The Effects of Body Mass Index on Complications and Survival Outcomes in Patients with Cervical Carcinoma Undergoing Curative Chemoradiation Therapy
Identifieur interne : 003369 ( Pmc/Curation ); précédent : 003368; suivant : 003370The Effects of Body Mass Index on Complications and Survival Outcomes in Patients with Cervical Carcinoma Undergoing Curative Chemoradiation Therapy
Auteurs : Nora T. Kizer [États-Unis] ; Premal H. Thaker [États-Unis] ; Feng Gao [États-Unis] ; Israel Zighelboim [États-Unis] ; Matthew A. Powell [États-Unis] ; Janet S. Rader [États-Unis] ; David G. Mutch [États-Unis] ; Perry W. Grigsby [États-Unis]Source :
- Cancer [ 0008-543X ] ; 2010.
Abstract
The effect of body mass index (BMI) on treatment outcomes for patients with locally advanced cervical carcinoma undergoing definitive chemoradiation is unclear.
This study cohort included all cervical carcinoma patients (n = 404) with stage IB1 and positive lymph nodes or stage ≥ IB2 treated at our facility from January 1998 to January 2008. Mean follow-up time was 47.2 months. BMI was calculated using the National Institute of Health online calculator. BMI categories were created according to the World Health Organization classification system. Primary outcomes were overall survival, disease free survival, and complication rate. Univariate and multivariate analyses were performed. Kaplan-Meier survival curves were generated and compared using Cox proportional hazard models.
On multivariate analysis, when compared to normal weight subjects (18.5-24.9 kg/m2), a BMI < 18.5 kg/m2 was associated with decreased overall survival (HR 2.37, 95% CI 1.28 - 4.38, p<0.01). The 5-year overall survivals were 33%, 60%, and 68% for a BMI < 18.5 kg/m2, BMI 18.5-24.9 kg/m2, and a BMI > 24.9 kg/m2 respectively. A BMI < 18.5 kg/m2 was associated with increased risk for grade 3 or 4 complications when compared to patients with a BMI > 24.9 kg/m2 (radiation enteritis: 16.7% vs. 13.6 % p= 0.03, fistula: 11.1% vs. 8.8% p= 0.05, bowel obstruction 33.3% vs. 4.4% p< 0.001, lymphedema: 5.6% vs. 1.2% p=0.02).
Underweight patients (BMI < 18.5 kg/m2) with locally advanced cervical cancer have diminished overall survival and more complications than normal weight and obese patients.
Url:
DOI: 10.1002/cncr.25544
PubMed: 20945318
PubMed Central: 4080792
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003370
Links to Exploration step
PMC:4080792Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Effects of Body Mass Index on Complications and Survival Outcomes in Patients with Cervical Carcinoma Undergoing Curative Chemoradiation Therapy</title>
<author><name sortKey="Kizer, Nora T" sort="Kizer, Nora T" uniqKey="Kizer N" first="Nora T." last="Kizer">Nora T. Kizer</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Thaker, Premal H" sort="Thaker, Premal H" uniqKey="Thaker P" first="Premal H." last="Thaker">Premal H. Thaker</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gao, Feng" sort="Gao, Feng" uniqKey="Gao F" first="Feng" last="Gao">Feng Gao</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Biostatistics, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Biostatistics, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zighelboim, Israel" sort="Zighelboim, Israel" uniqKey="Zighelboim I" first="Israel" last="Zighelboim">Israel Zighelboim</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Powell, Matthew A" sort="Powell, Matthew A" uniqKey="Powell M" first="Matthew A." last="Powell">Matthew A. Powell</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rader, Janet S" sort="Rader, Janet S" uniqKey="Rader J" first="Janet S." last="Rader">Janet S. Rader</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Division of Gynecologic Oncology, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mutch, David G" sort="Mutch, David G" uniqKey="Mutch D" first="David G." last="Mutch">David G. Mutch</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Grigsby, Perry W" sort="Grigsby, Perry W" uniqKey="Grigsby P" first="Perry W." last="Grigsby">Perry W. Grigsby</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Mallinckrodt Institute of Radiology, Division of Nuclear Medicine, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Mallinckrodt Institute of Radiology, Division of Nuclear Medicine, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20945318</idno>
<idno type="pmc">4080792</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080792</idno>
<idno type="RBID">PMC:4080792</idno>
<idno type="doi">10.1002/cncr.25544</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">003370</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003370</idno>
<idno type="wicri:Area/Pmc/Curation">003369</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003369</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Effects of Body Mass Index on Complications and Survival Outcomes in Patients with Cervical Carcinoma Undergoing Curative Chemoradiation Therapy</title>
<author><name sortKey="Kizer, Nora T" sort="Kizer, Nora T" uniqKey="Kizer N" first="Nora T." last="Kizer">Nora T. Kizer</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Thaker, Premal H" sort="Thaker, Premal H" uniqKey="Thaker P" first="Premal H." last="Thaker">Premal H. Thaker</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gao, Feng" sort="Gao, Feng" uniqKey="Gao F" first="Feng" last="Gao">Feng Gao</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Biostatistics, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Biostatistics, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zighelboim, Israel" sort="Zighelboim, Israel" uniqKey="Zighelboim I" first="Israel" last="Zighelboim">Israel Zighelboim</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Powell, Matthew A" sort="Powell, Matthew A" uniqKey="Powell M" first="Matthew A." last="Powell">Matthew A. Powell</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rader, Janet S" sort="Rader, Janet S" uniqKey="Rader J" first="Janet S." last="Rader">Janet S. Rader</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Division of Gynecologic Oncology, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mutch, David G" sort="Mutch, David G" uniqKey="Mutch D" first="David G." last="Mutch">David G. Mutch</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Grigsby, Perry W" sort="Grigsby, Perry W" uniqKey="Grigsby P" first="Perry W." last="Grigsby">Perry W. Grigsby</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Mallinckrodt Institute of Radiology, Division of Nuclear Medicine, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Mallinckrodt Institute of Radiology, Division of Nuclear Medicine, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Cancer</title>
<idno type="ISSN">0008-543X</idno>
<idno type="eISSN">1097-0142</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The effect of body mass index (BMI) on treatment outcomes for patients with locally advanced cervical carcinoma undergoing definitive chemoradiation is unclear.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">This study cohort included all cervical carcinoma patients (n = 404) with stage IB<sub>1</sub>
and positive lymph nodes or stage ≥ IB<sub>2</sub>
treated at our facility from January 1998 to January 2008. Mean follow-up time was 47.2 months. BMI was calculated using the National Institute of Health online calculator. BMI categories were created according to the World Health Organization classification system. Primary outcomes were overall survival, disease free survival, and complication rate. Univariate and multivariate analyses were performed. Kaplan-Meier survival curves were generated and compared using Cox proportional hazard models.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">On multivariate analysis, when compared to normal weight subjects (18.5-24.9 kg/m<sup>2</sup>
), a BMI < 18.5 kg/m<sup>2</sup>
was associated with decreased overall survival (HR 2.37, 95% CI 1.28 - 4.38, p<0.01). The 5-year overall survivals were 33%, 60%, and 68% for a BMI < 18.5 kg/m<sup>2</sup>
, BMI 18.5-24.9 kg/m<sup>2</sup>
, and a BMI > 24.9 kg/m<sup>2</sup>
respectively. A BMI < 18.5 kg/m<sup>2</sup>
was associated with increased risk for grade 3 or 4 complications when compared to patients with a BMI > 24.9 kg/m<sup>2</sup>
(radiation enteritis: 16.7% vs. 13.6 % p= 0.03, fistula: 11.1% vs. 8.8% p= 0.05, bowel obstruction 33.3% vs. 4.4% p< 0.001, lymphedema: 5.6% vs. 1.2% p=0.02).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Underweight patients (BMI < 18.5 kg/m<sup>2</sup>
) with locally advanced cervical cancer have diminished overall survival and more complications than normal weight and obese patients.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0374236</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2771</journal-id>
<journal-id journal-id-type="nlm-ta">Cancer</journal-id>
<journal-id journal-id-type="iso-abbrev">Cancer</journal-id>
<journal-title-group><journal-title>Cancer</journal-title>
</journal-title-group>
<issn pub-type="ppub">0008-543X</issn>
<issn pub-type="epub">1097-0142</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20945318</article-id>
<article-id pub-id-type="pmc">4080792</article-id>
<article-id pub-id-type="doi">10.1002/cncr.25544</article-id>
<article-id pub-id-type="manuscript">NIHMS302602</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The Effects of Body Mass Index on Complications and Survival Outcomes in Patients with Cervical Carcinoma Undergoing Curative Chemoradiation Therapy</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kizer</surname>
<given-names>Nora T.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thaker</surname>
<given-names>Premal H.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gao</surname>
<given-names>Feng</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zighelboim</surname>
<given-names>Israel</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Powell</surname>
<given-names>Matthew A.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rader</surname>
<given-names>Janet S.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mutch</surname>
<given-names>David G.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grigsby</surname>
<given-names>Perry W.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO</aff>
<aff id="A2"><label>2</label>
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO</aff>
<aff id="A3"><label>3</label>
Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO</aff>
<aff id="A4"><label>4</label>
Mallinckrodt Institute of Radiology, Division of Nuclear Medicine, Washington University School of Medicine, St. Louis, MO</aff>
<aff id="A5"><label>5</label>
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO</aff>
<aff id="A6"><label>6</label>
Division of Gynecologic Oncology, Medical College of Wisconsin, Milwaukee, WI</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding Author: Perry W. Grigsby, MD, Washington University School of Medicine, 660 S. Euclid Ave Campus Box 8224, Saint Louis, MO 63110, <email>pgrisby@radonc.wustl.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>22</day>
<month>5</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>13</day>
<month>10</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><day>1</day>
<month>3</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>03</day>
<month>7</month>
<year>2014</year>
</pub-date>
<volume>117</volume>
<issue>5</issue>
<fpage>948</fpage>
<lpage>956</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/cncr.25544</pmc-comment>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">The effect of body mass index (BMI) on treatment outcomes for patients with locally advanced cervical carcinoma undergoing definitive chemoradiation is unclear.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">This study cohort included all cervical carcinoma patients (n = 404) with stage IB<sub>1</sub>
and positive lymph nodes or stage ≥ IB<sub>2</sub>
treated at our facility from January 1998 to January 2008. Mean follow-up time was 47.2 months. BMI was calculated using the National Institute of Health online calculator. BMI categories were created according to the World Health Organization classification system. Primary outcomes were overall survival, disease free survival, and complication rate. Univariate and multivariate analyses were performed. Kaplan-Meier survival curves were generated and compared using Cox proportional hazard models.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">On multivariate analysis, when compared to normal weight subjects (18.5-24.9 kg/m<sup>2</sup>
), a BMI < 18.5 kg/m<sup>2</sup>
was associated with decreased overall survival (HR 2.37, 95% CI 1.28 - 4.38, p<0.01). The 5-year overall survivals were 33%, 60%, and 68% for a BMI < 18.5 kg/m<sup>2</sup>
, BMI 18.5-24.9 kg/m<sup>2</sup>
, and a BMI > 24.9 kg/m<sup>2</sup>
respectively. A BMI < 18.5 kg/m<sup>2</sup>
was associated with increased risk for grade 3 or 4 complications when compared to patients with a BMI > 24.9 kg/m<sup>2</sup>
(radiation enteritis: 16.7% vs. 13.6 % p= 0.03, fistula: 11.1% vs. 8.8% p= 0.05, bowel obstruction 33.3% vs. 4.4% p< 0.001, lymphedema: 5.6% vs. 1.2% p=0.02).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Underweight patients (BMI < 18.5 kg/m<sup>2</sup>
) with locally advanced cervical cancer have diminished overall survival and more complications than normal weight and obese patients.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003369 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 003369 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:4080792 |texte= The Effects of Body Mass Index on Complications and Survival Outcomes in Patients with Cervical Carcinoma Undergoing Curative Chemoradiation Therapy }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:20945318" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |