Associations between cytokine gene variations and severe persistent breast pain in women following breast cancer surgery
Identifieur interne : 003428 ( Pmc/Curation ); précédent : 003427; suivant : 003429Associations between cytokine gene variations and severe persistent breast pain in women following breast cancer surgery
Auteurs : Kimberly Stephens [États-Unis] ; Bruce A. Cooper [États-Unis] ; Claudia West [États-Unis] ; Steven M. Paul [États-Unis] ; Christina R. Baggott [États-Unis] ; John D. Merriman [États-Unis] ; Anand Dhruva [États-Unis] ; Kord M. Kober [États-Unis] ; Dale J. Langford [États-Unis] ; Heather Leutwyler [États-Unis] ; Judith A. Luce [États-Unis] ; Brian L. Schmidt [États-Unis] ; Gary M. Abrams [États-Unis] ; Charles Elboim [États-Unis] ; Deborah Hamolsky [États-Unis] ; Jon D. Levine [États-Unis] ; Christine Miaskowski [États-Unis] ; Bradley E. Aouizerat [États-Unis]Source :
- The journal of pain : official journal of the American Pain Society [ 1526-5900 ] ; 2013.
Abstract
Persistent pain following breast cancer surgery is a significant clinical problem. While immune mechanisms may play a role in the development and maintenance of persistent pain, few studies have evaluated for associations between persistent breast pain following breast cancer surgery and variations in cytokine genes. In this study, associations between previously identified extreme persistent breast pain phenotypes (i.e., no pain versus severe pain) and single nucleotide polymorphisms (SNPs) spanning 15 cytokine genes were evaluated. In unadjusted analyses, the frequency of 13 SNPs and 3 haplotypes in 7 genes differed significantly between the no pain and severe pain classes. After adjustment for preoperative breast pain and the severity of average postoperative pain, one SNPs (i.e., interleukin (IL) 1 receptor 2 rs11674595) and one haplotype (i.e., IL10 haplotype A8) were associated with pain group membership. These findings suggest a role for cytokine gene polymorphisms in the development of persistent breast pain following breast cancer surgery.
This study evaluated for associations between cytokine gene variations and the severity of persistent breast pain in women following breast cancer surgery. Variations in two cytokine genes were associated with severe breast pain. The results suggest that cytokines play a role in the development of persistent postsurgical pain.
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DOI: 10.1016/j.jpain.2013.09.015
PubMed: 24411993
PubMed Central: 4331184
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Langford</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Leutwyler, Heather" sort="Leutwyler, Heather" uniqKey="Leutwyler H" first="Heather" last="Leutwyler">Heather Leutwyler</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Luce, Judith A" sort="Luce, Judith A" uniqKey="Luce J" first="Judith A." last="Luce">Judith A. 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Abrams</name><affiliation wicri:level="1"><nlm:aff id="A2">School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0410, San Francisco, CA 94143-0410, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0410, San Francisco, CA 94143-0410</wicri:regionArea></affiliation></author><author><name sortKey="Elboim, Charles" sort="Elboim, Charles" uniqKey="Elboim C" first="Charles" last="Elboim">Charles Elboim</name><affiliation wicri:level="1"><nlm:aff id="A4">Redwood Regional Medical Group, 121 Sotoyome Street, Santa Rosa, CA 95405, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Redwood Regional Medical Group, 121 Sotoyome Street, Santa Rosa, CA 95405</wicri:regionArea></affiliation></author><author><name sortKey="Hamolsky, Deborah" sort="Hamolsky, Deborah" uniqKey="Hamolsky D" first="Deborah" last="Hamolsky">Deborah Hamolsky</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Levine, Jon D" sort="Levine, Jon D" uniqKey="Levine J" first="Jon D." last="Levine">Jon D. Levine</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Oral and Maxillofacial Surgery, University of California, San Francisco, 521 Parnassus Avenue, Box 0440, San Francisco, CA 94143-0440, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, University of California, San Francisco, 521 Parnassus Avenue, Box 0440, San Francisco, CA 94143-0440</wicri:regionArea></affiliation></author><author><name sortKey="Miaskowski, Christine" sort="Miaskowski, Christine" uniqKey="Miaskowski C" first="Christine" last="Miaskowski">Christine Miaskowski</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Aouizerat, Bradley E" sort="Aouizerat, Bradley E" uniqKey="Aouizerat B" first="Bradley E." last="Aouizerat">Bradley E. 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Cooper</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="West, Claudia" sort="West, Claudia" uniqKey="West C" first="Claudia" last="West">Claudia West</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Paul, Steven M" sort="Paul, Steven M" uniqKey="Paul S" first="Steven M." last="Paul">Steven M. Paul</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Baggott, Christina R" sort="Baggott, Christina R" uniqKey="Baggott C" first="Christina R." last="Baggott">Christina R. Baggott</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Merriman, John D" sort="Merriman, John D" uniqKey="Merriman J" first="John D." last="Merriman">John D. Merriman</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Dhruva, Anand" sort="Dhruva, Anand" uniqKey="Dhruva A" first="Anand" last="Dhruva">Anand Dhruva</name><affiliation wicri:level="1"><nlm:aff id="A2">School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0410, San Francisco, CA 94143-0410, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0410, San Francisco, CA 94143-0410</wicri:regionArea></affiliation></author><author><name sortKey="Kober, Kord M" sort="Kober, Kord M" uniqKey="Kober K" first="Kord M." last="Kober">Kord M. Kober</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Langford, Dale J" sort="Langford, Dale J" uniqKey="Langford D" first="Dale J." last="Langford">Dale J. Langford</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Leutwyler, Heather" sort="Leutwyler, Heather" uniqKey="Leutwyler H" first="Heather" last="Leutwyler">Heather Leutwyler</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Luce, Judith A" sort="Luce, Judith A" uniqKey="Luce J" first="Judith A." last="Luce">Judith A. Luce</name><affiliation wicri:level="1"><nlm:aff id="A2">School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0410, San Francisco, CA 94143-0410, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0410, San Francisco, CA 94143-0410</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Brian L" sort="Schmidt, Brian L" uniqKey="Schmidt B" first="Brian L." last="Schmidt">Brian L. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Oral Maxillofacial Surgery, New York University College of Dentistry, 421 First Avenue, 233W, New York, NY 10010, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Maxillofacial Surgery, New York University College of Dentistry, 421 First Avenue, 233W, New York, NY 10010</wicri:regionArea></affiliation></author><author><name sortKey="Abrams, Gary M" sort="Abrams, Gary M" uniqKey="Abrams G" first="Gary M." last="Abrams">Gary M. Abrams</name><affiliation wicri:level="1"><nlm:aff id="A2">School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0410, San Francisco, CA 94143-0410, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0410, San Francisco, CA 94143-0410</wicri:regionArea></affiliation></author><author><name sortKey="Elboim, Charles" sort="Elboim, Charles" uniqKey="Elboim C" first="Charles" last="Elboim">Charles Elboim</name><affiliation wicri:level="1"><nlm:aff id="A4">Redwood Regional Medical Group, 121 Sotoyome Street, Santa Rosa, CA 95405, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Redwood Regional Medical Group, 121 Sotoyome Street, Santa Rosa, CA 95405</wicri:regionArea></affiliation></author><author><name sortKey="Hamolsky, Deborah" sort="Hamolsky, Deborah" uniqKey="Hamolsky D" first="Deborah" last="Hamolsky">Deborah Hamolsky</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Levine, Jon D" sort="Levine, Jon D" uniqKey="Levine J" first="Jon D." last="Levine">Jon D. Levine</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Oral and Maxillofacial Surgery, University of California, San Francisco, 521 Parnassus Avenue, Box 0440, San Francisco, CA 94143-0440, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, University of California, San Francisco, 521 Parnassus Avenue, Box 0440, San Francisco, CA 94143-0440</wicri:regionArea></affiliation></author><author><name sortKey="Miaskowski, Christine" sort="Miaskowski, Christine" uniqKey="Miaskowski C" first="Christine" last="Miaskowski">Christine Miaskowski</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation></author><author><name sortKey="Aouizerat, Bradley E" sort="Aouizerat, Bradley E" uniqKey="Aouizerat B" first="Bradley E." last="Aouizerat">Bradley E. Aouizerat</name><affiliation wicri:level="1"><nlm:aff id="A1">School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Box 0794, San Francisco, CA 94143-0794, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Box 0794, San Francisco, CA 94143-0794</wicri:regionArea></affiliation></author></analytic><series><title level="j">The journal of pain : official journal of the American Pain Society</title><idno type="ISSN">1526-5900</idno><idno type="eISSN">1528-8447</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Persistent pain following breast cancer surgery is a significant clinical problem. While immune mechanisms may play a role in the development and maintenance of persistent pain, few studies have evaluated for associations between persistent breast pain following breast cancer surgery and variations in cytokine genes. In this study, associations between previously identified extreme persistent breast pain phenotypes (i.e., no pain versus severe pain) and single nucleotide polymorphisms (SNPs) spanning 15 cytokine genes were evaluated. In unadjusted analyses, the frequency of 13 SNPs and 3 haplotypes in 7 genes differed significantly between the no pain and severe pain classes. After adjustment for preoperative breast pain and the severity of average postoperative pain, one SNPs (i.e., interleukin (IL) 1 receptor 2 rs11674595) and one haplotype (i.e., IL10 haplotype A8) were associated with pain group membership. These findings suggest a role for cytokine gene polymorphisms in the development of persistent breast pain following breast cancer surgery.</p><sec id="S1"><title>Perspective</title><p id="P3">This study evaluated for associations between cytokine gene variations and the severity of persistent breast pain in women following breast cancer surgery. Variations in two cytokine genes were associated with severe breast pain. The results suggest that cytokines play a role in the development of persistent postsurgical pain.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100898657</journal-id><journal-id journal-id-type="pubmed-jr-id">31708</journal-id><journal-id journal-id-type="nlm-ta">J Pain</journal-id><journal-id journal-id-type="iso-abbrev">J Pain</journal-id><journal-title-group><journal-title>The journal of pain : official journal of the American Pain Society</journal-title></journal-title-group><issn pub-type="ppub">1526-5900</issn><issn pub-type="epub">1528-8447</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24411993</article-id><article-id pub-id-type="pmc">4331184</article-id><article-id pub-id-type="doi">10.1016/j.jpain.2013.09.015</article-id><article-id pub-id-type="manuscript">NIHMS555528</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Associations between cytokine gene variations and severe persistent breast pain in women following breast cancer surgery</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Stephens</surname><given-names>Kimberly</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>Bruce A.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>West</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Paul</surname><given-names>Steven M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Baggott</surname><given-names>Christina R.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Merriman</surname><given-names>John D.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Dhruva</surname><given-names>Anand</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kober</surname><given-names>Kord M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Langford</surname><given-names>Dale J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Leutwyler</surname><given-names>Heather</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Luce</surname><given-names>Judith A.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Brian L.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Abrams</surname><given-names>Gary M.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Elboim</surname><given-names>Charles</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Hamolsky</surname><given-names>Deborah</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Levine</surname><given-names>Jon D.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Miaskowski</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Aouizerat</surname><given-names>Bradley E.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A6">6</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="author-notes" rid="FN1">†</xref></contrib></contrib-group><aff id="A1"><label>1</label>School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States</aff><aff id="A2"><label>2</label>School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0410, San Francisco, CA 94143-0410, United States</aff><aff id="A3"><label>3</label>Department of Oral Maxillofacial Surgery, New York University College of Dentistry, 421 First Avenue, 233W, New York, NY 10010, United States</aff><aff id="A4"><label>4</label>Redwood Regional Medical Group, 121 Sotoyome Street, Santa Rosa, CA 95405, United States</aff><aff id="A5"><label>5</label>Department of Oral and Maxillofacial Surgery, University of California, San Francisco, 521 Parnassus Avenue, Box 0440, San Francisco, CA 94143-0440, United States</aff><aff id="A6"><label>6</label>Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Box 0794, San Francisco, CA 94143-0794, United States</aff><author-notes><corresp id="cor1"><label>*</label>Corresponding author. Address: School of Nursing, University of California, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, United States. Tel.: 1-415-476-4658, Fax: 1-415-476-8899, <email>bradley.aouizerat@nursing.ucsf.edu</email></corresp><fn id="FN1"><label>†</label><p id="P1">Dual authorship</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>12</day><month>10</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>2</month><year>2015</year></pub-date><volume>15</volume><issue>2</issue><fpage>169</fpage><lpage>180</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.jpain.2013.09.015</pmc-comment>
<permissions><copyright-statement>© 2013 The American Pain Society. Published by Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P2">Persistent pain following breast cancer surgery is a significant clinical problem. While immune mechanisms may play a role in the development and maintenance of persistent pain, few studies have evaluated for associations between persistent breast pain following breast cancer surgery and variations in cytokine genes. In this study, associations between previously identified extreme persistent breast pain phenotypes (i.e., no pain versus severe pain) and single nucleotide polymorphisms (SNPs) spanning 15 cytokine genes were evaluated. In unadjusted analyses, the frequency of 13 SNPs and 3 haplotypes in 7 genes differed significantly between the no pain and severe pain classes. After adjustment for preoperative breast pain and the severity of average postoperative pain, one SNPs (i.e., interleukin (IL) 1 receptor 2 rs11674595) and one haplotype (i.e., IL10 haplotype A8) were associated with pain group membership. These findings suggest a role for cytokine gene polymorphisms in the development of persistent breast pain following breast cancer surgery.</p><sec id="S1"><title>Perspective</title><p id="P3">This study evaluated for associations between cytokine gene variations and the severity of persistent breast pain in women following breast cancer surgery. Variations in two cytokine genes were associated with severe breast pain. The results suggest that cytokines play a role in the development of persistent postsurgical pain.</p></sec></abstract><kwd-group><kwd>cytokines</kwd><kwd>polymorphism</kwd><kwd>breast cancer surgery</kwd><kwd>candidate genes</kwd><kwd>persistent pain</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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