The Lymphatic System in Health and Disease
Identifieur interne : 003479 ( Pmc/Curation ); précédent : 003478; suivant : 003480The Lymphatic System in Health and Disease
Auteurs : Leah N. Cueni ; Michael DetmarSource :
- Lymphatic research and biology [ 1539-6851 ] ; 2008.
Abstract
The lymphatic vascular system has an important role in the regulation of tissue pressure, immune surveillance and the absorption of dietary fat in the intestine. There is growing evidence that the lymphatic system also contributes to a number of diseases, such as lymphedema, cancer metastasis and different inflammatory disorders. The discovery of various molecular markers allowing the distinction of blood and lymphatic vessels, together with the availability of a increasing number of
Url:
DOI: 10.1089/lrb.2008.1008
PubMed: 19093783
PubMed Central: 3572233
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Lymphatic System in Health and Disease</title><author><name sortKey="Cueni, Leah N" sort="Cueni, Leah N" uniqKey="Cueni L" first="Leah N." last="Cueni">Leah N. Cueni</name></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19093783</idno><idno type="pmc">3572233</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572233</idno><idno type="RBID">PMC:3572233</idno><idno type="doi">10.1089/lrb.2008.1008</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">003480</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003480</idno><idno type="wicri:Area/Pmc/Curation">003479</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003479</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Lymphatic System in Health and Disease</title><author><name sortKey="Cueni, Leah N" sort="Cueni, Leah N" uniqKey="Cueni L" first="Leah N." last="Cueni">Leah N. Cueni</name></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></analytic><series><title level="j">Lymphatic research and biology</title><idno type="ISSN">1539-6851</idno><idno type="eISSN">1557-8585</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The lymphatic vascular system has an important role in the regulation of tissue pressure, immune surveillance and the absorption of dietary fat in the intestine. There is growing evidence that the lymphatic system also contributes to a number of diseases, such as lymphedema, cancer metastasis and different inflammatory disorders. The discovery of various molecular markers allowing the distinction of blood and lymphatic vessels, together with the availability of a increasing number of <italic>in vitro</italic> and <italic>in vivo</italic> models to study various aspects of lymphatic biology, has enabled tremendous progress in research into the development and function of the lymphatic system. This review discusses recent advances in our understanding of the embryonic development of the lymphatic vasculature, the molecular mechanisms mediating lymphangiogenesis in the adult, the role of lymphangiogenesis in chronic inflammation and lymphatic cancer metastasis, and the emerging importance of the lymphatic vasculature as a therapeutic target.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101163587</journal-id><journal-id journal-id-type="pubmed-jr-id">32169</journal-id><journal-id journal-id-type="nlm-ta">Lymphat Res Biol</journal-id><journal-id journal-id-type="iso-abbrev">Lymphat Res Biol</journal-id><journal-title-group><journal-title>Lymphatic research and biology</journal-title></journal-title-group><issn pub-type="ppub">1539-6851</issn><issn pub-type="epub">1557-8585</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19093783</article-id><article-id pub-id-type="pmc">3572233</article-id><article-id pub-id-type="doi">10.1089/lrb.2008.1008</article-id><article-id pub-id-type="manuscript">NIHMS109746</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The Lymphatic System in Health and Disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cueni</surname><given-names>Leah N.</given-names></name><degrees>M.Sc.</degrees></contrib><contrib contrib-type="author"><name><surname>Detmar</surname><given-names>Michael</given-names></name><degrees>M.D.</degrees></contrib><aff id="A1">Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland</aff></contrib-group><author-notes><corresp id="CR1">Address reprint requests to: Michael Detmar, M.D. Institute of Pharmaceutical Sciences Swiss Federal Institute of Technology (ETH) Zurich Wolfgang-Pauli-Str. 10, HCI H303 CH-8093 Zurich, Switzerland <email>michael.detmar@pharma.ethz.ch</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>18</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="ppub"><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>14</day><month>2</month><year>2013</year></pub-date><volume>6</volume><issue>3-4</issue><fpage>109</fpage><lpage>122</lpage><permissions><copyright-statement>© Mary Ann Liebert, Inc.</copyright-statement></permissions><abstract><p id="P1">The lymphatic vascular system has an important role in the regulation of tissue pressure, immune surveillance and the absorption of dietary fat in the intestine. There is growing evidence that the lymphatic system also contributes to a number of diseases, such as lymphedema, cancer metastasis and different inflammatory disorders. The discovery of various molecular markers allowing the distinction of blood and lymphatic vessels, together with the availability of a increasing number of <italic>in vitro</italic> and <italic>in vivo</italic> models to study various aspects of lymphatic biology, has enabled tremendous progress in research into the development and function of the lymphatic system. This review discusses recent advances in our understanding of the embryonic development of the lymphatic vasculature, the molecular mechanisms mediating lymphangiogenesis in the adult, the role of lymphangiogenesis in chronic inflammation and lymphatic cancer metastasis, and the emerging importance of the lymphatic vasculature as a therapeutic target.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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