Associations Between Pro- and Anti-Inflammatory Cytokine Genes and Breast Pain in Women Prior to Breast Cancer Surgery
Identifieur interne : 003426 ( Pmc/Curation ); précédent : 003425; suivant : 003427Associations Between Pro- and Anti-Inflammatory Cytokine Genes and Breast Pain in Women Prior to Breast Cancer Surgery
Auteurs : Birha Mccann [États-Unis] ; Christine Miaskowski [États-Unis] ; Theresa Koetters [États-Unis] ; Christina Baggott [États-Unis] ; Claudia West [États-Unis] ; Jon D. Levine [États-Unis] ; Charles Elboim [États-Unis] ; Gary Abrams [États-Unis] ; Deborah Hamolsky [États-Unis] ; Laura Dunn [États-Unis] ; Hope Rugo [États-Unis] ; Marylin Dodd [États-Unis] ; Steven M. Paul [États-Unis] ; John Neuhaus [États-Unis] ; Bruce Cooper [États-Unis] ; Brian Schmidt [États-Unis] ; Dale Langford [États-Unis] ; Janine Cataldo [États-Unis] ; Bradley E. Aouizerat [États-Unis]Source :
- The Journal of Pain [ 1526-5900 ] ; 2012.
Abstract
Study purposes were to determine the occurrence rate for preoperative breast pain; describe the characteristics of this pain; evaluate for differences in demographic and clinical characteristics; and evaluate for variations in pro- and anti-inflammatory cytokine genes between women who did and did not report pain. Patients (n=398) were recruited prior to surgery and completed self-report questionnaires on a number of pain characteristics. Genotyping was done using a custom genotyping array. Women (28.2%) who reported breast pain were significantly younger (p < 0.001); more likely to be non-white (p= 0.032); reported significantly lower Karnofsky Performance Status scores (p = 0.008); were less likely to be post menopausal (p = 0.012), and had undergone significantly more biopsies (p=0.006). Carriers of the minor allele for a single nucleotide polymorphism (SNP) in interleukin (IL)1-receptor 1 (IL1R1) (rs2110726) were less likely to report breast pain prior to surgery (p = 0.007). Carriers of the minor allele for a SNP in IL13 (rs1295686) were more likely to report breast pain prior to surgery (p= 0.019). Findings suggest that breast pain occurs in over a quarter of women who are about to undergo breast cancer surgery. Based on phenotypic and genotypic characteristics found, inflammatory mechanisms contribute to preoperative breast pain.
Url:
DOI: 10.1016/j.jpain.2011.02.358
PubMed: 22515947
PubMed Central: 3348353
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<series><title level="j">The Journal of Pain</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Study purposes were to determine the occurrence rate for preoperative breast pain; describe the characteristics of this pain; evaluate for differences in demographic and clinical characteristics; and evaluate for variations in pro- and anti-inflammatory cytokine genes between women who did and did not report pain. Patients (n=398) were recruited prior to surgery and completed self-report questionnaires on a number of pain characteristics. Genotyping was done using a custom genotyping array. Women (28.2%) who reported breast pain were significantly younger (p < 0.001); more likely to be non-white (p= 0.032); reported significantly lower Karnofsky Performance Status scores (p = 0.008); were less likely to be post menopausal (p = 0.012), and had undergone significantly more biopsies (p=0.006). Carriers of the minor allele for a single nucleotide polymorphism (SNP) in interleukin (IL)1-receptor 1 (IL1R1) (rs2110726) were less likely to report breast pain prior to surgery (p = 0.007). Carriers of the minor allele for a SNP in IL13 (rs1295686) were more likely to report breast pain prior to surgery (p= 0.019). Findings suggest that breast pain occurs in over a quarter of women who are about to undergo breast cancer surgery. Based on phenotypic and genotypic characteristics found, inflammatory mechanisms contribute to preoperative breast pain.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100898657</journal-id>
<journal-id journal-id-type="pubmed-jr-id">31708</journal-id>
<journal-id journal-id-type="nlm-ta">J Pain</journal-id>
<journal-id journal-id-type="iso-abbrev">J Pain</journal-id>
<journal-title-group><journal-title>The Journal of Pain</journal-title>
</journal-title-group>
<issn pub-type="ppub">1526-5900</issn>
<issn pub-type="epub">1528-8447</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22515947</article-id>
<article-id pub-id-type="pmc">3348353</article-id>
<article-id pub-id-type="doi">10.1016/j.jpain.2011.02.358</article-id>
<article-id pub-id-type="manuscript">NIHMS371615</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Associations Between Pro- and Anti-Inflammatory Cytokine Genes and Breast Pain in Women Prior to Breast Cancer Surgery</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>McCann</surname>
<given-names>Birha</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miaskowski</surname>
<given-names>Christine</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koetters</surname>
<given-names>Theresa</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baggott</surname>
<given-names>Christina</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>West</surname>
<given-names>Claudia</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Levine</surname>
<given-names>Jon D.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Elboim</surname>
<given-names>Charles</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Abrams</surname>
<given-names>Gary</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hamolsky</surname>
<given-names>Deborah</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dunn</surname>
<given-names>Laura</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rugo</surname>
<given-names>Hope</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dodd</surname>
<given-names>Marylin</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Paul</surname>
<given-names>Steven M.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neuhaus</surname>
<given-names>John</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cooper</surname>
<given-names>Bruce</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmidt</surname>
<given-names>Brian</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Langford</surname>
<given-names>Dale</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cataldo</surname>
<given-names>Janine</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aouizerat</surname>
<given-names>Bradley E.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
School of Nursing, University of California, San Francisco, CA</aff>
<aff id="A2"><label>2</label>
School of Medicine, University of California, San Francisco, CA</aff>
<aff id="A3"><label>3</label>
Redwood Regional Oncology Group, Santa Rosa, CA</aff>
<aff id="A4"><label>4</label>
School of Dentistry, New York University, New York, NY</aff>
<aff id="A5"><label>5</label>
the Institute for Human Genetics, University of California, San Francisco, CA</aff>
<author-notes><corresp id="cor1">Address correspondence to: Christine Miaskowski, RN, PhD, FAAN, Professor, Department of Physiological Nursing, University of California, 2 Koret Way – N631Y, San Francisco, CA 94143-0610, 415-476-9407 (phone), 415-476-8899 (fax), <email>chris.miaskowski@nursing.ucsf.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>27</day>
<month>4</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>18</day>
<month>4</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><month>5</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>5</month>
<year>2013</year>
</pub-date>
<volume>13</volume>
<issue>5</issue>
<fpage>425</fpage>
<lpage>437</lpage>
<permissions><copyright-statement>© 2012 The American Pain Society. Published by Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<abstract><p id="P1">Study purposes were to determine the occurrence rate for preoperative breast pain; describe the characteristics of this pain; evaluate for differences in demographic and clinical characteristics; and evaluate for variations in pro- and anti-inflammatory cytokine genes between women who did and did not report pain. Patients (n=398) were recruited prior to surgery and completed self-report questionnaires on a number of pain characteristics. Genotyping was done using a custom genotyping array. Women (28.2%) who reported breast pain were significantly younger (p < 0.001); more likely to be non-white (p= 0.032); reported significantly lower Karnofsky Performance Status scores (p = 0.008); were less likely to be post menopausal (p = 0.012), and had undergone significantly more biopsies (p=0.006). Carriers of the minor allele for a single nucleotide polymorphism (SNP) in interleukin (IL)1-receptor 1 (IL1R1) (rs2110726) were less likely to report breast pain prior to surgery (p = 0.007). Carriers of the minor allele for a SNP in IL13 (rs1295686) were more likely to report breast pain prior to surgery (p= 0.019). Findings suggest that breast pain occurs in over a quarter of women who are about to undergo breast cancer surgery. Based on phenotypic and genotypic characteristics found, inflammatory mechanisms contribute to preoperative breast pain.</p>
</abstract>
<kwd-group><kwd>breast pain</kwd>
<kwd>inflammation</kwd>
<kwd>cytokine genes</kwd>
<kwd>preoperative pain</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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