PERSISTENCE OF BRUGIA MALAYI DNA IN VECTOR AND NON-VECTOR MOSQUITOES: IMPLICATIONS FOR XENOMONITORING AND TRANSMISSION MONITORING OF LYMPHATIC FILARIASIS
Identifieur interne : 003332 ( Pmc/Curation ); précédent : 003331; suivant : 003333PERSISTENCE OF BRUGIA MALAYI DNA IN VECTOR AND NON-VECTOR MOSQUITOES: IMPLICATIONS FOR XENOMONITORING AND TRANSMISSION MONITORING OF LYMPHATIC FILARIASIS
Auteurs : Peter Fischer ; Sara M. Erickson ; Kerstin Fischer ; Jeremy F. Fuchs ; Ramakrishna U. Rao ; Bruce M. Christensen ; Gary J. WeilSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 2007.
Abstract
Xenomonitoring (detection of filarial larvae or their DNA in mosquitoes) is a sensitive marker for assessing the endemicity of filariasis and a useful tool for evaluating elimination programs. To examine the fate of microfilariae (mf) and filarial DNA in vector competent and non-competent mosquito strains, we compared the detection of
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PubMed: 17360875
PubMed Central: 2196403
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">PERSISTENCE OF <italic>BRUGIA MALAYI</italic> DNA IN VECTOR AND NON-VECTOR MOSQUITOES: IMPLICATIONS FOR XENOMONITORING AND TRANSMISSION MONITORING OF LYMPHATIC FILARIASIS</title><author><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name></author><author><name sortKey="Erickson, Sara M" sort="Erickson, Sara M" uniqKey="Erickson S" first="Sara M." last="Erickson">Sara M. Erickson</name></author><author><name sortKey="Fischer, Kerstin" sort="Fischer, Kerstin" uniqKey="Fischer K" first="Kerstin" last="Fischer">Kerstin Fischer</name></author><author><name sortKey="Fuchs, Jeremy F" sort="Fuchs, Jeremy F" uniqKey="Fuchs J" first="Jeremy F." last="Fuchs">Jeremy F. Fuchs</name></author><author><name sortKey="Rao, Ramakrishna U" sort="Rao, Ramakrishna U" uniqKey="Rao R" first="Ramakrishna U." last="Rao">Ramakrishna U. Rao</name></author><author><name sortKey="Christensen, Bruce M" sort="Christensen, Bruce M" uniqKey="Christensen B" first="Bruce M." last="Christensen">Bruce M. Christensen</name></author><author><name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J." last="Weil">Gary J. Weil</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17360875</idno><idno type="pmc">2196403</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196403</idno><idno type="RBID">PMC:2196403</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">003333</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003333</idno><idno type="wicri:Area/Pmc/Curation">003332</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003332</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">PERSISTENCE OF <italic>BRUGIA MALAYI</italic> DNA IN VECTOR AND NON-VECTOR MOSQUITOES: IMPLICATIONS FOR XENOMONITORING AND TRANSMISSION MONITORING OF LYMPHATIC FILARIASIS</title><author><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name></author><author><name sortKey="Erickson, Sara M" sort="Erickson, Sara M" uniqKey="Erickson S" first="Sara M." last="Erickson">Sara M. Erickson</name></author><author><name sortKey="Fischer, Kerstin" sort="Fischer, Kerstin" uniqKey="Fischer K" first="Kerstin" last="Fischer">Kerstin Fischer</name></author><author><name sortKey="Fuchs, Jeremy F" sort="Fuchs, Jeremy F" uniqKey="Fuchs J" first="Jeremy F." last="Fuchs">Jeremy F. Fuchs</name></author><author><name sortKey="Rao, Ramakrishna U" sort="Rao, Ramakrishna U" uniqKey="Rao R" first="Ramakrishna U." last="Rao">Ramakrishna U. Rao</name></author><author><name sortKey="Christensen, Bruce M" sort="Christensen, Bruce M" uniqKey="Christensen B" first="Bruce M." last="Christensen">Bruce M. Christensen</name></author><author><name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J." last="Weil">Gary J. Weil</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><idno type="eISSN">1476-1645</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Xenomonitoring (detection of filarial larvae or their DNA in mosquitoes) is a sensitive marker for assessing the endemicity of filariasis and a useful tool for evaluating elimination programs. To examine the fate of microfilariae (mf) and filarial DNA in vector competent and non-competent mosquito strains, we compared the detection of <italic>Brugia malayi</italic> parasites by dissection and by quantitative real-time polymerase chain reaction (PCR) in three different mosquito strains. We conclude that PCR is much more sensitive than dissection for detecting filarial larvae, especially their remnants in mosquitoes. However, parasite DNA can be detected in both vector and non-vector mosquitoes for two weeks or longer after they ingest mf-positive blood. Thus, although xenomonitoring with vector and non-vector mosquito species may be a sensitive method for indirectly detecting filarial parasites in human populations, positive test results for parasite DNA in mosquitoes do not necessarily prove that transmission is ongoing in the study area.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370507</journal-id><journal-id journal-id-type="pubmed-jr-id">473</journal-id><journal-id journal-id-type="nlm-ta">Am J Trop Med Hyg</journal-id><journal-title>The American journal of tropical medicine and hygiene</journal-title><issn pub-type="ppub">0002-9637</issn><issn pub-type="epub">1476-1645</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17360875</article-id><article-id pub-id-type="pmc">2196403</article-id><article-id pub-id-type="manuscript">NIHMS36838</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>PERSISTENCE OF <italic>BRUGIA MALAYI</italic> DNA IN VECTOR AND NON-VECTOR MOSQUITOES: IMPLICATIONS FOR XENOMONITORING AND TRANSMISSION MONITORING OF LYMPHATIC FILARIASIS</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>FISCHER</surname><given-names>PETER</given-names></name><xref rid="FN1" ref-type="author-notes">*</xref><xref rid="FN2" ref-type="author-notes">†</xref></contrib><contrib contrib-type="author"><name><surname>ERICKSON</surname><given-names>SARA M.</given-names></name><xref rid="FN2" ref-type="author-notes">†</xref></contrib><contrib contrib-type="author"><name><surname>FISCHER</surname><given-names>KERSTIN</given-names></name></contrib><contrib contrib-type="author"><name><surname>FUCHS</surname><given-names>JEREMY F.</given-names></name></contrib><contrib contrib-type="author"><name><surname>RAO</surname><given-names>RAMAKRISHNA U.</given-names></name></contrib><contrib contrib-type="author"><name><surname>CHRISTENSEN</surname><given-names>BRUCE M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>WEIL</surname><given-names>GARY J.</given-names></name></contrib><aff id="A1">Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St. Louis, Missouri; Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison, Madison, Wisconsin</aff></contrib-group><author-notes><corresp id="FN1">* Address correspondence to Peter Fischer, Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8051, St. Louis, MO 63110. E-mail: <email>pufische@im.wustl.edu</email></corresp><fn id="FN2"><label>†</label><p>These authors contributed equally to the study.</p></fn><fn id="FN3"><p>Authors’ addresses: Peter Fischer, Kerstin Fischer, Ramakrishna U. Rao, and Gary J. Weil, Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, Campus Box 8051, 660 South Euclid Avenue, St. Louis, MO 63110, Fax: 314-454-5293, E-mails: <email>pufische@im.wustl.edu</email>, <email>kefische@im.wustl.edu</email>, <email>rrao@im.wustl.edu</email>, and <email>gweil@im.wustl.edu</email>. Sara M. Erickson, Jeremy F. Fuchs, and Bruce M. Christensen, Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, WI 53706, Fax: 608-262-7420, E-mails: <email>smerickson@wisc.edu</email>, <email>fuchs@svm.vetmed.wisc.edu</email>, and <email>christensen@svm.vetmed.wisc.edu</email>.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>1</month><year>2008</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2007</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>3</month><year>2008</year></pub-date><volume>76</volume><issue>3</issue><fpage>502</fpage><lpage>507</lpage><abstract><p id="P1">Xenomonitoring (detection of filarial larvae or their DNA in mosquitoes) is a sensitive marker for assessing the endemicity of filariasis and a useful tool for evaluating elimination programs. To examine the fate of microfilariae (mf) and filarial DNA in vector competent and non-competent mosquito strains, we compared the detection of <italic>Brugia malayi</italic> parasites by dissection and by quantitative real-time polymerase chain reaction (PCR) in three different mosquito strains. We conclude that PCR is much more sensitive than dissection for detecting filarial larvae, especially their remnants in mosquitoes. However, parasite DNA can be detected in both vector and non-vector mosquitoes for two weeks or longer after they ingest mf-positive blood. Thus, although xenomonitoring with vector and non-vector mosquito species may be a sensitive method for indirectly detecting filarial parasites in human populations, positive test results for parasite DNA in mosquitoes do not necessarily prove that transmission is ongoing in the study area.</p></abstract><contract-num rid="AI1">U19 AI065715-02</contract-num><contract-num rid="AI1">U19 AI065715-01</contract-num><contract-num rid="AI1">U01 AI035855-10S1</contract-num><contract-num rid="AI1">R01 AI019769-21</contract-num><contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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