xref>
]</td>
<td align="left" rowspan="1" colspan="1">(i) In cases of bilateral detection of sentinel nodes, the sentinel lymph node mapping method has a high sensitivity and a low false-negative rate.
<break></break>
(ii) Sentinel lymph node mapping and ultrastaging should become standard practice in the surgical management of early-stage cervical cancer.</td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
</record>

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