Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery
Identifieur interne : 003611 ( Pmc/Curation ); précédent : 003610; suivant : 003612Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery
Auteurs : Susan N. Thomas [États-Unis] ; Alex Schudel [États-Unis]Source :
- Current opinion in chemical engineering [ 2211-3398 ] ; 2015.
Abstract
Despite drug formulation improving circulation times and targeting, efficacy is stymied by inadequate penetration into and retention within target tissues. This review highlights the barriers restricting delivery to the connective tissue interstitium, lymphatics, and lymph nodes as well as advances in engineering drug carriers to overcome these delivery challenges. Three-dimensional tissue physiology is discussed in the context of providing material design principles for delivery to these tissues; in particular the influence of interstitial and lymphatic flows as well as differential permeabilities of the blood and lymphatic capillaries. Key examples of materials with different characteristics developed to overcome these transport barriers are discussed as well as potential areas for further development.
Url:
DOI: 10.1016/j.coche.2014.11.003
PubMed: 25745594
PubMed Central: 4345645
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Thomas</name><affiliation wicri:level="1"><nlm:aff id="A1">George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332</wicri:regionArea></affiliation></author><author><name sortKey="Schudel, Alex" sort="Schudel, Alex" uniqKey="Schudel A" first="Alex" last="Schudel">Alex Schudel</name><affiliation wicri:level="1"><nlm:aff id="A2">Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">School of Materials Science and Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Materials Science and Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332</wicri:regionArea></affiliation></author></analytic><series><title level="j">Current opinion in chemical engineering</title><idno type="eISSN">2211-3398</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Despite drug formulation improving circulation times and targeting, efficacy is stymied by inadequate penetration into and retention within target tissues. This review highlights the barriers restricting delivery to the connective tissue interstitium, lymphatics, and lymph nodes as well as advances in engineering drug carriers to overcome these delivery challenges. Three-dimensional tissue physiology is discussed in the context of providing material design principles for delivery to these tissues; in particular the influence of interstitial and lymphatic flows as well as differential permeabilities of the blood and lymphatic capillaries. Key examples of materials with different characteristics developed to overcome these transport barriers are discussed as well as potential areas for further development.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101590557</journal-id><journal-id journal-id-type="pubmed-jr-id">40594</journal-id><journal-id journal-id-type="nlm-ta">Curr Opin Chem Eng</journal-id><journal-id journal-id-type="iso-abbrev">Curr Opin Chem Eng</journal-id><journal-title-group><journal-title>Current opinion in chemical engineering</journal-title></journal-title-group><issn pub-type="epub">2211-3398</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25745594</article-id><article-id pub-id-type="pmc">4345645</article-id><article-id pub-id-type="doi">10.1016/j.coche.2014.11.003</article-id><article-id pub-id-type="manuscript">NIHMS643728</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Thomas</surname><given-names>Susan N.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Schudel</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref></contrib></contrib-group><aff id="A1"><label>a</label>George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332, USA</aff><aff id="A2"><label>b</label>Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332, USA</aff><aff id="A3"><label>c</label>School of Materials Science and Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332, USA</aff><author-notes><corresp id="FN1"><label>*</label>Address for Correspondence: Susan N. Thomas, Georgia Institute of Technology, 315 Ferst Drive NW, IBB 2315, Atlanta, GA 30332, Tel: +1 (404) 385 1126, Fax: +1 (404) 385 1397, <email>susan.thomas@gatech.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>1</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2016</year></pub-date><volume>7</volume><fpage>65</fpage><lpage>74</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.coche.2014.11.003</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p id="P1">Despite drug formulation improving circulation times and targeting, efficacy is stymied by inadequate penetration into and retention within target tissues. This review highlights the barriers restricting delivery to the connective tissue interstitium, lymphatics, and lymph nodes as well as advances in engineering drug carriers to overcome these delivery challenges. Three-dimensional tissue physiology is discussed in the context of providing material design principles for delivery to these tissues; in particular the influence of interstitial and lymphatic flows as well as differential permeabilities of the blood and lymphatic capillaries. Key examples of materials with different characteristics developed to overcome these transport barriers are discussed as well as potential areas for further development.</p></abstract><kwd-group><kwd>drug delivery</kwd><kwd>interstitium</kwd><kwd>lymphatics</kwd><kwd>lymph node</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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