Early Breast Cancer in the Older Woman
Identifieur interne : 003121 ( Pmc/Curation ); précédent : 003120; suivant : 003122Early Breast Cancer in the Older Woman
Auteurs : Sonal Gandhi [Canada] ; Sunil Verma [Canada]Source :
- The Oncologist [ 1083-7159 ] ; 2011.
Abstract
A literature review of recently published trials, reviews, and practice guidelines outlining the surgical and adjuvant management of early breast cancer in older women is presented.
Url:
DOI: 10.1634/theoncologist.2010-0279
PubMed: 21415085
PubMed Central: 3228114
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Early Breast Cancer in the Older Woman</title><author><name sortKey="Gandhi, Sonal" sort="Gandhi, Sonal" uniqKey="Gandhi S" first="Sonal" last="Gandhi">Sonal Gandhi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Verma, Sunil" sort="Verma, Sunil" uniqKey="Verma S" first="Sunil" last="Verma">Sunil Verma</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21415085</idno><idno type="pmc">3228114</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228114</idno><idno type="RBID">PMC:3228114</idno><idno type="doi">10.1634/theoncologist.2010-0279</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">003122</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003122</idno><idno type="wicri:Area/Pmc/Curation">003121</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003121</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Early Breast Cancer in the Older Woman</title><author><name sortKey="Gandhi, Sonal" sort="Gandhi, Sonal" uniqKey="Gandhi S" first="Sonal" last="Gandhi">Sonal Gandhi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Verma, Sunil" sort="Verma, Sunil" uniqKey="Verma S" first="Sunil" last="Verma">Sunil Verma</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Oncologist</title><idno type="ISSN">1083-7159</idno><idno type="eISSN">1549-490X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A literature review of recently published trials, reviews, and practice guidelines outlining the surgical and adjuvant management of early breast cancer in older women is presented.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Oncologist</journal-id><journal-id journal-id-type="iso-abbrev">Oncologist</journal-id><journal-id journal-id-type="pmc">oncologist</journal-id><journal-id journal-id-type="hwp">theoncologist</journal-id><journal-id journal-id-type="publisher-id">The Oncologist</journal-id><journal-title-group><journal-title>The Oncologist</journal-title></journal-title-group><issn pub-type="ppub">1083-7159</issn><issn pub-type="epub">1549-490X</issn><publisher><publisher-name>AlphaMed Press</publisher-name><publisher-loc>Durham, NC, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21415085</article-id><article-id pub-id-type="pmc">3228114</article-id><article-id pub-id-type="publisher-id">3685913</article-id><article-id pub-id-type="doi">10.1634/theoncologist.2010-0279</article-id><article-categories><subj-group subj-group-type="heading"><subject>Geriatric Oncology</subject></subj-group></article-categories><title-group><article-title>Early Breast Cancer in the Older Woman</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Gandhi</surname><given-names>Sonal</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Verma</surname><given-names>Sunil</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><aff id="aff1">Department of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada</aff></contrib-group><author-notes><corresp>Correspondence: Sonal Gandhi, B.Sc., M.D., F.R.C.P.C, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, T Wing Second Floor, Toronto, Ontario M4N 3M5, Canada. Telephone:
<phone>416-480-6100</phone>; Fax:
<fax>416-480-6002</fax>; e-mail: <email>sonal.gandhi@utoronto.ca</email></corresp><fn fn-type="conflict"><p><bold>Disclosures: Sonal Gandhi:</bold> None; <bold>Sunil Verma:</bold><italic>Honoraria:</italic> Novartis, Roche, GlaxoSmithKline, sanofi-aventis; <italic>Research funding/contracted research:</italic> sanofi-aventis, Roche.</p><p>The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. No financial relationships relevant to the content of this article have been disclosed by the independent peer reviewers.</p></fn></author-notes><pub-date pub-type="ppub"><month>4</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>17</day><month>3</month><year>2011</year></pub-date><volume>16</volume><issue>4</issue><fpage>479</fpage><lpage>485</lpage><history><date date-type="received"><day>20</day><month>8</month><year>2010</year></date><date date-type="accepted"><day>7</day><month>2</month><year>2011</year></date></history><permissions><copyright-statement>©AlphaMed Press</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="onc00411000479.pdf"></self-uri><abstract abstract-type="precis"><p>A literature review of recently published trials, reviews, and practice guidelines outlining the surgical and adjuvant management of early breast cancer in older women is presented.</p></abstract><abstract><sec><title>Background.</title><p>Women aged ≥65 are generally underrepresented in early breast cancer studies. Therefore, the optimal management of this group of women remains less certain.</p></sec><sec><title>Methods.</title><p>A literature review of recently published trials, reviews, and practice guidelines outlining the surgical and adjuvant management of early breast cancer in older women was performed.</p></sec><sec><title>Results.</title><p>Surgery remains as the cornerstone treatment for early breast cancer in the elderly. Adjuvant radiation is generally considered if the projected lifespan is >5 years. Hormone receptor–positive disease is best treated with adjuvant endocrine treatment; aromatase inhibitors and tamoxifen are both options. Evidence for the use of adjuvant chemotherapy and trastuzumab for high-risk disease in the elderly is more limited. Polychemotherapy is still preferred in fit older women. Certain toxicities from systemic treatments can be more pronounced and should be carefully managed. Treatment with systemic agents should be individualized, with consideration of patient preference, performance status, comorbidities, and projected lifespan. Molecular tumor signatures may help better select patients for treatment in the future.</p></sec><sec><title>Conclusions.</title><p>Age in itself should not be an absolute contraindication to any breast cancer therapy. Comprehensive, multidisciplinary assessment of elderly patients is imperative in evaluating eligibility for beneficial therapies.</p></sec></abstract><kwd-group><kwd>Breast neoplasms</kwd><kwd>Aged</kwd><kwd>Geriatrics</kwd><kwd>General surgery</kwd><kwd>Adjuvant chemotherapy</kwd><kwd>Adjuvant radiation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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