THE COMBINATION OF AXILLARY ULTRASOUND AND ULTRASOUND-GUIDED BIOPSY IS AN ACCURATE PREDICTOR OF AXILLARY STAGE IN CLINICALLY NODE-NEGATIVE BREAST CANCER PATIENTS
Identifieur interne : 003325 ( Pmc/Curation ); précédent : 003324; suivant : 003326THE COMBINATION OF AXILLARY ULTRASOUND AND ULTRASOUND-GUIDED BIOPSY IS AN ACCURATE PREDICTOR OF AXILLARY STAGE IN CLINICALLY NODE-NEGATIVE BREAST CANCER PATIENTS
Auteurs : Dana M. Holwitt [États-Unis] ; Mary Ellen Swatske [États-Unis] ; William E. Gillanders [États-Unis] ; Barbara S. Monsees [États-Unis] ; Feng Gao [États-Unis] ; Rebecca L. Aft [États-Unis] ; Timothy J. Eberlein [États-Unis] ; Julie A. Margenthaler [États-Unis]Source :
- American journal of surgery [ 0002-9610 ] ; 2008.
Abstract
The study aim was to determine the accuracy of axillary ultrasound (AUS) and fine needle aspiration biopsy (FNAB)/needle core biopsy in axillary breast cancer staging.
We reviewed 256 patients with clinically node-negative breast cancer who underwent AUS +/− FNAB/needle core biopsy. AUS-guided FNAB/needle core biopsy was compared to histopathology to determine sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV).
AUS-guided FNAB/needle core biopsy and final pathology were positive in 72/256 patients (28%). In 125/256 cases (49%), the AUS and final pathology were negative. Two of 110 patients had a false positive FNAB (1.8%); both received neoadjuvant chemotherapy. Nine patients (8%) had a false negative FNAB/needle core biopsy; the median size of lymph node metastasis was 3 mm. The sensitivity and specificity of AUS-guided FNAB/needle core biopsy was 71% and 99%, with a NPV of 84% and PPV of 97%.
AUS-guided FNAB/needle core biopsy is accurate in predicting the status of the axilla in 70% of clinically node-negative breast cancer patients. This technique is minimally invasive with a low complication rate and can obviate the need for staged lymph node procedures.
Url:
DOI: 10.1016/j.amjsurg.2008.06.006
PubMed: 18723153
PubMed Central: 3892698
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">THE COMBINATION OF AXILLARY ULTRASOUND AND ULTRASOUND-GUIDED BIOPSY IS AN ACCURATE PREDICTOR OF AXILLARY STAGE IN CLINICALLY NODE-NEGATIVE BREAST CANCER PATIENTS</title>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The study aim was to determine the accuracy of axillary ultrasound (AUS) and fine needle aspiration biopsy (FNAB)/needle core biopsy in axillary breast cancer staging.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We reviewed 256 patients with clinically node-negative breast cancer who underwent AUS +/− FNAB/needle core biopsy. AUS-guided FNAB/needle core biopsy was compared to histopathology to determine sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">AUS-guided FNAB/needle core biopsy and final pathology were positive in 72/256 patients (28%). In 125/256 cases (49%), the AUS and final pathology were negative. Two of 110 patients had a false positive FNAB (1.8%); both received neoadjuvant chemotherapy. Nine patients (8%) had a false negative FNAB/needle core biopsy; the median size of lymph node metastasis was 3 mm. The sensitivity and specificity of AUS-guided FNAB/needle core biopsy was 71% and 99%, with a NPV of 84% and PPV of 97%.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">AUS-guided FNAB/needle core biopsy is accurate in predicting the status of the axilla in 70% of clinically node-negative breast cancer patients. This technique is minimally invasive with a low complication rate and can obviate the need for staged lymph node procedures.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370473</journal-id>
<journal-id journal-id-type="pubmed-jr-id">471</journal-id>
<journal-id journal-id-type="nlm-ta">Am J Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">Am. J. Surg.</journal-id>
<journal-title-group><journal-title>American journal of surgery</journal-title>
</journal-title-group>
<issn pub-type="ppub">0002-9610</issn>
<issn pub-type="epub">1879-1883</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">18723153</article-id>
<article-id pub-id-type="pmc">3892698</article-id>
<article-id pub-id-type="doi">10.1016/j.amjsurg.2008.06.006</article-id>
<article-id pub-id-type="manuscript">NIHMS542017</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>THE COMBINATION OF AXILLARY ULTRASOUND AND ULTRASOUND-GUIDED BIOPSY IS AN ACCURATE PREDICTOR OF AXILLARY STAGE IN CLINICALLY NODE-NEGATIVE BREAST CANCER PATIENTS</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Holwitt</surname>
<given-names>Dana M.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Swatske</surname>
<given-names>Mary Ellen</given-names>
</name>
<degrees>RN</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gillanders</surname>
<given-names>William E.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Monsees</surname>
<given-names>Barbara S.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gao</surname>
<given-names>Feng</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aft</surname>
<given-names>Rebecca L.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eberlein</surname>
<given-names>Timothy J.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Margenthaler</surname>
<given-names>Julie A.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Surgery, Washington University School of Medicine, St. Louis, MO</aff>
<aff id="A2"><label>2</label>
Department of Radiology, Washington University School of Medicine, St. Louis, MO</aff>
<aff id="A3"><label>3</label>
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO</aff>
<aff id="A4"><label>4</label>
Department of Surgery, John Cochran Veterans Hospital, St. Louis, MO</aff>
<author-notes><corresp id="cor1">Address Correspondence: Julie A. Margenthaler, MD, Department of Surgery-WUSM, 660 S. Euclid Ave., Campus Box 8109, St. Louis, MO 63110, Telephone – 314-747-9724, Fax – 314-454-5509, <email>margenthalerj@wudosis.wustl.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>3</day>
<month>1</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>8</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>1</month>
<year>2014</year>
</pub-date>
<volume>196</volume>
<issue>4</issue>
<fpage>477</fpage>
<lpage>482</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.amjsurg.2008.06.006</pmc-comment>
<permissions><copyright-statement>© 2013 Excerpta Medica, Inc. All rights reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">The study aim was to determine the accuracy of axillary ultrasound (AUS) and fine needle aspiration biopsy (FNAB)/needle core biopsy in axillary breast cancer staging.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We reviewed 256 patients with clinically node-negative breast cancer who underwent AUS +/− FNAB/needle core biopsy. AUS-guided FNAB/needle core biopsy was compared to histopathology to determine sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">AUS-guided FNAB/needle core biopsy and final pathology were positive in 72/256 patients (28%). In 125/256 cases (49%), the AUS and final pathology were negative. Two of 110 patients had a false positive FNAB (1.8%); both received neoadjuvant chemotherapy. Nine patients (8%) had a false negative FNAB/needle core biopsy; the median size of lymph node metastasis was 3 mm. The sensitivity and specificity of AUS-guided FNAB/needle core biopsy was 71% and 99%, with a NPV of 84% and PPV of 97%.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">AUS-guided FNAB/needle core biopsy is accurate in predicting the status of the axilla in 70% of clinically node-negative breast cancer patients. This technique is minimally invasive with a low complication rate and can obviate the need for staged lymph node procedures.</p>
</sec>
</abstract>
<kwd-group><kwd>Breast cancer</kwd>
<kwd>Axillary ultrasound (AUS)</kwd>
<kwd>Fine needle aspiration biopsy (FNAB)</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>P30 CA091842 || CA</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
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